LOCUS       NM_008773               3011 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus purinergic receptor P2Y, G-protein coupled 2 (P2ry2),
            transcript variant 1, mRNA.
ACCESSION   NM_008773
VERSION     NM_008773.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3011)
  AUTHORS   Jeong,K., Je,J., Dusabimana,T., Karekezi,J., Nugroho,T.A.,
            Ndahigwa,E.N., Kim,H.J., Yun,S.P., Kim,H.J., Kim,H. and Park,S.W.
  TITLE     Deficiency of purinergic P2Y2 receptor impairs the recovery after
            renal ischemia-reperfusion injury and accelerates renal fibrosis
            and tubular senescence in mice
  JOURNAL   Sci Rep 14 (1), 31932 (2024)
   PUBMED   39738595
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3011)
  AUTHORS   Chougule,A., Zhang,C., Vinokurov,N., Mendez,D., Vojtisek,E.,
            Shi,C., Zhang,J. and Gardinier,J.
  TITLE     Purinergic signaling through the P2Y2 receptor regulates
            osteocytes' mechanosensitivity
  JOURNAL   J Cell Biol 223 (11) (2024)
   PUBMED   39212624
  REMARK    GeneRIF: Purinergic signaling through the P2Y2 receptor regulates
            osteocytes' mechanosensitivity.
REFERENCE   3  (bases 1 to 3011)
  AUTHORS   Qian,S., Shi,Y., Senfeld,J., Peng,Q. and Shen,J.
  TITLE     The P2Y2 receptor mediates terminal adipocyte differentiation and
            insulin resistance: Evidence for a dual G-protein coupling mode
  JOURNAL   J Biol Chem 300 (2), 105589 (2024)
   PUBMED   38141758
  REMARK    GeneRIF: The P2Y2 receptor mediates terminal adipocyte
            differentiation and insulin resistance: Evidence for a dual
            G-protein coupling mode.
REFERENCE   4  (bases 1 to 3011)
  AUTHORS   Oliveira,N.F., Monteiro,M.M.L.V., Mainieri,N.S., Tamura,A.S.,
            Pereira,L.M., Crepaldi,L.D., Coutinho-Silva,R., Savio,L.E.B. and
            Silva,C.L.M.
  TITLE     P2Y2-P2X7 receptors cross-talk in primed mesenteric endothelial
            cells upregulates NF-kappaB signaling favoring mononuclear cell
            adhesion in schistosomiasis
  JOURNAL   Front Immunol 14, 1328897 (2024)
   PUBMED   38239348
  REMARK    GeneRIF: P2Y2-P2X7 receptors cross-talk in primed mesenteric
            endothelial cells upregulates NF-kappaB signaling favoring
            mononuclear cell adhesion in schistosomiasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3011)
  AUTHORS   Kargarpour,Z., Cicko,S., Kohler,T.C., Zech,A., Stoshikj,S., Bal,C.,
            Renner,A., Idzko,M. and El-Gazzar,A.
  TITLE     Blocking P2Y2 purinergic receptor prevents the development of
            lipopolysaccharide-induced acute respiratory distress syndrome
  JOURNAL   Front Immunol 14, 1310098 (2023)
   PUBMED   38179047
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3011)
  AUTHORS   Janssens,R., Communi,D., Pirotton,S., Samson,M., Parmentier,M. and
            Boeynaems,J.M.
  TITLE     Cloning and tissue distribution of the human P2Y1 receptor
  JOURNAL   Biochem Biophys Res Commun 221 (3), 588-593 (1996)
   PUBMED   8630005
REFERENCE   7  (bases 1 to 3011)
  AUTHORS   Godecke,S., Decking,U.K., Godecke,A. and Schrader,J.
  TITLE     Cloning of the rat P2u receptor and its potential role in coronary
            vasodilation
  JOURNAL   Am J Physiol 270 (2 Pt 1), C570-C577 (1996)
   PUBMED   8779921
REFERENCE   8  (bases 1 to 3011)
  AUTHORS   Enomoto,K., Furuya,K., Moore,R.C., Yamagishi,S., Oka,T. and
            Maeno,T.
  TITLE     Expression cloning and signal transduction pathway of P2U receptor
            in mammary tumor cells
  JOURNAL   Biol Signals 5 (1), 9-21 (1996)
   PUBMED   8739319
REFERENCE   9  (bases 1 to 3011)
  AUTHORS   Erb,L., Garrad,R., Wang,Y., Quinn,T., Turner,J.T. and Weisman,G.A.
  TITLE     Site-directed mutagenesis of P2U purinoceptors. Positively charged
            amino acids in transmembrane helices 6 and 7 affect agonist potency
            and specificity
  JOURNAL   J Biol Chem 270 (9), 4185-4188 (1995)
   PUBMED   7876172
REFERENCE   10 (bases 1 to 3011)
  AUTHORS   Lustig,K.D., Shiau,A.K., Brake,A.J. and Julius,D.
  TITLE     Expression cloning of an ATP receptor from mouse neuroblastoma
            cells
  JOURNAL   Proc Natl Acad Sci U S A 90 (11), 5113-5117 (1993)
   PUBMED   7685114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK017378.1, AK005013.2 and AC151414.2.
            
            On Oct 11, 2014 this sequence version replaced NM_008773.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017378.1, AK005013.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AK017378.1         2-8
            8-2957              AK005013.2         2-2951
            2958-2958           AC151414.2         96124-96124         c
            2959-3007           AK005013.2         2953-3001
            3008-3011           AC151414.2         96071-96074         c
FEATURES             Location/Qualifiers
     source          1..3011
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.47 cM"
     gene            1..3011
                     /gene="P2ry2"
                     /gene_synonym="P2U1; P2Y2"
                     /note="purinergic receptor P2Y, G-protein coupled 2"
                     /db_xref="GeneID:18442"
                     /db_xref="MGI:MGI:105107"
     exon            1..287
                     /gene="P2ry2"
                     /gene_synonym="P2U1; P2Y2"
                     /inference="alignment:Splign:2.1.0"
     exon            288..478
                     /gene="P2ry2"
                     /gene_synonym="P2U1; P2Y2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..3011
                     /gene="P2ry2"
                     /gene_synonym="P2U1; P2Y2"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..1604
                     /gene="P2ry2"
                     /gene_synonym="P2U1; P2Y2"
                     /note="ATP receptor; P2U purinoceptor 1"
                     /codon_start=1
                     /product="P2Y purinoceptor 2"
                     /protein_id="NP_032799.2"
                     /db_xref="CCDS:CCDS21508.1"
                     /db_xref="GeneID:18442"
                     /db_xref="MGI:MGI:105107"
                     /translation="MAADLEPWNSTINGTWEGDELGYKCRFNEDFKYVLLPVSYGVVC
                     VLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYARGDHWPFS
                     TVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLHSLRWGRARYARRVAAVVWVL
                     VLACQAPVLYFVTTSVRGTRITCHDTSARELFSHFVAYSSVMLGLLFAVPFSVILVCY
                     VLMARRLLKPAYGTTGGLPRAKRKSVRTIALVLAVFALCFLPFHLTRTLYYSFRSLDL
                     SCHTLNAINMAYKITRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTEPTPSPQARR
                     KLGLHRPNRTVRKDLSVSSDDSRRTESTPAGSETKDIRL"
     regulatory      2520..2525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2ry2"
                     /gene_synonym="P2U1; P2Y2"
                     /note="hexamer: AATACA"
     polyA_site      2560
                     /gene="P2ry2"
                     /gene_synonym="P2U1; P2Y2"
                     /note="major polyA site"
     regulatory      2988..2993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2ry2"
                     /gene_synonym="P2U1; P2Y2"
                     /note="hexamer: ATTAAA"
     polyA_site      3008
                     /gene="P2ry2"
                     /gene_synonym="P2U1; P2Y2"
                     /note="major polyA site"
ORIGIN      
        1 actcggcatg ggactcgggc accaggaaca gcggcggcag cccttggagg ggaccagcgc
       61 agcggggagg tgagaggtgc ttcctagagg ggagcggaca ccaagagagg tcgccaagtg
      121 aggcctgggg acgggagcgc cggtcgagtc agcgccaaac agggagagcc cattacgtga
      181 ctgtcccgag ggctcgggct cccagccctt gtactgcgca aaactgggcg gtgagagccg
      241 gctgccggtg cgctgatgaa ctttgtttcc tctagagcgt gatctcggag tcctccgggc
      301 agctgcttgt cttaaaaaat gctggaggct gggcgggggc ccaggcctgg gaacctgttc
      361 ttcctgtttc ctgcctcagt cccagcagct ggtccaggcc tgtgcatatg tgagtgaaga
      421 actggagcag gcgctgagca tcctcaccac ctcaagagca ggagctgatc aggtccaggg
      481 caatggcagc agacctggaa ccctggaata gcaccatcaa tggcacctgg gagggggacg
      541 aactgggata caagtgtcgt ttcaacgagg acttcaagta cgtgctgttg cccgtgtcct
      601 atggcgtggt gtgcgtgctc gggttgtgcc tgaacgtcgt ggctctctat atcttcctat
      661 gccgcctcaa aacctggaac gcctccacca cctacatgtt tcacctggca gtttcggact
      721 ctctctacgc agcgtccctg ccgctgttgg tttattacta cgcccggggt gaccactggc
      781 catttagcac ggtgctctgc aagctggtgc gtttcctctt ctacaccaac ctctactgca
      841 gcatcctctt cctcacctgc atcagcgtgc accggtgcct gggagtcctg cgccctctgc
      901 actccctgcg ttggggccgg gcccgttatg cccgccgggt ggctgcggtt gtgtgggtgc
      961 tggtgctggc ctgccaggca cccgtgctct acttcgtcac caccagcgtg cggggaaccc
     1021 ggatcacttg ccatgacacc tcggcccgag agctctttag ccattttgtg gcttacagct
     1081 ccgtcatgct gggtctgctt tttgctgtgc ccttttccgt aatcctggtc tgttacgtgc
     1141 ttatggccag gcggctgctc aaaccggctt atgggaccac aggaggtctg cctcgggcca
     1201 agcgcaagtc tgtgcgcacc attgccttgg tactggccgt cttcgccctc tgcttcctgc
     1261 ctttccacct cacgcgcacc ctctactact ccttccgatc acttgacctc agctgccaca
     1321 ccctcaacgc catcaacatg gcatataaga tcacccggcc gctggccagc gccaacagtt
     1381 gtcttgaccc ggtactctac ttcctggcag ggcagagact tgtccgcttt gcccgagatg
     1441 ccaagccacc cacggagcct acccccagcc cacaggctcg tcgcaagctg ggcctgcaca
     1501 ggcctaacag aactgtgagg aaagatttgt cagtcagcag tgacgactca agacggacag
     1561 agtccacacc agctggaagt gagactaagg acattcggct atagcacctc agtcaggtgt
     1621 cagtttatgt aggggagctg taggggacca aggcttgtta aaggggctga tatcctctga
     1681 tgcggatcaa cagctctcac ttggcagggg ctcaggatac tcatcttgcg gtcccaagag
     1741 tagcaggact ccaaagtccc caatcatttg tacgtgtgag ttgggaaacc atatcttaag
     1801 aaaggcagtg ccacccgact cctatgcaga cagctgccat tcctgccaag gtacctaggc
     1861 tgaggttcag cctcccagat ccaaggggga agcaggctca gagaggacac agcagagccc
     1921 aggctacctg gattaggagt agaatcccaa ggtgactgga gggctcttgt tcccatggtg
     1981 atgtaggatg gacctgggca cgatggactt agctcagagg aggaccctca ggccaagaga
     2041 caaacctctg agagctaatg tcaggtccct ggagactccc ctggctggca gcaggtggga
     2101 accataactt atatgaaagg ctgtgccacc cattgggctg tgctctgggg catgacctgg
     2161 gaagctgtca ccacccacac aaaggcctgt tatctctgcc tcctgccttc cttcagtagt
     2221 aggaagtctt ggatgggtgt gtgtgtgtgt gtgtggtggg ggtgatccct tctcagtccc
     2281 ccaggtcaac cctgcctttc agccacttgt cttctgtatt gtactgtgcc aagcatggag
     2341 aggagtcaaa tagagttctg gttcttgggg ttccccagtt cacaaaacct ctcatgtgct
     2401 ggcaaatgtc aaaccattaa ctgaactggg ttggggaggg gcttttattt ataacactgc
     2461 caatccctgt ggtgcaagca attccactgt ggccaatcct atttcaattt aaaattacca
     2521 atacaaaggc gaacccattg caaaattcct gaaaaatcaa caactggttc ttttttctgg
     2581 gctcgtgggg gagagtagtg tagctgatga ggctcatctc ggagaaccaa aggcggactt
     2641 tgaattagcc atgtagctga aactggcctt gaacctctta ccctcttgcc tccatcgaca
     2701 aagcgctggg attacaggta gatgccacac ctatccaaca actggttctt aaaagcagat
     2761 gcagggtact tcagcacaaa ccatgctgac tagctgggac cgtgtgagcc ccagtcaggg
     2821 aggggtccct ggaatgcatg acagtggacc atgccagctc tggagtttag gcaggaatgg
     2881 gcaaaggtga caagcctcat gatctcaagg acaggaggtc ccttgtaagg accctctccc
     2941 cattccaccc tgcccatctc ctctatctcc cctcccccct ctcagccatt aaagctgagg
     3001 catcaccagt t
//
