LOCUS       NM_153400               1919 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus purinergic receptor P2X, ligand-gated ion channel, 2
            (P2rx2), transcript variant 1, mRNA.
ACCESSION   NM_153400
VERSION     NM_153400.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1919)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1919)
  AUTHORS   Zhang,Y., Pan,Y.D., Zheng,W.Y., Li,H.Y., Zhu,M.Z., Ou Yang,W.J.,
            Qian,Y., Turecki,G., Mechawar,N. and Zhu,X.H.
  TITLE     Enhancing HIF-1alpha-P2X2 signaling in dorsal raphe serotonergic
            neurons promotes psychological resilience
  JOURNAL   Redox Biol 69, 103005 (2024)
   PUBMED   38150991
REFERENCE   3  (bases 1 to 1919)
  AUTHORS   Sun,C., Zheng,S., Perry,J.S.A., Norris,G.T., Cheng,M., Kong,F.,
            Skyberg,R., Cang,J., Erisir,A., Kipnis,J. and Hill,D.L.
  TITLE     Maternal diet during early gestation influences postnatal taste
            activity-dependent pruning by microglia
  JOURNAL   J Exp Med 220 (12) (2023)
   PUBMED   37733279
REFERENCE   4  (bases 1 to 1919)
  AUTHORS   Vermeiren,S., Cabochette,P., Dannawi,M., Desiderio,S., San
            Jose,A.S., Achouri,Y., Kricha,S., Sitte,M., Salinas-Riester,G.,
            Vanhollebeke,B., Brunet,J.F. and Bellefroid,E.J.
  TITLE     Prdm12 represses the expression of the visceral neuron determinants
            Phox2a/b in developing somatosensory ganglia
  JOURNAL   iScience 26 (12), 108364 (2023)
   PUBMED   38025786
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1919)
  AUTHORS   Ohmoto,M., Jyotaki,M., Yee,K.K. and Matsumoto,I.
  TITLE     A Transcription Factor Etv1/Er81 Is Involved in the Differentiation
            of Sweet, Umami, and Sodium Taste Cells
  JOURNAL   eNeuro 10 (4) (2023)
   PUBMED   37045597
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1919)
  AUTHORS   Rong,W., Gourine,A.V., Cockayne,D.A., Xiang,Z., Ford,A.P.,
            Spyer,K.M. and Burnstock,G.
  TITLE     Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated
            ion channel mediating ventilatory responses to hypoxia
  JOURNAL   J Neurosci 23 (36), 11315-11321 (2003)
   PUBMED   14672995
  REMARK    GeneRIF: P2X2 receptor subunit play a pivotal role in carotid body
            function and in mediating ventilatory responses to hypoxia.
REFERENCE   7  (bases 1 to 1919)
  AUTHORS   Ren,J., Bian,X., DeVries,M., Schnegelsberg,B., Cockayne,D.A.,
            Ford,A.P. and Galligan,J.J.
  TITLE     P2X2 subunits contribute to fast synaptic excitation in myenteric
            neurons of the mouse small intestine
  JOURNAL   J Physiol 552 (Pt 3), 809-821 (2003)
   PUBMED   12937291
  REMARK    GeneRIF: P2X2 homomeric receptors contribute to fEPSPs in neural
            pathways underlying peristalsis studied in vitro.
REFERENCE   8  (bases 1 to 1919)
  AUTHORS   Khakh,B.S., Gittermann,D., Cockayne,D.A. and Jones,A.
  TITLE     ATP modulation of excitatory synapses onto interneurons
  JOURNAL   J Neurosci 23 (19), 7426-7437 (2003)
   PUBMED   12917379
REFERENCE   9  (bases 1 to 1919)
  AUTHORS   Castelucci,P., Robbins,H.L. and Furness,J.B.
  TITLE     P2X(2) purine receptor immunoreactivity of intraganglionic laminar
            endings in the mouse gastrointestinal tract
  JOURNAL   Cell Tissue Res 312 (2), 167-174 (2003)
   PUBMED   12690440
  REMARK    GeneRIF: P2X(2) purine receptor immunoreactivity is a feature of
            intraganglionic laminar endings in the mouse, and that P2X receptor
            agonists may modulate sensitivity of the intraganglionic laminar
            endings
REFERENCE   10 (bases 1 to 1919)
  AUTHORS   Koshimizu,T.A., Ueno,S., Tanoue,A., Yanagihara,N., Stojilkovic,S.S.
            and Tsujimoto,G.
  TITLE     Heteromultimerization modulates P2X receptor functions through
            participating extracellular and C-terminal subdomains
  JOURNAL   J Biol Chem 277 (49), 46891-46899 (2002)
   PUBMED   12361958
  REMARK    GeneRIF: heteromeric receptors formed by distinct P2XR subunits
            develop new functions resulting from integrative effects of the
            participating extracellular and C-terminal subdomains
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY236715.1, AB094664.1, AK141196.1 and AB094663.1.
            
            On Sep 19, 2009 this sequence version replaced NM_153400.3.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY044240.2, AK141196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                BY236715.1         4-83
            81-857              AB094664.1         1-777
            858-1918            AK141196.1         817-1877
            1919-1919           AB094663.1         1569-1569
FEATURES             Location/Qualifiers
     source          1..1919
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.49 cM"
     gene            1..1919
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /note="purinergic receptor P2X, ligand-gated ion channel,
                     2"
                     /db_xref="GeneID:231602"
                     /db_xref="MGI:MGI:2665170"
     exon            1..256
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1538
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /note="isoform a is encoded by transcript variant 1; P2X
                     purinoceptor 2"
                     /codon_start=1
                     /product="P2X purinoceptor 2 isoform a"
                     /protein_id="NP_700449.2"
                     /db_xref="CCDS:CCDS51607.1"
                     /db_xref="GeneID:231602"
                     /db_xref="MGI:MGI:2665170"
                     /translation="MAAAQPRLPAGAAMVRRLARGCWSAFWDYETPKVIVVRNRRLGF
                     VHRMVQLLILLYFVWYVFIVQKSYQDSETGPESSIITKVKGITMSEHKVWDVEEYVKP
                     PEGGSVVSIITRIEVTPSQTLGTCPESMRVHSSTCHLDDDCVAGQLDMQGNGIRTGRC
                     VPYYHGDSKTCEVSAWCPVEDGTSENHFLGKMAPNFTILIKNSIHYPKFKFSKGNIAS
                     QKSDYLKHCTFDQDSDPYCPIFRLGFIVEQAGENFTELAHKGGVIGVIINWNCDLDLS
                     ESECNPKYSFRRLDPKYDPASSGYNFRFAKYYKINGTTTTRTLIKAYGIRIDVIVHGQ
                     AGKFSLIPTIINLATALTSIGVGSFLCDWILLTFMNKNKLYSHKKFDKVRTPRHPSSR
                     WPVTLALVLGQIPPPPSHYSQDQPPSLPSGEGPALGEGAELPLAVQPPRSCSSSALTE
                     QVVDTLDQHMGQRPPVPEPSQQDSTSTDPKGLAQL"
     exon            257..392
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /inference="alignment:Splign:2.1.0"
     exon            393..464
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /inference="alignment:Splign:2.1.0"
     exon            465..540
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /inference="alignment:Splign:2.1.0"
     exon            541..637
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /inference="alignment:Splign:2.1.0"
     exon            638..718
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /inference="alignment:Splign:2.1.0"
     exon            719..857
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /inference="alignment:Splign:2.1.0"
     exon            858..988
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1082
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1148
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1919
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1901..1906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /note="hexamer: AATAAA"
     polyA_site      1918
                     /gene="P2rx2"
                     /gene_synonym="P2x2; P2X2a"
                     /note="major polyA site"
ORIGIN      
        1 ggccacaccc ccagcctgcc cacgagaggc cgagagtgtg aggcgctcca gcagctcttg
       61 tggaccgagc tccttgggcc atggccgctg cacagccccg gcttcccgcg ggggcggcca
      121 tggtccggcg cttggcccgg ggctgctggt ccgcgttctg ggactacgag acgcccaagg
      181 tgatcgtggt gcggaatcgg cgcctgggat tcgtgcaccg catggtgcag ctgctcattc
      241 tgctttactt cgtgtggtac gtcttcatcg tgcagaaaag ctaccaggat agcgaaaccg
      301 gtccggagag ctccatcatc accaaagtca aggggatcac catgtcggaa cacaaagtgt
      361 gggacgtgga ggaatacgta aagcccccgg aggggggcag tgtagtcagc atcatcacca
      421 ggatcgaggt tactccttcc cagaccctgg gaacatgccc agagagcatg agggttcaca
      481 gctctacctg ccatttagat gacgactgtg tggccggaca gctggacatg cagggcaatg
      541 ggattcggac aggacgctgt gtaccctatt accatgggga ctccaagacc tgcgaggtgt
      601 cagcctggtg cccggtggag gatgggactt ctgaaaacca ttttctgggt aaaatggccc
      661 caaatttcac catcctcatc aagaacagca tccactatcc caagttcaag ttctccaagg
      721 gcaacattgc aagccagaag agtgactacc tgaagcactg cacgtttgat caggactctg
      781 atccatactg tcccatcttc aggctgggct tcattgtaga gcaagcagga gagaacttca
      841 cagaactggc acacaagggc ggtgtcattg gggtcatcat caactggaac tgtgacctgg
      901 acttgtctga atcagagtgc aaccccaaat attctttccg gaggctcgac cccaagtatg
      961 accctgcctc ttcaggctac aacttcaggt ttgccaaata ttacaagata aacggcacca
     1021 ccaccactcg aactctcatc aaagcctatg ggattcgaat tgacgttatt gtgcatggac
     1081 aggcagggaa attcagtctc attcccacca tcatcaatct ggccactgct ctgacctcca
     1141 tcggggtggg ctcctttctg tgtgactgga ttttgttaac gttcatgaac aaaaacaagc
     1201 tctacagcca taagaagttc gacaaggtgc gtaccccaag gcacccctca agtagatggc
     1261 ctgtgaccct tgcccttgtc ttgggccaga tccctccccc acctagtcac tactcccagg
     1321 accagccacc cagccttcca tcaggtgaag gaccagcttt gggagaaggg gcagagctac
     1381 cactggctgt ccagcctcct cggtcttgct ccagctctgc tctgactgag caggtggtgg
     1441 acactcttga ccagcatatg ggacaaaggc ctcctgtccc tgagccttcc caacaggact
     1501 ccacatccac ggaccccaaa ggtttggccc aactttgatc tcatcctcac taagctacag
     1561 acctggatct gggagggcag agacagcttc tgctgctagg cagccctagg gaagatctgc
     1621 gctcttcagt aaccatgtcc acgtgactgg gaaacagaca cctgtgcaag aagataggca
     1681 tcttgctctg ggccaggctt acattcttcc tctccctaag gcttctgggg agaagtgggt
     1741 ccctgccatt tcctttccca acagaactcc tcataggatc ccctgtcctt tccctgccca
     1801 ccttttgtac tctcacacag cactctggga ccccaaatta gagctgtctt ccggttgtat
     1861 tttaagcccc cctttagaag tcacacagcg tgctgagtcc aataaaccag tgatgagct
//
