LOCUS       NM_011027               4920 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus purinergic receptor P2X, ligand-gated ion channel, 7
            (P2rx7), transcript variant 1, mRNA.
ACCESSION   NM_011027
VERSION     NM_011027.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4920)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   2  (bases 1 to 4920)
  AUTHORS   Saller,B.S., Wohrle,S., Fischer,L., Dufossez,C., Ingerl,I.L.,
            Kessler,S., Mateo-Tortola,M., Gorka,O., Lange,F., Cheng,Y.,
            Neuwirt,E., Marada,A., Koentges,C., Urban,C., Aktories,P.,
            Reuther,P., Giese,S., Kirschnek,S., Mayer,C., Pilic,J.,
            Falquez-Medina,H., Oelgeklaus,A., Deepagan,V.G., Shojaee,F.,
            Zimmermann,J.A., Weber,D., Tai,Y.H., Crois,A., Ciminski,K.,
            Peyronnet,R., Brandenburg,K.S., Wu,G., Baumeister,R.,
            Heimbucher,T., Rizzi,M., Riedel,D., Helmstadter,M., Buescher,J.,
            Neumann,K., Misgeld,T., Kerschensteiner,M., Walentek,P., Kreutz,C.,
            Maurer,U., Rambold,A.S., Vince,J.E., Edlich,F., Malli,R.,
            Hacker,G., Kierdorf,K., Meisinger,C., Kottgen,A., Jakobs,S.,
            Weber,A.N.R., Schwemmle,M., Gross,C.J. and Gross,O.
  TITLE     Acute suppression of mitochondrial ATP production prevents
            apoptosis and provides an essential signal for NLRP3 inflammasome
            activation
  JOURNAL   Immunity 58 (1), 90-107 (2025)
   PUBMED   39571574
REFERENCE   3  (bases 1 to 4920)
  AUTHORS   Domingos,L.B., Silva Junior,A.F.D., Diniz,C.R.A.F., Rosa,J.,
            Terzian,A.L.B. and Resstel,L.B.M.
  TITLE     P2X7 receptors modulate acquisition of cue fear extinction and
            contextual background memory generalization in male mice
  JOURNAL   Neuropharmacology 261, 110177 (2024)
   PUBMED   39366651
  REMARK    GeneRIF: P2X7 receptors modulate acquisition of cue fear extinction
            and contextual background memory generalization in male mice.
REFERENCE   4  (bases 1 to 4920)
  AUTHORS   Li,C., Liu,Q., Han,L., Zhang,H., Immler,R., Rathkolb,B.,
            Secklehner,J., de Angelis,M.H., Yildirim,A.O., Zeuschner,D.,
            Nicke,A., Carlin,L.M., Sperandio,M., Stoeger,T. and Rehberg,M.
  TITLE     The eATP/P2x7R Axis Drives Quantum Dot-Nanoparticle Induced
            Neutrophil Recruitment in the Pulmonary Microcirculation
  JOURNAL   Adv Sci (Weinh) 11 (45), e2404661 (2024)
   PUBMED   39364760
REFERENCE   5  (bases 1 to 4920)
  AUTHORS   Napier,M., Kumar,A., Szulist,N., Martin,D. and Scott,A.L.
  TITLE     P2X7 expression patterns in the developing Fmr1-knockout mouse
            hippocampus
  JOURNAL   Hippocampus 34 (11), 633-644 (2024)
   PUBMED   39269925
  REMARK    GeneRIF: P2X7 expression patterns in the developing Fmr1-knockout
            mouse hippocampus.
REFERENCE   6  (bases 1 to 4920)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 4920)
  AUTHORS   Denlinger,L.C., Fisette,P.L., Sommer,J.A., Watters,J.J., Prabhu,U.,
            Dubyak,G.R., Proctor,R.A. and Bertics,P.J.
  TITLE     Cutting edge: the nucleotide receptor P2X7 contains multiple
            protein- and lipid-interaction motifs including a potential binding
            site for bacterial lipopolysaccharide
  JOURNAL   J Immunol 167 (4), 1871-1876 (2001)
   PUBMED   11489964
REFERENCE   8  (bases 1 to 4920)
  AUTHORS   Solle,M., Labasi,J., Perregaux,D.G., Stam,E., Petrushova,N.,
            Koller,B.H., Griffiths,R.J. and Gabel,C.A.
  TITLE     Altered cytokine production in mice lacking P2X(7) receptors
  JOURNAL   J Biol Chem 276 (1), 125-132 (2001)
   PUBMED   11016935
REFERENCE   9  (bases 1 to 4920)
  AUTHORS   Sikora,A., Liu,J., Brosnan,C., Buell,G., Chessel,I. and Bloom,B.R.
  TITLE     Cutting edge: purinergic signaling regulates radical-mediated
            bacterial killing mechanisms in macrophages through a
            P2X7-independent mechanism
  JOURNAL   J Immunol 163 (2), 558-561 (1999)
   PUBMED   10395640
REFERENCE   10 (bases 1 to 4920)
  AUTHORS   Chessell,I.P., Simon,J., Hibell,A.D., Michel,A.D., Barnard,E.A. and
            Humphrey,P.P.
  TITLE     Cloning and functional characterisation of the mouse P2X7 receptor
  JOURNAL   FEBS Lett 439 (1-2), 26-30 (1998)
   PUBMED   9849870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114632.9, BY752747.1, AJ489296.1 and FJ436444.1.
            
            On Jun 18, 2019 this sequence version replaced NM_011027.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141120.1, AK145050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC114632.9         102820-102865
            47-147              BY752747.1         5-105
            148-917             AJ489296.1         1-770
            918-1910            FJ436444.1         762-1754
            1911-4920           AC114632.9         140173-143182
FEATURES             Location/Qualifiers
     source          1..4920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.5 cM"
     gene            1..4920
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="purinergic receptor P2X, ligand-gated ion channel,
                     7"
                     /db_xref="GeneID:18439"
                     /db_xref="MGI:MGI:1339957"
     exon            1..272
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1935
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="isoform a is encoded by transcript variant 1; P2X
                     purinoceptor 7; P2X7 purinoceptor; ATP receptor; P2Z
                     receptor; P2X7 receptor"
                     /codon_start=1
                     /product="P2X purinoceptor 7 isoform a"
                     /protein_id="NP_035157.2"
                     /db_xref="CCDS:CCDS19652.1"
                     /db_xref="GeneID:18439"
                     /db_xref="MGI:MGI:1339957"
                     /translation="MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFA
                     LVSDKLYQRKEPVISSVHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSF
                     FVMTNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRK
                     TCEVSAWCPTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTF
                     HKTWDPQCSIFRLGDIFQEAGENFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFR
                     RLDDKNTDESFVPGYNFRYAKYYKENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLV
                     VYIGSTLSYFGLATVCIDLLINTYSSAFCRSGVYPYCKCCEPCTVNEYYYRKKCESIM
                     EPKPTLKYVSFVDEPHIRMVDQQLLGKSLQVVKGQEVPRPQMDFSDLSRLSLSLHDSP
                     LTPGQSEEIQLLHEEVAPKSGDSPSWCQCGNCLPSRLPEQRRALEELCCRRKPGRCIT
                     TSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEATNSRLRHRAYRCYATWRFGSQDMADF
                     AILPSCCRWRIRKEFPKTEGQYSGFKYPY"
     exon            273..441
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            442..510
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            511..583
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            584..680
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            681..761
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            762..891
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1028
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1119
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1185
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1335
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1437
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..4920
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4137..4142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="hexamer: AGTAAA"
     polyA_site      4156
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="major polyA site"
     regulatory      4895..4900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="hexamer: AATAAA"
     polyA_site      4920
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
ORIGIN      
        1 gcagtcactg gaggaactgg aagttaaccg ttcctgctga gaaatcggtg tgtttccttt
       61 ggctgctcct aggtgagggt ttgctgtggt ctagcctggg aagtaggtct agcccaagtc
      121 cagcctgaac agagcgagcc tgtcgccatg ccggcttgct gcagctggaa cgatgtcttg
      181 cagtatgaga caaacaaagt cacccggatc cagagcacga attatggcac cgtcaagtgg
      241 gtcttgcaca tgatcgtctt ttcctacatt agctttgctt tggtgagcga taagctgtac
      301 cagcggaaag agcctgttat cagctccgtg cacaccaagg tcaaaggcat agcagaggtg
      361 acggagaatg tcacagaggg tggggtgacg aagttaggac acagcatctt tgacactgca
      421 gactacacct tccctttgca ggggaactca ttctttgtca tgacaaacta tgtcaagtca
      481 gaaggccaag tgcagacgct gtgtcctgag tatcccaggc gcggtgcaca gtgctcttct
      541 gaccggcgtt gtaaaaaggg gtggatggac ccacagagca aaggaatcca gactggcagg
      601 tgtgttccat atgacaagac aaggaagacc tgtgaagtct ctgcctggtg tcctactgag
      661 gaggagaaag aagctccccg acctgcactc ttgaggagcg ccgaaaactt caccgtactc
      721 atcaagaata atatccactt ccccggccac aactatacca cgagaaacat cttgccaact
      781 atgaacggct cttgtacctt tcacaagact tgggaccctc agtgttccat cttccgacta
      841 ggggacatct tccaggaagc aggagagaac tttacagagg tggcagttca gggaggaatc
      901 atgggtatcg agatctactg ggattgcaac ctagacagct ggtcccatca ctgccgaccc
      961 aggtacagct tccgccgcct ggatgacaag aacacggatg agtccttcgt ccccggctac
     1021 aacttcagat atgccaagta ctataaggag aacaatgtgg aaaagcggac gttgatcaaa
     1081 gccttcggca tccgttttga catcctggtt ttcggcactg gaggaaaatt tgacatcatc
     1141 cagctggttg tatacattgg atccaccctg tcctactttg gcttggccac tgtgtgcatt
     1201 gacttgctca tcaacacata ctccagtgct ttctgcaggt cgggggttta cccctactgt
     1261 aagtgctgtg agccctgcac agtgaacgag tattactaca gaaagaagtg tgagtccatc
     1321 atggaaccca agccgacgtt gaagtatgtg tcctttgtcg acgagccgca cattcgcatg
     1381 gtggaccagc agctgcttgg gaaaagtctg caagttgtca aaggccaaga agttccaaga
     1441 ccccagatgg acttctccga cctgtctagg ctgtccctat ctctccacga ctcacccctg
     1501 actcctggac aatctgagga aattcagctg ctccatgaag aggtggcccc taagtccggg
     1561 gacagcccga gttggtgcca gtgtggaaat tgcctcccgt ctcgcctacc ggagcaacgc
     1621 agggccctgg aggagctgtg ctgccggagg aagccggggc ggtgcatcac cacctccaag
     1681 ctcttccata agctcgtgct gtcccgagac accctgcagc tcctcctgct ttaccaggat
     1741 cccttgctgg tgctggggga agaggccacc aacagcaggc tgcgacaccg tgcttacagg
     1801 tgctatgcca cctggcgctt cggctcccag gacatggccg actttgccat tctgcccagc
     1861 tgttgccgct ggaggatccg gaaggagttc cccaagaccg aggggcagta tagtggcttc
     1921 aagtatccct actgatggta cggctgccac atcatggtgg ctcacaatac agcttccctt
     1981 ggaaagacct agagacacgt tttcaaccca ctggaactta aggtttgccc ctcgtaagct
     2041 gtgttgaaga agagagctga ttagaccaat ggcgagctcg caaaccattc tccacgtgga
     2101 tgagaaccgg atgcacatct gagcctgcag cctgaccctg gtctgcggcg ccaccctcag
     2161 cttaaaatgt gtacataggc tcctcatatc ccaacctccc cacctacttt ctctgaacta
     2221 gcattgcgga ggtggtgaag gtgttctctc ccgtccacgt ttacacagct ccatggatgc
     2281 aaaggtgcaa ccctgaaaac caaaccttta gagattcgag agtactctga gaaattaaat
     2341 atggccccaa attctttgac atcctccgca acccaaccca taagacccaa aggtgttttt
     2401 ttctctcctc tcatcccgta gcagatgtga tgttacatct attatttggg gcccttgttt
     2461 taagaggcta gcaacttctg attcctatgc ttggaactct tgctgagagg aagccagccc
     2521 aagttaaaag tctgataata agagcttctc cgctgtgaag aagtccaagc agctttagga
     2581 cgaagtaccc aatccgagcc agctcatcac ctctaagtgc agtcaccaca cagggaaaga
     2641 agctgccact ttcaggtgat ttcagaccca tgacttaaac tgcaggagac gactgcccag
     2701 tcagccccga ggaccactct gctgccttaa gtcattacat ttgggagagg cgggttgaca
     2761 cacagcaata ggcaactggg acaagagatg ctgactgagg cccagagtca ctacaaaata
     2821 taacagctac ttctattggg cagctgtaag aggtcacatt aaccagacta gaagccatca
     2881 aatctaactg catacaagtt acagtctgac ctgccttgct ctcctatggt tccaagtcac
     2941 tagtactgtg agaaaccggt tggtaaaagc tgcctctgtg cctttcacgt cccggactgt
     3001 acagccaacg agtccgaggc aatctgaatg ctcctttaga aagtagccca agctgccagg
     3061 agaggcgtca acccatgctc agaaggccga ctctaggcca gcctgagcta catcgcaaga
     3121 ccatgtcttt attttttatt tttgtaagat ttattttatg tttgagtgtt ttgcctgcac
     3181 catgtgtgtg cctggtgccg gtggaggtca gaagagagtg ttggaccccc tggaactgga
     3241 actgcaggtg gttgggagcc accatggtgg tgttgggaag tgaacttgag tcctccgcaa
     3301 tagcaacaag ggctcttaac tactgagcca tctctccacc ttcaaaacca cgtcttaaaa
     3361 tcataatctt gataattaga aaagggaggg ggaagagagg ctagggagat ggttctgtgg
     3421 gttagagcat tttctcctca ggcatgagga ctgacctacg ttgggatcac agcagccaca
     3481 taaagtctgg atgtggcctg tcatgatggc ttggcagggg taggggtggg aaaagagctt
     3541 gctttgcaat ctgatgacct tgaaagccat ggtgaaactg gagagccatg ttctctgact
     3601 tccacatgaa ccacacacat actcacacac atacacacat ataaatcata catgcacact
     3661 agtaataaat aaaatagatg taatttttaa gggaagccag tgcccttcat cgttttctac
     3721 aaccactaaa catggaagag ggaaccttta caggtttggg gtcctgcctc gggatttcat
     3781 tttgatagtt ttctttttct tctagaccta gatacttgtt tctcacagaa cagagacttt
     3841 gagtattatg agatgctttg actgactcta agacttgcca ttttaaggcg tctaagatca
     3901 agaagccatg ctctcaatgg agagggtggg gctgaggcac cttcatgaag gaggcccatg
     3961 ctcacaagcc tgacggatga cctcagacgg atgacctcag acggatgacc tcagacggat
     4021 gacctcagac ggatgacctc agacggatga cctcagttcc atcctcggga cccacacagt
     4081 ggagagagca ctgacttcca catgcaagca tggcatgtgt ccacccccag tctcccagta
     4141 aatgaattta agtccatttt cactgtattt ttgtttgttt ttggttttgt tattcttttt
     4201 caagactgga aagccctggc tgtcctggaa ttcacgtgta gaccaggctg gccttgaact
     4261 cagagattcc acctgcctct gcctcccgag tgctgggatt aaagggtgta gcaccaccac
     4321 caggctcgga gatatttttt taaagtagac tgtatttgac ttcagagttg agctttttac
     4381 tccaagcatt ctatggaaga gctacaggct tccctccctg tagcctccca gtctctacac
     4441 ctttatcttt gatgcctact tccaagtgta cttatatcgc cttgctaagg cttcagacag
     4501 tgactgacca ctggactctt ctagtgtttc cttgtgcctt tggccactgg tgctctcctg
     4561 agggtgacat gccactctgt ggataaaaat gacgctttct tcagcagcaa tgatatttgc
     4621 atctttattt ttggtctact gcgtgggcaa tgccgtggtc tgaggccgtg agcagttcat
     4681 ttctcagggt aaagttcttg ttgttagatg cattctgttc tgtcagttgc ccggtagcca
     4741 tgccttcctt ggtcagaact gagagcagct tcctgacgca gcccggctga cttcctggac
     4801 gactgggggt gggttttcac ttctctcttt aaagggaacc atcttctaaa ctcttcctaa
     4861 tttcgtgtaa gggttttttt taaaactatt tcataataaa acttgatttc aattcattta
//
