LOCUS       NM_011032               2884 bp    mRNA    linear   ROD 13-MAY-2024
DEFINITION  Mus musculus prolyl 4-hydroxylase, beta polypeptide (P4hb), mRNA.
ACCESSION   NM_011032 XM_126743
VERSION     NM_011032.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2884)
  AUTHORS   Kij,A., Bar,A., Czyzynska-Cichon,I., Przyborowski,K.,
            Proniewski,B., Mateuszuk,L., Kurylowicz,Z., Jasztal,A., Buczek,E.,
            Kurpinska,A., Suraj-Prazmowska,J., Marczyk,B.,
            Matyjaszczyk-Gwarda,K., Daiber,A., Oelze,M., Walczak,M. and
            Chlopicki,S.
  TITLE     Vascular protein disulfide isomerase A1 mediates endothelial
            dysfunction induced by angiotensin II in mice
  JOURNAL   Acta Physiol (Oxf) 240 (4), e14116 (2024)
   PUBMED   38400621
  REMARK    GeneRIF: Vascular protein disulfide isomerase A1 mediates
            endothelial dysfunction induced by angiotensin II in mice.
REFERENCE   2  (bases 1 to 2884)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2884)
  AUTHORS   Wang,S., Matsumoto,K., Mehlferber,M.M., Zhang,G., Aronova,M.A. and
            Yamada,K.M.
  TITLE     Microtubule-dependent apical polarization of basement membrane
            matrix mRNAs in mouse epithelial cells
  JOURNAL   Cells Dev 177, 203898 (2024)
   PUBMED   38103869
REFERENCE   4  (bases 1 to 2884)
  AUTHORS   Chen,Z., Wang,S., Pottekat,A., Duffey,A., Jang,I., Chang,B.H.,
            Cho,J., Finck,B.N., Davidson,N.O. and Kaufman,R.J.
  TITLE     Conditional hepatocyte ablation of PDIA1 uncovers indispensable
            roles in both APOB and MTTP folding to support VLDL secretion
  JOURNAL   Mol Metab 80, 101874 (2024)
   PUBMED   38211723
  REMARK    GeneRIF: Conditional hepatocyte ablation of PDIA1 uncovers
            indispensable roles in both APOB and MTTP folding to support VLDL
            secretion.
REFERENCE   5  (bases 1 to 2884)
  AUTHORS   Guo,C.G., Sun,R., Wang,X., Yuan,Y., Xu,Y., Li,S., Sun,X., Wang,J.,
            Hu,X., Guo,T., Chen,X.W., Xiao,R.P. and Zhang,X.
  TITLE     Intestinal SURF4 is essential for apolipoprotein transport and
            lipoprotein secretion
  JOURNAL   Mol Metab 79, 101847 (2024)
   PUBMED   38042368
REFERENCE   6  (bases 1 to 2884)
  AUTHORS   Haque,N.S., Buchberg,A.M. and Khalili,K.
  TITLE     Isolation and characterization of MRF-1, a brain-derived
            DNA-binding protein with a capacity to regulate expression of
            myelin basic protein gene
  JOURNAL   J Biol Chem 269 (49), 31149-31156 (1994)
   PUBMED   7527040
REFERENCE   7  (bases 1 to 2884)
  AUTHORS   Morris,D.J. and Robinson,T.J.
  TITLE     Thymidine kinase (Tk-1) maps below the T42H breakpoint on mouse
            chromosome 11
  JOURNAL   Mamm Genome 1 (4), 263-264 (1991)
   PUBMED   1794055
REFERENCE   8  (bases 1 to 2884)
  AUTHORS   Helaakoski,T., Pajunen,L., Kivirikko,K.I. and Pihlajaniemi,T.
  TITLE     Increases in mRNA concentrations of the alpha and beta subunits of
            prolyl 4-hydroxylase accompany increased gene expression of type IV
            collagen during differentiation of mouse F9 cells
  JOURNAL   J Biol Chem 265 (20), 11413-11416 (1990)
   PUBMED   1694844
REFERENCE   9  (bases 1 to 2884)
  AUTHORS   Mazzarella,R.A., Srinivasan,M., Haugejorden,S.M. and Green,M.
  TITLE     ERp72, an abundant luminal endoplasmic reticulum protein, contains
            three copies of the active site sequences of protein disulfide
            isomerase
  JOURNAL   J Biol Chem 265 (2), 1094-1101 (1990)
   PUBMED   2295602
REFERENCE   10 (bases 1 to 2884)
  AUTHORS   Gong,Q.H., Fukuda,T., Parkison,C. and Cheng,S.Y.
  TITLE     Nucleotide sequence of a full-length cDNA clone encoding a mouse
            cellular thyroid hormone binding protein (p55) that is homologous
            to protein disulfide isomerase and the beta-subunit of
            prolyl-4-hydroxylase
  JOURNAL   Nucleic Acids Res 16 (3), 1203 (1988)
   PUBMED   2830592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA317831.1, AK159606.1 and BP766087.1.
            
            On Feb 22, 2018 this sequence version replaced NM_011032.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05185.1, AK150002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               CA317831.1         1-380
            381-2858            AK159606.1         2-2479
            2859-2884           BP766087.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..2884
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.27 cM"
     gene            1..2884
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /note="prolyl 4-hydroxylase, beta polypeptide"
                     /db_xref="GeneID:18453"
                     /db_xref="MGI:MGI:97464"
     exon            1..597
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             447..1976
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /EC_number="5.3.4.1"
                     /note="protein disulfide-isomerase; p55; prolyl
                     4-hydroxylase subunit beta; cellular thyroid
                     hormone-binding protein; endoplasmic reticulum resident
                     protein 59; ER protein 59"
                     /codon_start=1
                     /product="protein disulfide-isomerase precursor"
                     /protein_id="NP_035162.1"
                     /db_xref="CCDS:CCDS25742.1"
                     /db_xref="GeneID:18453"
                     /db_xref="MGI:MGI:97464"
                     /translation="MLSRALLCLALAWAARVGADALEEEDNVLVLKKSNFEEALAAHK
                     YLLVEFYAPWCGHCKALAPEYAKAAAKLKAEGSEIRLAKVDATEESDLAQQYGVRGYP
                     TIKFFKNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLSDTAAAESLVDSSEVTVI
                     GFFKDVESDSAKQFLLAAEAIDDIPFGITSNSGVFSKYQLDKDGVVLFKKFDEGRNNF
                     EGEITKEKLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSS
                     FKRAAEGFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESD
                     ELTAEKITEFCHRFLEGKIKPHLMSQEVPEDWDKQPVKVLVGANFEEVAFDEKKNVFV
                     EFYAPWCGHCKQLAPIWDKLGETYKDHENIIIAKMDSTANEVEAVKVHSFPTLKFFPA
                     SADRTVIDYNGERTLDGFKKFLESGGQDGAGDDEDLDLEEALEPDMEEDDDQKAVKDE
                     L"
     exon            598..804
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /inference="alignment:Splign:2.1.0"
     exon            805..938
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1076
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1181
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1307
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1508
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1629
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1811
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1898
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2861
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2836..2841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /note="hexamer: AATAAA"
     polyA_site      2856
                     /gene="P4hb"
                     /gene_synonym="ERp59; PDI; Pdia1; Thbp"
                     /note="major polyA site"
ORIGIN      
        1 cgaggccggg cagcggaaag ccgcagccat tccagacgtg tggaaggcgt gggaaaagtc
       61 gccagtcaga agtccagaaa gagaaagttg gctttcgcca gcgaatcaga cgctggggga
      121 cattgggttt gtgcgcgcgc gcgcgcgccg tggccaatcc caggcaagaa ccgaaaggcc
      181 tccgggtctt tgtcgacttg gtggcccagc cttgagtggg tgtccagtcc ccgcacggcg
      241 agggcgggtc tctcagctcc ttggccaatc ggagggcgcg gcggggcgca tgcgcacggc
      301 ggctgacgcg cgcagcgagg gggaggcgtg ggcgcgtccc cggcccagga tttataaagg
      361 cgaggtctgg accgacgcgc gctctcgtcg ccttggctgt cccggcggcg ccaacccaac
      421 tgccccgccc gctgcagacg tccgacatgc tgagccgtgc tttgctgtgc ctagccctgg
      481 cctgggcggc tagggtgggc gccgacgccc tggaggagga ggacaacgtc ctggtgttga
      541 agaagagcaa cttcgaggag gcgctggcgg cgcacaagta cctgctggtg gagttctatg
      601 ccccgtggtg tggccactgc aaagctctgg ctcccgagta tgccaaagct gccgcaaaac
      661 tgaaggcaga aggctctgag attcgactag caaaggtgga tgccacagaa gagtctgacc
      721 tggctcagca gtatggtgtc cgtggctacc ccacaatcaa gttcttcaag aatggagaca
      781 cagcctcccc aaaggaatat acagctggca gggaagctga tgacattgtc aactggctga
      841 agaaacgcac gggcccagca gctacaaccc tgtctgacac tgcagctgca gagtccttgg
      901 tggactcaag cgaagtgacg gtcatcggtt tcttcaagga cgtagagtca gactctgcca
      961 agcagttctt gctggcagca gaggctattg atgacatacc ttttggaatc acgtccaaca
     1021 gtggtgtgtt ctccaagtac cagctggaca aagatggggt ggtcctcttt aagaagtttg
     1081 atgaaggccg caacaacttt gagggtgaga tcaccaagga gaagcttcta gacttcatca
     1141 agcacaatca gctgcctttg gtcatcgagt tcactgaaca gacagctccg aagatttttg
     1201 gaggtgagat caagacacac attctgctgt tcctgcccaa gagtgtatct gactatgacg
     1261 gcaagctgag cagcttcaag agagcagccg agggcttcaa gggcaagatc ctatttatct
     1321 tcatcgatag cgaccacact gataaccagc gcatacttga gttctttggc ctgaagaagg
     1381 aggagtgtcc cgctgtgcgg cttattaccc tagaggaaga gatgaccaag tacaaaccag
     1441 agtcagatga gctgacggct gagaaaatca cagagttttg ccaccgcttc ttagagggca
     1501 agatcaagcc ccacctgatg agccaagaag tgcctgaaga ctgggacaaa cagccggtaa
     1561 aagtactggt tggggcgaac tttgaagagg tcgcttttga tgagaaaaag aacgtgtttg
     1621 ttgaattcta tgccccttgg tgtggtcact gcaagcagct agcccccatt tgggataaac
     1681 tgggagagac atacaaggat catgagaata tcatcattgc taagatggac tcaacagcca
     1741 atgaggtgga agctgtcaaa gtacatagct ttcccacact gaagttcttc ccagcaagtg
     1801 cagacagaac ggtcattgat tacaacggcg agcggacact ggacggtttt aagaaattct
     1861 tggagagtgg tggccaggat ggagcagggg acgatgagga cctcgaccta gaagaagctt
     1921 tagagccaga catggaggaa gacgacgatc agaaagctgt gaaggatgaa ctgtagtgca
     1981 gaagccagat ctgggcgcct gaacccaaaa cctcggtggg ccacgctccc agcagcccac
     2041 atctccggag cctgagcctc accccaggag ggagcgccat cagaacccag ggaatctttc
     2101 tgaagccaca ctcatctgac acacgtacac ttagacctgt ctcttctttt gcttttcaat
     2161 tttggaaagg gatctctgtc caggtcagcc cctcttgaag ggctaccttt tgttttaatt
     2221 ggtggtgtac ttttttgtat gtggaatttg tcccatgtgc ttgctaaaat gtttggggat
     2281 ctcctcacac tggtaatgtc tttcctgtta gagaggttta tgctaccact tcgcatttca
     2341 tctgtgaggc atttcatctt ttagacatgt cttcatgtcc agctacttgt ttcaccatgg
     2401 cagacctccc tgagccttct tcctgccctg ggtaggaagt gtggctctgg gtctgtggtc
     2461 actctccacc ttgtcctagt gttgccatgg tagcatggct ttgtagtttg catttaacct
     2521 ggggatctat gcatcctgtc aagagggtgg gtccccatcc ccgtgtgtgg aaaagagaca
     2581 gtgtggcttg ctgccaggct caggccaggt ctggacagct ctcactctcc tcaagccagg
     2641 actaccgacc agccggctat gggcacatta ctctgtggct gctggattct tttccagcat
     2701 ggcctgtggc ctgtgtgagg cagaactggg acccttgatt cccagattgg gagtcagcca
     2761 aggacactgg ggctgaatga aatgcccatt cttcaggcat ttctaccata atattggaat
     2821 tgaacacatt ggctaaataa agttgaaatt ttactaccca taaaaaaaaa aaaaaaaaaa
     2881 aaaa
//
