LOCUS       NM_008772               3899 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus purinergic receptor P2Y, G-protein coupled 1 (P2ry1),
            transcript variant 1, mRNA.
ACCESSION   NM_008772
VERSION     NM_008772.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3899)
  AUTHORS   Shigetomi,E., Suzuki,H., Hirayama,Y.J., Sano,F., Nagai,Y.,
            Yoshihara,K., Koga,K., Tateoka,T., Yoshioka,H., Shinozaki,Y.,
            Kinouchi,H., Tanaka,K.F., Bito,H., Tsuda,M. and Koizumi,S.
  TITLE     Disease-relevant upregulation of P2Y1 receptor in astrocytes
            enhances neuronal excitability via IGFBP2
  JOURNAL   Nat Commun 15 (1), 6525 (2024)
   PUBMED   39117630
  REMARK    GeneRIF: Disease-relevant upregulation of P2Y1 receptor in
            astrocytes enhances neuronal excitability via IGFBP2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3899)
  AUTHORS   Schappe,M.S., Brinn,P.A., Joshi,N.R., Greenberg,R.S., Min,S.,
            Alabi,A.A., Zhang,C. and Liberles,S.D.
  TITLE     A vagal reflex evoked by airway closure
  JOURNAL   Nature 627 (8005), 830-838 (2024)
   PUBMED   38448588
REFERENCE   3  (bases 1 to 3899)
  AUTHORS   de Ceglia,R., Ledonne,A., Litvin,D.G., Lind,B.L., Carriero,G.,
            Latagliata,E.C., Bindocci,E., Di Castro,M.A., Savtchouk,I.,
            Vitali,I., Ranjak,A., Congiu,M., Canonica,T., Wisden,W., Harris,K.,
            Mameli,M., Mercuri,N., Telley,L. and Volterra,A.
  TITLE     Specialized astrocytes mediate glutamatergic gliotransmission in
            the CNS
  JOURNAL   Nature 622 (7981), 120-129 (2023)
   PUBMED   37674083
REFERENCE   4  (bases 1 to 3899)
  AUTHORS   Paul,D.S., Blatt,T.N., Schug,W.J., Clark,E.G., Kawano,T.,
            Mackman,N., Murcia,S., Poe,K.O., Mwiza,J.M.N., Harden,T.K.,
            Bergmeier,W. and Nicholas,R.A.
  TITLE     Loss of P2Y1 receptor desensitization does not impact hemostasis or
            thrombosis despite increased platelet reactivity in vitro
  JOURNAL   J Thromb Haemost 21 (7), 1891-1902 (2023)
   PUBMED   36958516
  REMARK    GeneRIF: Loss of P2Y1 receptor desensitization does not impact
            hemostasis or thrombosis despite increased platelet reactivity in
            vitro.
REFERENCE   5  (bases 1 to 3899)
  AUTHORS   Bsharat,S., Monni,E., Singh,T., Johansson,J.K., Achanta,K.,
            Bertonnier-Brouty,L., Schmidt-Christensen,A., Holmberg,D.,
            Kokaia,Z., Prasad,R.B. and Artner,I.
  TITLE     MafB-dependent neurotransmitter signaling promotes beta cell
            migration in the developing pancreas
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36897571
REFERENCE   6  (bases 1 to 3899)
  AUTHORS   Fabre,J.E., Nguyen,M., Latour,A., Keifer,J.A., Audoly,L.P.,
            Coffman,T.M. and Koller,B.H.
  TITLE     Decreased platelet aggregation, increased bleeding time and
            resistance to thromboembolism in P2Y1-deficient mice
  JOURNAL   Nat Med 5 (10), 1199-1202 (1999)
   PUBMED   10502826
REFERENCE   7  (bases 1 to 3899)
  AUTHORS   Kunapuli,S.P. and Daniel,J.L.
  TITLE     P2 receptor subtypes in the cardiovascular system
  JOURNAL   Biochem J 336 (Pt 3) (Pt 3), 513-523 (1998)
   PUBMED   9841859
  REMARK    Review article
REFERENCE   8  (bases 1 to 3899)
  AUTHORS   Schachter,J.B., Li,Q., Boyer,J.L., Nicholas,R.A. and Harden,T.K.
  TITLE     Second messenger cascade specificity and pharmacological
            selectivity of the human P2Y1-purinoceptor
  JOURNAL   Br J Pharmacol 118 (1), 167-173 (1996)
   PUBMED   8733591
REFERENCE   9  (bases 1 to 3899)
  AUTHORS   Janssens,R., Communi,D., Pirotton,S., Samson,M., Parmentier,M. and
            Boeynaems,J.M.
  TITLE     Cloning and tissue distribution of the human P2Y1 receptor
  JOURNAL   Biochem Biophys Res Commun 221 (3), 588-593 (1996)
   PUBMED   8630005
REFERENCE   10 (bases 1 to 3899)
  AUTHORS   Tokuyama,Y., Hara,M., Jones,E.M., Fan,Z. and Bell,G.I.
  TITLE     Cloning of rat and mouse P2Y purinoceptors
  JOURNAL   Biochem Biophys Res Commun 211 (1), 211-218 (1995)
   PUBMED   7779087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY780693.1, AK030759.1, AK033660.1 and AK036611.1.
            
            On Aug 14, 2013 this sequence version replaced NM_008772.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036611.1, BC138635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY780693.1         1-10
            11-209              AK030759.1         1-199
            210-434             AK033660.1         196-420
            435-2606            AK036611.1         426-2597
            2607-3899           AK030759.1         2321-3613
FEATURES             Location/Qualifiers
     source          1..3899
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.24 cM"
     gene            1..3899
                     /gene="P2ry1"
                     /gene_synonym="P2Y1; P2y1r"
                     /note="purinergic receptor P2Y, G-protein coupled 1"
                     /db_xref="GeneID:18441"
                     /db_xref="MGI:MGI:105049"
     exon            1..1815
                     /gene="P2ry1"
                     /gene_synonym="P2Y1; P2y1r"
                     /inference="alignment:Splign:2.1.0"
     CDS             658..1779
                     /gene="P2ry1"
                     /gene_synonym="P2Y1; P2y1r"
                     /note="ATP receptor; P2Y1 receptor; ADP receptor"
                     /codon_start=1
                     /product="P2Y purinoceptor 1"
                     /protein_id="NP_032798.1"
                     /db_xref="CCDS:CCDS17377.1"
                     /db_xref="GeneID:18441"
                     /db_xref="MGI:MGI:105049"
                     /translation="MTEVPWSVVPNGTDAAFLAGLGSLWGNSTVASTAAVSSSFQCAL
                     TKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVL
                     TLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSL
                     GRLKKKNAIYVSVLVWLIVVVAISPILFYSGTGTRKNKTVTCYDTTSNDYLRSYFIYS
                     MCTTVAMFCIPLVLILGCYGLIVKALIYNDLDNSPLRRKSIYLVIIVLTVFAVSYIPF
                     HVMKTMNLRARLDFQTPEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRR
                     LSRATRKASRRSEANLQSKSEEMTLNILSEFKQNGDTSL"
     exon            1816..3899
                     /gene="P2ry1"
                     /gene_synonym="P2Y1; P2y1r"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3878..3883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2ry1"
                     /gene_synonym="P2Y1; P2y1r"
                     /note="hexamer: AATAAA"
     polyA_site      3897
                     /gene="P2ry1"
                     /gene_synonym="P2Y1; P2y1r"
                     /note="major polyA site"
ORIGIN      
        1 tgccccctgc actcgagacc cagccgagcg cggagacgag ctgcagcctt catggactgt
       61 gagcggggta cagggtaggt agtacgccag ggtccgaggc cacgcgctct ccaaaagacc
      121 tccaaggttg agcgcgggct cagaatgtgg ccggaagaag agtcgcggcg tccctggtga
      181 aggtcccggg ttgcaaggta gggagtaggc agatggccag gcaaagttga tcagagagga
      241 ggtggttggc ctgcgccttc gggccgctgg gaacagccga actacttgga cttgacccgc
      301 cgcgccccag gcgctctgag cagcgcctat cagtcgccct gcgcgggagc gcacttgcaa
      361 acttggtgga ggtgccctgc gcgtcctgtt gtgtaacctc cgcgccgcca gctggaccgg
      421 gaagttgccc gcacgtcctt cagcttagat cggtcgcagc tccgggcgaa tttcatggcc
      481 cgcgacaaaa gcgcggccag agccggcgtg ggcgagcccc tgcgcgctcc gacccgtggg
      541 gaactcccgc gcgcggtccc tggcctgcgc ctccgatgcg cgctgagtct ctcgccgctg
      601 ctgcccgctc gccgcggtct gccctttcta gtagctgcct gagttggaaa gaagaggatg
      661 accgaggtgc cttggtcggt tgtccccaac gggacggatg ctgcctttct ggcgggcctg
      721 ggctcgcttt ggggaaacag tactgtcgcc tcaactgcag cagtttcctc ttcattccaa
      781 tgtgccctga ccaagaccgg tttccagttc tactacctgc cggctgtcta cattttagtg
      841 ttcatcatag gcttcctagg caacagcgtg gctatctgga tgttcgtttt ccacatgaag
      901 ccttggagcg gcatctccgt gtacatgttc aatttggctc tggctgactt tttatacgtg
      961 ctcaccctac cagccctcat cttctactac ttcaacaaga ctgactggat cttcggggat
     1021 gctatgtgca agctgcagag attcatcttc cacgtaaatc tctacggtag catcttgttc
     1081 ctcacctgca tcagcgcaca caggtacagt ggcgtggtgt accctctcaa gtctctgggc
     1141 aggctcaaga agaagaatgc catttatgtc agcgtgctgg tgtggctcat tgtggtggtg
     1201 gccatctccc ctattctctt ctactctggc actgggactc ggaaaaacaa aactgtcacc
     1261 tgctatgaca ccacgtccaa tgattacctg cgaagttatt tcatctacag tatgtgcacg
     1321 actgtggcca tgttctgcat ccctttggtg ctgatcttgg gctgttatgg attaattgtt
     1381 aaagctttga tttacaatga cctggacaac tctccgctcc ggaggaaatc catttacctg
     1441 gtgataattg tcctgacggt gtttgctgtg tcttatatcc ctttccatgt gatgaaaacg
     1501 atgaatttgc gagcacggtt ggatttccag accccagaaa tgtgtgattt caacgacagg
     1561 gtttatgcca cttatcaggt aacaagaggt ctagcaagtc tcaacagctg tgtggacccc
     1621 attctttatt tcttggctgg agatacattc agaaggagac tgtcccgagc caccaggaaa
     1681 gcttccagga ggagtgaggc caatttacaa tccaagagtg aagaaatgac tctcaatatt
     1741 ttatctgagt tcaagcagaa tggagacacg agtttgtgaa ggcacgagat cctagctcct
     1801 gagttttgta acatggtcac aagacatccc tgagatgatc tatgcataca caggtcaaga
     1861 agaagcaaca ctctattgac caaaagacca gtgtgtgcca cctgagtgag ggttttccta
     1921 taaagacagt tatgttgacg ttttgttgaa agacacctaa aactgtaaga tttagcgagt
     1981 cattaaacat cacactgcaa agatgtcttc attccattcc aagctcaagg gtttttcttg
     2041 ttgctctctg ttgttattcc ttacgaagtg ctgtctctga ctctttgaag gttgctttga
     2101 acctgcattg aactaaaatg ataaattaag aagaaacttc gcacaggaga cagaattcaa
     2161 aactaaaacc gtgacgtggc cactgagaag aaacttggaa acccattctt cgtgaagagg
     2221 aaaagtgaca ggacaccatt tgttgatgcc gtaggtgctg tggtaaacct tggaaagcag
     2281 tgagaactgt ttggaatctg ctcctctgct tcctaggact ctgcagtcca gtctttggct
     2341 agagttctca ttttccacca actgtggtat ggaaaggttg aaacttgtaa atctctgctc
     2401 acttagccag gacactaacc catcgtgata taacacatat cagtacttag tagcggctag
     2461 aattcaacta tggacaggac gtagaagatg tgttactcgt aaatatacat tgaagctttt
     2521 cttctattgg ttgaatgtaa tcattgtaat agtatttatt gaagaggttt gtgggccttc
     2581 agttgtacag attgaagata cagtgtacta gtgtaaattc tatttattgc agtgtataat
     2641 gttcaaatgt cacacgtata ttttacagta atatataatg ctagataaaa tgagaatttt
     2701 atttaggagg ttttttctca gatattagta actttggact tctaagacca gtttgtattt
     2761 gtatctaaaa tgatgaaaat gtggtttata acaagtgttt aattttctct agatttgaat
     2821 ttgcatgctt tccttttgtg tggggctctt gctatacaga catgatttgg tgttagatta
     2881 ttgtaagatt tataacaagt ataggatatt ttagacaggt tatatattac atacattata
     2941 tgtgtatatt tatattatag aaagtttgtg tgctattttc agaaagttta gaatattgct
     3001 ctaactatgg ttgcagcacc cactgccaaa ggctaaaggc ttgtctcctt tcaaaattga
     3061 tgatttagct gtctagtagg ttgggtggtg tggatataat gtgagaattt aaagacaaac
     3121 tttagtgata caggaagatt aaagtgcagc tgatagtttt ctgctagatc ttgaagcttt
     3181 acattttgtt tgtttgtttg tttgtttttc ttaaggcaac acagtacaat cttttttgag
     3241 gtgatttttt gttttgtttt gtttttttgt tttgtaacac taccaagaaa ttgagcattg
     3301 ctattggttt taatctgttt tcttcaggca gttggtaact ttaatgccaa catgttaagt
     3361 gataactatg tcatttggct gctaaattct gtcatttttt aaatgaaggt gaatttatgt
     3421 tacatatcaa aatttgtaca tttgagtaac gttgttttag cgcttttgca agaaaaagtt
     3481 tatttttata acatttgtga ttttcatgta gaagattgaa acagatatct gtggttaaca
     3541 gtgctattga gtggtatgga acagtgttac ttggcatttt gagccttctc aggtttgtct
     3601 catcagtggt agcttaacaa cctctggatt gattgtgtat aattgtcttt gtattcaaaa
     3661 gaggttcatg tcctgtaaaa gcacagtatt gtttggctgg agggagctgc agaatcgccc
     3721 atgtttctgt gactttgctc gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttccagg
     3781 catggcagcc aaccttgtat ctgctattta aaataacagc agagcttcat aattgtggtc
     3841 attagagttg ttcttatcat aattaaaact gagattcaat aaaactatga aacatggtg
//
