LOCUS       NM_001403567            4410 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus phosphofurin acidic cluster sorting protein 1 (Pacs1),
            transcript variant 3, mRNA.
ACCESSION   NM_001403567
VERSION     NM_001403567.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4410)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4410)
  AUTHORS   Villar-Pazos,S., Thomas,L., Yang,Y., Chen,K., Lyles,J.B.,
            Deitch,B.J., Ochaba,J., Ling,K., Powers,B., Gingras,S.,
            Kordasiewicz,H.B., Grubisha,M.J., Huang,Y.H. and Thomas,G.
  TITLE     Neural deficits in a mouse model of PACS1 syndrome are corrected
            with PACS1- or HDAC6-targeting therapy
  JOURNAL   Nat Commun 14 (1), 6547 (2023)
   PUBMED   37848409
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4410)
  AUTHORS   Villar-Pazos,S., Thomas,L., Yang,Y., Chen,K., Lyles,J.B.,
            Deitch,B.J., Ochaba,J., Ling,K., Powers,B., Gingras,S.,
            Kordasiewicz,H.B., Grubisha,M.J., Huang,Y.H. and Thomas,G.
  TITLE     RNA-targeted therapy corrects neuronal deficits in PACS1 syndrome
            mice
  JOURNAL   Res Sq (2023)
   PUBMED   36747781
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4410)
  AUTHORS   Nair-Gill,E., Bonora,M., Zhong,X., Liu,A., Miranda,A., Stewart,N.,
            Ludwig,S., Russell,J., Gallagher,T., Pinton,P. and Beutler,B.
  TITLE     Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence
            and lymphoproliferative diseases
  JOURNAL   EMBO J 40 (9), e104888 (2021)
   PUBMED   33630350
  REMARK    GeneRIF: Calcium flux control by Pacs1-Wdr37 promotes lymphocyte
            quiescence and lymphoproliferative diseases.
REFERENCE   5  (bases 1 to 4410)
  AUTHORS   Dirk,B.S., End,C., Pawlak,E.N., Van Nynatten,L.R., Jacob,R.A.,
            Heit,B. and Dikeakos,J.D.
  TITLE     PACS-1 and adaptor protein-1 mediate ACTH trafficking to the
            regulated secretory pathway
  JOURNAL   Biochem Biophys Res Commun 507 (1-4), 519-525 (2018)
   PUBMED   30458990
  REMARK    GeneRIF: the roles of the phosphofurin acidic cluster sorting
            protein - 1 (PACS-1) and the clathrin adaptor protein 1 (AP-1) in
            the targeting of Pro-opiomelanocortin to dense core secretory
            granules.
REFERENCE   6  (bases 1 to 4410)
  AUTHORS   Burgert,T., Schmidt,V., Caglayan,S., Lin,F., Fuchtbauer,A.,
            Fuchtbauer,E.M., Nykjaer,A., Carlo,A.S. and Willnow,T.E.
  TITLE     SORLA-dependent and -independent functions for PACS1 in control of
            amyloidogenic processes
  JOURNAL   Mol Cell Biol 33 (21), 4308-4320 (2013)
   PUBMED   24001769
REFERENCE   7  (bases 1 to 4410)
  AUTHORS   Schermer,B., Hopker,K., Omran,H., Ghenoiu,C., Fliegauf,M.,
            Fekete,A., Horvath,J., Kottgen,M., Hackl,M., Zschiedrich,S.,
            Huber,T.B., Kramer-Zucker,A., Zentgraf,H., Blaukat,A., Walz,G. and
            Benzing,T.
  TITLE     Phosphorylation by casein kinase 2 induces PACS-1 binding of
            nephrocystin and targeting to cilia
  JOURNAL   EMBO J 24 (24), 4415-4424 (2005)
   PUBMED   16308564
  REMARK    GeneRIF: casein kinase 2 induces PACS-1 binding of nephrocystin and
            targeting to cilia
REFERENCE   8  (bases 1 to 4410)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4410)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 4410)
  AUTHORS   Wan,L., Molloy,S.S., Thomas,L., Liu,G., Xiang,Y., Rybak,S.L. and
            Thomas,G.
  TITLE     PACS-1 defines a novel gene family of cytosolic sorting proteins
            required for trans-Golgi network localization
  JOURNAL   Cell 94 (2), 205-216 (1998)
   PUBMED   9695949
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125059.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1079418.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164139 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-572               AC125059.4         35250-35821
            573-660             AC125059.4         140349-140436
            661-750             AC125059.4         147553-147642
            751-876             AC125059.4         148267-148392
            877-939             AC125059.4         150749-150811
            940-1084            AC125059.4         151859-152003
            1085-1176           AC125059.4         152413-152504
            1177-1257           AC125059.4         152591-152671
            1258-1317           AC125059.4         154637-154696
            1318-1478           AC125059.4         155540-155700
            1479-1587           AC125059.4         155993-156101
            1588-1668           AC125059.4         161153-161233
            1669-1784           AC125059.4         163174-163289
            1785-1920           AC125059.4         163425-163560
            1921-2025           AC125059.4         164481-164585
            2026-2132           AC125059.4         164903-165009
            2133-2287           AC125059.4         165690-165844
            2288-2398           AC125059.4         166006-166116
            2399-2501           AC125059.4         166651-166753
            2502-2544           AC125059.4         167158-167200
            2545-2587           AC125059.4         169038-169080
            2588-2723           AC125059.4         169295-169430
            2724-2950           AC125059.4         171441-171667
            2951-3070           AC125059.4         173121-173240
            3071-4410           AC125059.4         173335-174674
FEATURES             Location/Qualifiers
     source          1..4410
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.25 cM"
     gene            1..4410
                     /gene="Pacs1"
                     /note="phosphofurin acidic cluster sorting protein 1"
                     /db_xref="GeneID:107975"
                     /db_xref="MGI:MGI:1277113"
     exon            1..572
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..3186
                     /gene="Pacs1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     cytosolic sorting protein PACS-1"
                     /codon_start=1
                     /product="phosphofurin acidic cluster sorting protein 1
                     isoform 3"
                     /protein_id="NP_001390496.1"
                     /db_xref="GeneID:107975"
                     /db_xref="MGI:MGI:1277113"
                     /translation="MAERGGAGGGPGGSGGGSSQRGSGVAQSPQQQPQQQPPQPQQPT
                     PPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGPGPGRTPAPVQMNLY
                     ATWEVDRSSSSCVPRLFSLTLKKLVMLKEMDKDLNSVVIAVKLQGSKRILRSNEIILP
                     ASGLVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKNRTILGYKTLAVGLINMAE
                     YSYVSKTKKKEAARQLFKLFLVMQHPNEGALVLGLHSNVKDVSVPVAEIKIYSLSSQP
                     IDHEGIKSKLSDRSPDIDNYSEEEEESFSSEQEGSDDPLHGQDLFYEDEDLRKVKKTR
                     RKLTSTSAITRQPNIKQKFVALLKRFKVSDEVGFGLEHVSREQIREVEEDLDELYDSL
                     EMYNPSDSGPEMEETESILSTPKPKLKPFFEGMSQSSSQTEIGSLNSKGSLGKDTTSP
                     VSRTMMELAALEKVKSTWIKNQDDSLTETDTLEITDQDMFGDVSTSLVVPEKVKTPMK
                     SSKADLQGSASPSKVEGTHTPRQKRSTPLKERQLSKPLSERTNSSDSERSPDLGHSTQ
                     IPRKVVYDQLNQILVSDAALPENVILVNTTDWQGQYVAELLQDQRKPVVCTCSTVEVQ
                     AVLSALLTRIQRYCNCNSSMPRPVKVAAVGSQSYLSSILRFFVKSLASKTPDWLGYMR
                     FLIIPLGSHPVAKYLGSVDSRYSSTFLDSAWRDLFSRSEPPVSEPLDVVGRVMQYVNG
                     ATTTHQLPVAEAMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSPSTAGDGDDSPVVS
                     LTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPG
                     ERRREGDKRDASSKNTLKSVFRSVQVSRLPHAGEAQLSGTMAMTVVTKEKNKKVPTIF
                     LSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKFFQLAAQWPTH
                     VKHFPVGLFSGSKTT"
     exon            573..660
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..750
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..876
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..939
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1084
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1176
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1257
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1317
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1478
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1587
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1668
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1784
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1920
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2025
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2132
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2287
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2398
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2501
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2544
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2587
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2723
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2950
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3070
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..4410
                     /gene="Pacs1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4387..4392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pacs1"
                     /note="hexamer: AATAAA"
     polyA_site      4410
                     /gene="Pacs1"
                     /note="major polyA site"
ORIGIN      
        1 agtgtctggg cctcgcgggc cgcaacaggc ggcggcgggc gagcgcgagg accgcgcgca
       61 gcgaaagccc gcgcgtgcgt gcagattcgc tggtggctcg cgctccgccg ggcgttctga
      121 ggagacgcgc tgagccgctg ccgccgcggg gggaagcctg agagtcgctc gcgtgccctc
      181 agtctgcgta agccccgcgc cccttcctcc cctggccagg ccatggcgga acgcggaggg
      241 gcgggcggtg gtcccggagg ctccgggggc ggcagcagtc agcggggctc tggggtcgcc
      301 cagtccccgc agcagcagcc gcagcagcag ccgccgcagc ctcaacagcc gacgcccccc
      361 aagctggccc aggccacctc gtcctcctcg tccacctcgg ctgcggccgc ctcctcctcg
      421 tcctcctcca cctccacctc catggccgtc gcggtggcct cgggctctgc gcctccgggc
      481 ggtccaggac caggccgcac ccccgcccca gtgcagatga atttgtatgc tacctgggag
      541 gtggaccgga gctcatccag ctgcgtgccc aggctcttca gcttaactct gaagaaactt
      601 gttatgctta aagaaatgga caaagatctt aactcagtag tcattgctgt gaagctgcag
      661 ggttcaaaaa ggattcttcg ctccaatgag atcatccttc cagccagtgg cctggtggag
      721 acagagctcc agttaacctt ctccctccag taccctcatt tccttaagcg agatgccaac
      781 aaactgcaga ttatgttgca aaggaggaag cggtacaaga accgaactat cttgggctat
      841 aaaaccttag ctgtgggact catcaacatg gcagagtact cctatgtgtc aaagacaaag
      901 aagaaagagg ctgcaagaca gctttttaaa ttatttctgg tgatgcaaca ccctaatgag
      961 ggcgctttag tacttggcct gcacagcaat gtgaaggatg tctctgtgcc agtggcagaa
     1021 ataaaaatct actctttatc cagccagccc attgaccatg aaggaatcaa gtctaagctg
     1081 tctgatcgct ccccagatat tgacaactac tctgaagaag aggaggaaag cttctcctca
     1141 gagcaggaag gcagtgacga cccattgcat gggcaggacc tattctatga agatgaagat
     1201 cttcggaaag taaagaagac tcggaggaaa ctgacctcaa cctcagccat cactaggcaa
     1261 cctaacatca aacagaagtt tgtggccctc ctgaaacgat tcaaagtttc tgacgaggtg
     1321 ggctttgggc tagaacacgt gtcccgggag cagattcggg aagtggagga ggacttggat
     1381 gaactgtacg acagtctaga gatgtacaac cccagcgaca gtggccctga gatggaggaa
     1441 acagaaagca tcctcagcac cccaaagccc aagctcaagc ccttctttga ggggatgtct
     1501 cagtccagct cacagacgga gattggcagt ctcaacagca agggcagcct cgggaaagac
     1561 accaccagtc ctgtgagcag aacgatgatg gagttggctg ctttagaaaa agtcaaatct
     1621 acctggatta aaaaccaaga tgacagcttg actgaaacag acactttaga aatcactgac
     1681 caggacatgt ttggagatgt gagcacaagt ctggttgtac cagaaaaagt caaaactcct
     1741 atgaagtcca gcaaagctga tctgcagggc tctgcctctc ccagcaaggt ggaagggaca
     1801 cacacacctc ggcagaagag gagcactccc ctgaaggagc gacagctctc caagcccctg
     1861 agtgagagaa ccaacagctc tgacagtgag cgatctcctg atctgggcca cagcacacag
     1921 attccaagga aggtggtata cgaccaactg aatcagatcc tggtatcgga tgcagccctc
     1981 cctgaaaatg tcatcctggt gaacaccaca gactggcagg gccagtacgt ggctgaattg
     2041 cttcaagacc agaggaagcc tgtggtatgc acctgctcaa cagtggaggt ccaggcagtg
     2101 ctgtccgccc ttctcactag gattcagcgc tactgcaact gcaactcatc catgccgagg
     2161 ccggtcaagg tggcagctgt gggcagccag agctacctga gctccatcct ccgttttttt
     2221 gtcaagtccc ttgccagcaa gaccccagac tggctgggtt acatgcgctt cctcatcatt
     2281 cccctaggtt ctcatccagt ggccaaatac ttgggctcag tagatagtag atatagcagc
     2341 acctttcttg attctgcctg gagagaccta ttcagtcgct cagagcctcc agtgtcagag
     2401 ccactggacg tggtgggtcg tgtgatgcag tatgtcaatg gagctaccac aacacaccag
     2461 ctgcctgtgg ctgaagccat gttgacctgc aggcataagt tccctgatga ggactcctac
     2521 cagaagttca tccccttcat tggcgttgtg aaagtgggcc ttgttgaaga ctcgccctcc
     2581 actgcaggtg atggggacga ttcacctgtg gtcagcctta ctgtgccctc cacatcacca
     2641 ccctcaagct caggcctgag ccgagatgcc acagctaccc ctccctcgtc cccatccatg
     2701 agcagtgccc tcgccatcgt ggggagccca aatagcccat atggggatgt gattggtctc
     2761 caggtggact actggctggg ccaccctggg gagcgaagga gagaaggtga taagagggat
     2821 gccagctcaa agaacaccct caagagtgtc ttccgctcgg tgcaggtttc tcgcctgcca
     2881 catgcagggg aagcccagct ttctggcacc atggcaatga ctgtggtcac caaagagaag
     2941 aacaagaaag tgcccactat cttcctgagc aagaagcccc gagaaaagga ggtggattct
     3001 aagagccagg tcatcgaggg catcagccgc ctcatctgtt ctgcaaagca gcagcaaacc
     3061 atgctgagag tgtccatcga tggagttgag tggagtgaca tcaagttctt ccagctggca
     3121 gcccagtggc caactcatgt caagcacttt ccagtgggac tcttcagtgg cagcaagacc
     3181 acctgagacc ctgcctccca accactccct cctggcactg ccacccagcc tcaccacctg
     3241 caggcagggg aaggccagca agccccagcc cagcctccct ttcccagcac tggggcttgt
     3301 ctctacacac ccagtcctaa aggacactgc cactggggat acagccctcc cctctcactg
     3361 cccagcccat ctctggacta cccttcctcc tgttccaggc ccagagctgg gtggtcctga
     3421 ctctggtacc cataatccct gtaattgaat actctgggcc ttccttcacc tcactcaccc
     3481 ctgcagcact ggtacccttt ctggaaatga aaaacctgga gttctggtac agtgagacag
     3541 cccagcaccc tacatagcct ggccacctgg ctctgcattt ccaaggctct gttgcctgtt
     3601 gtactccccc tgccttcctc cagcagggct ggggcctcct acccttcctg tgacctcacc
     3661 tgccgcgcaa cttcccagta gggggaatga ggctggcacc tgggcatccc ggtatttctg
     3721 ggattgaagg ggccttccca gtctctccca tgcatgattt cctggcatct caaatcactt
     3781 ggatgtcctg tgttttgtgt gtgttttagt tgtttgggta acttgtcctg tgcacaggtc
     3841 cttgaggctc ctccctctgc ctcccagcct cccacctaag attgttctgt ggcttcatga
     3901 ggtaggagac agcaaaccca cccctccaca tacattatct gtgactctta cccagtcata
     3961 tgtctccctt ttcctgtgtc agcttgcgtc cccatccctg ctttgtcttc ccacttctgt
     4021 catggcaggg cagcagaaag aggcccatct ccaccaggtc tccctccagc agcctccttc
     4081 cctctctcag ccatggatgg gtcccagacc tatctcagcc tcctcatcag tgtcttcatg
     4141 agaggctgag gacacgtgac agagctagcc cagcctccat gccctctggc acttcagagc
     4201 ttctctgttg ccctctcact gcttcctagc agtgtggcac agaactgcac tcagaacata
     4261 gttttggcat tcttcacatc caagactcca gcccttcctg ctgcccagcc ctactgtcca
     4321 gagtgtctct tgggcctgag aataagtggg gtgggaagac tggggccatg ttgggttttt
     4381 tcattcaata aactggtgat ttcttaccaa
//
