LOCUS       NM_001038845            2521 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus purinergic receptor P2X, ligand-gated ion channel, 7
            (P2rx7), transcript variant 2, mRNA.
ACCESSION   NM_001038845
VERSION     NM_001038845.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2521)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   2  (bases 1 to 2521)
  AUTHORS   Saller,B.S., Wohrle,S., Fischer,L., Dufossez,C., Ingerl,I.L.,
            Kessler,S., Mateo-Tortola,M., Gorka,O., Lange,F., Cheng,Y.,
            Neuwirt,E., Marada,A., Koentges,C., Urban,C., Aktories,P.,
            Reuther,P., Giese,S., Kirschnek,S., Mayer,C., Pilic,J.,
            Falquez-Medina,H., Oelgeklaus,A., Deepagan,V.G., Shojaee,F.,
            Zimmermann,J.A., Weber,D., Tai,Y.H., Crois,A., Ciminski,K.,
            Peyronnet,R., Brandenburg,K.S., Wu,G., Baumeister,R.,
            Heimbucher,T., Rizzi,M., Riedel,D., Helmstadter,M., Buescher,J.,
            Neumann,K., Misgeld,T., Kerschensteiner,M., Walentek,P., Kreutz,C.,
            Maurer,U., Rambold,A.S., Vince,J.E., Edlich,F., Malli,R.,
            Hacker,G., Kierdorf,K., Meisinger,C., Kottgen,A., Jakobs,S.,
            Weber,A.N.R., Schwemmle,M., Gross,C.J. and Gross,O.
  TITLE     Acute suppression of mitochondrial ATP production prevents
            apoptosis and provides an essential signal for NLRP3 inflammasome
            activation
  JOURNAL   Immunity 58 (1), 90-107 (2025)
   PUBMED   39571574
REFERENCE   3  (bases 1 to 2521)
  AUTHORS   Domingos,L.B., Silva Junior,A.F.D., Diniz,C.R.A.F., Rosa,J.,
            Terzian,A.L.B. and Resstel,L.B.M.
  TITLE     P2X7 receptors modulate acquisition of cue fear extinction and
            contextual background memory generalization in male mice
  JOURNAL   Neuropharmacology 261, 110177 (2024)
   PUBMED   39366651
  REMARK    GeneRIF: P2X7 receptors modulate acquisition of cue fear extinction
            and contextual background memory generalization in male mice.
REFERENCE   4  (bases 1 to 2521)
  AUTHORS   Li,C., Liu,Q., Han,L., Zhang,H., Immler,R., Rathkolb,B.,
            Secklehner,J., de Angelis,M.H., Yildirim,A.O., Zeuschner,D.,
            Nicke,A., Carlin,L.M., Sperandio,M., Stoeger,T. and Rehberg,M.
  TITLE     The eATP/P2x7R Axis Drives Quantum Dot-Nanoparticle Induced
            Neutrophil Recruitment in the Pulmonary Microcirculation
  JOURNAL   Adv Sci (Weinh) 11 (45), e2404661 (2024)
   PUBMED   39364760
REFERENCE   5  (bases 1 to 2521)
  AUTHORS   Napier,M., Kumar,A., Szulist,N., Martin,D. and Scott,A.L.
  TITLE     P2X7 expression patterns in the developing Fmr1-knockout mouse
            hippocampus
  JOURNAL   Hippocampus 34 (11), 633-644 (2024)
   PUBMED   39269925
  REMARK    GeneRIF: P2X7 expression patterns in the developing Fmr1-knockout
            mouse hippocampus.
REFERENCE   6  (bases 1 to 2521)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 2521)
  AUTHORS   Denlinger,L.C., Fisette,P.L., Sommer,J.A., Watters,J.J., Prabhu,U.,
            Dubyak,G.R., Proctor,R.A. and Bertics,P.J.
  TITLE     Cutting edge: the nucleotide receptor P2X7 contains multiple
            protein- and lipid-interaction motifs including a potential binding
            site for bacterial lipopolysaccharide
  JOURNAL   J Immunol 167 (4), 1871-1876 (2001)
   PUBMED   11489964
REFERENCE   8  (bases 1 to 2521)
  AUTHORS   Solle,M., Labasi,J., Perregaux,D.G., Stam,E., Petrushova,N.,
            Koller,B.H., Griffiths,R.J. and Gabel,C.A.
  TITLE     Altered cytokine production in mice lacking P2X(7) receptors
  JOURNAL   J Biol Chem 276 (1), 125-132 (2001)
   PUBMED   11016935
REFERENCE   9  (bases 1 to 2521)
  AUTHORS   Sikora,A., Liu,J., Brosnan,C., Buell,G., Chessel,I. and Bloom,B.R.
  TITLE     Cutting edge: purinergic signaling regulates radical-mediated
            bacterial killing mechanisms in macrophages through a
            P2X7-independent mechanism
  JOURNAL   J Immunol 163 (2), 558-561 (1999)
   PUBMED   10395640
REFERENCE   10 (bases 1 to 2521)
  AUTHORS   Chessell,I.P., Simon,J., Hibell,A.D., Michel,A.D., Barnard,E.A. and
            Humphrey,P.P.
  TITLE     Cloning and functional characterisation of the mouse P2X7 receptor
  JOURNAL   FEBS Lett 439 (1-2), 26-30 (1998)
   PUBMED   9849870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114632.9.
            
            On Jun 18, 2019 this sequence version replaced NM_001038845.2.
            
            Transcript Variant: This variant (2) contains an alternate 3'
            terminal exon and differs in the 3' UTR and the 3' coding region,
            compared to variant 1. It encodes isoform b, which is shorter and
            has a distinct C-terminus, compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               AC114632.9         102820-103091
            273-441             AC114632.9         111620-111788
            442-510             AC114632.9         113054-113122
            511-583             AC114632.9         115905-115977
            584-680             AC114632.9         117601-117697
            681-761             AC114632.9         122470-122550
            762-891             AC114632.9         123438-123567
            892-1028            AC114632.9         125037-125173
            1029-1119           AC114632.9         129331-129421
            1120-1185           AC114632.9         132248-132313
            1186-1335           AC114632.9         132559-132708
            1336-1437           AC114632.9         135555-135656
            1438-2521           AC114632.9         150146-151229
FEATURES             Location/Qualifiers
     source          1..2521
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.5 cM"
     gene            1..2521
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="purinergic receptor P2X, ligand-gated ion channel,
                     7"
                     /db_xref="GeneID:18439"
                     /db_xref="MGI:MGI:1339957"
     exon            1..272
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1476
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="isoform b is encoded by transcript variant 2; P2X
                     purinoceptor 7; P2X7 purinoceptor; ATP receptor; P2Z
                     receptor; P2X7 receptor"
                     /codon_start=1
                     /product="P2X purinoceptor 7 isoform b"
                     /protein_id="NP_001033934.1"
                     /db_xref="CCDS:CCDS19651.1"
                     /db_xref="GeneID:18439"
                     /db_xref="MGI:MGI:1339957"
                     /translation="MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFA
                     LVSDKLYQRKEPVISSVHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSF
                     FVMTNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRK
                     TCEVSAWCPTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTF
                     HKTWDPQCSIFRLGDIFQEAGENFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFR
                     RLDDKNTDESFVPGYNFRYAKYYKENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLV
                     VYIGSTLSYFGLATVCIDLLINTYSSAFCRSGVYPYCKCCEPCTVNEYYYRKKCESIM
                     EPKPTLKYVSFVDEPHIRMVDQQLLGKSLQVVKGQEVPVRVLCLHVCMRT"
     exon            273..441
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            442..510
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            511..583
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            584..680
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            681..761
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            762..891
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1028
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1119
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1185
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1335
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1437
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..2521
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2504..2509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="hexamer: AATAAA"
     polyA_site      2521
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcactg gaggaactgg aagttaaccg ttcctgctga gaaatcggtg tgtttccttt
       61 ggctgctcct aggtgagggt ttgctgtggt ctagcctggg aagtaggtct agcccaagtc
      121 cagcctgaac agagcgagcc tgtcgccatg ccggcttgct gcagctggaa cgatgtcttg
      181 cagtatgaga caaacaaagt cacccggatc cagagcacga attatggcac cgtcaagtgg
      241 gtcttgcaca tgatcgtctt ttcctacatt agctttgctt tggtgagcga taagctgtac
      301 cagcggaaag agcctgttat cagctccgtg cacaccaagg tcaaaggcat agcagaggtg
      361 acggagaatg tcacagaggg tggggtgacg aagttaggac acagcatctt tgacactgca
      421 gactacacct tccctttgca ggggaactca ttctttgtca tgacaaacta tgtcaagtca
      481 gaaggccaag tgcagacgct gtgtcctgag tatcccaggc gcggtgcaca gtgctcttct
      541 gaccggcgtt gtaaaaaggg gtggatggac ccacagagca aaggaatcca gactggcagg
      601 tgtgttccat atgacaagac aaggaagacc tgtgaagtct ctgcctggtg tcctactgag
      661 gaggagaaag aagctccccg acctgcactc ttgaggagcg ccgaaaactt caccgtactc
      721 atcaagaata atatccactt ccccggccac aactatacca cgagaaacat cttgccaact
      781 atgaacggct cttgtacctt tcacaagact tgggaccctc agtgttccat cttccgacta
      841 ggggacatct tccaggaagc aggagagaac tttacagagg tggcagttca gggaggaatc
      901 atgggtatcg agatctactg ggattgcaac ctagacagct ggtcccatca ctgccgaccc
      961 aggtacagct tccgccgcct ggatgacaag aacacggatg agtccttcgt ccccggctac
     1021 aacttcagat atgccaagta ctataaggag aacaatgtgg aaaagcggac gttgatcaaa
     1081 gccttcggca tccgttttga catcctggtt ttcggcactg gaggaaaatt tgacatcatc
     1141 cagctggttg tatacattgg atccaccctg tcctactttg gcttggccac tgtgtgcatt
     1201 gacttgctca tcaacacata ctccagtgct ttctgcaggt cgggggttta cccctactgt
     1261 aagtgctgtg agccctgcac agtgaacgag tattactaca gaaagaagtg tgagtccatc
     1321 atggaaccca agccgacgtt gaagtatgtg tcctttgtcg acgagccgca cattcgcatg
     1381 gtggaccagc agctgcttgg gaaaagtctg caagttgtca aaggccaaga agttccagta
     1441 cgggtgcttt gcctgcatgt atgtatgcgc acctgatgcc atcagatgtc agaaggaagg
     1501 ggtcggatct actggatctg gagttacaga tgattgtaaa ccacgatgtt ggtgctggga
     1561 accaaaccca ggtcctctca aaaacagcaa gtggtcgtaa ccattcagcc atctctccag
     1621 cctggtttgt tcttgttgtt ttttgttttc atttcacttc ttgagtggat atggctatct
     1681 tgccttgcac acgtatctgt gcactgtgtg catcgtgtgc atgcctggcg cctatggaaa
     1741 cagcatgggc atccagaaga cagcatggct ggattccctg catctggggt tatggccagt
     1801 tgtgggctcc catgtgagtg ctgggaacca aacctgggct ctctggaaga gcagcaagtt
     1861 caattaacga ctgagccatc tctccagccc cattcgcgtt ttgtttgctt ttaagcatat
     1921 cttatttaca ttgtgtgtgt gtgtatttac atataccatg gtatacacac gtggaggtta
     1981 gaggacaaca catggagtcg gctccctcct tccaccatgt ggggtctgga ggcagaactt
     2041 ggttgcccag aacttggtga caagtgccag agatgaccct gagccatccc tctggccctg
     2101 ccagaaagtc ttagctaaaa taaagaagag gcctcttcga aggtgcatta gcagcagagg
     2161 ctgcccctaa aggcgcttgt cttgcttgct tggcaggttg ggaaactgct gcaccagtca
     2221 gtacactggg ttattactgt gttttgccag gtgaagactt ttgaatgggg cccaaaggcc
     2281 tcatcaaaaa agggctggga tggactgtcc tggagatgaa ggaggcacct tggggaaagc
     2341 agggatggct gaggcagctg tctcagaaac aaacccacac aggcaaagga aaagatcaca
     2401 gaaaggggtg atcagagcca acagaaggtt ttagaagaag ggggagacct tttgggaaat
     2461 tgacttcaaa ctaacttgga tctgtaaaaa cctacagtta caaaataaat aattggatgg
     2521 g
//
