LOCUS       NM_020621               4434 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus pyrimidinergic receptor P2Y, G-protein coupled, 4
            (P2ry4), mRNA.
ACCESSION   NM_020621
VERSION     NM_020621.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4434)
  AUTHORS   Horckmans,M., Diaz Villamil,E., Verdier,C., Laurell,H.,
            Ruidavets,J.B., De Roeck,L., Combes,G., Martinez,L.O. and
            Communi,D.
  TITLE     Loss-of-function N178T variant of the human P2Y4 receptor is
            associated with decreased severity of coronary artery disease and
            improved glucose homeostasis
  JOURNAL   Front Pharmacol 13, 1049696 (2022)
   PUBMED   36532779
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4434)
  AUTHORS   Horckmans,M., Diaz Villamil,E., Bianchini,M., De Roeck,L. and
            Communi,D.
  TITLE     Central role of PD-L1 in cardioprotection resulting from P2Y4
            nucleotide receptor loss
  JOURNAL   Front Immunol 13, 1006934 (2022)
   PUBMED   36248854
  REMARK    GeneRIF: Central role of PD-L1 in cardioprotection resulting from
            P2Y4 nucleotide receptor loss.
            Erratum:[Front Immunol. 2022 Oct 28;13:1061958. doi:
            10.3389/fimmu.2022.1061958. PMID: 36389796]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4434)
  AUTHORS   Lemaire,A., Vanorle,M., Horckmans,M., di Pietrantonio,L.,
            Clouet,S., Robaye,B., Boeynaems,J.M. and Communi,D.
  TITLE     Mouse P2Y4 Nucleotide Receptor Is a Negative Regulator of Cardiac
            Adipose-Derived Stem Cell Differentiation and Cardiac Fat Formation
  JOURNAL   Stem Cells Dev 26 (5), 363-373 (2017)
   PUBMED   27855539
  REMARK    GeneRIF: These data highlight the P2Y4 receptor as an inhibitor of
            cardiac fat formation
REFERENCE   4  (bases 1 to 4434)
  AUTHORS   Orcen,A., Yilmaz,V., Giris,M., Akcan,U., Tuzun,E. and Erten,G.
  TITLE     Viability of SH-SY5Y cells is associated with purinergic P2
            receptor expression alterations
  JOURNAL   Acta Biol Hung 68 (1), 22-34 (2017)
   PUBMED   28322086
  REMARK    GeneRIF: In the brain samples, expressions of P2Y4 and P2X7 were
            significantly reduced, whereas that of P2Y1 was significantly
            elevated in an age-dependent manner.
REFERENCE   5  (bases 1 to 4434)
  AUTHORS   Uda,Y., Xu,S., Matsumura,T. and Takei,Y.
  TITLE     P2Y4 Nucleotide Receptor in Neuronal Precursors Induces
            Glutamatergic Subtype Markers in Their Descendant Neurons
  JOURNAL   Stem Cell Reports 6 (4), 474-482 (2016)
   PUBMED   26972684
  REMARK    GeneRIF: Data show that activation of nucleotide receptor P2Y4
            (P2Y4) in the differentiating embryonic stem cells (ESCs) resulted
            in an increased proportion of neurons expressing vesicular
            glutamate transporter (vGluT).
REFERENCE   6  (bases 1 to 4434)
  AUTHORS   Coutinho-Silva,R., Ojcius,D.M., Gorecki,D.C., Persechini,P.M.,
            Bisaggio,R.C., Mendes,A.N., Marks,J., Burnstock,G. and Dunn,P.M.
  TITLE     Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and
            peritoneal macrophages
  JOURNAL   Biochem Pharmacol 69 (4), 641-655 (2005)
   PUBMED   15670583
REFERENCE   7  (bases 1 to 4434)
  AUTHORS   Boucsein,C., Zacharias,R., Farber,K., Pavlovic,S., Hanisch,U.K. and
            Kettenmann,H.
  TITLE     Purinergic receptors on microglial cells: functional expression in
            acute brain slices and modulation of microglial activation in vitro
  JOURNAL   Eur J Neurosci 17 (11), 2267-2276 (2003)
   PUBMED   12814360
  REMARK    GeneRIF: Purinergic receptors on microglial cells: functional
            expression in acute brain slices and modulation of microglial
            activation in vitro.
REFERENCE   8  (bases 1 to 4434)
  AUTHORS   Robaye,B., Ghanem,E., Wilkin,F., Fokan,D., Van Driessche,W.,
            Schurmans,S., Boeynaems,J.M. and Beauwens,R.
  TITLE     Loss of nucleotide regulation of epithelial chloride transport in
            the jejunum of P2Y4-null mice
  JOURNAL   Mol Pharmacol 63 (4), 777-783 (2003)
   PUBMED   12644577
  REMARK    GeneRIF: Knock-out mice reveal tissue-specific roles of P2Y
            receptor subtypes in different epithelia.
REFERENCE   9  (bases 1 to 4434)
  AUTHORS   Lazarowski,E.R., Rochelle,L.G., O'Neal,W.K., Ribeiro,C.M.,
            Grubb,B.R., Zhang,V., Harden,T.K. and Boucher,R.C.
  TITLE     Cloning and functional characterization of two murine uridine
            nucleotide receptors reveal a potential target for correcting ion
            transport deficiency in cystic fibrosis gallbladder
  JOURNAL   J Pharmacol Exp Ther 297 (1), 43-49 (2001)
   PUBMED   11259526
REFERENCE   10 (bases 1 to 4434)
  AUTHORS   Suarez-Huerta,N., Pouillon,V., Boeynaems,J. and Robaye,B.
  TITLE     Molecular cloning and characterization of the mouse P2Y4 nucleotide
            receptor
  JOURNAL   Eur J Pharmacol 416 (3), 197-202 (2001)
   PUBMED   11290369
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671299.18.
            
            On Oct 31, 2009 this sequence version replaced NM_020621.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076364.1, BB612642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AL671299.18        200134-200285       c
            153-291             AL671299.18        199903-200041       c
            292-4434            AL671299.18        195570-199712       c
FEATURES             Location/Qualifiers
     source          1..4434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.72 cM"
     gene            1..4434
                     /gene="P2ry4"
                     /gene_synonym="P2Y4; P2Y4R"
                     /note="pyrimidinergic receptor P2Y, G-protein coupled, 4"
                     /db_xref="GeneID:57385"
                     /db_xref="MGI:MGI:1926594"
     exon            1..152
                     /gene="P2ry4"
                     /gene_synonym="P2Y4; P2Y4R"
                     /inference="alignment:Splign:2.1.0"
     exon            153..291
                     /gene="P2ry4"
                     /gene_synonym="P2Y4; P2Y4R"
                     /inference="alignment:Splign:2.1.0"
     exon            292..4434
                     /gene="P2ry4"
                     /gene_synonym="P2Y4; P2Y4R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagagtca gctgggctca gcttcaaggg caccgggtag gagtcttgtc aaggttccta
       61 ggcaagggtg gtggtggtac tcctgggctg gaggcaggcg tgaagtgagg ccacatcagg
      121 gggaactaag agtacagaga actggaacta agatggtgct ccttaccctc caccctcttc
      181 agctagccag gttctgcagg ccagaggaag cagcagaaca ccattgactg cctccctgag
      241 cccgagcact gcctgatgcc atcagtccct ggactggact aaggaagctg gggggccatg
      301 accagtgcag actccttgct attcacatca ctaggtccca gcccaagttc tggagatggt
      361 gattgtaagt ttaatgagga attcaagttc atcctgttgc ctctgagcta tgcagttgtc
      421 tttgtgctgg gcctggccct caatgcccca accctttggc tgttcctctt ccgccttcga
      481 ccctgggatg caacagccac ttacatgttc catttggcat tgtcagacac cttgtatgtg
      541 ctgtcactgc ccaccctcgt ctactactat gctgccagaa accactggcc ctttggcact
      601 ggcttctgca agttcgtccg ctttcttttc tactggaacc tctactgcag tgtccttttc
      661 ctcacctgca tcagtgtgca ccgctacatg ggcatctgcc atccactgcg ggcaatacgc
      721 tggggccgcc ctcgatttgc aggtcttctc tgcctaggtg tttggttggt agtagctggc
      781 tgcctcgtgc ccaacctctt ctttgtgaca accaatgcca atggaaccac catcctgtgc
      841 catgacacga ctctgcctga ggagtttgac cactacgtat acttcagttc cacaatcatg
      901 gtgctgctct ttggctttcc cttcttgatc actctggtct gctatggact catggcccgg
      961 cgactgtatc gacctttgcc aggagctgga cagtcatctt ctcggctccg ttctctccgc
     1021 accattgctg tggtgctgac tgtctttgct gtctgctttg tgcctttcca catcacccgc
     1081 acaatttatt acctggcaag actgttgaac gccgaatgcc gggtgctgaa cattgtcaat
     1141 gtggtttaca aagtgactcg tcccctggcc agtgctaata gctgtcttga tccagtgctc
     1201 tatctgttca cgggggacaa gtatcgaaac cagctccagc agctatgcag aggtagcaca
     1261 cctaagcgcc gaacaactgc ttcctccctg gcattggtga ccctacatga agaaagcatc
     1321 agcaggtggg cggacatcca ccaagacagc atcttccctg cttatgaggg tgaccgatta
     1381 taacagtggg cactggatat gacaggaagg ggactaactg caggcagagg ggagggagct
     1441 ccttagtgac agttgatagg ggcatcagct atcctctttt taagccaaag tttgaagtag
     1501 ttactcctat gcttctttct ctttttctgt cccttcctgg ggccactgtt cccgtttctc
     1561 aaacctcagt actctttgct ggttctgctt cccccaggtc cttccacagc atgtgtttct
     1621 tcaaccagag tagtgacttc aactagagga gtgaaggtag agcaatctca agacgggcct
     1681 gatgtgtatc atgaaacaag gcagaaccag gaagctgggg tactagcata gcacagatac
     1741 catataagtc acatgcagca ttcacaccca cttcctggct ccctctcaaa gacaagatag
     1801 tcctacctgt caaggtgctg aaatagggta cagggcatgt gaacctgcct tgcagggccc
     1861 tacataccct ctcgaagcct gctggtgttt aactgcagag cagccatgaa acagaatact
     1921 gctcttggtt gctgacccta aggaacctcc ggaggcaggg tccaggttga tagcagcctt
     1981 ggaagcagga ataagattac acctacctct aggacttcgg gagaacacac ttgatagctc
     2041 ccacctgttt aatgagagga ggaatggaca gctctgactg agaaggaaga aaacctccaa
     2101 gctctcctag tgatgggcaa agcaggtttg tgcagaaccg ggtggtaaca ggagtagacg
     2161 cccagaactg gctcttcact gctctcttcc ctttcctagc tctagttaga taaagcataa
     2221 ataaacctgt caccagatct ttttgaatca ggcgatagga tttcaaggat ttcaaggcta
     2281 gggtggggca ctcagttttc ctacctgttc agtcctcttg ccgcaacact tatgggtttg
     2341 gaggatctgg tgggtgtatg gagcagagga agctaaaccc tgagctcgag aagaaagagt
     2401 ttctgggcgg gcattcattt tcagcctcgt ttcctgtgaa agtcacctgc tagcctattg
     2461 gccttctgag tcagccccca acctttgctg ctctttgtga tcactactca tctacacaca
     2521 ccaacttctt attggcctca agtgttctct ctgtctggag tgtaggggag ggaggtacta
     2581 ggctacagag taaaacagct aaatcataat gcccctctgc ctttcttttt gttctttaaa
     2641 tacatctttc tcccttggag cacaagagtt cttctattag aagtaaatta aggggccctt
     2701 ttgagtctta ccaggtcccc actcttatga gcacaatctc cttgcccgtc actgctgcta
     2761 gccataggct ccatgtggta acgttattct cttcattaca actcattcaa gctcctccat
     2821 cattgggccc cagaactcca agctgcttag tcaagactaa cttcctggac ttcatagttt
     2881 gctattttat cctcccctgt ctctccacaa gatctcactg tgtaccactg tctagcctag
     2941 aactagctac agagacctgg gtgaccttga cctcataggg atccacctgg ttttgttttt
     3001 tgttttttgt gggtttgctt cccaattcct gggattaaag acatatgcta gcaggctggg
     3061 taaacacctc agtgtctcta tgcttcattc caatctgcgt acctgtgctg cattgtcttt
     3121 atcactttct tccccatggc cccttaatga gggaccttgt tccttttttc ctttgtcttc
     3181 atctttgtta gttactttca tcactgattt tatatcacca tataaaaaaa agacacaact
     3241 ttgctgtctc attttgccac agttctgtta gtgtctcctc atttcactac tgctataaac
     3301 acaaatctga gttcctccca ttctttggca cttagaacac aaattatgtc tttggcaaga
     3361 acgttaatat tttctctact cttatccctc tttgacctct acttcacttg actctactgc
     3421 atgtaatttt ataggtattt tttaaatata aaaataacat ttaaaataac ctcactgtga
     3481 caacactgaa ggaaatgtgg agagaaaata tttacctatt tcaaccccaa atttctgttt
     3541 tccatactca acattttctt ggtttgaagt catgtattat agaagtataa ccacagttat
     3601 atcttttaaa agtctgcttt ttagggtatt tagagtttgg tgatgtatgc ctataatccc
     3661 aagagttggt agtagacaca agagggttat aaactggaag ttagcctaga ctacatagtg
     3721 agaccttttg tcaaaacaaa caaataagta taatcctctt attgcaaact ttctccaggt
     3781 tgatgcaatc tttttgtttg tttgtttgtt tgttttttgg tttgtttttt gtttgttttt
     3841 tttgtttttt tgttttttgt ttttttgaga cagggttttt ctgtgtagcc ctgactgtcc
     3901 tggaactcac tctatagacc aggctggcct cgacctcaga aatctgcctg cctctgcctc
     3961 ccaagtgctg ggattaaagg cgtgcgccaa tagttacata aacttacttc cattggtaga
     4021 ccatatctta ataggctatt cccttattat tattattcca cttaggtagg ttagtttttc
     4081 tgtgctttga atattttcct gtttgtgact tttttctttt tgcaattcta gctctagtac
     4141 aagttctcaa gagtgagatt accagaccaa agagcacgaa catttttatg gattgtgatt
     4201 tttcccaatg actgcataca ttttcactgt cacagtgata tatggctagc ttagttccat
     4261 tgctgttcca gcatcagact ttatgggaaa tctttctgga agagaaacat tcaatttgtt
     4321 aatttcactt ctttgcttac ctatggcatt gaacactttc tcccatgttt actatttgca
     4381 ttctttttca actactactt atcttctatt gaaatattat attatttaat gtgt
//
