LOCUS       NM_001284402            4805 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus purinergic receptor P2X, ligand-gated ion channel, 7
            (P2rx7), transcript variant 5, mRNA.
ACCESSION   NM_001284402
VERSION     NM_001284402.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4805)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   2  (bases 1 to 4805)
  AUTHORS   Saller,B.S., Wohrle,S., Fischer,L., Dufossez,C., Ingerl,I.L.,
            Kessler,S., Mateo-Tortola,M., Gorka,O., Lange,F., Cheng,Y.,
            Neuwirt,E., Marada,A., Koentges,C., Urban,C., Aktories,P.,
            Reuther,P., Giese,S., Kirschnek,S., Mayer,C., Pilic,J.,
            Falquez-Medina,H., Oelgeklaus,A., Deepagan,V.G., Shojaee,F.,
            Zimmermann,J.A., Weber,D., Tai,Y.H., Crois,A., Ciminski,K.,
            Peyronnet,R., Brandenburg,K.S., Wu,G., Baumeister,R.,
            Heimbucher,T., Rizzi,M., Riedel,D., Helmstadter,M., Buescher,J.,
            Neumann,K., Misgeld,T., Kerschensteiner,M., Walentek,P., Kreutz,C.,
            Maurer,U., Rambold,A.S., Vince,J.E., Edlich,F., Malli,R.,
            Hacker,G., Kierdorf,K., Meisinger,C., Kottgen,A., Jakobs,S.,
            Weber,A.N.R., Schwemmle,M., Gross,C.J. and Gross,O.
  TITLE     Acute suppression of mitochondrial ATP production prevents
            apoptosis and provides an essential signal for NLRP3 inflammasome
            activation
  JOURNAL   Immunity 58 (1), 90-107 (2025)
   PUBMED   39571574
REFERENCE   3  (bases 1 to 4805)
  AUTHORS   Domingos,L.B., Silva Junior,A.F.D., Diniz,C.R.A.F., Rosa,J.,
            Terzian,A.L.B. and Resstel,L.B.M.
  TITLE     P2X7 receptors modulate acquisition of cue fear extinction and
            contextual background memory generalization in male mice
  JOURNAL   Neuropharmacology 261, 110177 (2024)
   PUBMED   39366651
  REMARK    GeneRIF: P2X7 receptors modulate acquisition of cue fear extinction
            and contextual background memory generalization in male mice.
REFERENCE   4  (bases 1 to 4805)
  AUTHORS   Li,C., Liu,Q., Han,L., Zhang,H., Immler,R., Rathkolb,B.,
            Secklehner,J., de Angelis,M.H., Yildirim,A.O., Zeuschner,D.,
            Nicke,A., Carlin,L.M., Sperandio,M., Stoeger,T. and Rehberg,M.
  TITLE     The eATP/P2x7R Axis Drives Quantum Dot-Nanoparticle Induced
            Neutrophil Recruitment in the Pulmonary Microcirculation
  JOURNAL   Adv Sci (Weinh) 11 (45), e2404661 (2024)
   PUBMED   39364760
REFERENCE   5  (bases 1 to 4805)
  AUTHORS   Napier,M., Kumar,A., Szulist,N., Martin,D. and Scott,A.L.
  TITLE     P2X7 expression patterns in the developing Fmr1-knockout mouse
            hippocampus
  JOURNAL   Hippocampus 34 (11), 633-644 (2024)
   PUBMED   39269925
  REMARK    GeneRIF: P2X7 expression patterns in the developing Fmr1-knockout
            mouse hippocampus.
REFERENCE   6  (bases 1 to 4805)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 4805)
  AUTHORS   Denlinger,L.C., Fisette,P.L., Sommer,J.A., Watters,J.J., Prabhu,U.,
            Dubyak,G.R., Proctor,R.A. and Bertics,P.J.
  TITLE     Cutting edge: the nucleotide receptor P2X7 contains multiple
            protein- and lipid-interaction motifs including a potential binding
            site for bacterial lipopolysaccharide
  JOURNAL   J Immunol 167 (4), 1871-1876 (2001)
   PUBMED   11489964
REFERENCE   8  (bases 1 to 4805)
  AUTHORS   Solle,M., Labasi,J., Perregaux,D.G., Stam,E., Petrushova,N.,
            Koller,B.H., Griffiths,R.J. and Gabel,C.A.
  TITLE     Altered cytokine production in mice lacking P2X(7) receptors
  JOURNAL   J Biol Chem 276 (1), 125-132 (2001)
   PUBMED   11016935
REFERENCE   9  (bases 1 to 4805)
  AUTHORS   Sikora,A., Liu,J., Brosnan,C., Buell,G., Chessel,I. and Bloom,B.R.
  TITLE     Cutting edge: purinergic signaling regulates radical-mediated
            bacterial killing mechanisms in macrophages through a
            P2X7-independent mechanism
  JOURNAL   J Immunol 163 (2), 558-561 (1999)
   PUBMED   10395640
REFERENCE   10 (bases 1 to 4805)
  AUTHORS   Chessell,I.P., Simon,J., Hibell,A.D., Michel,A.D., Barnard,E.A. and
            Humphrey,P.P.
  TITLE     Cloning and functional characterisation of the mouse P2X7 receptor
  JOURNAL   FEBS Lett 439 (1-2), 26-30 (1998)
   PUBMED   9849870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114632.9 and FJ436444.1.
            
            On Jun 18, 2019 this sequence version replaced NM_001284402.1.
            
            Transcript Variant: This variant (5) includes an alternate 5'
            terminal exon and differs in the 5' UTR and the 5' coding region,
            compared to variant 1. It encodes isoform e, which is shorter and
            has a distinct N-terminus, compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ436444.1, SRR13422600.544939.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC114632.9         109276-109316
            42-1820             FJ436444.1         1-1779
            1821-4805           AC114632.9         140198-143182
FEATURES             Location/Qualifiers
     source          1..4805
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.5 cM"
     gene            1..4805
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="purinergic receptor P2X, ligand-gated ion channel,
                     7"
                     /db_xref="GeneID:18439"
                     /db_xref="MGI:MGI:1339957"
     exon            1..157
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1820
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="isoform e is encoded by transcript variant 5; P2X
                     purinoceptor 7; P2X7 purinoceptor; ATP receptor; P2Z
                     receptor; P2X7 receptor"
                     /codon_start=1
                     /product="P2X purinoceptor 7 isoform e"
                     /protein_id="NP_001271331.1"
                     /db_xref="CCDS:CCDS89983.1"
                     /db_xref="GeneID:18439"
                     /db_xref="MGI:MGI:1339957"
                     /translation="MLPVSHLCSHKSGKVLEIHSIWIGTLKNTFLGAICVYICFALVS
                     DKLYQRKEPVISSVHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVM
                     TNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCE
                     VSAWCPTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKT
                     WDPQCSIFRLGDIFQEAGENFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLD
                     DKNTDESFVPGYNFRYAKYYKENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYI
                     GSTLSYFGLATVCIDLLINTYSSAFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPK
                     PTLKYVSFVDEPHIRMVDQQLLGKSLQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTP
                     GQSEEIQLLHEEVAPKSGDSPSWCQCGNCLPSRLPEQRRALEELCCRRKPGRCITTSK
                     LFHKLVLSRDTLQLLLLYQDPLLVLGEEATNSRLRHRAYRCYATWRFGSQDMADFAIL
                     PSCCRWRIRKEFPKTEGQYSGFKYPY"
     exon            158..326
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            327..395
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            396..468
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            469..565
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            566..646
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            647..776
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            777..913
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1004
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1070
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1220
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1322
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..4805
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4022..4027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="hexamer: AGTAAA"
     polyA_site      4041
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="major polyA site"
     regulatory      4780..4785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="hexamer: AATAAA"
     polyA_site      4805
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
ORIGIN      
        1 gtcacttcct cccctggtgg tgctctgaga accttctcac catgctgccc gtgagccact
       61 tatgcagcca taaatccggg aaagtccttg aaatccatag catatggatc gggacgctga
      121 agaacacctt cctaggggcc atctgcgtct atatctgctt tgctttggtg agcgataagc
      181 tgtaccagcg gaaagagcct gttatcagct ccgtgcacac caaggtcaaa ggcatagcag
      241 aggtgacgga gaatgtcaca gagggtgggg tgacgaagtt aggacacagc atctttgaca
      301 ctgcagacta caccttccct ttgcagggga actcattctt tgtcatgaca aactatgtca
      361 agtcagaagg ccaagtgcag acgctgtgtc ctgagtatcc caggcgcggt gcacagtgct
      421 cttctgaccg gcgttgtaaa aaggggtgga tggacccaca gagcaaagga atccagactg
      481 gcaggtgtgt tccatatgac aagacaagga agacctgtga agtctctgcc tggtgtccta
      541 ctgaggagga gaaagaagct ccccgacctg cactcttgag gagcgccgaa aacttcaccg
      601 tactcatcaa gaataatatc cacttccccg gccacaacta taccacgaga aacatcttgc
      661 caactatgaa cggctcttgt acctttcaca agacttggga ccctcagtgt tccatcttcc
      721 gactagggga catcttccag gaagcaggag agaactttac agaggtggca gttcagggag
      781 gaatcatggg tatcgagatc tactgggatt gcaacctaga cagctggtcc catcactgcc
      841 gacccaggta cagcttccgc cgcctggatg acaagaacac ggatgagtcc ttcgtccccg
      901 gctacaactt cagatatgcc aagtactata aggagaacaa tgtggaaaag cggacgttga
      961 tcaaagcctt cggcatccgt tttgacatcc tggttttcgg cactggagga aaatttgaca
     1021 tcatccagct ggttgtatac attggatcca ccctgtccta ctttggcttg gccactgtgt
     1081 gcattgactt gctcatcaac acatactcca gtgctttctg caggtcgggg gtttacccct
     1141 actgtaagtg ctgtgagccc tgcacagtga acgagtatta ctacagaaag aagtgtgagt
     1201 ccatcatgga acccaagccg acgttgaagt atgtgtcctt tgtcgacgag ccgcacattc
     1261 gcatggtgga ccagcagctg cttgggaaaa gtctgcaagt tgtcaaaggc caagaagttc
     1321 caagacccca gatggacttc tccgacctgt ctaggctgtc cctatctctc cacgactcac
     1381 ccctgactcc tggacaatct gaggaaattc agctgctcca tgaagaggtg gcccctaagt
     1441 ccggggacag cccgagttgg tgccagtgtg gaaattgcct cccgtctcgc ctaccggagc
     1501 aacgcagggc cctggaggag ctgtgctgcc ggaggaagcc ggggcggtgc atcaccacct
     1561 ccaagctctt ccataagctc gtgctgtccc gagacaccct gcagctcctc ctgctttacc
     1621 aggatccctt gctggtgctg ggggaagagg ccaccaacag caggctgcga caccgtgctt
     1681 acaggtgcta tgccacctgg cgcttcggct cccaggacat ggccgacttt gccattctgc
     1741 ccagctgttg ccgctggagg atccggaagg agttccccaa gaccgagggg cagtatagtg
     1801 gcttcaagta tccctactga tggtacggct gccacatcat ggtggctcac aatacagctt
     1861 cccttggaaa gacctagaga cacgttttca acccactgga acttaaggtt tgcccctcgt
     1921 aagctgtgtt gaagaagaga gctgattaga ccaatggcga gctcgcaaac cattctccac
     1981 gtggatgaga accggatgca catctgagcc tgcagcctga ccctggtctg cggcgccacc
     2041 ctcagcttaa aatgtgtaca taggctcctc atatcccaac ctccccacct actttctctg
     2101 aactagcatt gcggaggtgg tgaaggtgtt ctctcccgtc cacgtttaca cagctccatg
     2161 gatgcaaagg tgcaaccctg aaaaccaaac ctttagagat tcgagagtac tctgagaaat
     2221 taaatatggc cccaaattct ttgacatcct ccgcaaccca acccataaga cccaaaggtg
     2281 tttttttctc tcctctcatc ccgtagcaga tgtgatgtta catctattat ttggggccct
     2341 tgttttaaga ggctagcaac ttctgattcc tatgcttgga actcttgctg agaggaagcc
     2401 agcccaagtt aaaagtctga taataagagc ttctccgctg tgaagaagtc caagcagctt
     2461 taggacgaag tacccaatcc gagccagctc atcacctcta agtgcagtca ccacacaggg
     2521 aaagaagctg ccactttcag gtgatttcag acccatgact taaactgcag gagacgactg
     2581 cccagtcagc cccgaggacc actctgctgc cttaagtcat tacatttggg agaggcgggt
     2641 tgacacacag caataggcaa ctgggacaag agatgctgac tgaggcccag agtcactaca
     2701 aaatataaca gctacttcta ttgggcagct gtaagaggtc acattaacca gactagaagc
     2761 catcaaatct aactgcatac aagttacagt ctgacctgcc ttgctctcct atggttccaa
     2821 gtcactagta ctgtgagaaa ccggttggta aaagctgcct ctgtgccttt cacgtcccgg
     2881 actgtacagc caacgagtcc gaggcaatct gaatgctcct ttagaaagta gcccaagctg
     2941 ccaggagagg cgtcaaccca tgctcagaag gccgactcta ggccagcctg agctacatcg
     3001 caagaccatg tctttatttt ttatttttgt aagatttatt ttatgtttga gtgttttgcc
     3061 tgcaccatgt gtgtgcctgg tgccggtgga ggtcagaaga gagtgttgga ccccctggaa
     3121 ctggaactgc aggtggttgg gagccaccat ggtggtgttg ggaagtgaac ttgagtcctc
     3181 cgcaatagca acaagggctc ttaactactg agccatctct ccaccttcaa aaccacgtct
     3241 taaaatcata atcttgataa ttagaaaagg gagggggaag agaggctagg gagatggttc
     3301 tgtgggttag agcattttct cctcaggcat gaggactgac ctacgttggg atcacagcag
     3361 ccacataaag tctggatgtg gcctgtcatg atggcttggc aggggtaggg gtgggaaaag
     3421 agcttgcttt gcaatctgat gaccttgaaa gccatggtga aactggagag ccatgttctc
     3481 tgacttccac atgaaccaca cacatactca cacacataca cacatataaa tcatacatgc
     3541 acactagtaa taaataaaat agatgtaatt tttaagggaa gccagtgccc ttcatcgttt
     3601 tctacaacca ctaaacatgg aagagggaac ctttacaggt ttggggtcct gcctcgggat
     3661 ttcattttga tagttttctt tttcttctag acctagatac ttgtttctca cagaacagag
     3721 actttgagta ttatgagatg ctttgactga ctctaagact tgccatttta aggcgtctaa
     3781 gatcaagaag ccatgctctc aatggagagg gtggggctga ggcaccttca tgaaggaggc
     3841 ccatgctcac aagcctgacg gatgacctca gacggatgac ctcagacgga tgacctcaga
     3901 cggatgacct cagacggatg acctcagacg gatgacctca gttccatcct cgggacccac
     3961 acagtggaga gagcactgac ttccacatgc aagcatggca tgtgtccacc cccagtctcc
     4021 cagtaaatga atttaagtcc attttcactg tatttttgtt tgtttttggt tttgttattc
     4081 tttttcaaga ctggaaagcc ctggctgtcc tggaattcac gtgtagacca ggctggcctt
     4141 gaactcagag attccacctg cctctgcctc ccgagtgctg ggattaaagg gtgtagcacc
     4201 accaccaggc tcggagatat ttttttaaag tagactgtat ttgacttcag agttgagctt
     4261 tttactccaa gcattctatg gaagagctac aggcttccct ccctgtagcc tcccagtctc
     4321 tacaccttta tctttgatgc ctacttccaa gtgtacttat atcgccttgc taaggcttca
     4381 gacagtgact gaccactgga ctcttctagt gtttccttgt gcctttggcc actggtgctc
     4441 tcctgagggt gacatgccac tctgtggata aaaatgacgc tttcttcagc agcaatgata
     4501 tttgcatctt tatttttggt ctactgcgtg ggcaatgccg tggtctgagg ccgtgagcag
     4561 ttcatttctc agggtaaagt tcttgttgtt agatgcattc tgttctgtca gttgcccggt
     4621 agccatgcct tccttggtca gaactgagag cagcttcctg acgcagcccg gctgacttcc
     4681 tggacgactg ggggtgggtt ttcacttctc tctttaaagg gaaccatctt ctaaactctt
     4741 cctaatttcg tgtaagggtt ttttttaaaa ctatttcata ataaaacttg atttcaattc
     4801 attta
//
