LOCUS       NM_001114079            2580 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus poly(A) binding protein, cytoplasmic 1-like (Pabpc1l),
            mRNA.
ACCESSION   NM_001114079 XM_001480780 XM_909287
VERSION     NM_001114079.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2580)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2580)
  AUTHORS   Wang,W., Guo,J., Shi,J., Li,Q., Chen,B., Pan,Z., Qu,R., Fu,J.,
            Shi,R., Xue,X., Mu,J., Zhang,Z., Wu,T., Wang,W., Zhao,L., Li,Q.,
            He,L., Sun,X., Sang,Q., Lin,G. and Wang,L.
  TITLE     Bi-allelic pathogenic variants in PABPC1L cause oocyte maturation
            arrest and female infertility
  JOURNAL   EMBO Mol Med 15 (6), e17177 (2023)
   PUBMED   37052235
REFERENCE   3  (bases 1 to 2580)
  AUTHORS   Ozturk,S., Kosebent,E.G., Talibova,G., Bilmez,Y., Tire,B. and
            Can,A.
  TITLE     Embryonic poly(A)-binding protein interacts with
            translation-related proteins and undergoes phosphorylation on the
            serine, threonine, and tyrosine residues in the mouse oocytes and
            early embryos
  JOURNAL   J Assist Reprod Genet 40 (4), 929-941 (2023)
   PUBMED   36823316
  REMARK    GeneRIF: Embryonic poly(A)-binding protein interacts with
            translation-related proteins and undergoes phosphorylation on the
            serine, threonine, and tyrosine residues in the mouse oocytes and
            early embryos.
REFERENCE   4  (bases 1 to 2580)
  AUTHORS   Zhang,J., Liu,W., Li,G., Xu,C., Nie,X., Qin,D., Wang,Q., Lu,X.,
            Liu,J. and Li,L.
  TITLE     BCAS2 is involved in alternative splicing and mouse oocyte
            development
  JOURNAL   FASEB J 36 (2), e22128 (2022)
   PUBMED   34972250
REFERENCE   5  (bases 1 to 2580)
  AUTHORS   Rong,Y., Ji,S.Y., Zhu,Y.Z., Wu,Y.W., Shen,L. and Fan,H.Y.
  TITLE     ZAR1 and ZAR2 are required for oocyte meiotic maturation by
            regulating the maternal transcriptome and mRNA translational
            activation
  JOURNAL   Nucleic Acids Res 47 (21), 11387-11402 (2019)
   PUBMED   31598710
REFERENCE   6  (bases 1 to 2580)
  AUTHORS   Ozturk,S., Guzeloglu-Kayisli,O., Lowther,K.M., Lalioti,M.D.,
            Sakkas,D. and Seli,E.
  TITLE     Epab is dispensable for mouse spermatogenesis and male fertility
  JOURNAL   Mol Reprod Dev 81 (5), 390 (2014)
   PUBMED   24599567
REFERENCE   7  (bases 1 to 2580)
  AUTHORS   Ozturk,S., Guzeloglu-Kayisli,O., Demir,N., Sozen,B., Ilbay,O.,
            Lalioti,M.D. and Seli,E.
  TITLE     Epab and Pabpc1 are differentially expressed during male germ cell
            development
  JOURNAL   Reprod Sci 19 (9), 911-922 (2012)
   PUBMED   22814100
  REMARK    GeneRIF: In mature testis the highest levels of Epab are in
            spermatogonia, while Pabpc1 expression is detected in spermatocytes
            and round spermatids.
REFERENCE   8  (bases 1 to 2580)
  AUTHORS   Guzeloglu-Kayisli,O., Lalioti,M.D., Aydiner,F., Sasson,I.,
            Ilbay,O., Sakkas,D., Lowther,K.M., Mehlmann,L.M. and Seli,E.
  TITLE     Embryonic poly(A)-binding protein (EPAB) is required for oocyte
            maturation and female fertility in mice
  JOURNAL   Biochem J 446 (1), 47-58 (2012)
   PUBMED   22621333
REFERENCE   9  (bases 1 to 2580)
  AUTHORS   Seli,E., Lalioti,M.D., Flaherty,S.M., Sakkas,D., Terzi,N. and
            Steitz,J.A.
  TITLE     An embryonic poly(A)-binding protein (ePAB) is expressed in mouse
            oocytes and early preimplantation embryos
  JOURNAL   Proc Natl Acad Sci U S A 102 (2), 367-372 (2005)
   PUBMED   15630085
REFERENCE   10 (bases 1 to 2580)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591542.20 and EU669908.1.
            
            On Feb 15, 2013 this sequence version replaced NM_001114079.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158030.1, EU669908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AL591542.20        150939-151195
            258-2099            EU669908.1         1-1842
            2100-2580           AL591542.20        175773-176253
FEATURES             Location/Qualifiers
     source          1..2580
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.6 cM"
     gene            1..2580
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /note="poly(A) binding protein, cytoplasmic 1-like"
                     /db_xref="GeneID:381404"
                     /db_xref="MGI:MGI:1922908"
     exon            1..450
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..2081
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /note="embryonic poly(A)-binding protein"
                     /codon_start=1
                     /product="polyadenylate-binding protein 1-like"
                     /protein_id="NP_001107551.1"
                     /db_xref="CCDS:CCDS50792.1"
                     /db_xref="GeneID:381404"
                     /db_xref="MGI:MGI:1922908"
                     /translation="MDTGGHGCSLSSLYVGDLHPDVTESMLYEMFSPIGNILSIRVCR
                     DVATRRSLGYAYINFQQPADAERALDTMNFEVIKGQPIRIMWSHRDPGLRKSGMGNIF
                     IKNLENSIDNKALYDTFSTFGSILSSKVVYNEHGSRGFGFVHFETHEAAQKAINTMNG
                     MLLNDRKVFVGHFKSRQKREAELGARALGFTNIYVKNLHANVDEQRLQDLFSQFGNMQ
                     SVKVMRDSNGQSRGFGFVNFEKHEEAQKAVDHMNGKEVSGQLLYVGRAQKRAERQSEL
                     KRRFEQMKQERQNRYQGVNLYVKNLDDSINDERLKEVFSTYGVITSAKVMTESSHSKG
                     FGFVCFSSPEEATKAVTEMNGRIVGTKPLYVALAQRKEERKAILTNQYRRRPSHPVLS
                     SFQQPTSYLLPAVPQSTAQAVYYSSGSITPMQPDPRWTAQPHGPPSTCPPAASVVQPL
                     STTQHPCIHLRGASQVSSQVPHTQRVVNIGTQTTGPGGEGSSIPGQLLVPHRGTSAVH
                     SAHGVQESAVYVPGHQPLTVSMLAAAPLHEQKQMIGERLYSLIHDACAPLTGKITGML
                     LELDNLELLLLLESPESLHAKIEEAVAVLQVHREMESTDRN"
     exon            451..644
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /inference="alignment:Splign:2.1.0"
     exon            645..760
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /inference="alignment:Splign:2.1.0"
     exon            761..900
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /inference="alignment:Splign:2.1.0"
     exon            901..995
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1133
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1229
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1478
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1569
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1686
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1793
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1887
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2018
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2580
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2559..2564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /note="hexamer: ATTAAA"
     polyA_site      2578
                     /gene="Pabpc1l"
                     /gene_synonym="1810053B01Rik; Epab"
                     /note="major polyA site"
ORIGIN      
        1 agacctctct ggccttcctc ctaggcaagg cgggagatgg cagccacctg cgcctttctc
       61 agcctgagga ctcccaggtg ggtggggctg ggcaccagga ttggcttgca agcgtggtaa
      121 aggcaagggg ctagcgcagg caaacaagac aactggcaga gccctgctac agccaccacc
      181 acgcttgcca ggccccggcc ccggccccct gtgagctggg gccgtttgct ggcccgcttc
      241 tgggtgccct gcgcatcatg gacacaggtg gccatggctg ctcactctcc tcgctctatg
      301 tgggcgatct gcaccccgac gtgactgaat ctatgctcta tgagatgttc tccccgatcg
      361 gcaatatcct ttccatccgc gtgtgtcggg atgtggctac ccggcgctct ctgggctatg
      421 cctacatcaa tttccagcag cctgctgacg cggaacgggc actagacaca atgaactttg
      481 aggtgatcaa aggccagccc atccgaatca tgtggtccca ccgagaccca ggccttcgga
      541 agtctggtat gggcaacatc tttatcaaaa acttggagaa ttccatcgac aacaaggctc
      601 tgtatgacac cttctctact tttgggagca ttctctcttc taaggtagta tacaatgaac
      661 atggatcgcg gggtttcggc tttgtgcatt tcgagaccca cgaggctgcc cagaaggcca
      721 tcaacaccat gaatgggatg ttgctgaacg accggaaagt ctttgtaggc catttcaagt
      781 ctcgacagaa gcgggaggca gagctggggg ctcgggccct cgggttcacc aacatctatg
      841 tgaagaacct gcacgcgaac gtggacgagc agaggctcca ggacctcttc tcccagtttg
      901 gaaatatgca gagtgtgaag gtgatgagag acagcaatgg gcaatcccgg ggcttcggct
      961 ttgtcaactt tgagaagcat gaggaagccc agaaggccgt ggaccacatg aatgggaagg
     1021 aggtgagcgg gcagctgctc tatgtgggtc gggcccagaa gcgggcagaa cggcagagcg
     1081 agctgaagcg caggtttgaa caaatgaagc aggagaggca gaaccgctac cagggtgtga
     1141 acctttatgt gaagaacctg gacgactcca ttaatgatga gaggctgaag gaagttttct
     1201 ctacctatgg cgtgatcacc agcgctaagg tgatgacaga aagtagccac agcaagggct
     1261 ttggctttgt gtgcttttcc tctccagaag aggcaacgaa ggccgtgacg gagatgaacg
     1321 ggcgcatcgt gggcacgaaa ccgctctatg tggccctggc acagcgcaag gaggagcgga
     1381 aggccatctt gaccaaccag tataggcgac gcccctctca ccctgtcttg agctccttcc
     1441 agcagcctac cagctacctg ctccctgctg taccccagtc tacagcccag gctgtgtact
     1501 acagttctgg ctccataact ccaatgcaac ctgaccccag gtggacagcc cagccacatg
     1561 gacctccatc tacctgccct ccagctgcct ctgtggtcca gcctctaagc acgacgcagc
     1621 atccctgtat ccacctgagg ggtgccagcc aggtctccag ccaggtgcct cacacgcaga
     1681 gagtagtcaa cattggtacc cagactacag gaccaggtgg ggagggatcc tctatcccag
     1741 gccagcttct cgtgccacat agaggaacct cagctgtaca cagtgcccat ggggtccagg
     1801 agtcggccgt gtatgtccct ggccatcagc ctctgactgt gtccatgctg gccgctgcac
     1861 ccctacacga gcaaaagcag atgattgggg agcgtctcta ctccctcatc cacgatgcct
     1921 gcgccccact gactggcaag atcacgggca tgctgctgga gctggacaac ctggagcttc
     1981 tgttattgct ggagtcccca gagtccctcc atgccaagat agaagaggcg gtggcagtac
     2041 tgcaggtgca tcgagaaatg gagtcaacag ataggaactg aactctgtgg gttcctgggg
     2101 atggaaggac cgacagagcg gctgagctgc tggctctctg gagactccgt agagaaccca
     2161 gcgatcaaaa acccactgtg atgtgttggt ggctttgtct gaagcaccag ggagtttggt
     2221 gaagctaaag gagtcatagg agacttgcag tggctggatg ttctcacgcc tggctccgtt
     2281 ctgcctgtct ggaggcctgg tctgctggtc caccttcttg actgaagatt gggtgttttc
     2341 catattctgg gaacattttt ttccctccac tccccctccc cccaccccca ctgaaaatgg
     2401 aatcttcact cccttgacta cttgattact gcatttctgc tcttggttct agctgtgtga
     2461 actctaactt ctttcctgat ggggatctct gtgttcttga gctctgatta tgtaatgaag
     2521 gctgacacag tccccctgct gatcattttg ctttatatat taaaaaatgc tgcaaaaatc
//
