LOCUS       NM_001038839            2552 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus purinergic receptor P2X, ligand-gated ion channel, 7
            (P2rx7), transcript variant 3, mRNA.
ACCESSION   NM_001038839
VERSION     NM_001038839.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2552)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   2  (bases 1 to 2552)
  AUTHORS   Saller,B.S., Wohrle,S., Fischer,L., Dufossez,C., Ingerl,I.L.,
            Kessler,S., Mateo-Tortola,M., Gorka,O., Lange,F., Cheng,Y.,
            Neuwirt,E., Marada,A., Koentges,C., Urban,C., Aktories,P.,
            Reuther,P., Giese,S., Kirschnek,S., Mayer,C., Pilic,J.,
            Falquez-Medina,H., Oelgeklaus,A., Deepagan,V.G., Shojaee,F.,
            Zimmermann,J.A., Weber,D., Tai,Y.H., Crois,A., Ciminski,K.,
            Peyronnet,R., Brandenburg,K.S., Wu,G., Baumeister,R.,
            Heimbucher,T., Rizzi,M., Riedel,D., Helmstadter,M., Buescher,J.,
            Neumann,K., Misgeld,T., Kerschensteiner,M., Walentek,P., Kreutz,C.,
            Maurer,U., Rambold,A.S., Vince,J.E., Edlich,F., Malli,R.,
            Hacker,G., Kierdorf,K., Meisinger,C., Kottgen,A., Jakobs,S.,
            Weber,A.N.R., Schwemmle,M., Gross,C.J. and Gross,O.
  TITLE     Acute suppression of mitochondrial ATP production prevents
            apoptosis and provides an essential signal for NLRP3 inflammasome
            activation
  JOURNAL   Immunity 58 (1), 90-107 (2025)
   PUBMED   39571574
REFERENCE   3  (bases 1 to 2552)
  AUTHORS   Domingos,L.B., Silva Junior,A.F.D., Diniz,C.R.A.F., Rosa,J.,
            Terzian,A.L.B. and Resstel,L.B.M.
  TITLE     P2X7 receptors modulate acquisition of cue fear extinction and
            contextual background memory generalization in male mice
  JOURNAL   Neuropharmacology 261, 110177 (2024)
   PUBMED   39366651
  REMARK    GeneRIF: P2X7 receptors modulate acquisition of cue fear extinction
            and contextual background memory generalization in male mice.
REFERENCE   4  (bases 1 to 2552)
  AUTHORS   Li,C., Liu,Q., Han,L., Zhang,H., Immler,R., Rathkolb,B.,
            Secklehner,J., de Angelis,M.H., Yildirim,A.O., Zeuschner,D.,
            Nicke,A., Carlin,L.M., Sperandio,M., Stoeger,T. and Rehberg,M.
  TITLE     The eATP/P2x7R Axis Drives Quantum Dot-Nanoparticle Induced
            Neutrophil Recruitment in the Pulmonary Microcirculation
  JOURNAL   Adv Sci (Weinh) 11 (45), e2404661 (2024)
   PUBMED   39364760
REFERENCE   5  (bases 1 to 2552)
  AUTHORS   Napier,M., Kumar,A., Szulist,N., Martin,D. and Scott,A.L.
  TITLE     P2X7 expression patterns in the developing Fmr1-knockout mouse
            hippocampus
  JOURNAL   Hippocampus 34 (11), 633-644 (2024)
   PUBMED   39269925
  REMARK    GeneRIF: P2X7 expression patterns in the developing Fmr1-knockout
            mouse hippocampus.
REFERENCE   6  (bases 1 to 2552)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 2552)
  AUTHORS   Denlinger,L.C., Fisette,P.L., Sommer,J.A., Watters,J.J., Prabhu,U.,
            Dubyak,G.R., Proctor,R.A. and Bertics,P.J.
  TITLE     Cutting edge: the nucleotide receptor P2X7 contains multiple
            protein- and lipid-interaction motifs including a potential binding
            site for bacterial lipopolysaccharide
  JOURNAL   J Immunol 167 (4), 1871-1876 (2001)
   PUBMED   11489964
REFERENCE   8  (bases 1 to 2552)
  AUTHORS   Solle,M., Labasi,J., Perregaux,D.G., Stam,E., Petrushova,N.,
            Koller,B.H., Griffiths,R.J. and Gabel,C.A.
  TITLE     Altered cytokine production in mice lacking P2X(7) receptors
  JOURNAL   J Biol Chem 276 (1), 125-132 (2001)
   PUBMED   11016935
REFERENCE   9  (bases 1 to 2552)
  AUTHORS   Sikora,A., Liu,J., Brosnan,C., Buell,G., Chessel,I. and Bloom,B.R.
  TITLE     Cutting edge: purinergic signaling regulates radical-mediated
            bacterial killing mechanisms in macrophages through a
            P2X7-independent mechanism
  JOURNAL   J Immunol 163 (2), 558-561 (1999)
   PUBMED   10395640
REFERENCE   10 (bases 1 to 2552)
  AUTHORS   Chessell,I.P., Simon,J., Hibell,A.D., Michel,A.D., Barnard,E.A. and
            Humphrey,P.P.
  TITLE     Cloning and functional characterisation of the mouse P2X7 receptor
  JOURNAL   FEBS Lett 439 (1-2), 26-30 (1998)
   PUBMED   9849870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114632.9, BY752747.1, AJ489296.1, FJ436444.1 and AK162805.1.
            
            On Jun 18, 2019 this sequence version replaced NM_001038839.2.
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in the 3' terminal exon and differs in the 3' UTR and the 3' coding
            region, compared to variant 1. It encodes isoform c, which is
            shorter and has a distinct C-terminus, compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144585.1, SRR7345562.2223091.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC114632.9         102820-102865
            47-147              BY752747.1         5-105
            148-917             AJ489296.1         1-770
            918-918             FJ436444.1         762-762
            919-1437            AJ489296.1         772-1290
            1438-1803           AK162805.1         994-1359
            1804-2552           AC114632.9         142434-143182
FEATURES             Location/Qualifiers
     source          1..2552
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.5 cM"
     gene            1..2552
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="purinergic receptor P2X, ligand-gated ion channel,
                     7"
                     /db_xref="GeneID:18439"
                     /db_xref="MGI:MGI:1339957"
     exon            1..272
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1443
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="isoform c is encoded by transcript variant 3; P2X
                     purinoceptor 7; P2X7 purinoceptor; ATP receptor; P2Z
                     receptor; P2X7 receptor"
                     /codon_start=1
                     /product="P2X purinoceptor 7 isoform c"
                     /protein_id="NP_001033928.1"
                     /db_xref="CCDS:CCDS51644.1"
                     /db_xref="GeneID:18439"
                     /db_xref="MGI:MGI:1339957"
                     /translation="MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFA
                     LVSDKLYQRKEPVISSVHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSF
                     FVMTNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRK
                     TCEVSAWCPTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTF
                     HKTWDPQCSIFRLGDIFQEAGENFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFR
                     RLDDKNTDESFVPGYNFRYAKYYKENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLV
                     VYIGSTLSYFGLATVCIDLLINTYSSAFCRSGVYPYCKCCEPCTVNEYYYRKKCESIM
                     EPKPTLKYVSFVDEPHIRMVDQQLLGKSLQVVKGQEVPT"
     exon            273..441
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            442..510
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            511..583
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            584..680
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            681..761
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            762..891
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1028
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1119
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1185
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1335
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1437
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..2552
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1769..1774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="hexamer: AGTAAA"
     polyA_site      1788
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="major polyA site"
     regulatory      2527..2532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
                     /note="hexamer: AATAAA"
     polyA_site      2552
                     /gene="P2rx7"
                     /gene_synonym="P2X(7); P2X7R"
ORIGIN      
        1 gcagtcactg gaggaactgg aagttaaccg ttcctgctga gaaatcggtg tgtttccttt
       61 ggctgctcct aggtgagggt ttgctgtggt ctagcctggg aagtaggtct agcccaagtc
      121 cagcctgaac agagcgagcc tgtcgccatg ccggcttgct gcagctggaa cgatgtcttg
      181 cagtatgaga caaacaaagt cacccggatc cagagcacga attatggcac cgtcaagtgg
      241 gtcttgcaca tgatcgtctt ttcctacatt agctttgctt tggtgagcga taagctgtac
      301 cagcggaaag agcctgttat cagctccgtg cacaccaagg tcaaaggcat agcagaggtg
      361 acggagaatg tcacagaggg tggggtgacg aagttaggac acagcatctt tgacactgca
      421 gactacacct tccctttgca ggggaactca ttctttgtca tgacaaacta tgtcaagtca
      481 gaaggccaag tgcagacgct gtgtcctgag tatcccaggc gcggtgcaca gtgctcttct
      541 gaccggcgtt gtaaaaaggg gtggatggac ccacagagca aaggaatcca gactggcagg
      601 tgtgttccat atgacaagac aaggaagacc tgtgaagtct ctgcctggtg tcctactgag
      661 gaggagaaag aagctccccg acctgcactc ttgaggagcg ccgaaaactt caccgtactc
      721 atcaagaata atatccactt ccccggccac aactatacca cgagaaacat cttgccaact
      781 atgaacggct cttgtacctt tcacaagact tgggaccctc agtgttccat cttccgacta
      841 ggggacatct tccaggaagc aggagagaac tttacagagg tggcagttca gggaggaatc
      901 atgggtatcg agatctactg ggattgcaac ctagacagct ggtcccatca ctgccgaccc
      961 aggtacagct tccgccgcct ggatgacaag aacacggatg agtccttcgt ccccggctac
     1021 aacttcagat atgccaagta ctataaggag aacaatgtgg aaaagcggac gttgatcaaa
     1081 gccttcggca tccgttttga catcctggtt ttcggcactg gaggaaaatt tgacatcatc
     1141 cagctggttg tatacattgg atccaccctg tcctactttg gcttggccac tgtgtgcatt
     1201 gacttgctca tcaacacata ctccagtgct ttctgcaggt cgggggttta cccctactgt
     1261 aagtgctgtg agccctgcac agtgaacgag tattactaca gaaagaagtg tgagtccatc
     1321 atggaaccca agccgacgtt gaagtatgtg tcctttgtcg acgagccgca cattcgcatg
     1381 gtggaccagc agctgcttgg gaaaagtctg caagttgtca aaggccaaga agttccaacc
     1441 tagatacttg tttctcacag aacagagact ttgagtatta tgagatgctt tgactgactc
     1501 taagacttgc cattttaagg cgtctaagat caagaagcca tgctctcaat ggagagggtg
     1561 gggctgaggc accttcatga aggaggccca tgctcacaag cctgacggat gacctcagac
     1621 ggatgacctc agacggatga cctcagacgg atgacctcag acggatgacc tcagacggat
     1681 gacctcagtt ccatcctcgg gacccacaca gtggagagag cactgacttc cacatgcaag
     1741 catggcatgt gtccaccccc agtctcccag taaatgaatt taagtccatt ttcactgtat
     1801 ttttgtttgt ttttggtttt gttattcttt ttcaagactg gaaagccctg gctgtcctgg
     1861 aattcacgtg tagaccaggc tggccttgaa ctcagagatt ccacctgcct ctgcctcccg
     1921 agtgctggga ttaaagggtg tagcaccacc accaggctcg gagatatttt tttaaagtag
     1981 actgtatttg acttcagagt tgagcttttt actccaagca ttctatggaa gagctacagg
     2041 cttccctccc tgtagcctcc cagtctctac acctttatct ttgatgccta cttccaagtg
     2101 tacttatatc gccttgctaa ggcttcagac agtgactgac cactggactc ttctagtgtt
     2161 tccttgtgcc tttggccact ggtgctctcc tgagggtgac atgccactct gtggataaaa
     2221 atgacgcttt cttcagcagc aatgatattt gcatctttat ttttggtcta ctgcgtgggc
     2281 aatgccgtgg tctgaggccg tgagcagttc atttctcagg gtaaagttct tgttgttaga
     2341 tgcattctgt tctgtcagtt gcccggtagc catgccttcc ttggtcagaa ctgagagcag
     2401 cttcctgacg cagcccggct gacttcctgg acgactgggg gtgggttttc acttctctct
     2461 ttaaagggaa ccatcttcta aactcttcct aatttcgtgt aagggttttt tttaaaacta
     2521 tttcataata aaacttgatt tcaattcatt ta
//
