LOCUS       NM_027032               1355 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus PARK2 co-regulated (Pacrg), mRNA.
ACCESSION   NM_027032 XM_128418
VERSION     NM_027032.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1355)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1355)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1355)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   4  (bases 1 to 1355)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   5  (bases 1 to 1355)
  AUTHORS   Stephenson,S.E.M., Aumann,T.D., Taylor,J.M., Riseley,J.R., Li,R.,
            Mann,J.R., Tomas,D. and Lockhart,P.J.
  TITLE     Generation and characterisation of a parkin-Pacrg knockout mouse
            line and a Pacrg knockout mouse line
  JOURNAL   Sci Rep 8 (1), 7528 (2018)
   PUBMED   29760428
  REMARK    GeneRIF: Results show that aged single knockout Pacrg mouse and
            double knockout parkin-Pacrg mouse do not show behavioral or
            neuropathological deficits of the dopaminergic system.
            Collectively, these studies suggest that gene mediated deficiency
            in the mouse may alter pathways common to human pathogenesis but
            for as yet unknown reasons do not cause a pronounced Parkinson
            disease-like phenotype.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1355)
  AUTHORS   Lorenzetti,D., Bishop,C.E. and Justice,M.J.
  TITLE     Deletion of the Parkin coregulated gene causes male sterility in
            the quaking(viable) mouse mutant
  JOURNAL   Proc Natl Acad Sci U S A 101 (22), 8402-8407 (2004)
   PUBMED   15148410
  REMARK    GeneRIF: Results demonstrate that the deletion of Pacrg
            (PARKIN-coregulated gene) is the cause of male sterility in the
            Quaking(viable) (qk(v)) mutant mouse.
REFERENCE   7  (bases 1 to 1355)
  AUTHORS   Lorenzetti,D., Antalffy,B., Vogel,H., Noveroske,J., Armstrong,D.
            and Justice,M.
  TITLE     The neurological mutant quaking(viable) is Parkin deficient
  JOURNAL   Mamm Genome 15 (3), 210-217 (2004)
   PUBMED   15014970
REFERENCE   8  (bases 1 to 1355)
  AUTHORS   Lockhart,P.J., O'Farrell,C.A. and Farrer,M.J.
  TITLE     It's a double knock-out! The quaking mouse is a spontaneous
            deletion of parkin and parkin co-regulated gene (PACRG)
  JOURNAL   Mov Disord 19 (1), 101-104 (2004)
   PUBMED   14743368
  REMARK    GeneRIF: The quaking mutation is a deletion of approximately 1.17
            Mb of mouse chromosome 17, resulting in the deletion of the entire
            promoter and first five coding exons of PRKN. The recently
            described Parkin Co-Regulated Gene (PACRG) is completely deleted.
REFERENCE   9  (bases 1 to 1355)
  AUTHORS   Imai,Y., Soda,M., Murakami,T., Shoji,M., Abe,K. and Takahashi,R.
  TITLE     A product of the human gene adjacent to parkin is a component of
            Lewy bodies and suppresses Pael receptor-induced cell death
  JOURNAL   J Biol Chem 278 (51), 51901-51910 (2003)
   PUBMED   14532270
REFERENCE   10 (bases 1 to 1355)
  AUTHORS   West,A.B., Lockhart,P.J., O'Farell,C. and Farrer,M.J.
  TITLE     Identification of a novel gene linked to parkin via a
            bi-directional promoter
  JOURNAL   J Mol Biol 326 (1), 11-19 (2003)
   PUBMED   12547187
  REMARK    GeneRIF: PACRG is linked to parkin via a bi-directional promoter
            [PACRG]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135510.1 and AK005771.1.
            
            On Nov 10, 2006 this sequence version replaced NM_027032.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135510.1, AK005771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-618               AK135510.1         3-620
            619-679             AK005771.1         615-675
            680-1355            AK135510.1         682-1357
FEATURES             Location/Qualifiers
     source          1..1355
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 7.8 cM"
     gene            1..1355
                     /gene="Pacrg"
                     /gene_synonym="1700008H23Rik"
                     /note="PARK2 co-regulated"
                     /db_xref="GeneID:69310"
                     /db_xref="MGI:MGI:1916560"
     exon            1..431
                     /gene="Pacrg"
                     /gene_synonym="1700008H23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1049
                     /gene="Pacrg"
                     /gene_synonym="1700008H23Rik"
                     /note="parkin co-regulated gene protein; PARK2 coregulated
                     gene protein; hypertension-related protein 1-like protein"
                     /codon_start=1
                     /product="parkin coregulated gene protein homolog"
                     /protein_id="NP_081308.1"
                     /db_xref="CCDS:CCDS28388.1"
                     /db_xref="GeneID:69310"
                     /db_xref="MGI:MGI:1916560"
                     /translation="MPKRTKLLPQQTFQVHQPRSLVSEGFTVKAMMKNSVVRGPPVAG
                     AFKERPAKPTTFRKCYERGDFPIALEHDSKGNKIAWKVEIEKLDYHHYLPLFFDGLSE
                     MTFPYEFFARRGIHDMLEHGGNKILPVIPQLIIPIKNALNLRNRQIICVTLKVLQHLV
                     VSSEMVGEALLPYYRQILPILNIFKNMNVNSGDGIDYSQQKRENIGDLIQETLEAFER
                     YGGEDAFINIKYMVPTYESCLLN"
     exon            432..566
                     /gene="Pacrg"
                     /gene_synonym="1700008H23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            567..738
                     /gene="Pacrg"
                     /gene_synonym="1700008H23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            739..888
                     /gene="Pacrg"
                     /gene_synonym="1700008H23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1355
                     /gene="Pacrg"
                     /gene_synonym="1700008H23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1202..1207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pacrg"
                     /gene_synonym="1700008H23Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1228
                     /gene="Pacrg"
                     /gene_synonym="1700008H23Rik"
                     /note="major polyA site"
ORIGIN      
        1 atgttgacta atcgcttagc aaccgggagg cttacacctt tggaagctct tagagactct
       61 agcctcggat cccagccctc ttcccgcccc tctcctcccc taaactccct ccaccttggt
      121 gctgccaaac atctggatct ccctgggcag cacgaggggt tgaatttcta ccactagagc
      181 cttttagagt gttttcccga ccccctgctc acttctgtaa aagccactgg tttttcttcc
      241 acacctctga taagaacaag acgttttcta ggaagaatgt ggtagaaaaa gagaccctga
      301 ccttaaacaa atgcccagac aagatgccga agaggactaa actgctgcca caacagacgt
      361 tccaggtgca ccagcctcgt tccctggttt ctgagggctt cacagtcaaa gccatgatga
      421 aaaactcagt cgtgcggggt cctccagttg caggggcatt taaagaaagg ccggccaaac
      481 ccaccacttt ccgaaaatgt tatgagcgag gagacttccc aatcgccctt gagcatgact
      541 cgaaaggaaa caaaattgcc tggaaggttg agattgagaa gttggactac catcattacc
      601 tgcctctgtt ttttgatggg ctttctgaaa tgacgtttcc ctatgagttt tttgctcggc
      661 gaggaatcca cgacatgctg gaacacggag ggaacaagat tctacctgtc attcctcagc
      721 tcattatccc aataaaaaat gccttgaacc tccgaaacag acagatcatc tgtgtgacgc
      781 tcaaggttct ccagcatctg gttgtgtctt cggagatggt gggcgaagct ttgttgccct
      841 actaccgtca gatcctgcca atcctgaaca tctttaagaa catgaatgtg aactccgggg
      901 atggcatcga ctacagccag cagaagaggg agaacattgg cgacctgatc caggagaccc
      961 tagaagcctt cgagcgctac ggaggggagg acgccttcat caacatcaaa tacatggtgc
     1021 ctacctatga gtcgtgcttg ctgaactgac cgggcagctg ccggagggag cctcccttgg
     1081 tgtcacagcc gtctgtccct aaagtcctag catctcatta cttgtgactt ctacagctgc
     1141 aaacatagta gtttctgggc caaaagactg ttagccctat tgtaagcaag gctttcccat
     1201 atataaatag tgcctgtttc ttagattaca atagtgtact gtgcttttct tcttctcccc
     1261 acaaggagaa ttgcgtctct atctggctca gatggaggca ggagtctgag ttaaaccttc
     1321 agttgtatag acaataaaac cataattctc acatg
//
