LOCUS       NM_145526               3859 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus purinergic receptor P2X, ligand-gated ion channel, 3
            (P2rx3), mRNA.
ACCESSION   NM_145526 XR_104778 XR_107442
VERSION     NM_145526.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3859)
  AUTHORS   Lin,Y.Y., Lu,Y., Li,C.Y., Ma,X.F., Shao,M.Q., Gao,Y.H., Zhang,Y.Q.,
            Jiang,H.N., Liu,Y., Yang,Y., Huang,L.D., Cao,P., Wang,H.S., Wang,J.
            and Yu,Y.
  TITLE     Finely ordered intracellular domain harbors an allosteric site to
            modulate physiopathological function of P2X3 receptors
  JOURNAL   Nat Commun 15 (1), 7652 (2024)
   PUBMED   39227563
  REMARK    GeneRIF: Finely ordered intracellular domain harbors an allosteric
            site to modulate physiopathological function of P2X3 receptors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3859)
  AUTHORS   Yin,D., Zhang,T. and Dai,P.
  TITLE     The purinergic receptors 2X3 on spiral ganglion neurons enhance the
            medial olivocochlear reflex in mice after long-term moderate noise
            exposure
  JOURNAL   Neuroreport 33 (18), 786-790 (2022)
   PUBMED   36367795
  REMARK    GeneRIF: The purinergic receptors 2X3 on spiral ganglion neurons
            enhance the medial olivocochlear reflex in mice after long-term
            moderate noise exposure.
REFERENCE   3  (bases 1 to 3859)
  AUTHORS   Banerjee,P., Kubo,F., Nakaoka,H., Ajima,R., Sato,T., Hirata,T. and
            Iwasato,T.
  TITLE     Spontaneous activity in whisker-innervating region of neonatal
            mouse trigeminal ganglion
  JOURNAL   Sci Rep 12 (1), 16311 (2022)
   PUBMED   36175429
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3859)
  AUTHORS   Lu,R., Metzner,K., Zhou,F., Flauaus,C., Balzulat,A., Engel,P.,
            Petersen,J., Ehinger,R., Bausch,A., Ruth,P., Lukowski,R. and
            Schmidtko,A.
  TITLE     Functional Coupling of Slack Channels and P2X3 Receptors
            Contributes to Neuropathic Pain Processing
  JOURNAL   Int J Mol Sci 22 (1), 405 (2021)
   PUBMED   33401689
  REMARK    GeneRIF: Functional Coupling of Slack Channels and P2X3 Receptors
            Contributes to Neuropathic Pain Processing.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3859)
  AUTHORS   Ueda,N., Kondo,M., Takezawa,K., Kiuchi,H., Sekii,Y., Inagaki,Y.,
            Soda,T., Fukuhara,S., Fujita,K., Uemura,M., Imamura,R.,
            Miyagawa,Y., Nonomura,N. and Shimada,S.
  TITLE     Bladder urothelium converts bacterial lipopolysaccharide
            information into neural signaling via an ATP-mediated pathway to
            enhance the micturition reflex for rapid defense
  JOURNAL   Sci Rep 10 (1), 21167 (2020)
   PUBMED   33273625
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3859)
  AUTHORS   Vlaskovska,M., Kasakov,L., Rong,W., Bodin,P., Bardini,M.,
            Cockayne,D.A., Ford,A.P. and Burnstock,G.
  TITLE     P2X3 knock-out mice reveal a major sensory role for urothelially
            released ATP
  JOURNAL   J Neurosci 21 (15), 5670-5677 (2001)
   PUBMED   11466438
REFERENCE   7  (bases 1 to 3859)
  AUTHORS   Souslova,V., Cesare,P., Ding,Y., Akopian,A.N., Stanfa,L.,
            Suzuki,R., Carpenter,K., Dickenson,A., Boyce,S., Hill,R.,
            Nebenuis-Oosthuizen,D., Smith,A.J., Kidd,E.J. and Wood,J.N.
  TITLE     Warm-coding deficits and aberrant inflammatory pain in mice lacking
            P2X3 receptors
  JOURNAL   Nature 407 (6807), 1015-1017 (2000)
   PUBMED   11069182
REFERENCE   8  (bases 1 to 3859)
  AUTHORS   Cockayne,D.A., Hamilton,S.G., Zhu,Q.M., Dunn,P.M., Zhong,Y.,
            Novakovic,S., Malmberg,A.B., Cain,G., Berson,A., Kassotakis,L.,
            Hedley,L., Lachnit,W.G., Burnstock,G., McMahon,S.B. and Ford,A.P.
  TITLE     Urinary bladder hyporeflexia and reduced pain-related behaviour in
            P2X3-deficient mice
  JOURNAL   Nature 407 (6807), 1011-1015 (2000)
   PUBMED   11069181
REFERENCE   9  (bases 1 to 3859)
  AUTHORS   Kunapuli,S.P. and Daniel,J.L.
  TITLE     P2 receptor subtypes in the cardiovascular system
  JOURNAL   Biochem J 336 (Pt 3) (Pt 3), 513-523 (1998)
   PUBMED   9841859
  REMARK    Review article
REFERENCE   10 (bases 1 to 3859)
  AUTHORS   Souslova,V., Ravenall,S., Fox,M., Wells,D., Wood,J.N. and
            Akopian,A.N.
  TITLE     Structure and chromosomal mapping of the mouse P2X3 gene
  JOURNAL   Gene 195 (1), 101-111 (1997)
   PUBMED   9300827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935159.11.
            
            On Dec 21, 2022 this sequence version replaced NM_145526.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141847.1, AK140283.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AL935159.11        119661-119980       c
            321-456             AL935159.11        109336-109471       c
            457-528             AL935159.11        108862-108933       c
            529-592             AL935159.11        108590-108653       c
            593-686             AL935159.11        107963-108056       c
            687-764             AL935159.11        107634-107711       c
            765-906             AL935159.11        106828-106969       c
            907-1043            AL935159.11        106209-106345       c
            1044-1137           AL935159.11        85137-85230         c
            1138-1203           AL935159.11        84804-84869         c
            1204-1281           AL935159.11        84086-84163         c
            1282-3859           AL935159.11        81029-83606         c
FEATURES             Location/Qualifiers
     source          1..3859
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     gene            1..3859
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /note="purinergic receptor P2X, ligand-gated ion channel,
                     3"
                     /db_xref="GeneID:228139"
                     /db_xref="MGI:MGI:1097160"
     exon            1..320
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1395
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /note="ATP receptor; purinergic receptor P2X3"
                     /codon_start=1
                     /product="P2X purinoceptor 3"
                     /protein_id="NP_663501.2"
                     /db_xref="CCDS:CCDS16200.1"
                     /db_xref="GeneID:228139"
                     /db_xref="MGI:MGI:1097160"
                     /translation="MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFL
                     HEKAYQVRDTAIESSVVTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQ
                     MQGFCPENEEKYRCVSDSQCGPERFPGGGILTGRCVNYSSVRRTCEIQGWCPTEVDTV
                     EMPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTDKDIKKCRFHPEKAPFCPILRV
                     GDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSP
                     GYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGV
                     GTVLCDIILLNFLKGADHYKARKFEEVTETTLKGTASTNPVFTSDQATVEKQSTDSGA
                     YSIGH"
     exon            321..456
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /inference="alignment:Splign:2.1.0"
     exon            457..528
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /inference="alignment:Splign:2.1.0"
     exon            529..592
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..686
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /inference="alignment:Splign:2.1.0"
     exon            687..764
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /inference="alignment:Splign:2.1.0"
     exon            765..906
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1043
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1137
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1203
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1281
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..3859
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1820..1825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /note="hexamer: AATGAA"
     polyA_site      1840
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /note="major polyA site"
     regulatory      1967..1972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /note="hexamer: TATAAA"
     polyA_site      2007
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /note="major polyA site"
     regulatory      3702..3707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /note="hexamer: ATTACA"
     polyA_site      3726
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /note="major polyA site"
     regulatory      3837..3842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
                     /note="hexamer: AATAGA"
     polyA_site      3859
                     /gene="P2rx3"
                     /gene_synonym="4930513E20Rik; P2X3"
ORIGIN      
        1 ggactgttgg cttctagagt gtcaagagga gagacgaggc actggactac agttgcctgg
       61 cttataggaa ctggctcttt tcctcaagcc ccattaagca gcccactcca gttcttgatc
      121 tctgtctccc agtcctgagg tcttttctct ccttgggctg catccacagc ctttctgggt
      181 ggctgtgagc actttctcag tatgaactgt atatcagact tcttcaccta cgagactacc
      241 aagtcggtgg ttgtgaaaag ctggaccatt gggatcatca accgagccgt tcagctgctg
      301 attatctcct actttgtggg gtgggttttc ttgcacgaga aggcctacca agtgcgggac
      361 acggccattg agtcctcagt agtaacaaag gtaaaaggct tcggacgcta tgccaacaga
      421 gtcatggatg tgtcggatta tgtgacccca ccccagggca cttctgtctt tgtcatcatc
      481 accaaaatga tcgttactga aaatcaaatg caaggattct gtccagagaa tgaggagaag
      541 taccgctgtg tgtctgacag ccagtgtggg cctgagcgct tcccgggtgg ggggatcctc
      601 accggccgct gcgtgaacta cagctctgtc cgtcggacct gtgagatcca gggctggtgc
      661 cccaccgagg tggacaccgt ggagatgcct atcatgatgg aagccgagaa cttcaccatt
      721 ttcatcaaga acagcatccg tttccctctc ttcaactttg agaagggaaa cctccttcct
      781 aacctcaccg acaaggacat aaagaagtgc cgcttccatc ctgaaaaggc cccattttgc
      841 cccatcttga gggtagggga cgtggttaag tttgctgggc aggattttgc caagctggcc
      901 cgcacgggtg gagttctggg cattaagatc ggctgggtgt gtgatctgga caaggcctgg
      961 gaccagtgca ttcccaaata ttccttcact cggctagatg gagtttctga gaaaagcagt
     1021 gtttcccctg gctacaactt caggtttgcc aaatactaca agatggagaa tggcagcgag
     1081 taccgcacgc tcctgaaggc tttcggcatc cgctttgatg tgctggtata cgggaacgct
     1141 ggcaagttca acatcattcc caccatcatc agctcggtgg ctgccttcac ttccgtggga
     1201 gtggggactg ttctctgtga catcatcctg ctcaatttcc tcaaaggggc tgatcactac
     1261 aaagccagga agtttgagga ggtgactgag acaacactga agggtactgc ttcaaccaac
     1321 ccagtgttca ccagtgacca ggccactgta gagaagcagt ccacagactc gggggcctat
     1381 tctattggtc actagggcct cttcccaggg tgccatgctt atccttgggc tgcagaacct
     1441 tcaacaggcc actctatctc agcagacaga ggtgggaggg ggagaagagg ggctcttatt
     1501 tctgatgttc accccaaaga ccaggtatct agaccctcac tgttcagcag acaggcagtg
     1561 cttcccgcta agacctgaat cttgccttta ccccttgcat gcctcccatc tgcttccctg
     1621 ggtcccaagc atccatccat ttccaaagga tagagaaaat ggtagctaag gttacatcca
     1681 tagaacctac cacataccag ggactcccat acacattatc tctttgcacc cttaaaataa
     1741 tcctataagg tagatttctg ggggtggggg gtggggggtg ttttgttttt gtttttgttg
     1801 tgtttttaag agaaggagga atgaactctc taggtgtcta ctcttctgtg tcagttgcct
     1861 tccctgcctt cccatgatgc ccaacagtga gctttctcag gaatgcagac cctactttag
     1921 gagagcccag ggaaatgcaa tataaactct gatataaatt ctgcaatata aatttctgat
     1981 atggccaagt ccagcttcag caggaaatag aaggtgtgac tgtcagtgga tttttccttg
     2041 cctcaccccg aatctcaagc tcaagctgag gaatagacct ttattctccc atgaggtcct
     2101 cacacatcca cacatctgga ccctcctcca gaatctagac agaagacaca cacatacatg
     2161 actgacaaga ggcagtttct aaacctagca ccatgcccca ggacatcagc tgtcctagtt
     2221 tacagcattg ttggtaaagc cacagttagg ggctggggat gtagttgagt aggcagagtg
     2281 tgttgtctat catgtcagcc ctagggccaa cctgcaagac ttcataagcc aggcacgatg
     2341 gtacacattt gtaatcccag cactcaggag gtagacatgg aggatcaaaa gttcaaattc
     2401 atccttgaca acacaacaag tttgaaccca gcctgggacc cacgaaactt tcaaaaagaa
     2461 gtggggagac ccagtaagat ccaataccct acgagcattt ggccaggtca gccaggcctg
     2521 ttttcacagg atcctaacag gtgatcagtg agaagctaaa gaagcctcat aaaccatcat
     2581 gggcagcatt cttgcttata gatcactaac cccgaggcta aaaatgaaaa atggcttgcc
     2641 ttgtgccatt gtgaggggcc atgagagggc acaggtgtcc tgtctccatt gcccaggtgt
     2701 cccatctcct ttttgagtct ttaaagaaaa caggagatga agaggaagct ctaaattgta
     2761 gagggcaaag ctcaagaaca gatcaaggtg taggaaagaa gcagcttgag aggctctttt
     2821 ggtttggctt gtttatttgg ttggttggtt ggttggttgg ttggttggtt ggttggctgg
     2881 ctggctggct ggctggctgg ctggctggtt ggttggttgg ttggttggtt ttgatgaaaa
     2941 gactttccta tgtatttctg gctggcctaa atttacagat ctcctccctc aactcaactc
     3001 ttccccagta ttgggattta taggcaagtg ccgtcataca gctgggggca tctcttttaa
     3061 aagaatatat aactaagtgt cagaaaagtt catgcaaatg agtgggcctg aggtataagt
     3121 ttaattagta tcagggtcaa tctgcctctt aaacatgggc acaatgctga aagcttagca
     3181 gagatgagca tgcatgtaga cagagggctg gcccctcact ggaaggtgca gaaagatgtg
     3241 ggggaaggat agtctaggag gaccacagga gtgctcacac agacccaacc ccaatggtcc
     3301 ccacccacca gtttcatcaa cctcccctct gcttgctcac agccccatca ttatgggtga
     3361 tggggtactg tctccctaat agcaatgtca agtcctggat agtgtccaga gacctggcca
     3421 ggcttcatct ctccagcaga gacatcagca aaggaaagaa cgcagcctcc aagaaggagg
     3481 tgcacaaccc ccttacgccg aggctgagtt caccaagatg ctccctagaa gaagatggag
     3541 acactgtgtc ctaagaggat cctgtacccc aggctagggt aattctcccc caggtgccta
     3601 agcctcttct gggacatcaa taagtgtgta aactccaccc tgtactcccc ttgtccaaaa
     3661 caagtccact tctatgtgct agatgccagc taatagtaga aattacaatc gccagcttat
     3721 atctgatata ctgtggttta ctcagcgcca tccctaacat ggtcacacag gccctgacca
     3781 cacctagggg ggaggggttc tgtggtttgt tattaacctt gtttggaaga aaaacaaata
     3841 gacagttctt ggaactaga
//
