LOCUS       NM_008774               2842 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus poly(A) binding protein, cytoplasmic 1 (Pabpc1), mRNA.
ACCESSION   NM_008774
VERSION     NM_008774.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2842)
  AUTHORS   Herron,R.S., Kunisky,A.K., Madden,J.R., Anyaeche,V.I., Maung,M.Z.
            and Hwang,H.W.
  TITLE     A twin UGUA motif directs the balance between gene isoforms through
            CFIm and the mTORC1 signaling pathway
  JOURNAL   Elife 12, e85036 (2023)
   PUBMED   37665675
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2842)
  AUTHORS   Sharma,S., Kajjo,S., Harra,Z., Hasaj,B., Delisle,V., Ray,D.,
            Gutierrez,R.L., Carrier,I., Kleinman,C., Morris,Q., Hughes,T.R.,
            McInnes,R. and Fabian,M.R.
  TITLE     Uncovering a mammalian neural-specific poly(A) binding protein with
            unique properties
  JOURNAL   Genes Dev 37 (15-16), 760-777 (2023)
   PUBMED   37704377
REFERENCE   3  (bases 1 to 2842)
  AUTHORS   Qian,B., Li,Y., Yan,R., Han,S., Bu,Z., Gong,J., Zheng,B., Yuan,Z.,
            Ren,S., He,Q., Zhang,J., Xu,C., Wang,R., Sun,Z., Lin,M., Zhou,J.
            and Ye,L.
  TITLE     RNA binding protein RBM46 regulates mitotic-to-meiotic transition
            in spermatogenesis
  JOURNAL   Sci Adv 8 (34), eabq2945 (2022)
   PUBMED   36001654
REFERENCE   4  (bases 1 to 2842)
  AUTHORS   Wegler,M., Jia,X., Alders,M., Bouman,A., Chen,J., Duan,X.,
            Lauzon,J.L., Mathijssen,I.B., Sticht,H., Syrbe,S., Tan,S., Guo,H.
            and Abou Jamra,R.
  TITLE     De novo variants in the PABP domain of PABPC1 lead to developmental
            delay
  JOURNAL   Genet Med 24 (8), 1761-1773 (2022)
   PUBMED   35511136
  REMARK    GeneRIF: De novo variants in the PABP domain of PABPC1 lead to
            developmental delay.
REFERENCE   5  (bases 1 to 2842)
  AUTHORS   Kurosaki,T., Sakano,H., Proschel,C., Wheeler,J., Hewko,A. and
            Maquat,L.E.
  TITLE     NMD abnormalities during brain development in the Fmr1-knockout
            mouse model of fragile X syndrome
  JOURNAL   Genome Biol 22 (1), 317 (2021)
   PUBMED   34784943
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2842)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (bases 1 to 2842)
  AUTHORS   Paynton,B.V.
  TITLE     RNA-binding proteins in mouse oocytes and embryos: expression of
            genes encoding Y box, DEAD box RNA helicase, and polyA binding
            proteins
  JOURNAL   Dev Genet 23 (4), 285-298 (1998)
   PUBMED   9883581
REFERENCE   8  (bases 1 to 2842)
  AUTHORS   Kleene,K.C., Wang,M.Y., Cutler,M., Hall,C. and Shih,D.
  TITLE     Developmental expression of poly(A) binding protein mRNAs during
            spermatogenesis in the mouse
  JOURNAL   Mol Reprod Dev 39 (4), 355-364 (1994)
   PUBMED   7893484
REFERENCE   9  (bases 1 to 2842)
  AUTHORS   Wang,M.Y., Cutler,M., Karimpour,I. and Kleene,K.C.
  TITLE     Nucleotide sequence of a mouse testis poly(A) binding protein cDNA
  JOURNAL   Nucleic Acids Res 20 (13), 3519 (1992)
   PUBMED   1630930
REFERENCE   10 (bases 1 to 2842)
  AUTHORS   Rhyner,T.A., Lecain,E., Mallet,J. and Pessac,B.
  TITLE     Isolation of cDNAs from a mouse astroglial cell line by a
            subtracted cDNA library
  JOURNAL   J Neurosci Res 27 (2), 144-152 (1990)
   PUBMED   1701491
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133196.1 and CF553208.1.
            
            On Dec 12, 2009 this sequence version replaced NM_008774.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133196.1, AK161123.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2817              AK133196.1         2-2818
            2818-2842           CF553208.1         406-430
FEATURES             Location/Qualifiers
     source          1..2842
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.51 cM"
     gene            1..2842
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /note="poly(A) binding protein, cytoplasmic 1"
                     /db_xref="GeneID:18458"
                     /db_xref="MGI:MGI:1349722"
     exon            1..660
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..854
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..970
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1110
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1205
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1343
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1439
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1712
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1803
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1914
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2069
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2154
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2285
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2378
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2820
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2578..2583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /note="hexamer: AACAAA"
     regulatory      2586..2591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /note="hexamer: AATACA"
     polyA_site      2597
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
     polyA_site      2605
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
     regulatory      2797..2802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /note="hexamer: AATAAA"
     polyA_site      2818
                     /gene="Pabpc1"
                     /gene_synonym="ePAB; PABP; Pabp1; PabpI; Pabpl1"
                     /note="major polyA site"
ORIGIN      
        1 ccccttctcc ccggcggtta gtgctgagag tgcggagtgt gtgctccggg ctcggaacac
       61 acatttatta ttaaaaaatc caaaaaaaat ctaaaaaatc ctttgaaaaa acccaaaaaa
      121 aatttacaaa aaaatccgcg tctcccccgc cggagacttt tatttttttt cttcctcttt
      181 tataaaataa cccggtgaag cagccgagac cgacccgccc gcccgcggcc ccgcagctcc
      241 aagcaggaac ccagagaccg aggccttcct gccgcccgga cccagcaccg ccagcctcgc
      301 tcccccggtt ccacggccgt tgagtacgcg tcgattccgg ttgaattttg tccctctgcg
      361 ctcgcccccg ctcccctccc cccggctccg tcccccggcc ccgcactcgc tctcctcctc
      421 tcacgggaaa ggtcgcggcc tgcggccccg cgggcagccg tgccgagatg aaccccagcg
      481 cccccagcta ccccatggcc tctctgtacg tgggggacct gcaccccgac gtgaccgagg
      541 cgatgctcta cgagaagttc agcccggccg ggcccatcct ctccatccgg gtctgcaggg
      601 acatgatcac ccgccgctcc ttgggctacg cgtacgtgaa cttccagcag ccggcggacg
      661 cggaacgtgc tttggacacc atgaattttg atgttataaa gggcaagcca gtacgcatca
      721 tgtggtctca gcgtgatcca tcacttcgca aaagtggagt aggcaacata ttcattaaaa
      781 atttggacaa atccatcgac aataaagcac tatatgatac gttttctgcg tttggtaaca
      841 tcctttcatg taaggtggtt tgtgatgaaa atggctccaa gggctatgga tttgtacact
      901 ttgaaacaca ggaagcagct gaaagagcta ttgaaaaaat gaatgggatg cttctaaatg
      961 atcgtaaagt gtttgttgga cgatttaaat ctcggaagga acgagaagca gagcttggag
     1021 ccagggcaaa ggagttcacc aatgtttaca tcaagaactt tggagaagac atggatgatg
     1081 agcgccttaa ggaactcttt ggcaagtttg ggcctgcctt aagtgtgaaa gtaatgacag
     1141 atgaaagtgg aaaatccaaa ggatttggat ttgtaagctt tgaaaggcat gaagatgcgc
     1201 agaaagctgt ggatgagatg aatgggaagg agctcaatgg aaaacagatt tatgttggac
     1261 gagctcagaa aaaagtggaa cggcagacgg aacttaagcg caaatttgag cagatgaagc
     1321 aagataggat caccagatat cagggtgtga acctttatgt gaaaaatctt gatgacggga
     1381 ttgatgatga gcgtctccgg aaggagtttt ctccgtttgg tacaatcacc agtgcaaaag
     1441 taatgatgga gggtgggcgc agcaaagggt ttggttttgt atgtttctca tcccctgaag
     1501 aagccactaa agcagttaca gagatgaatg gtagaattgt ggccacgaag ccactgtatg
     1561 tagctttagc tcagcgcaaa gaagagcgcc aggctcacct cactaaccag tatatgcaga
     1621 ggatggcaag tgtacgagct gtgcccaacc ccgtgatcaa cccctaccag ccagcacctc
     1681 cttcaggtta cttcatggca gctatcccac agactcagaa ccgtgctgca tactatcctc
     1741 ctagccaaat tgctcaacta agaccaagtc ctcgctggac tgctcagggt gccagacctc
     1801 atccattcca gaatatgccc ggtgctatcc gcccagctgc tcctagacca ccatttagta
     1861 cgatgagacc agcttcctca caggttccac gagtcatgtc aacacagcgt gttgctaaca
     1921 catcaacaca gacaatgggt ccacgtcctg cagctgctgc tgctgcagcc actcctgctg
     1981 tccgcaccgt tccccagtat aaatatgctg cgggagtccg caatccccag caacatctta
     2041 atgcacagcc acaagttacc atgcaacagc ctgctgttca tgtgcaaggt caagaacctt
     2101 taactgcttc catgttggca tctgcgcccc cgcaagagca gaagcaaatg ttgggtgaac
     2161 ggctgtttcc tcttatccaa gccatgcacc cttctcttgc tggtaaaatc actggcatgc
     2221 tgttggagat tgataactca gaattacttc acatgctcga gtctccagag tctctccgct
     2281 caaaggttga tgaagctgta gctgtactac aagcccacca agcgaaagag gctgcccaga
     2341 aagcagtgaa cagtgccact ggtgttccaa ctgtctaaat tgatcaggga ccacgaacag
     2401 aaactcgtgc ttcaccgaag aaaaatatct taaacatcga aaaatttaaa tattatgaaa
     2461 aaaaacattg caaaatataa aataaataaa aaaaggaaag gaaactttga accttatgta
     2521 ccgagcaaat gccaggtcta gcaaacagtg ctagtcctag attacttgat ttaaaacaac
     2581 aaaaaaatac aaaaaaatag taaaatataa aaacaaatta atgttttata gaccctggga
     2641 aaagaatttt cagcaaagta caaaaattta aagcattcct ttctttaatt ttgtaattct
     2701 ttactgtgga atagcttggg acatcagctc tgttttaagg agcagaactg atgactgagc
     2761 aaggaaacgt aatttggatt ataaaattct tgctttaata aaaattcctt aaacagtaga
     2821 aaaaaaaaaa aaaaaaaaaa aa
//
