LOCUS       NM_183168               1917 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus pyrimidinergic receptor P2Y, G-protein coupled, 6
            (P2ry6), mRNA.
ACCESSION   NM_183168
VERSION     NM_183168.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1917)
  AUTHORS   Umpierre,A.D., Li,B., Ayasoufi,K., Simon,W.L., Zhao,S., Xie,M.,
            Thyen,G., Hur,B., Zheng,J., Liang,Y., Bosco,D.B., Maynes,M.A.,
            Wu,Z., Yu,X., Sung,J., Johnson,A.J., Li,Y. and Wu,L.J.
  TITLE     Microglial P2Y6 calcium signaling promotes phagocytosis and shapes
            neuroimmune responses in epileptogenesis
  JOURNAL   Neuron 112 (12), 1959-1977 (2024)
   PUBMED   38614103
  REMARK    GeneRIF: Microglial P2Y6 calcium signaling promotes phagocytosis
            and shapes neuroimmune responses in epileptogenesis.
REFERENCE   2  (bases 1 to 1917)
  AUTHORS   Li,Y., Zhou,M., Li,H., Dai,C., Yin,L., Liu,C., Li,Y., Zhang,E.,
            Dong,X., Ji,H. and Hu,Q.
  TITLE     Macrophage P2Y6 receptor deletion attenuates atherosclerosis by
            limiting foam cell formation through phospholipase
            Cbeta/store-operated calcium entry/calreticulin/scavenger receptor
            A pathways
  JOURNAL   Eur Heart J 45 (4), 268-283 (2024)
   PUBMED   38036416
  REMARK    GeneRIF: Macrophage P2Y6 receptor deletion attenuates
            atherosclerosis by limiting foam cell formation through
            phospholipase Cbeta/store-operated calcium
            entry/calreticulin/scavenger receptor A pathways.
REFERENCE   3  (bases 1 to 1917)
  AUTHORS   Dundee,J.M., Puigdellivol,M., Butler,R. and Brown,G.C.
  TITLE     P2Y6 Receptor-Dependent Microglial Phagocytosis of Synapses during
            Development Regulates Synapse Density and Memory
  JOURNAL   J Neurosci 43 (48), 8090-8103 (2023)
   PUBMED   37758475
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1917)
  AUTHORS   Nishiyama,K., Ariyoshi,K., Nishimura,A., Kato,Y., Mi,X., Kurose,H.,
            Kim,S.G. and Nishida,M.
  TITLE     Knockout of Purinergic P2Y6 Receptor Fails to Improve Liver Injury
            and Inflammation in Non-Alcoholic Steatohepatitis
  JOURNAL   Int J Mol Sci 24 (4), 3800 (2023)
   PUBMED   36835211
  REMARK    GeneRIF: Knockout of Purinergic P2Y6 Receptor Fails to Improve
            Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1917)
  AUTHORS   Nagai,J., Lin,J. and Boyce,J.A.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   6  (bases 1 to 1917)
  AUTHORS   Bar,I., Guns,P.J., Metallo,J., Cammarata,D., Wilkin,F.,
            Boeynams,J.M., Bult,H. and Robaye,B.
  TITLE     Knockout mice reveal a role for P2Y6 receptor in macrophages,
            endothelial cells, and vascular smooth muscle cells
  JOURNAL   Mol Pharmacol 74 (3), 777-784 (2008)
   PUBMED   18523137
  REMARK    GeneRIF: P2Y(6)-deficient mice have a defective response to UDP in
            macrophages, endothelial cells, and vascular smooth muscle cells.
REFERENCE   7  (bases 1 to 1917)
  AUTHORS   Grbic,D.M., Degagne,E., Langlois,C., Dupuis,A.A. and Gendron,F.P.
  TITLE     Intestinal inflammation increases the expression of the P2Y6
            receptor on epithelial cells and the release of CXC chemokine
            ligand 8 by UDP
  JOURNAL   J Immunol 180 (4), 2659-2668 (2008)
   PUBMED   18250478
  REMARK    GeneRIF: Inflammation up-regulates P2Y2 as well as P2Y6 receptor
            expression in the colonic mucosa of colitic mice.
REFERENCE   8  (bases 1 to 1917)
  AUTHORS   Koizumi,S., Shigemoto-Mogami,Y., Nasu-Tada,K., Shinozaki,Y.,
            Ohsawa,K., Tsuda,M., Joshi,B.V., Jacobson,K.A., Kohsaka,S. and
            Inoue,K.
  TITLE     UDP acting at P2Y6 receptors is a mediator of microglial
            phagocytosis
  JOURNAL   Nature 446 (7139), 1091-1095 (2007)
   PUBMED   17410128
REFERENCE   9  (bases 1 to 1917)
  AUTHORS   Coutinho-Silva,R., Ojcius,D.M., Gorecki,D.C., Persechini,P.M.,
            Bisaggio,R.C., Mendes,A.N., Marks,J., Burnstock,G. and Dunn,P.M.
  TITLE     Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and
            peritoneal macrophages
  JOURNAL   Biochem Pharmacol 69 (4), 641-655 (2005)
   PUBMED   15670583
REFERENCE   10 (bases 1 to 1917)
  AUTHORS   Lazarowski,E.R., Rochelle,L.G., O'Neal,W.K., Ribeiro,C.M.,
            Grubb,B.R., Zhang,V., Harden,T.K. and Boucher,R.C.
  TITLE     Cloning and functional characterization of two murine uridine
            nucleotide receptors reveal a potential target for correcting ion
            transport deficiency in cystic fibrosis gallbladder
  JOURNAL   J Pharmacol Exp Ther 297 (1), 43-49 (2001)
   PUBMED   11259526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151414.2.
            
            On Jan 20, 2010 this sequence version replaced NM_183168.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027331.1, AK142680.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849380,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC151414.2         63722-63869         c
            149-366             AC151414.2         39304-39521         c
            367-1917            AC151414.2         37137-38687         c
FEATURES             Location/Qualifiers
     source          1..1917
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.46 cM"
     gene            1..1917
                     /gene="P2ry6"
                     /gene_synonym="2010204J23Rik; P2Y6"
                     /note="pyrimidinergic receptor P2Y, G-protein coupled, 6"
                     /db_xref="GeneID:233571"
                     /db_xref="MGI:MGI:2673874"
     exon            1..148
                     /gene="P2ry6"
                     /gene_synonym="2010204J23Rik; P2Y6"
                     /inference="alignment:Splign:2.1.0"
     exon            149..366
                     /gene="P2ry6"
                     /gene_synonym="2010204J23Rik; P2Y6"
                     /inference="alignment:Splign:2.1.0"
     exon            367..1917
                     /gene="P2ry6"
                     /gene_synonym="2010204J23Rik; P2Y6"
                     /inference="alignment:Splign:2.1.0"
     CDS             401..1387
                     /gene="P2ry6"
                     /gene_synonym="2010204J23Rik; P2Y6"
                     /codon_start=1
                     /product="P2Y purinoceptor 6"
                     /protein_id="NP_898991.1"
                     /db_xref="CCDS:CCDS21507.1"
                     /db_xref="GeneID:233571"
                     /db_xref="MGI:MGI:2673874"
                     /translation="MEQDNGTIQAPGLPPTTCVYREDFKRLLLTPVYSVVLVVGLPLN
                     ICVIAQICASRRTLTRSAVYTLNLALADLMYACSLPLLIYNYARGDHWPFGDLACRFV
                     RFLFYANLHGSILFLTCISFQRYLGICHPLASWHKRGGRRAAWVVCGVVWLAVTAQCL
                     PTAVFAATGIQRNRTVCYDLSPPILSTRYLPYGMALTVIGFLLPFIALLACYCRMARR
                     LCRQDGPAGPVAQERRSKAARMAVVVAAVFAISFLPFHITKTAYLAVRSTPGVSCPVL
                     ETFAAAYKGTRPFASVNSVLDPILFYFTQQKFRRQPHDLLQRLTAKWQRQRV"
     regulatory      1895..1900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2ry6"
                     /gene_synonym="2010204J23Rik; P2Y6"
                     /note="hexamer: AATAAA"
     polyA_site      1913
                     /gene="P2ry6"
                     /gene_synonym="2010204J23Rik; P2Y6"
                     /note="major polyA site"
ORIGIN      
        1 ggtagtccca gttacctcat ctgccacctc ccagactcct gcactctggg gcacaagaac
       61 tgcctggtgg caggggctgc ttcgggagtc tagcttgctc cagttctcat ggcttgcagg
      121 cggttgctgt gtcagaggga gttttcagat aaacggtgac tgaaagaaca tggcttccca
      181 aggtggaatt cagactgagg acgtcagtgc ttccctccgt gagctctgcg tgtgtgtgca
      241 ctgtccacag gggtaaacta aaagccacca gagctctctg tcctggaccc aacctgcctt
      301 gaaaacaacg aggaacacca aatctggcac ttcctcctaa aacatcttcc atcttgcatg
      361 agacagactc tccgagcata ggaaaggctg acaggcagtt atggagcagg acaatggcac
      421 catccaggct ccaggcttgc cgcccaccac ctgcgtctac cgtgaggatt tcaagcgact
      481 gctgctaacc ccggtatact cggtggtgct ggtggtcggc ctgccactga acatctgcgt
      541 cattgcccag atctgcgcat cccgccggac cctgacccgt tccgctgtgt acaccctgaa
      601 cctggcactg gcggacctga tgtatgcctg ttcactaccc ctacttatct ataactacgc
      661 cagaggggac cactggccct tcggagacct cgcctgccgc tttgtacgct tcctcttcta
      721 tgccaatcta catggcagca tcctgttcct cacctgcatt agcttccagc gctacctggg
      781 catctgccac cccctggctt cctggcacaa gcgtggaggt cgccgtgctg cttgggtagt
      841 gtgtggagtc gtgtggctgg ctgtgacagc ccagtgcctg cccacggcag tctttgctgc
      901 cacaggcatc cagcgcaacc gcactgtgtg ctacgacctg agcccaccca tcctgtctac
      961 tcgctacctg ccctatggta tggccctcac ggtcatcggc ttcttgctgc ccttcatagc
     1021 cttactggct tgttattgtc gcatggcccg ccgcctgtgt cgccaggatg gcccagcagg
     1081 tcctgtggcc caagagcggc gcagcaaggc ggctcgtatg gctgtggtgg tggcagctgt
     1141 ctttgccatc agcttcctgc ctttccacat caccaagaca gcctacttgg ctgtgcgctc
     1201 cacgcccggt gtctcttgcc ctgtgctgga gaccttcgct gctgcctaca aaggcactcg
     1261 gcccttcgcc agtgtcaaca gtgttctgga ccccattctc ttctacttca cacaacagaa
     1321 gttccggcgg caaccccacg atctcttaca gaggctcaca gccaagtggc agaggcagag
     1381 agtctgaggc cccagaggag gccctggggc actggctgca atgtgtttgt cactggggcc
     1441 atggttgaag ctttctctca atcccaaacc atacagagaa gcaaaacttg gctcaacatg
     1501 cctgggcctc cagaatttcc acatcaacca caaaactaag acacctgtga tttggcaact
     1561 ggtcaattca tgcttgttac attcagaact caggatgttg tgacaagata acaagttctg
     1621 gtccagcctg gtctacacag tgaaacccca ctgtgaaacc ccatctcaga tgatcaagga
     1681 tctgctagac atctcaggat gtgctaggcc ctggaatagc aatgcagatt ccaacaaagg
     1741 tcttctccac ccccaccccc accccacctt tcttgtgttt acagggtgga ggggactgct
     1801 ggtgcactgt cacgtgaggg caaggtccct cctgtccaag agcccggaaa gctcacgttc
     1861 acatccattt gccaagactt ttgcataaga gagaaataaa tgtgtttttg tggttgg
//
