LOCUS       NM_001287124            1708 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus purinergic receptor P2Y, G-protein coupled, 14
            (P2ry14), transcript variant 8, mRNA.
ACCESSION   NM_001287124
VERSION     NM_001287124.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1708)
  AUTHORS   Patritti-Cram,J., Rahrmann,E.P., Rizvi,T.A., Scheffer,K.C.,
            Phoenix,T.N., Largaespada,D.A. and Ratner,N.
  TITLE     NF1-dependent disruption of the blood-nerve-barrier is improved by
            blockade of P2RY14
  JOURNAL   iScience 27 (7), 110294 (2024)
   PUBMED   39100928
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1708)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1708)
  AUTHORS   Baalmann,F., Brendler,J., Butthof,A., Popkova,Y., Engel,K.M.,
            Schiller,J., Winter,K., Lede,V., Ricken,A., Schoneberg,T. and
            Schulz,A.
  TITLE     Reduced urine volume and changed renal sphingolipid metabolism in
            P2ry14-deficient mice
  JOURNAL   Front Cell Dev Biol 11, 1128456 (2023)
   PUBMED   37250906
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1708)
  AUTHORS   Whitehead,G.S., Karcz,T.P., Tosh,D.K., Jung,Y.H., Wen,Z.,
            Campbell,R.G., Gopinatth,V., Gao,Z.G., Jacobson,K.A. and Cook,D.N.
  TITLE     Effects of Purinergic Receptor Deletion or Pharmacologic Modulation
            on Pulmonary Inflammation in Mice
  JOURNAL   ACS Pharmacol Transl Sci 5 (10), 973-984 (2022)
   PUBMED   36268115
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1708)
  AUTHORS   Liu,C., Zhou,M., Jiang,W., Ye,S., Tian,S., Jiang,C., Hao,K., Li,H.
            and Hu,Q.
  TITLE     GPR105-Targeted Therapy Promotes Gout Resolution as a Switch
            Between NETosis and Apoptosis of Neutrophils
  JOURNAL   Front Immunol 13, 870183 (2022)
   PUBMED   35432308
  REMARK    GeneRIF: GPR105-Targeted Therapy Promotes Gout Resolution as a
            Switch Between NETosis and Apoptosis of Neutrophils.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1708)
  AUTHORS   Schulz,A. and Schoneberg,T.
  TITLE     The structural evolution of a P2Y-like G-protein-coupled receptor
  JOURNAL   J Biol Chem 278 (37), 35531-35541 (2003)
   PUBMED   12835326
REFERENCE   7  (bases 1 to 1708)
  AUTHORS   Lee,B.C., Cheng,T., Adams,G.B., Attar,E.C., Miura,N., Lee,S.B.,
            Saito,Y., Olszak,I., Dombkowski,D., Olson,D.P., Hancock,J.,
            Choi,P.S., Haber,D.A., Luster,A.D. and Scadden,D.T.
  TITLE     P2Y-like receptor, GPR105 (P2Y14), identifies and mediates
            chemotaxis of bone-marrow hematopoietic stem cells
  JOURNAL   Genes Dev 17 (13), 1592-1604 (2003)
   PUBMED   12842911
REFERENCE   8  (bases 1 to 1708)
  AUTHORS   Freeman,K., Tsui,P., Moore,D., Emson,P.C., Vawter,L., Naheed,S.,
            Lane,P., Bawagan,H., Herrity,N., Murphy,K., Sarau,H.M., Ames,R.S.,
            Wilson,S., Livi,G.P. and Chambers,J.K.
  TITLE     Cloning, pharmacology, and tissue distribution of G-protein-coupled
            receptor GPR105 (KIAA0001) rodent orthologs
  JOURNAL   Genomics 78 (3), 124-128 (2001)
   PUBMED   11735218
REFERENCE   9  (bases 1 to 1708)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 1708)
  AUTHORS   Chambers,J.K., Macdonald,L.E., Sarau,H.M., Ames,R.S., Freeman,K.,
            Foley,J.J., Zhu,Y., McLaughlin,M.M., Murdock,P., McMillan,L.,
            Trill,J., Swift,A., Aiyar,N., Taylor,P., Vawter,L., Naheed,S.,
            Szekeres,P., Hervieu,G., Scott,C., Watson,J.M., Murphy,A.J.,
            Duzic,E., Klein,C., Bergsma,D.J., Wilson,S. and Livi,G.P.
  TITLE     A G protein-coupled receptor for UDP-glucose
  JOURNAL   J Biol Chem 275 (15), 10767-10771 (2000)
   PUBMED   10753868
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115919.14.
            
            Transcript Variant: This variant (8) uses an alternate splice site
            in the 3' terminal exon which results in a distinct 5' UTR and
            causes translation initiation at an upstream start codon compared
            to variant 1. It encodes isoform b which is longer and has a
            distinct N-terminus compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3149820.1, BB866812.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               AC115919.14        52293-52561
            270-1708            AC115919.14        66994-68432
FEATURES             Location/Qualifiers
     source          1..1708
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 28.96 cM"
     gene            1..1708
                     /gene="P2ry14"
                     /gene_synonym="A330108O13Rik; Gpr105; P2Y14"
                     /note="purinergic receptor P2Y, G-protein coupled, 14"
                     /db_xref="GeneID:140795"
                     /db_xref="MGI:MGI:2155705"
     exon            1..269
                     /gene="P2ry14"
                     /gene_synonym="A330108O13Rik; Gpr105; P2Y14"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1310
                     /gene="P2ry14"
                     /gene_synonym="A330108O13Rik; Gpr105; P2Y14"
                     /note="isoform b is encoded by transcript variant 8; P2Y
                     purinoceptor 14; UDP-glucose receptor; G-protein coupled
                     receptor 105"
                     /codon_start=1
                     /product="P2Y purinoceptor 14 isoform b"
                     /protein_id="NP_001274053.1"
                     /db_xref="CCDS:CCDS79913.1"
                     /db_xref="GeneID:140795"
                     /db_xref="MGI:MGI:2155705"
                     /translation="MIFASRGEKMNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFIT
                     GLLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFV
                     CRVSAVIFYVNMYVSIVFFGLISFDRYYKIVKPLLTSIVQSVNYSKLLSVLVWMLMLL
                     LAVPNIILTNQGVKEVTKIQCMELKNELGRKWHKASNYIFVSIFWVVFLLLIVFYTAI
                     TRKIFKSHLKSRKNSTSVKRKSSRNIFSIVLVFVVCFVPYHIARIPYTKSQTEGHYSC
                     RTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLHMSLKVQNDLEVSKT
                     KRENAIHESTDTL"
     exon            270..1708
                     /gene="P2ry14"
                     /gene_synonym="A330108O13Rik; Gpr105; P2Y14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1686..1691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2ry14"
                     /gene_synonym="A330108O13Rik; Gpr105; P2Y14"
                     /note="hexamer: AACAAG"
     polyA_site      1706
                     /gene="P2ry14"
                     /gene_synonym="A330108O13Rik; Gpr105; P2Y14"
                     /note="major polyA site"
ORIGIN      
        1 gcagaatagc agtgtgcagt agcagagatg gggttaaaag gagttatctg atcctgtgaa
       61 ggggacaagt gcagctgggt tatgacgcaa ccctcggagc aaaggcagct caataactaa
      121 aatgcttagg aaagaaaaca aatacagagc atgaaggccg ccaccccagc agagctgaag
      181 ccagacgtga aggagttcat gtaagggagt ccctgctgtc ctccagacac actgatgcct
      241 gggctacgga tggggacggg gacgcaatga tctttgcctc cagaggtgag aagatgaaca
      301 actccaccac cacagaccct ccaaaccagc cctgctcctg gaacaccctg atcacaaagc
      361 agatcattcc cgtgttgtac ggtatggtct tcatcacggg gctcctcctc aatgggatat
      421 caggatggat attcttttat gtgcccagct ccaagagttt tatcatctat ctcaagaaca
      481 tagtggtggc tgactttctc atgggcctga ctttcccttt caaagtcctt ggtgactcag
      541 gcctcggccc ctggcaggtg aatgtgtttg tgtgcagggt ctctgccgtc atcttctatg
      601 ttaatatgta cgtcagcatc gtgttctttg ggctcatcag ctttgacagg tactataaaa
      661 ttgtgaagcc ccttctgacg tctattgtgc agtcggtgaa ctatagcaag ctgctttctg
      721 tgctcgtgtg gatgctcatg cttctccttg ctgtcccaaa catcatcctg acaaaccagg
      781 gtgtcaagga ggtcacgaag atacagtgca tggagctcaa aaacgagctg gggcggaagt
      841 ggcacaaggc gtctaactat atcttcgtga gtatcttctg ggtcgtgttt cttctgctaa
      901 tcgtcttcta cacggccatc acgaggaaga tcttcaagtc tcacctcaag tccaggaaga
      961 attccacctc cgtcaagagg aagtccagcc gcaatatctt cagcatcgtg ctcgtttttg
     1021 tcgtctgctt tgtgccttac cacattgcca gaatccccta cacaaagagt cagacggaag
     1081 gtcactacag ctgccggacg aaggagaccc tgctctatgc gaaagaattc actctgctac
     1141 tctcggctgc caatgtgtgt ctggacccca ttatttattt cttcttatgc cagccattta
     1201 gagaagtctt aaataagaag ttacacatgt cactcaaagt ccagaatgac ctagaggttt
     1261 ccaaaaccaa aagggaaaat gcgattcatg aaagcacaga tactttgtaa attcccatcc
     1321 ccttccaagt attatcagtc ttgttacatg ataattaaga tacatgaata aaaagcaggc
     1381 atatgatgat aagtaactta gctagcaata tatctaataa tatgtatgaa gtccaaaaag
     1441 gtataataaa aataaaatat aagtttccat gcaaaatgga agtctgtagc acatcacatt
     1501 tttttagaaa tcaaaggaac agagaagtgg ctttgtgggt gctggcgtat gagttaccaa
     1561 aaccaaactt ctcttctatt aactggcttc ttagaagaca cccagtcttt ccgaccttcc
     1621 tcctaagcat tcttccaagc aacactcgta tctatttcat gctttgtact atgcatgtgc
     1681 caataaacaa gttgtcttca aaaccatc
//
