LOCUS       NM_028808               2541 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus purinergic receptor P2Y, G-protein coupled 13
            (P2ry13), mRNA.
ACCESSION   NM_028808
VERSION     NM_028808.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2541)
  AUTHORS   Duparc,T., Gore,E., Combes,G., Beuzelin,D., Pires Da Silva,J.,
            Bouguetoch,V., Marques,M.A., Velazquez,A., Viguerie,N.,
            Tavernier,G., Arner,P., Ryden,M., Langin,D., Sioufi,N., Nasser,M.,
            Cabou,C., Najib,S. and Martinez,L.O.
  TITLE     P2Y13 receptor deficiency favors adipose tissue lipolysis and
            worsens insulin resistance and fatty liver disease
  JOURNAL   JCI Insight 9 (8), e175623 (2024)
   PUBMED   38470490
  REMARK    GeneRIF: P2Y13 receptor deficiency favors adipose tissue lipolysis
            and worsens insulin resistance and fatty liver disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2541)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2541)
  AUTHORS   Werder,R.B., Ullah,M.A., Rahman,M.M., Simpson,J., Lynch,J.P.,
            Collinson,N., Rittchen,S., Rashid,R.B., Sikder,M.A.A.,
            Handoko,H.Y., Curren,B.F., Sebina,I., Hartel,G., Bissell,A.,
            Ngo,S., Yarlagadda,T., Hasnain,S.Z., Lu,W., Sohal,S.S., Martin,M.,
            Bowler,S., Burr,L.D., Martinez,L.O., Robaye,B., Spann,K.,
            Ferreira,M.A.R. and Phipps,S.
  TITLE     Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1 Release and
            Ameliorates Experimental Asthma
  JOURNAL   Am J Respir Crit Care Med 205 (3), 300-312 (2022)
   PUBMED   34860143
  REMARK    GeneRIF: Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1
            Release and Ameliorates Experimental Asthma.
REFERENCE   4  (bases 1 to 2541)
  AUTHORS   Kyrargyri,V., Madry,C., Rifat,A., Arancibia-Carcamo,I.L.,
            Jones,S.P., Chan,V.T.T., Xu,Y., Robaye,B. and Attwell,D.
  TITLE     P2Y13 receptors regulate microglial morphology, surveillance, and
            resting levels of interleukin 1beta release
  JOURNAL   Glia 68 (2), 328-344 (2020)
   PUBMED   31520551
REFERENCE   5  (bases 1 to 2541)
  AUTHORS   Stefani,J., Tschesnokowa,O., Parrilla,M., Robaye,B.,
            Boeynaems,J.M., Acker-Palmer,A., Zimmermann,H. and Gampe,K.
  TITLE     Disruption of the Microglial ADP Receptor P2Y13 Enhances Adult
            Hippocampal Neurogenesis
  JOURNAL   Front Cell Neurosci 12, 134 (2018)
   PUBMED   29867367
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2541)
  AUTHORS   Tan,C., Salehi,A., Svensson,S., Olde,B. and Erlinge,D.
  TITLE     ADP receptor P2Y(13) induce apoptosis in pancreatic beta-cells
  JOURNAL   Cell Mol Life Sci 67 (3), 445-453 (2010)
   PUBMED   19915796
  REMARK    GeneRIF: The brackage of P2ry13 protein receptor results in
            enhanced ERK1/2, Akt/PKB and CREB phosphorylation mechanisms
            involved in beta-cell survival.
REFERENCE   7  (bases 1 to 2541)
  AUTHORS   Grimm,I., Messemer,N., Stanke,M., Gachet,C. and Zimmermann,H.
  TITLE     Coordinate pathways for nucleotide and EGF signaling in cultured
            adult neural progenitor cells
  JOURNAL   J Cell Sci 122 (Pt 14), 2524-2533 (2009)
   PUBMED   19549686
REFERENCE   8  (bases 1 to 2541)
  AUTHORS   Park,S.W., Zhen,G., Verhaeghe,C., Nakagami,Y., Nguyenvu,L.T.,
            Barczak,A.J., Killeen,N. and Erle,D.J.
  TITLE     The protein disulfide isomerase AGR2 is essential for production of
            intestinal mucus
  JOURNAL   Proc Natl Acad Sci U S A 106 (17), 6950-6955 (2009)
   PUBMED   19359471
REFERENCE   9  (bases 1 to 2541)
  AUTHORS   De Lorenzo,S., Veggetti,M., Muchnik,S. and Losavio,A.
  TITLE     Presynaptic inhibition of spontaneous acetylcholine release
            mediated by P2Y receptors at the mouse neuromuscular junction
  JOURNAL   Neuroscience 142 (1), 71-85 (2006)
   PUBMED   16843602
REFERENCE   10 (bases 1 to 2541)
  AUTHORS   Tominaga,M., Kurihara,H., Honda,S., Amakawa,G., Sakai,T. and
            Tomooka,Y.
  TITLE     Molecular characterization of mitocalcin, a novel mitochondrial
            Ca2+-binding protein with EF-hand and coiled-coil domains
  JOURNAL   J Neurochem 96 (1), 292-304 (2006)
   PUBMED   16336229
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK083264.1 and AW489196.1.
            
            On Jun 20, 2009 this sequence version replaced NM_028808.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK038560.1, AK008013.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2514              AK083264.1         2-2515
            2515-2541           AW489196.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..2541
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.01 cM"
     gene            1..2541
                     /gene="P2ry13"
                     /gene_synonym="2010001L06Rik; GPCR1; Gpr86; GPR94; P2Y13;
                     P2yr13; SP174"
                     /note="purinergic receptor P2Y, G-protein coupled 13"
                     /db_xref="GeneID:74191"
                     /db_xref="MGI:MGI:1921441"
     exon            1..61
                     /gene="P2ry13"
                     /gene_synonym="2010001L06Rik; GPCR1; Gpr86; GPR94; P2Y13;
                     P2yr13; SP174"
                     /inference="alignment:Splign:2.1.0"
     exon            62..2528
                     /gene="P2ry13"
                     /gene_synonym="2010001L06Rik; GPCR1; Gpr86; GPR94; P2Y13;
                     P2yr13; SP174"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2502..2507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2ry13"
                     /gene_synonym="2010001L06Rik; GPCR1; Gpr86; GPR94; P2Y13;
                     P2yr13; SP174"
                     /note="hexamer: AATAAA"
     polyA_site      2522
                     /gene="P2ry13"
                     /gene_synonym="2010001L06Rik; GPCR1; Gpr86; GPR94; P2Y13;
                     P2yr13; SP174"
                     /note="major polyA site"
ORIGIN      
        1 attcgtgggt tgagctagta actgccacaa ctcatacagc tgagtctctt ccaaaacaaa
       61 gctgatgctc gggacaatca acaccactgg gatgcagggc ttcaacaagt ctgagcggtg
      121 ccccagggac actcggatga cacagctgct gttcccggtt ctctatactg tggtcttcct
      181 ggcaggcatc ctgctgaaca ccgtggccct ctgggtgttc gtccacatcc ccagcaattc
      241 cacctttatc gtctacctca agaacactct ggtggcagac ttgataatgg cactcatgct
      301 gcctttcaaa atcctttccg actcacacct tgcgccctgg cagctccgag gatttgtgtg
      361 cacgctctcc tccgtggtct tctatgagac gatgtatgtg ggtatcatga tgctgggcct
      421 catcgctttc gacaggttcc tcaagatcat catgccgttc aggaaaacct ttgtcaaaaa
      481 gacggctttc gcaaaaacag tctccatttc cgtctggtcc ctgatgttct tcatctccct
      541 gccaaacatg atcttgaaca aggaggcaac gccatcatcc gtgaagaagt gtgcatcttt
      601 gaagagtccc cttgggctgt ggtggcatca ggtggtcagt cacacctgcc agttcatttt
      661 ctgggctgtg tttattctga tgcttctgtt ttatgcggtg attaccaaaa aggtgtacaa
      721 ctcctatagg aagtttagga gtaaggacag caggcacaag cggctggagg tgaaggtatt
      781 tatcgtcatg gctgtcttct ttgtctgctt tgccccactg cattttgtca gaataccata
      841 cacttacagt caaaccacca ataagactga ctgtaggtta gaaaaccagc tgtttattgc
      901 taaagaagca actctctttc tggcaacaac taacatttgt atggacccct taatatacat
      961 aattttatgc aagaagttca cacaaaaggt gccatgtgtg agatggggaa aggcaagaac
     1021 agcaggatca agcgaagacc accacagtag tcagacagac aacatcaccc tagcctgacc
     1081 actgtgtccc acaggttaat ttcacgcatg gcctcacgtc tatttatgga tgggatttca
     1141 aaagatcatt tatgtggaga cctcatttaa gcattacagg aaaaaagagg ggaacaaaca
     1201 gttccctaca ttttattatc ctagtgtatg gaaaaacatt atgcccattt taaccacata
     1261 gacgtattta taagcaggat aaattaagag accatgtaat acagcaaatg gccactagat
     1321 gtcacctttt caagggcatt catgtactat ggaaaaggtt aatgggaaac aggtttgcct
     1381 gaaaaatctt ccttctagtt accaccccac catctctcac acacataatt cctaaaacac
     1441 caggctggct tttacagcct tcagaatgct gacacttgtg aacagaaacc aaccaacttg
     1501 catatccagt gcctgtgtgg aaaggctaag gtgggggctc aaagagatgc agtctgagga
     1561 accaaagtgg gttggtcaaa ataaccccag gcatctcaaa agatttcctc cttacaagtg
     1621 caaagggctg ctcctacatc taaacagagc accagaagag aggcacatgc aacaggcaaa
     1681 gccagttcac agccatgtgc aatccagaga ggggaagtgt ttagtcagca aaaccttcct
     1741 gggcaacagc atctgcatcc tgttggaaaa tacttatttc cctcactgtt tatctataaa
     1801 ttaggttcct tgctacacac tgtcttatat taactgcttt cattcttagc cacatttccc
     1861 aaaaacaggg ttcgtaaaaa gacagcaaaa tcacacattt ttacaaaaga aatggggtaa
     1921 ggatatccta gacgggatgt ttgttgtaca ctatccttag tgcatgtgag caaggggatg
     1981 gttggcctgg cattagtaat attcatgtgg gaagattttt caaagcctga ttcattttat
     2041 ttgggcctat ctacttccct ggatctcatt atgggtttaa gaaaattaaa atatgtggct
     2101 ggtgatgctg ggttttctgg agaacacgac gactcttccc ctaaccgcgc ctgtaatgtg
     2161 aaatcctggc ttctctcttt ccatagcctc agaagccaca gaggcaagag aacttccttg
     2221 tcttcctgga atcacttgct aatcttgacc tttacaaact ccatttaata tggcacattt
     2281 ggtccgcact gcactgtaca tagaaccttc catctgaccc actttgtaag ttcctattga
     2341 ttagtgacac ccaaagttgc tgtcccttac tccaggtaac cttacctgcc caacctcctc
     2401 cgagtcctcc agcccagtca cttcctcatc tgtgtgacat cattcctcat ctacttatcg
     2461 aattgattta ggataatttg ctaaatatgc actgtgcaat taataaattt tgctaaaaca
     2521 aatcaaaaaa aaaaaaaaaa a
//
