LOCUS       NM_130881               3112 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus poly(A) binding protein, cytoplasmic 4 (Pabpc4),
            transcript variant 1, mRNA.
ACCESSION   NM_130881
VERSION     NM_130881.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3112)
  AUTHORS   Borisova,E., Newman,A.G., Couce Iglesias,M., Dannenberg,R.,
            Schaub,T., Qin,B., Rusanova,A., Brockmann,M., Koch,J., Daniels,M.,
            Turko,P., Jahn,O., Kaplan,D.R., Rosario,M., Iwawaki,T.,
            Spahn,C.M.T., Rosenmund,C., Meierhofer,D., Kraushar,M.L.,
            Tarabykin,V. and Ambrozkiewicz,M.C.
  TITLE     Protein translation rate determines neocortical neuron fate
  JOURNAL   Nat Commun 15 (1), 4879 (2024)
   PUBMED   38849354
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3112)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3112)
  AUTHORS   Oliveira,A.G., Oliveira,L.D., Cruz,M.V., Guimaraes,D.S.P.S.F.,
            Lima,T.I., Santos-Favero,B.C., Luchessi,A.D., Pauletti,B.A.,
            Leme,A.P., Bajgelman,M.C., Afonso,J., Regitano,L.C.A.,
            Carvalho,H.F., Carneiro,E.M., Kobarg,J., Perissi,V., Auwerx,J. and
            Silveira,L.R.
  TITLE     Interaction between poly(A)-binding protein PABPC4 and nuclear
            receptor corepressor NCoR1 modulates a metabolic stress response
  JOURNAL   J Biol Chem 299 (6), 104702 (2023)
   PUBMED   37059182
  REMARK    GeneRIF: Interaction between poly(A)-binding protein PABPC4 and
            nuclear receptor corepressor NCoR1 modulates a metabolic stress
            response.
REFERENCE   4  (bases 1 to 3112)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3112)
  AUTHORS   Tuck,E., Estabel,J., Oellrich,A., Maguire,A.K., Adissu,H.A.,
            Souter,L., Siragher,E., Lillistone,C., Green,A.L., Wardle-Jones,H.,
            Carragher,D.M., Karp,N.A., Smedley,D., Adams,N.C., Bussell,J.N.,
            Adams,D.J., Ramirez-Solis,R., Steel,K.P., Galli,A. and White,J.K.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     A gene expression resource generated by genome-wide lacZ profiling
            in the mouse
  JOURNAL   Dis Model Mech 8 (11), 1467-1478 (2015)
   PUBMED   26398943
REFERENCE   6  (bases 1 to 3112)
  AUTHORS   Ryder,E., Gleeson,D., Sethi,D., Vyas,S., Miklejewska,E., Dalvi,P.,
            Habib,B., Cook,R., Hardy,M., Jhaveri,K., Bottomley,J.,
            Wardle-Jones,H., Bussell,J.N., Houghton,R., Salisbury,J.,
            Skarnes,W.C. and Ramirez-Solis,R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Molecular characterization of mutant mouse strains generated from
            the EUCOMM/KOMP-CSD ES cell resource
  JOURNAL   Mamm Genome 24 (7-8), 286-294 (2013)
   PUBMED   23912999
REFERENCE   7  (bases 1 to 3112)
  AUTHORS   Burgess,H.M., Richardson,W.A., Anderson,R.C., Salaun,C.,
            Graham,S.V. and Gray,N.K.
  TITLE     Nuclear relocalisation of cytoplasmic poly(A)-binding proteins
            PABP1 and PABP4 in response to UV irradiation reveals
            mRNA-dependent export of metazoan PABPs
  JOURNAL   J Cell Sci 124 (Pt 19), 3344-3355 (2011)
   PUBMED   21940797
REFERENCE   8  (bases 1 to 3112)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3112)
  AUTHORS   Onishi,M., Yasunaga,T., Tanaka,H., Nishimune,Y. and Nozaki,M.
  TITLE     Gene structure and evolution of testicular haploid germ
            cell-specific genes, Oxct2a and Oxct2b
  JOURNAL   Genomics 83 (4), 647-657 (2004)
   PUBMED   15028287
REFERENCE   10 (bases 1 to 3112)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC056432.1 and AL606917.12.
            
            On Oct 4, 2017 this sequence version replaced NM_130881.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056432.1, SRR7345562.1292994.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3019              BC056432.1         1-3019
            3020-3112           AL606917.12        10568-10660
FEATURES             Location/Qualifiers
     source          1..3112
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.42 cM"
     gene            1..3112
                     /gene="Pabpc4"
                     /note="poly(A) binding protein, cytoplasmic 4"
                     /db_xref="GeneID:230721"
                     /db_xref="MGI:MGI:2385206"
     exon            1..897
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1091
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1207
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1347
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1442
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1580
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1676
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1949
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2037
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2157
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2244
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2372
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2466
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2699
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..3112
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2993..2998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pabpc4"
                     /note="hexamer: AATAAA"
     polyA_site      3024
                     /gene="Pabpc4"
                     /note="major polyA site"
ORIGIN      
        1 gaaaagaaga ggaaaaaaaa aagcaaaagg gaaaaaaaga agaaaaagaa ccagacagcg
       61 acttgtgctg ggagcccgtg gggaagtgac tttcacagct tccggcctgc ctgtccgtca
      121 gcgtctgtct gtccgtccgg tggtgagcca tccccctcgg cccggcccgc ccctgcacgc
      181 ctctgcgccg cgtggcagcc ccgcgccccg gctggccgca ccacgtgtcc gcactgccct
      241 tcgccggcac ccgcaaagat ttggtttccc ccttcctggg ctgctgtaac tgtaaaccgc
      301 cgggagtccg gggcctatat ttatcacgaa acgcgtgttc ccaaggcggc cgtgagcgca
      361 gcatctgatt gcctcttgaa aattttttgc cccctttacg aggggatttc ctactttaat
      421 ttttattttt taagcctcaa gccaggacag ctggagagta caaactccag gagcgggcca
      481 tattgttttt gagagccttt tgtcttgggg cttttgcagt cccgtgcaag tcgtcccgca
      541 cacgggtccc ggctcggagc ctccctgctc cagccttctc cggcgtcgct ggtgccacct
      601 gtgcgctgcg gcgcgtgcca tagctcctcg gagccccttt tgtcctgcag taggccttgt
      661 tagaagtcct cctggcgggg ctcggggtcg tggggggtgg ggagatgaac gctgcagcca
      721 gcagctaccc catggcctcc ttatacgtgg gcgatttgca ctcggacgtc accgaagcca
      781 tgctgtatga aaagtttagc cctgcggggc ctgtgctgtc catccgggtc tgtcgcgata
      841 tgatcacccg gcgctctctg ggttatgcct acgtcaactt ccagcagcca gctgacgctg
      901 agagggcctt ggacaccatg aacttcgacg tgatgaaggg aaagccgatc cgcatcatgt
      961 ggtcgcagag ggatccctcg ttgagaaaat ctggggtggg aaatgtcttc atcaagaacc
     1021 tggacaaatc catagacaac aaggcactgt atgacacttt ctctgccttt ggaaacatct
     1081 tgtcctgtaa ggtggtctgt gatgagaacg gctctaaggg ctatgctttt gttcacttcg
     1141 agacccaaga ggccgccgac aaggccatcg agaagatgaa tggcatgctt ctcaatgacc
     1201 gtaaagtgtt cgtgggtaga ttcaagtctc gcaaagagcg ggaagcggag cttggagcca
     1261 aggccaagga attcaccaat gtttatatca aaaactttgg agaagaggtg gatgatggga
     1321 atctgaaaga gctcttcagc cagtttggta agaccctaag tgtcaaggtg atgagagact
     1381 ccagtgggaa gtccaaaggc tttggctttg taagttacga gaaacacgag gatgccaata
     1441 aggctgtgga agaaatgaat ggaaaggaaa tgagcgggaa agccatattt gtaggccgtg
     1501 cacagaaaaa ggtagaaagg caggctgagc tgaagcggaa gtttgagcag ctcaagcagg
     1561 agaggattag ccggtaccag ggggtgaatc tctacattaa gaacttggat gacaccattg
     1621 atgatgagaa attgaggaga gagttttctc cctttggatc aatcaccagc gcgaaggtga
     1681 tgctagaaga tgggagaagc aaagggtttg gctttgtctg tttctcctct cctgaagagg
     1741 cgaccaaagc tgtcaccgag atgaatggac gcattgtggg ctccaagcct ctgtacgtcg
     1801 ccctggccca gaggaaggaa gagcggaagg ctcatctgac caaccagtac atgcagcgtg
     1861 tggcggggat gagagcactc cctgccagtg ccatcttaaa tcagttccag cctgcagctg
     1921 gtggctattt tgtgcctgca gttccgcagg ctcagggaag acccccatat tacacgccta
     1981 accagttagc acagatgagg cctaatccac gctggcagca aggcgggaga cctcaaggct
     2041 tccaaggaat gccaagtgcc ctgcggcagt ctgggcctcg tccagctctt cgacatctgg
     2101 ctccaactgg taatgctccg gcctctcgtg gccttcctac tactgctcag agagtcgggt
     2161 ctgagtgccc ggaccgcttg gctatggact ttggtggggc tggtgccgcc cagcaagggc
     2221 tgactgacag ctgccagtct ggaggcgtcc ctacagccgt gccaaacctt gcacctcggg
     2281 ccgcagttgc tgccgccgct cccagggctg tggctccata caagtacgcc tccagtgtcc
     2341 gcagcccaca ccctgccatc cagccgctgc aggcccccca gcctgcagtc cacgtccagg
     2401 gtcaggagcc cctgactgcc tccatgcttg ctgcagcgcc cccccaggag cagaagcaga
     2461 tgctggggga gcgtctgttc ccgcttatcc aaacaatgca ttcaaacctg gctgggaaaa
     2521 tcaccgggat gctgctggaa atcgacaact ctgagctgct gcacatgctg gagtcccccg
     2581 agtccctccg ctccaaggta gatgaagcgg tggcagtcct gcaggctcac catgccaaga
     2641 aagaagctgc ccagaaggtg ggcactgttg ctgctgctac ctcttagaca agaaaaaaag
     2701 agtcgaaagc caaataaccc ctcatggcat ccagctaagg tctgaagaca tcctagtttg
     2761 tctgtggacc tccacaccaa gaaccaagtt gcaaattcaa taggtcattt tgtatcagaa
     2821 ggtcaattat gaagcaccta taagtttttc aattataaga atatattctc tgggttctgt
     2881 tgtgacccag atgataactt ttttttttct attatgggtt ctggtttttt ttttccctca
     2941 tcccagaaat tggttttgat gtacccaaga cttaagtttc tcaaataaag gaaataaaat
     3001 ctccataaat atggctgaat ttgatgccag ttttatgtta caatcttggg cttttgctag
     3061 aactgttggg ctctgcatat attaaataaa tttactttcc cttttggttt tt
//
