LOCUS       NM_019402               1793 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus poly(A) binding protein, nuclear 1 (Pabpn1), mRNA.
ACCESSION   NM_019402
VERSION     NM_019402.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1793)
  AUTHORS   Shademan,M., Mei,H., van Engelen,B., Ariyurek,Y., Kloet,S. and
            Raz,V.
  TITLE     PABPN1 loss-of-function causes APA-shift in oculopharyngeal
            muscular dystrophy
  JOURNAL   HGG Adv 5 (2), 100269 (2024)
   PUBMED   38213032
  REMARK    GeneRIF: PABPN1 loss-of-function causes APA-shift in
            oculopharyngeal muscular dystrophy.
REFERENCE   2  (bases 1 to 1793)
  AUTHORS   Huang,L., Li,G., Du,C., Jia,Y., Yang,J., Fan,W., Xu,Y.Z., Cheng,H.
            and Zhou,Y.
  TITLE     The polyA tail facilitates splicing of last introns with weak 3'
            splice sites via PABPN1
  JOURNAL   EMBO Rep 24 (10), e57128 (2023)
   PUBMED   37661812
  REMARK    GeneRIF: The polyA tail facilitates splicing of last introns with
            weak 3' splice sites via PABPN1.
REFERENCE   3  (bases 1 to 1793)
  AUTHORS   Kases,K., Schubert,E., Hajikhezri,Z., Larsson,M., Devi,P.,
            Darweesh,M., Andersson,L., Akusjarvi,G., Punga,T. and Younis,S.
  TITLE     The RNA-binding protein ZC3H11A interacts with the nuclear
            poly(A)-binding protein PABPN1 and alters polyadenylation of viral
            transcripts
  JOURNAL   J Biol Chem 299 (8), 104959 (2023)
   PUBMED   37356722
  REMARK    GeneRIF: The RNA-binding protein ZC3H11A interacts with the nuclear
            poly(A)-binding protein PABPN1 and alters polyadenylation of viral
            transcripts.
REFERENCE   4  (bases 1 to 1793)
  AUTHORS   Dai,X.X., Pi,S.B., Zhao,L.W., Wu,Y.W., Shen,J.L., Zhang,S.Y.,
            Sha,Q.Q. and Fan,H.Y.
  TITLE     PABPN1 functions as a hub in the assembly of nuclear poly(A)
            domains that are essential for mouse oocyte development
  JOURNAL   Sci Adv 8 (43), eabn9016 (2022)
   PUBMED   36306357
  REMARK    GeneRIF: PABPN1 functions as a hub in the assembly of nuclear
            poly(A) domains that are essential for mouse oocyte development.
REFERENCE   5  (bases 1 to 1793)
  AUTHORS   Sommerkamp,P., Sommerkamp,A.C., Zeisberger,P., Eiben,P.L., Narr,A.,
            Korkmaz,A., Przybylla,A., Sohn,M., van der Hoeven,F., Schonig,K.
            and Trumpp,A.
  TITLE     CRISPR-Cas9 mediated generation of a conditional poly(A) binding
            protein nuclear 1 (Pabpn1) mouse model reveals an essential role
            for hematopoietic stem cells
  JOURNAL   Sci Rep 12 (1), 7181 (2022)
   PUBMED   35504940
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1793)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1793)
  AUTHORS   Dion,P., Shanmugam,V., Gaspar,C., Messaed,C., Meijer,I.,
            Toulouse,A., Laganiere,J., Roussel,J., Rochefort,D., Laganiere,S.,
            Allen,C., Karpati,G., Bouchard,J.P., Brais,B. and Rouleau,G.A.
  TITLE     Transgenic expression of an expanded (GCG)13 repeat PABPN1 leads to
            weakness and coordination defects in mice
  JOURNAL   Neurobiol Dis 18 (3), 528-536 (2005)
   PUBMED   15755680
REFERENCE   8  (bases 1 to 1793)
  AUTHORS   Pfisterer,P., Ehlermann,J., Hegen,M. and Schorle,H.
  TITLE     A subtractive gene expression screen suggests a role of
            transcription factor AP-2 alpha in control of proliferation and
            differentiation
  JOURNAL   J Biol Chem 277 (8), 6637-6644 (2002)
   PUBMED   11741941
REFERENCE   9  (bases 1 to 1793)
  AUTHORS   Okamura,T., Imai,Y., Kon,Y., Goto,M., Yamamoto,M. and Watanabe,T.
  TITLE     Molecular cloning and characterization of mouse testis poly(A)
            binding protein II encoded by the Pabp3 gene, which
            transcomplements meiotic mutant sme2 of S. pombe
  JOURNAL   Biochem Genet 38 (1-2), 1-11 (2000)
   PUBMED   10862355
REFERENCE   10 (bases 1 to 1793)
  AUTHORS   Lee,Y.J., Lee,J., Yang,I.C., Hahn,Y., Lee,Y. and Chung,J.H.
  TITLE     Genomic structure and expression of murine poly(A) binding protein
            II gene
  JOURNAL   Biochim Biophys Acta 1395 (1), 40-46 (1998)
   PUBMED   9434149
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY266376.1, AK032172.1 and AC116591.4.
            
            On Dec 9, 2009 this sequence version replaced NM_019402.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055866.1, SRR11927935.3567422.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BY266376.1         2-6
            6-882               AK032172.1         2-878
            883-1793            AC116591.4         4176-5086           c
FEATURES             Location/Qualifiers
     source          1..1793
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.98 cM"
     gene            1..1793
                     /gene="Pabpn1"
                     /gene_synonym="mPABII; PAB2; Pabp3"
                     /note="poly(A) binding protein, nuclear 1"
                     /db_xref="GeneID:54196"
                     /db_xref="MGI:MGI:1859158"
     exon            1..352
                     /gene="Pabpn1"
                     /gene_synonym="mPABII; PAB2; Pabp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..922
                     /gene="Pabpn1"
                     /gene_synonym="mPABII; PAB2; Pabp3"
                     /note="poly(A) binding protein II; PABII; PABP-2;
                     poly(A)-binding protein 2; nuclear poly(A)-binding protein
                     1; polyadenylate-binding nuclear protein 1"
                     /codon_start=1
                     /product="polyadenylate-binding protein 2"
                     /protein_id="NP_062275.1"
                     /db_xref="CCDS:CCDS27104.1"
                     /db_xref="GeneID:54196"
                     /db_xref="MGI:MGI:1859158"
                     /translation="MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGDPGGAG
                     DYGNGLESEELEPGELLPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVE
                     ADPGDGAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSLE
                     EKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSD
                     KESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRSRYRARTTNYNSSRSRF
                     YSGFNSRPRGRIYRGRARATSWYSPY"
     exon            353..467
                     /gene="Pabpn1"
                     /gene_synonym="mPABII; PAB2; Pabp3"
                     /inference="alignment:Splign:2.1.0"
     exon            468..535
                     /gene="Pabpn1"
                     /gene_synonym="mPABII; PAB2; Pabp3"
                     /inference="alignment:Splign:2.1.0"
     exon            536..642
                     /gene="Pabpn1"
                     /gene_synonym="mPABII; PAB2; Pabp3"
                     /inference="alignment:Splign:2.1.0"
     exon            643..730
                     /gene="Pabpn1"
                     /gene_synonym="mPABII; PAB2; Pabp3"
                     /inference="alignment:Splign:2.1.0"
     exon            731..882
                     /gene="Pabpn1"
                     /gene_synonym="mPABII; PAB2; Pabp3"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1793
                     /gene="Pabpn1"
                     /gene_synonym="mPABII; PAB2; Pabp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1768..1773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pabpn1"
                     /gene_synonym="mPABII; PAB2; Pabp3"
                     /note="hexamer: AATAAA"
     polyA_site      1790
                     /gene="Pabpn1"
                     /gene_synonym="mPABII; PAB2; Pabp3"
                     /note="major polyA site"
ORIGIN      
        1 agtctgagcg gcgatggcgg cggcggcggc ggcggcagca gcagcggggg ctgcgggcgg
       61 tcggggctcc gggccggggc ggcggcgcca tcttgtgccc ggggccggtg gggaggccgg
      121 ggagggggac ccggggggcg caggggacta cgggaacggc ctggagtctg aggagctgga
      181 gcctggggag ctgctgccgg agcccgagcc cgaagaggag ccgccccggc cccgcgcccc
      241 tccgggagct ccgggtcctg ggcccggctc gggagccccc ggcagtcagg aggaggagga
      301 agagccggga ctggttgagg ccgaccccgg cgacggcgcc attgaggacc cggagctaga
      361 agcgatcaaa gctcgagtca gggagatgga ggaagaggct gagaagctaa aggagctaca
      421 aaacgaggta gagaagcaga tgaatatgag tccaccccca ggcaatgctg gcccagtgat
      481 catgtctctt gaggagaaga tggaggctga tgcccgctct atctacgttg gcaatgtgga
      541 ctatggtgca acagcagaag agctggaagc ccattttcat ggctgtggtt cagtcaaccg
      601 tgttactata ctctgtgaca aatttagtgg ccatcccaaa gggtttgcat atatagagtt
      661 ctcggacaaa gagtcagtga ggacgtccct ggccttagat gagtccctgt tcagaggaag
      721 acaaatcaag gtgattccca aacgaaccaa cagaccaggc atcagcacaa cagaccgggg
      781 tttcccgcgc tcccgatacc gtgcccggac taccaactac aacagctccc gatctcgatt
      841 ctacagtggt tttaacagca ggccccgggg tcgaatctac aggggccggg ctagagcgac
      901 atcatggtat tccccttact aaaaaaagtg tgtattagga ggagagagag gaaaaaaaga
      961 ggaaagaagg aaaaaaaaaa gaattaaaaa aaaaaaagaa aaacagaaga tgaccttgat
     1021 ggaaaaaaaa tatttaaaaa aaaaaaaaag atatactgtg gaagggggga gaatcctata
     1081 actaactgag gagggacctg ctctgggagt aggggaggcc cagggcgcgg ggcaggggct
     1141 acagagtccc tctggggatt cgccatggac acatctcaac tgtgcaagct gctccctgtt
     1201 tccctgcccc cctccatcct ctctgggcct gctcaggggt aggtgggctc gggtggtagg
     1261 agggcttttt tttacccagg gctctctgga aggacaccaa actgttcagc ttgttccctt
     1321 ccctcgtctt ctccctgcct tttgcagtcc ccgcctgcct gctcctgtcc taccaggtct
     1381 ccgcccaccc tacacctctt tcctccggct ccctgcccct ccagtttgcc tggtgatcta
     1441 ttttgtttcc ttttgtgttt ctttttctgt tttgagtgtc tttctttgca ggtttctgta
     1501 gccggaagat ctcgctccca gcggctccag tgtaaattcc ccttaccctt ggggaaatgc
     1561 actactttgt tttggggagt ttgggggtgt ttttgttttt caggtggttt tgttttgttt
     1621 tgtttttttc tttacctttt ttttcccttt tatttggagg gaatgggagg aagtgggaac
     1681 agggtggtgg gggtggcttt tgtttttttg ttttttttta actcatttcc aggggatggg
     1741 attttttttt ttaaataatg tgtcatgaat aaagttgttt tatgaaaaaa ttg
//
