LOCUS       NM_025864               2626 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus proton activated chloride channel 1 (Pacc1), mRNA.
ACCESSION   NM_025864
VERSION     NM_025864.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2626)
  AUTHORS   Zeziulia,M., Blin,S., Schmitt,F.W., Lehmann,M. and Jentsch,T.J.
  TITLE     Proton-gated anion transport governs macropinosome shrinkage
  JOURNAL   Nat Cell Biol 24 (6), 885-895 (2022)
   PUBMED   35590106
REFERENCE   2  (bases 1 to 2626)
  AUTHORS   Yang,J., Chen,J., Del Carmen Vitery,M., Osei-Owusu,J., Chu,J.,
            Yu,H., Sun,S. and Qiu,Z.
  TITLE     PAC, an evolutionarily conserved membrane protein, is a
            proton-activated chloride channel
  JOURNAL   Science 364 (6438), 395-399 (2019)
   PUBMED   31023925
REFERENCE   3  (bases 1 to 2626)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115896.9.
            
            On Feb 2, 2019 this sequence version replaced NM_025864.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044482.1, AK049641.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AC115896.9         28760-28934         c
            176-272             AC115896.9         26557-26653         c
            273-482             AC115896.9         15845-16054         c
            483-634             AC115896.9         13958-14109         c
            635-777             AC115896.9         9717-9859           c
            778-922             AC115896.9         7932-8076           c
            923-1030            AC115896.9         6361-6468           c
            1031-2626           AC115896.9         3552-5147           c
FEATURES             Location/Qualifiers
     source          1..2626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 96.28 cM"
     gene            1..2626
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /note="proton activated chloride channel 1"
                     /db_xref="GeneID:66950"
                     /db_xref="MGI:MGI:1914200"
     exon            1..175
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1192
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /note="transmembrane protein 206"
                     /codon_start=1
                     /product="proton-activated chloride channel"
                     /protein_id="NP_080140.1"
                     /db_xref="CCDS:CCDS15619.1"
                     /db_xref="GeneID:66950"
                     /db_xref="MGI:MGI:1914200"
                     /translation="MIRQELSTSYQELSEELEQVVENSEQADERDKELVQVQGPGVVP
                     GVDNESASSSIRFSKACLKNVFSVLLILIYLLLMAVAVFLVYQTITDFREKLKHPVMS
                     VSYKEVDRYDAPGIAFYPGQAQLLSCKHHYEVIPPLASPGQPGDRNCTTQRINYTHPF
                     FNHTMQSALIVQGPQEVKKRELVFLQFRLNQSNEDFSAIDYLLFSSFREFMQSPDKAG
                     FMQACESAYSSWKFSGGFRTWVKMSLVKTKEEDGREAVEFRQETSVVNYIDQRPAAER
                     SAQLFFVVFEWKDPFIQKVQDIITANPWNTIALLCGAFLALFKAAEFAKLSVKWMIKI
                     RKRYLKRRGQATNHIS"
     exon            176..272
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     exon            273..482
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     exon            483..634
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     exon            635..777
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     exon            778..922
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1030
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..2626
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1522..1527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /note="hexamer: AACAAG"
     polyA_site      1543
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /note="major polyA site"
     regulatory      2237..2242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /note="hexamer: AATAAA"
     polyA_site      2258
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /note="major polyA site"
     regulatory      2592..2597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
                     /note="hexamer: AATAAA"
     polyA_site      2626
                     /gene="Pacc1"
                     /gene_synonym="2310028N02Rik; PAC; Tmem206"
ORIGIN      
        1 atgcgcatgc gttgagcgcc gccacgcctg gtcttgggcg gtagactaga gcgggtcttg
       61 cttagtagag cgggcacatc ttggagctcg cgcctcctgc ggcgtcgcgg tccctggtga
      121 gccgtagagg gccagtgcca tgatccgaca agaactctcc acgtcctacc aggagctcag
      181 cgaggagttg gagcaggtgg ttgagaactc ggagcaggca gacgaacgag acaaggagct
      241 ggtccaagta caaggtccag gtgtcgtgcc aggcgtggac aacgagtccg cctccagcag
      301 catccgcttc agcaaggctt gcctgaagaa tgtcttctcg gtcctgctca tcctcatcta
      361 cctgctgctc atggcggtgg ccgtcttcct ggtctaccag accatcacgg acttccggga
      421 aaagctcaag caccctgtca tgtccgtgtc ttacaaggag gtggatcgct acgacgctcc
      481 agggattgcc ttttaccctg gtcaggctca gctgctcagc tgtaagcacc actatgaggt
      541 tattccacct cttgccagcc ctggccagcc gggagacagg aactgcacca ctcagaggat
      601 caattacacc caccccttct tcaaccacac catgcagtca gccctgattg tccaggggcc
      661 ccaggaagtg aagaagcgag agctggtgtt cctccagttt cgcctgaacc agagcaatga
      721 ggacttcagt gccatagact acctcctctt ctcttctttc cgggagttca tgcaaagccc
      781 ggacaaggcg ggcttcatgc aggcctgtga gagtgcttac tccagttgga agttctccgg
      841 aggcttccgc acctgggtca agatgtcact ggtgaagacc aaagaagagg acgggcgaga
      901 agctgttgag ttccgtcaag agaccagcgt ggttaactat attgaccaga gacccgcagc
      961 cgagaggagt gctcagttgt tctttgtggt cttcgaatgg aaagatccct tcatccagaa
     1021 ggtccaggac ataatcacag ccaatccttg gaacaccatc gccctgctct gcggggcttt
     1081 cctggcgttg tttaaagcag cagagtttgc caaactaagc gtgaaatgga tgatcaaaat
     1141 caggaaacga taccttaaac ggagaggcca ggcgacaaac cacataagct gaagcgcccg
     1201 tgccacggca ctccgacaga gcgagacacc agcaatcctg aactcacttg aagggaccct
     1261 gcagggaagg acagtcccgt ccatcgcact ggaggctcaa acccggcccg ggagggaaac
     1321 gcccagtgaa taacctgaaa cttatttaag tacttaaatt attaacggac atcttgcaga
     1381 gctgcctagt gccttggaga ggttcctcct atttggtcac taaatagtta aggcttcttc
     1441 tttcccttag ggcttttttt ctttaaagcg gactgatgtg ccctgtacgc agaattcctt
     1501 ttagaccatc tactgttact taacaagaac ttgttagagc ctagatttga cttttttgtt
     1561 tttccttaaa tgtagccccg ctgtaatcac tgtgtagacc aggccttcct cgtgccttcc
     1621 cattgctgag actaagagcc tacatcactc cccgcaagct ttacacgaga ccttaaaggc
     1681 tactagaaac ttgtgattgt atttctgatg tgctagaagt gctagcagag gtatatacag
     1741 taggcaccta cttagtgtat cttgatttca ttaacaggta aataaggttg ggcaagcaca
     1801 aaagggatgg gagtgaatac ccagtaagcc agcgggcagc aacgctggac gctgatgctg
     1861 tatggccagc aaacccagaa ggtagtgtaa gtctggaccg cagcataatg gctctgactc
     1921 agcacacatc actgccaaca gggaggtaag ctgtgcactg tccacaggtg gccaagaggg
     1981 atggccacac cacatgagct agtccctgcg tcctacagaa acacacacct aaaagggtgg
     2041 cctttagggc tttgataaac agcacctcta cataaaacca aaaactctat aatagagttc
     2101 cacatgtggc cagaggtaac attgaagaac ttgtaattat gccttaggga atcggaaggg
     2161 aaatactcac aggtataagg aggacatttt tgtctctaaa ttagcagcaa gaaactgttt
     2221 tgcccaaatc cctagaaata aacttgtact gtgaaatatt cctgctacct ttgtctcaca
     2281 tatatacaag aatttagatt tttagcctaa aacttttatt ataaaacacc attttagcac
     2341 aaatgccaag cataaagcat cagtgacatt aaaaatatgt gaaggacaga aagtcgaggg
     2401 gcaggggtgc agtccagtca caggatgtgt gcttaccacg cagggccctt aaagttcaca
     2461 gttgcatagc acttcagtag ttaaatatct gcctcagtga acactaaagc tttattttcc
     2521 tgtattgtga aagctgagct gcttttaatt ttgctttaga taactaggaa gtaatttttg
     2581 cctattcata gaataaaaac ccgacttcca ctttctggaa aggcaa
//
