LOCUS       NM_001081170            5480 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus phosphofurin acidic cluster sorting protein 2 (Pacs2),
            transcript variant 2, mRNA.
ACCESSION   NM_001081170 XM_203601
VERSION     NM_001081170.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5480)
  AUTHORS   Krzysiak,T.C., Choi,Y.J., Kim,Y.J., Yang,Y., DeHaven,C.,
            Thompson,L., Ponticelli,R., Mermigos,M.M., Thomas,L., Marquez,A.,
            Sipula,I., Kemper,J.K., Jurczak,M., Thomas,G. and Gronenborn,A.M.
  TITLE     Inhibitory protein-protein interactions of the SIRT1 deacetylase
            are choreographed by post-translational modification
  JOURNAL   Protein Sci 33 (4), e4938 (2024)
   PUBMED   38533551
REFERENCE   2  (bases 1 to 5480)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5480)
  AUTHORS   Liu,S., Han,S., Wang,C., Chen,H., Xu,Q., Feng,S., Wang,Y., Yao,J.,
            Zhou,Q., Tang,X., Lin,L., Hu,L., Davidson,A.J., Yang,B., Ye,C.,
            Yang,F., Mao,J., Tong,C., Chen,J. and Jiang,H.
  TITLE     MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in
            Diabetic Kidney Disease via the PACS-2-Dependent Mechanism
  JOURNAL   Int J Biol Sci 20 (2), 569-584 (2024)
   PUBMED   38169625
  REMARK    GeneRIF: MAPK1 Mediates MAM Disruption and Mitochondrial
            Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent
            Mechanism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5480)
  AUTHORS   Yang,J., Li,L., Li,C., Chen,W., Liu,Y., Luo,S., Zhao,C., Han,Y.,
            Yang,M., Zhao,H., Jiang,N., Xi,Y., Tang,C., Cai,J., Xiao,L., Liu,H.
            and Sun,L.
  TITLE     PACS-2 deficiency aggravates tubular injury in diabetic kidney
            disease by inhibiting ER-phagy
  JOURNAL   Cell Death Dis 14 (10), 649 (2023)
   PUBMED   37794057
  REMARK    GeneRIF: PACS-2 deficiency aggravates tubular injury in diabetic
            kidney disease by inhibiting ER-phagy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5480)
  AUTHORS   Yang,J., Sun,M., Chen,R., Ye,X., Wu,B., Liu,Z., Zhang,J., Gao,X.,
            Cheng,R., He,C., He,J., Wang,X. and Huang,L.
  TITLE     Mitochondria-associated membrane protein PACS2 maintains right
            cardiac function in hypobaric hypoxia
  JOURNAL   iScience 26 (4), 106328 (2023)
   PUBMED   36968068
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5480)
  AUTHORS   Barroso-Gonzalez,J., Auclair,S., Luan,S., Thomas,L., Atkins,K.M.,
            Aslan,J.E., Thomas,L.L., Zhao,J., Zhao,Y. and Thomas,G.
  TITLE     PACS-2 mediates the ATM and NF-kappaB-dependent induction of
            anti-apoptotic Bcl-xL in response to DNA damage
  JOURNAL   Cell Death Differ 23 (9), 1448-1457 (2016)
   PUBMED   26943323
  REMARK    GeneRIF: PACS-2 coordinates p53/p21- dependent cell cycle arrest
            with NF-kappaB/Bcl-xL-dependent pro-survival signaling to support
            DNA repair in response to genotoxic damage.
REFERENCE   7  (bases 1 to 5480)
  AUTHORS   Dombernowsky,S.L., Samsoe-Petersen,J., Petersen,C.H., Instrell,R.,
            Hedegaard,A.M., Thomas,L., Atkins,K.M., Auclair,S., Albrechtsen,R.,
            Mygind,K.J., Frohlich,C., Howell,M., Parker,P., Thomas,G. and
            Kveiborg,M.
  TITLE     The sorting protein PACS-2 promotes ErbB signalling by regulating
            recycling of the metalloproteinase ADAM17
  JOURNAL   Nat Commun 6, 7518 (2015)
   PUBMED   26108729
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5480)
  AUTHORS   Atkins,K.M., Thomas,L.L., Barroso-Gonzalez,J., Thomas,L.,
            Auclair,S., Yin,J., Kang,H., Chung,J.H., Dikeakos,J.D. and
            Thomas,G.
  TITLE     The multifunctional sorting protein PACS-2 regulates SIRT1-mediated
            deacetylation of p53 to modulate p21-dependent cell-cycle arrest
  JOURNAL   Cell Rep 8 (5), 1545-1557 (2014)
   PUBMED   25159152
  REMARK    GeneRIF: CS-2 traffics to the nucleus where it regulates
            SIRT1-mediated p53 deacetylation.  PACS-2 binds SIRT1 in vitro and
            directly inhibits SIRT1-catalyzed p53 deacetylation.
REFERENCE   9  (bases 1 to 5480)
  AUTHORS   Aslan,J.E., You,H., Williamson,D.M., Endig,J., Youker,R.T.,
            Thomas,L., Shu,H., Du,Y., Milewski,R.L., Brush,M.H., Possemato,A.,
            Sprott,K., Fu,H., Greis,K.D., Runckel,D.N., Vogel,A. and Thomas,G.
  TITLE     Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates
            membrane traffic with TRAIL-induced apoptosis
  JOURNAL   Mol Cell 34 (4), 497-509 (2009)
   PUBMED   19481529
  REMARK    GeneRIF: Results identify PACS-2 as an essential TRAIL effector,
            and show that Akt cooperates with 14-3-3 to regulate the
            homeostatic and apoptotic properties of PACS-2 that mediate TRAIL
            action.
REFERENCE   10 (bases 1 to 5480)
  AUTHORS   Atkins,K.M., Thomas,L., Youker,R.T., Harriff,M.J., Pissani,F.,
            You,H. and Thomas,G.
  TITLE     HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that
            triggers major histocompatibility complex class I (MHC-I)
            down-regulation: analysis using short interfering RNA and knock-out
            mice
  JOURNAL   J Biol Chem 283 (17), 11772-11784 (2008)
   PUBMED   18296443
  REMARK    GeneRIF: PACS-2 is required for Nef action and sorting of itinerant
            membrane cargo in the TGN/endosomal system
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073562.6.
            
            On Feb 6, 2007 this sequence version replaced XM_203601.7.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the coding region compared to variant 1. The resulting protein
            (isoform 2) is shorter but has the same N- and C-termini compared
            to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AC073562.6         128078-128252       c
            176-263             AC073562.6         98447-98534         c
            264-353             AC073562.6         97193-97282         c
            354-479             AC073562.6         95606-95731         c
            480-642             AC073562.6         92791-92953         c
            643-716             AC073562.6         92170-92243         c
            717-797             AC073562.6         91799-91879         c
            798-857             AC073562.6         90470-90529         c
            858-1015            AC073562.6         85793-85950         c
            1016-1106           AC073562.6         82947-83037         c
            1107-1184           AC073562.6         82600-82677         c
            1185-1327           AC073562.6         81989-82131         c
            1328-1460           AC073562.6         81555-81687         c
            1461-1565           AC073562.6         81016-81120         c
            1566-1672           AC073562.6         80805-80911         c
            1673-1827           AC073562.6         80159-80313         c
            1828-1938           AC073562.6         79318-79428         c
            1939-2047           AC073562.6         78822-78930         c
            2048-2090           AC073562.6         74641-74683         c
            2091-2133           AC073562.6         73738-73780         c
            2134-2275           AC073562.6         73337-73478         c
            2276-2502           AC073562.6         72477-72703         c
            2503-2616           AC073562.6         71979-72092         c
            2617-5480           AC073562.6         68359-71222         c
FEATURES             Location/Qualifiers
     source          1..5480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.57 cM"
     gene            1..5480
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /note="phosphofurin acidic cluster sorting protein 2"
                     /db_xref="GeneID:217893"
                     /db_xref="MGI:MGI:1924399"
     exon            1..175
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            176..263
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            264..353
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            354..479
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            480..642
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            643..716
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            717..797
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            798..857
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1015
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1106
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1184
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1327
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1460
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1565
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1672
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1827
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1938
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2047
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2090
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2133
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2275
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2502
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2616
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..5480
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5436..5441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /note="hexamer: AATAAA"
     polyA_site      5472
                     /gene="Pacs2"
                     /gene_synonym="6720425G15Rik; E230011J22; mKIAA0602;
                     Pacs1l"
                     /note="major polyA site"
ORIGIN      
        1 gcgctcccgc ggcccggcgc agccccaggc cgccgaggga cggcggggcc ggcgccatgg
       61 ccgagcgggg ccgcctcggc ctgcccggcg cgcccggagc gctcaacact ccggtgccca
      121 tgaacctgtt tgccacctgg gaggtggacg gctccagccc cagctgcgtg cccaggttgt
      181 gtagcctgac cctgaagaag ctggcagtgc tccgggaact ggaaaaagaa ctcctgtccg
      241 tggtgattgc cgtcaagatg cagggttcca agcgtgtctt gagatcacat gagattgtgt
      301 tgcctcctag tggacaagtg gaaactgacc tggctctgac cttctctctc cagtaccccc
      361 acttcctgaa gcgggaaggc aacaagctgc agatcatgct acagcgcagg aagcggtaca
      421 agaacaggac gatcctgggc tacaaaacgc tggccgcggg ctccatcaac atggctgagg
      481 tgatgcagca cccctctgag ggcggccaag ttctgagcct ctgcagcagc atcaaagagg
      541 cctctgtcaa ggtggccgag atctggatcg tctccctgtc cagccagccc atcgaccatg
      601 aggatagtgc catgcaggct ggccccaaga ccaagtccac agataactac tctgaggagg
      661 agtatgagag cttttcctct gaacaagaag ccagtgacga tgctgtacaa gggcaggatc
      721 ttgacgagga cgactttgat gtgggaaaac ccaagaagca gcggcgctcg atagtaagaa
      781 cgacgtccat gaccaggcaa cagaacttca agcagaaggt ggtggcgcta ctgcgcaggt
      841 tcaaggtgtc agaggaggtc ttggattcgg agcaggaccc tgcagaacat gttcccgagg
      901 tggaggagga cctggatctt ctctatgaca cgctggatgt ggagaacccc agcgacagtg
      961 gccctgacat ggatgacgat gacagtgtcc ttagcacccc caagcccaag ctcaggcctt
     1021 acttcgaagg cctgtctcac tccagctcac agacagagat agggagcatc cacagtgccc
     1081 ggagccacag ggagcctcca agcccggctg atgtacctga gaagacgcga tccctgggag
     1141 gcaagcagca gctcagcgac agcgtctctg acacggtggc ccttagtgca gcagtccccc
     1201 gggaaccatc agggcaacct gaggacagcc cagaggctga gacctccacc ttagatgtgt
     1261 tcaccgagaa gctgcctccc agtggaagaa tcatcaagac tgagtcactt gtcatcccct
     1321 ccaccaggtc agaatcaaag ccggccggcc gccggggccg gagcacatcc ctgaaggagc
     1381 gacagcctgc tcggccacag aatgaacggg ccaacagcct agacaatgag cgctgtccag
     1441 acacgaggag ccagcttcag attcccagga aaactgtgta tgaccaattg aaccacatcc
     1501 tcatctctga tgaccaactc cccgagaata tcattctcgt caacacctct gactggcagg
     1561 gacagttcct ctcagatgtc ctgcagaagc atacacttcc tgtggtctgc acgtgctctg
     1621 ctgctgacgt gcaggctgcc ttcagcacca ttgtctctcg gatacagcga tactgcaact
     1681 gcaattctca gccaccgacc cctgtgaaga tcgcagtggc gggagcgcag cattacctca
     1741 gcgccatcct gcggctcttc gtggagcagc tgtctcacaa gacacctgac tggctcggct
     1801 acatgcgctt cctcatcatc ccactgggct cccaccccgt ggccaggtac ctgggctctg
     1861 tggactaccg ctacaacaac ttcttccagg atctggcctg gagagacctg ttcaacaagc
     1921 tggaagccca gagcagtgtg caggacacac cagacatcgt gtcacgcatc acccagtaca
     1981 tctcaggagc caactgtgct caccagctcc ccatcgcaga ggccatgctg acctacaagc
     2041 agaagagccc tgatgaagaa tcctctcaga ggttcattcc ctttgtcggg gttgtgaagg
     2101 ttggaatcgt ggaaccatct tcagccacat caggagactc tgacgacgca gccccctcaa
     2161 gctccagcat actctcttct accccaccgt ctgcatctac atctccggcg gccaaggagg
     2221 cttcgcctac cccaccctcc tccccttcag tgagtggagg cctgtcctcc cccagccagg
     2281 gcgtcggtgc tgagctcatg gggctgcagg tggactactg gacagcagcg cagcctgcgg
     2341 acaggaagag agatgccgag aagaaggaca tgcccaccac caaaaacacg ctcaagtgca
     2401 ctttccggtc cctccaggtc agcaggctgc ccagcagtgg tgaggctgca gccacaccca
     2461 ccatgtccat gactgtcgtc accaaggaga agaacaagaa ggtgatgttt ttgcccaaga
     2521 aaacaaagga caaggaagtg gaatccaaaa gccagtgcat cgagggcatc agccggctga
     2581 tctgcacagc taagcaccaa cagaacatgc ttcgggtcct catcgacggc gtggaatgca
     2641 gcgatgtcaa gttcttccag ctggctgccc agtggtcttc tcacgtgaag cacttcccca
     2701 tctgcatctt tggacactcc aaagccacct tctagcccca cccacggaag ggctgacact
     2761 ggacagtgac tctgtgccag ccattgatgg agggacagct gtatttctgt taacacgtgg
     2821 ttactacaga gacagactct taaaaacaca aagaaacagt cttaagtatg aatgtgctca
     2881 tagcccagct agctccctgt gggccactga gtaactttgc tcggcttact aaccagaata
     2941 tgtgggcaag tggaaaggct ggtaagaaag gaggtgaact ctggtcccat gaaagcccag
     3001 accacaagca agaaatgttc ttgcctttgt atcctgccct ttgctgacgt caggattctg
     3061 cttcctcagg gagtagggag cacggggagc tttggagttt agtggccaga agctaaaggt
     3121 caagggcatg tttgctctcc tagcatgaga tgtcagtccc tggcacccca tgcgtggttc
     3181 ccaataaact ccagcctcat ggcggaggtt ttatagtagc agatctttct aatgctctca
     3241 aatacatttg acaacgtagc tgccaagcag atgttgctct tgtgaagtcc ccttgctggg
     3301 gcagagccag caggagctgc atccctaccc tacccctgtg gctcccattc cacgggcacc
     3361 tttaggcttc tgctgctcag atcgggtggt cctttcatat gttccagtgt ccgtcctgga
     3421 aatgggagac acttctgggg tctgtctgag cccttccctc tattctgctt gctggacagg
     3481 atcatccagg attggccatg tgggatctga gctgagaatt gaggttgtaa actggaaaca
     3541 ggcatctaga ggttgtgtgt gtgtgccatg tgggatctga gctgagaatt gaggttgtaa
     3601 actggaaaca ggcatctaga ggttgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3661 gtgtgtgtgt gtgtgtgtgt gtgtgagaga gagagagaga gagatttgtt tgtagcccgt
     3721 gaaggctcca gcatgctggt ctgactacaa aggccacctc ccttacagga ctaggtctag
     3781 ccaagccaag ctcctcatag ccacctggat ctggttcttg gtggcagctc caccattttc
     3841 ccatccaact tgaaagggtt gtgctggtgt ccgacagctc aggtcatcct ggctgtacac
     3901 gctccaccag actcatgaag gggtcactgc ctcagtccta attttcttaa gaatcctttc
     3961 tccccgaggt atctaattag aagagttcct gtcaccctgg aagctagggc tctctcgggg
     4021 gctctggtgg tccattggga agcatggtgt ctgaagaatg gtgtctcgac cttgagacct
     4081 tcctaagagt atgttgagaa aattgtcgag agcaggacag gctgagtttg aggactgctc
     4141 gcccttcctg gggtgaaaga tggcaggttt ttatttactt acctccctta ttgacttgct
     4201 gaacagggtc tatttgtcct ggataatagg tccccaggtc cctgggtcca gggcttctta
     4261 gtggaactcc tggtgaggta ttctctgaaa agatcttgtg ctgagtcagg ccactgtaat
     4321 ccttggagcc taagagccta gtttacctgc cccttgtgtt ttttcccaaa agtcaacctt
     4381 catatgaaac atttgaccta gatttctagc cttgaggcca caggggttca agctcttgcc
     4441 tgagggcagc ccttttccag aaccttcccc tgtacatacg tgctccttcc ttgactggtt
     4501 ccaggggtct gactttacac acacaagagg aaggtgtagg cagcgtcttt gtcccacagc
     4561 tggcccaggg tggagtcagg aaagcctagc acctgagcac catacacctt ccccccaacc
     4621 cccaccatgg cagtgctagg tgcagaccta gacagcagtc cttcctccct gtgcctcact
     4681 cccccagtgg ttagagagat ggtccatttt ccttgcctac ctcatggagc tgtaatgaga
     4741 agtcatggag aagcactttg tccctttgaa ggatgacacc aaagcccccc tgacaggcag
     4801 tgcagtggta cgaaccgcag agtgtgtttg catccgaagc tctgaggcat caccctcaga
     4861 gcctgccagt cttagaggtc cctgtcaagc aacaccagtt gccattgctc attgctgtca
     4921 gttgggggcc ctgcctctac cttcaagttg gttcctgcca ccaccctctg agtacgcagc
     4981 tcagtatcac tgtaaaggta ccagtgctgg gaggtggggg tggggaggcg tggggaggcg
     5041 ggaggctcag ccctgaagca atggcttgcc ctagccttat cctgcaagcc tcacttcttc
     5101 ctctagcctc catctcaaat gaattccgca taaaaacgtc ctggcacttc tccccagggc
     5161 cagggtactt gctccctaaa tccctgtgcc cttcagagac tgctctgtcc tggaaggggg
     5221 ccagcagaag ctgacagcct tgcgtgagga tgactccgtt cgcttctgca gactgcccag
     5281 cgcgctgtga ctgatttcta gagtgtgtat gttgctagtt ttgtttttgt ttttttaata
     5341 aaaagcagga ttcatgtaaa tagctttttt tgggagcaga tactgatctg tcccatgcga
     5401 ccatgtggac gatttcaagg tgctgaagcg acactaataa actgacggcg ctcaggccgc
     5461 ccactgctgt gatttctctg
//
