LOCUS       NM_001357008            2557 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus purinergic receptor P2Y, G-protein coupled 12
            (P2ry12), transcript variant 3, mRNA.
ACCESSION   NM_001357008 XM_006502083
VERSION     NM_001357008.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2557)
  AUTHORS   Lehtonen,H., Jokela,H., Hofmann,J., Tola,L., Mehmood,A.,
            Ginhoux,F., Becher,B., Greter,M., Yegutkin,G.G., Salmi,M., Gerke,H.
            and Rantakari,P.
  TITLE     Early precursor-derived pituitary gland tissue-resident macrophages
            play a pivotal role in modulating hormonal balance
  JOURNAL   Cell Rep 44 (2), 115227 (2025)
   PUBMED   39841599
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2557)
  AUTHORS   Wei,B., Cheng,G., Bi,Q., Lu,C., Sun,Q., Li,L., Chen,N., Hu,M.,
            Lu,H., Xu,X., Mao,G., Wan,S., Hu,Z., Gu,Y., Zheng,J., Zhao,L.,
            Shen,X.Z., Liu,X. and Shi,P.
  TITLE     Microglia in the hypothalamic paraventricular nucleus sense
            hemodynamic disturbance and promote sympathetic excitation in
            hypertension
  JOURNAL   Immunity 57 (9), 2030-2042 (2024)
   PUBMED   39116878
REFERENCE   3  (bases 1 to 2557)
  AUTHORS   Bedolla,A., Wegman,E., Weed,M., Stevens,M.K., Ware,K., Paranjpe,A.,
            Alkhimovitch,A., Ifergan,I., Taranov,A., Peter,J.D.,
            Gonzalez,R.M.S., Robinson,J.E., McClain,L., Roskin,K.M., Greig,N.H.
            and Luo,Y.
  TITLE     Adult microglial TGFbeta1 is required for microglia homeostasis via
            an autocrine mechanism to maintain cognitive function in mice
  JOURNAL   Nat Commun 15 (1), 5306 (2024)
   PUBMED   38906887
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2557)
  AUTHORS   Morimoto,K., Takahashi,R., Takahashi,G., Miyajima,M. and
            Nakajima,K.
  TITLE     Maternal immunoglobulins are distributed in the offspring's brain
            to support the maintenance of cortical interneurons in the
            postnatal period
  JOURNAL   Inflamm Regen 44 (1), 24 (2024)
   PUBMED   38750507
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2557)
  AUTHORS   Uweru,O.J., Okojie,A.K., Trivedi,A., Benderoth,J., Thomas,L.S.,
            Davidson,G., Cox,K. and Eyo,U.B.
  TITLE     A P2RY12 deficiency results in sex-specific cellular perturbations
            and sexually dimorphic behavioral anomalies
  JOURNAL   J Neuroinflammation 21 (1), 95 (2024)
   PUBMED   38622726
  REMARK    GeneRIF: A P2RY12 deficiency results in sex-specific cellular
            perturbations and sexually dimorphic behavioral anomalies.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2557)
  AUTHORS   Pausch,M.H., Lai,M., Tseng,E., Paulsen,J., Bates,B. and Kwak,S.
  TITLE     Functional expression of human and mouse P2Y12 receptors in
            Saccharomyces cerevisiae
  JOURNAL   Biochem Biophys Res Commun 324 (1), 171-177 (2004)
   PUBMED   15464998
  REMARK    GeneRIF: Results describe the cloning of DNA sequences encoding the
            murine ortholog of the human P2Y12 receptor, and its expression in
            the mouse brain.
REFERENCE   7  (bases 1 to 2557)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   8  (bases 1 to 2557)
  AUTHORS   Schulz,A. and Schoneberg,T.
  TITLE     The structural evolution of a P2Y-like G-protein-coupled receptor
  JOURNAL   J Biol Chem 278 (37), 35531-35541 (2003)
   PUBMED   12835326
REFERENCE   9  (bases 1 to 2557)
  AUTHORS   Andre,P., Delaney,S.M., LaRocca,T., Vincent,D., DeGuzman,F.,
            Jurek,M., Koller,B., Phillips,D.R. and Conley,P.B.
  TITLE     P2Y12 regulates platelet adhesion/activation, thrombus growth, and
            thrombus stability in injured arteries
  JOURNAL   J Clin Invest 112 (3), 398-406 (2003)
   PUBMED   12897207
  REMARK    GeneRIF: role of P2Y12 in platelet thrombosis and how its complete
            absence affects the thrombotic process
REFERENCE   10 (bases 1 to 2557)
  AUTHORS   Foster,C.J., Prosser,D.M., Agans,J.M., Zhai,Y., Smith,M.D.,
            Lachowicz,J.E., Zhang,F.L., Gustafson,E., Monsma,F.J. Jr.,
            Wiekowski,M.T., Abbondanzo,S.J., Cook,D.N., Bayne,M.L., Lira,S.A.
            and Chintala,M.S.
  TITLE     Molecular identification and characterization of the platelet ADP
            receptor targeted by thienopyridine antithrombotic drugs
  JOURNAL   J Clin Invest 107 (12), 1591-1598 (2001)
   PUBMED   11413167
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122038.3.
            
            On Oct 14, 2017 this sequence version replaced XM_006502083.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.192097.1,
                                           ERR3363658.5465037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AC122038.3         63549-63760
            213-343             AC122038.3         98953-99083
            344-408             AC122038.3         106251-106315
            409-571             AC122038.3         106438-106600
            572-2557            AC122038.3         108278-110263
FEATURES             Location/Qualifiers
     source          1..2557
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.01 cM"
     gene            1..2557
                     /gene="P2ry12"
                     /gene_synonym="2900079B22Rik; 4921504D23Rik; P2Y12"
                     /note="purinergic receptor P2Y, G-protein coupled 12"
                     /db_xref="GeneID:70839"
                     /db_xref="MGI:MGI:1918089"
     exon            1..212
                     /gene="P2ry12"
                     /gene_synonym="2900079B22Rik; 4921504D23Rik; P2Y12"
                     /inference="alignment:Splign:2.1.0"
     exon            213..343
                     /gene="P2ry12"
                     /gene_synonym="2900079B22Rik; 4921504D23Rik; P2Y12"
                     /inference="alignment:Splign:2.1.0"
     exon            344..408
                     /gene="P2ry12"
                     /gene_synonym="2900079B22Rik; 4921504D23Rik; P2Y12"
                     /inference="alignment:Splign:2.1.0"
     exon            409..571
                     /gene="P2ry12"
                     /gene_synonym="2900079B22Rik; 4921504D23Rik; P2Y12"
                     /inference="alignment:Splign:2.1.0"
     exon            572..2557
                     /gene="P2ry12"
                     /gene_synonym="2900079B22Rik; 4921504D23Rik; P2Y12"
                     /inference="alignment:Splign:2.1.0"
     CDS             576..1619
                     /gene="P2ry12"
                     /gene_synonym="2900079B22Rik; 4921504D23Rik; P2Y12"
                     /codon_start=1
                     /product="P2Y purinoceptor 12"
                     /protein_id="NP_001343937.1"
                     /db_xref="CCDS:CCDS17373.1"
                     /db_xref="GeneID:70839"
                     /db_xref="MGI:MGI:1918089"
                     /translation="MDVPGVNTTSANTTFSPGTSTLCVRDYKITQVLFPLLYTVLFFA
                     GLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGPLRTLV
                     CQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVVIWAFMFL
                     ISLPNMILTNRRPKDKDVTKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLI
                     TKELYRSYVRTRGSAKVPKKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDC
                     SAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLTSMLRCSNSTSTSGTNKKK
                     GQEGGEPSEETPM"
     regulatory      2448..2453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2ry12"
                     /gene_synonym="2900079B22Rik; 4921504D23Rik; P2Y12"
                     /note="hexamer: ATTAAA"
     polyA_site      2469
                     /gene="P2ry12"
                     /gene_synonym="2900079B22Rik; 4921504D23Rik; P2Y12"
                     /note="major polyA site"
     regulatory      2535..2540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2ry12"
                     /gene_synonym="2900079B22Rik; 4921504D23Rik; P2Y12"
                     /note="hexamer: ATTAAA"
     polyA_site      2556
                     /gene="P2ry12"
                     /gene_synonym="2900079B22Rik; 4921504D23Rik; P2Y12"
ORIGIN      
        1 gtccttagcg cagtctatgg aacagctgca aattggactg gtgaaatgtt tcatttcttc
       61 tattcaagta gaaaatcagg gtgcacacaa aggcagtctt gttctccatg acaaatcaga
      121 gtgctgaaat gacaaaacgc cagtgtcatt tgctgtcaca cagcaggagc tgccgcacgg
      181 acactttccc gtatccaggg tcacagtgca aggggtggca tctacctgct tggcaactca
      241 ccttcaccgg caccacccct gtttttccag tttggaacat gctaaagtaa aataataacg
      301 tgctacccga cctgaagcac ttgatgtggg cgtaccctac agaaataaaa ggagaagtcc
      361 taaaaacaga cagactggag tctgcagagc tctgaatatt cacagaagaa cactcaaggc
      421 tgccttgctg aagtctctgc agagtctcta tcacagaggg ctttgggaac ttatgcaagt
      481 cactgagaag aaagcaacag atgccagtct gcaagttcca ctaactagta ttcccggaga
      541 cactcatatc cttcagattc agcagaacca ggaccatgga tgtgcctggt gtcaacacca
      601 cctcagccaa taccaccttc tcccctggga ccagcaccct gtgcgtcaga gactacaaga
      661 tcacccaggt tctcttccca ttgctgtaca ccgtcctgtt ctttgctggg ctcatcacga
      721 acagcttggc aatgaggatt ttctttcaga tccgcagtaa atccaacttc atcatttttc
      781 ttaagaacac ggtcatctct gatctactaa tgattctaac ttttccattt aaaattctta
      841 gtgatgctaa actgggagcc gggcctctga gaaccttggt gtgccaagtt acttcagtca
      901 cattttattt tacaatgtat atcagtatat cgttcctggg gttgataacc attgaccgct
      961 acctgaagac caccaggcca tttaaaacgt ccagccccag caatctcttg ggtgcaaaga
     1021 ttctttctgt tgtcatctgg gccttcatgt tcttaatttc actgcctaac atgattctca
     1081 ccaacaggag gccaaaagat aaggacgtaa caaaatgttc tttcttaaag tcagagtttg
     1141 gtctagtttg gcacgaaata gtcaattaca tctgccaagt cattttctgg attaattttt
     1201 taattgtcat cgtttgttat agcctcatta ccaaagaact ctatcggtct tatgtcagaa
     1261 caaggggttc agccaaagtt cccaagaaaa aggtaaacgt caaggttttc atcatcattg
     1321 ctgtattctt tatttgcttt gttcccttcc actttgcacg gattccctac accctgagcc
     1381 aaactcgggc cgtctttgac tgcagtgctg agaacaccct gttctacgtg aaggagagca
     1441 ccctatggct gacgtcactg aacgcctgcc ttgatccatt catctacttt tttctttgca
     1501 agtctttcag aaattccttg acaagcatgc tgaggtgctc aaactctaca tcaacatctg
     1561 ggacaaacaa gaagaaagga caagaaggtg gcgaaccaag cgaagagacc ccaatgtaga
     1621 acattaccca aggggctgct tcagtcttta atatccagac tgctccaagg aaatcaccat
     1681 acaaatatat taacattcac taaaaagaag ttgagttaat gattctttaa ataatcaata
     1741 aagtaagaaa ataattttta actacctttt ctgtacatat atgggaaaaa tcttagtctg
     1801 caggtgtatt ttaaaatgaa ctgcatccca ttgctatact gcaggcaaac cacaaaaaaa
     1861 aatcatttat ctgatttctt caaaattagc aacatgaaat gtaatattca ttgtcatttt
     1921 aaaataaatt accaataaca atattatttt tgtaataagt gagaatgtat gtatgatctg
     1981 atacatcaaa cacagtaatt accaacttcc catttataac aaggataaca acaaaaccaa
     2041 agggacgtaa atcaaatgaa atgacaatgg ataaggcctg gattattgta aatgcacatt
     2101 aagatggtag aggtttaaaa agcgaatctt accataaagg acagacatga tgaataaaat
     2161 tattaactta acaaaagtac actttcataa cattctaaca ttaaaaatat ttactccttc
     2221 cttaacacta gaggcagcaa ttttactaag gttctaagtt tactgggtag agtgtcatta
     2281 tcggtactta tctgctaact agctttgaaa atgcctgctg cttgaatgaa cagaacactt
     2341 cttaataaga aaacataagc aactacaatt accaaatcac acatcacatc taccaataag
     2401 aaagtgattg aactacttga gattatgttt gtaatcatgt gtataatatt aaaatgcatt
     2461 tattctgtat cgttttgttg gaatttcttc attcaaaaac tattaggtat aatggttcaa
     2521 ccttctttgc ctctattaaa cagtaaatgt atttaag
//
