LOCUS       NM_011028               2362 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus purinergic receptor P2X, ligand-gated ion channel, 6
            (P2rx6), transcript variant 1, mRNA.
ACCESSION   NM_011028
VERSION     NM_011028.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2362)
  AUTHORS   Vong,K.I., Lee,S., Au,K.S., Crowley,T.B., Capra,V., Martino,J.,
            Haller,M., Araujo,C., Machado,H.R., George,R., Gerding,B.,
            James,K.N., Stanley,V., Jiang,N., Alu,K., Meave,N., Nidhiry,A.S.,
            Jiwani,F., Tang,I., Nisal,A., Jhamb,I., Patel,A., Patel,A.,
            McEvoy-Venneri,J., Barrows,C., Shen,C., Ha,Y.J., Howarth,R.,
            Strain,M., Ashley-Koch,A.E., Azam,M., Mumtaz,S., Bot,G.M.,
            Finnell,R.H., Kibar,Z., Marwan,A.I., Melikishvili,G., Meltzer,H.S.,
            Mutchinick,O.M., Stevenson,D.A., Mroczkowski,H.J., Ostrander,B.,
            Schindewolf,E., Moldenhauer,J., Zackai,E.H., Emanuel,B.S.,
            Garcia-Minaur,S., Nowakowska,B.A., Stevenson,R.E., Zaki,M.S.,
            Northrup,H., McNamara,H.K., Aldinger,K.A., Phelps,I.G., Deng,M.,
            Glass,I.A., Morrow,B., McDonald-McGinn,D.M., Sanna-Cherchi,S.,
            Lamb,D.J. and Gleeson,J.G.
  CONSRTM   Spina Bifida Sequencing Consortiumdouble dagger
  TITLE     Risk of meningomyelocele mediated by the common 22q11.2 deletion
  JOURNAL   Science 384 (6695), 584-590 (2024)
   PUBMED   38696583
REFERENCE   2  (bases 1 to 2362)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2362)
  AUTHORS   Illes,P., Muller,C.E., Jacobson,K.A., Grutter,T., Nicke,A.,
            Fountain,S.J., Kennedy,C., Schmalzing,G., Jarvis,M.F.,
            Stojilkovic,S.S., King,B.F. and Di Virgilio,F.
  TITLE     Update of P2X receptor properties and their pharmacology: IUPHAR
            Review 30
  JOURNAL   Br J Pharmacol 178 (3), 489-514 (2021)
   PUBMED   33125712
  REMARK    Review article
REFERENCE   4  (bases 1 to 2362)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2362)
  AUTHORS   de Baaij,J.H., Kompatscher,A., Viering,D.H., Bos,C., Bindels,R.J.
            and Hoenderop,J.G.
  TITLE     P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis
  JOURNAL   PLoS One 11 (6), e0156803 (2016)
   PUBMED   27254077
  REMARK    GeneRIF: purinergic signaling via P2X6 is not significantly
            involved in the regulation of renal electrolyte handling under
            normal physiological conditions.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2362)
  AUTHORS   Barth,K. and Kasper,M.
  TITLE     Membrane compartments and purinergic signalling: occurrence and
            function of P2X receptors in lung
  JOURNAL   FEBS J 276 (2), 341-353 (2009)
   PUBMED   19076210
  REMARK    Review article
REFERENCE   7  (bases 1 to 2362)
  AUTHORS   Jarvis,M.F. and Khakh,B.S.
  TITLE     ATP-gated P2X cation-channels
  JOURNAL   Neuropharmacology 56 (1), 208-215 (2009)
   PUBMED   18657557
  REMARK    Review article
REFERENCE   8  (bases 1 to 2362)
  AUTHORS   Shigematsu,Y., Shimoda,Y. and Kaneda,M.
  TITLE     Distribution of immunoreactivity for P2X3, P2X5, and
            P2X6-purinoceptors in mouse retina
  JOURNAL   J Mol Histol 38 (4), 369-371 (2007)
   PUBMED   17605080
  REMARK    GeneRIF: Immunoreactivity for P2X3-, P2X5-, and P2X6-purinoceptors
            was observed in mouse retina.
REFERENCE   9  (bases 1 to 2362)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   10 (bases 1 to 2362)
  AUTHORS   Nawa,G., Urano,T., Tokino,T., Ochi,T. and Miyoshi,Y.
  TITLE     Cloning and characterization of the murine P2XM receptor gene
  JOURNAL   J Hum Genet 43 (4), 262-267 (1998)
   PUBMED   9852680
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY303078.1, AK138541.1 and AW490413.1.
            
            On Apr 21, 2009 this sequence version replaced NM_011028.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081308.1, AK138541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               BY303078.1         2-149
            149-2122            AK138541.1         1-1974
            2123-2362           AW490413.1         1-240               c
FEATURES             Location/Qualifiers
     source          1..2362
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.88 cM"
     gene            1..2362
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; P2xm"
                     /note="purinergic receptor P2X, ligand-gated ion channel,
                     6"
                     /db_xref="GeneID:18440"
                     /db_xref="MGI:MGI:1337113"
     exon            1..299
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; P2xm"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1299
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; P2xm"
                     /note="isoform 1 is encoded by transcript variant 1; P2X
                     purinoceptor 6; ATP receptor; purinergic receptor P2X-like
                     1, orphan receptor"
                     /codon_start=1
                     /product="P2X purinoceptor 6 isoform 1"
                     /protein_id="NP_035158.2"
                     /db_xref="CCDS:CCDS28007.2"
                     /db_xref="GeneID:18440"
                     /db_xref="MGI:MGI:1337113"
                     /translation="MQLQPAGTGNMASAAAAALVSWGFLDYKTEKYVLTRNCRVGVSQ
                     RLLQLAVVVYVIGWALLAKKGYQERDLAPQTSVITKLKGVSVTQVKELENRLWDVADF
                     VKPSQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWADEDCPEGETGTYSHGIKT
                     GQCVVFNGTHRTCEIWSWCPVESGAVPRKPLLAQAKNFTLFIKNTVTFSKFNFSRSNA
                     LLTWDNTYFKHCLYDPLSSPYCPVFRIGDLVAMAGGDFEDLALLGGAVGISIHWDCNL
                     DTKGSDCCPQYSFQLQQKGYNFRTANHWWAASGVETRSLLKLYGIRFDILVTGQAGKF
                     ALIPTAITVGTGAAWLGMVTFLCDLLLLYVDREAGFYWRTKYEEARAPKTTTNSS"
     exon            300..450
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; P2xm"
                     /inference="alignment:Splign:2.1.0"
     exon            451..522
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; P2xm"
                     /inference="alignment:Splign:2.1.0"
     exon            523..598
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; P2xm"
                     /inference="alignment:Splign:2.1.0"
     exon            599..692
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; P2xm"
                     /inference="alignment:Splign:2.1.0"
     exon            693..773
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; P2xm"
                     /inference="alignment:Splign:2.1.0"
     exon            774..915
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; P2xm"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1025
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; P2xm"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1119
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; P2xm"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1185
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; P2xm"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1263
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; P2xm"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..2346
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; P2xm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggtttggg aatgaggcag gagccagctc ctactgaatt tgagatgtcc ctttaacaac
       61 actggcctga atcccatgca tggcttcttg gcctccagtt cagctgcggc taaagttgcc
      121 tgctgactca tgcagttgca gccagcagga actgggaaca tggcttctgc agccgcagca
      181 gcactcgtga gctgggggtt tctggattac aagacggaga aatatgtgct aaccaggaac
      241 tgtcgggtgg gcgtctccca gaggctgctg cagctggcag tggtagtcta cgtgataggg
      301 tgggccctct tggccaaaaa aggctaccag gaacgggact tggcccctca gacttctgtc
      361 atcaccaaac tcaagggggt ttctgtaacc caggttaagg agctggagaa ccggctgtgg
      421 gacgtggctg actttgtgaa gccatcacag ggagagaacg tgttcttcct ggtaaccaac
      481 ttcctcgtga caccagctca agtccagggc agatgtccag agcatccttc cgttcctctg
      541 gctaactgct gggctgatga agactgcccc gaaggggaga cggggacata cagccatggc
      601 ataaaaactg gtcagtgtgt ggtgttcaac ggaacccaca ggacctgtga gatctggagc
      661 tggtgcccag tggagagtgg tgctgtgccc aggaagcccc tgctagctca ggccaagaac
      721 ttcacactct tcatcaaaaa tactgtaacc ttcagcaagt tcaacttctc cagatccaat
      781 gccttattaa cctgggacaa cacatatttc aagcattgtc tctatgatcc actctccagt
      841 ccgtactgcc cagtgttccg catcggggac cttgtggcca tggctggagg ggactttgag
      901 gacctggcct tgctgggtgg tgctgtgggc atcagcattc actgggattg caacctggac
      961 acgaaaggct ctgactgctg tccccagtac tccttccagc tgcagcagaa agggtacaac
     1021 ttcaggacag ccaatcactg gtgggcagcc tcaggcgtgg agacccggag cctgctcaag
     1081 ctctatggaa tccgttttga cattcttgtc actgggcagg cagggaagtt cgcgctcatc
     1141 cctacggcca tcacagtggg cacaggagcg gcttggctgg gcatggtcac cttcctctgt
     1201 gacctgctgc tactgtatgt ggatagagag gccggtttct actggagaac caaatatgaa
     1261 gaggcaagag ccccaaagac gactaccaac agttcataga ccgagccagc cttctcaccc
     1321 gctaaccctg ttacccaagt gtcctaggag tggtttgcac ctgccccatg tctgctgctg
     1381 ctgggatcca ggcatccacg caccgcaccg caccgatggc ctgtctggat ggctgccacc
     1441 cactggccta ttcattcctg aggcttacac cctctccctg ctggttaaag tttagggctt
     1501 gggaaggaag agggttctgg cttgggaaaa tggaggacaa agcttcagcg ggactagagg
     1561 ggagttggga taattccgac agactccgaa tgcagattcc ctcctgggtt cagtcagagg
     1621 ggtggggtgg ggggcgatgt ggctgaataa gtggtggctg gtatccttgg aactttctat
     1681 atgtctgctg ggggactctg ccatccagtt catgccctcc atccctgccc tggccctggt
     1741 taccaaggtt tctcaggagc ctaaggtgtg agaaattgca tgtctgggat tcactgccat
     1801 caagtcagtc ctggaagcct caacctactc tgaaacacct gcctgccaga accttaactc
     1861 tggctccagc cagagcgcca tagtttcaag gtataatctc taatgaagcg cactaaggtt
     1921 ccttaggact ggctggttct ggatctataa ccatgtgagg cctcgatcct tccctcagtg
     1981 agactttccc cacgcaccag agcccataga aaggatagca aggacgggct gcagagacga
     2041 tcctggtcca agtgtagggc atagtttagg aagtacagag gcagttttgt tgtgcatgtg
     2101 tggtcaccga gagagaacca aggctgaggt gaaaacagca gcaacagctg ggatctccag
     2161 gcttccacag cctccaaaaa cccttggagt tcctggtgcc actcagctct caggactgtg
     2221 gcctgcaaag ggctatgatg ggaaggcgcg gctcctggag gtggttcatg tggacactgt
     2281 agtcctgggg gtagggggac ccaaagaacc ctgatatcac tgctgaagta aagcttgcca
     2341 aagccaaaaa aaaaaaaaaa aa
//
