LOCUS       NM_008771               2441 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus purinergic receptor P2X, ligand-gated ion channel, 1
            (P2rx1), mRNA.
ACCESSION   NM_008771
VERSION     NM_008771.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2441)
  AUTHORS   Yu,Y., Chang,L., Hu,Q., Zhu,J., Zhang,J., Xia,Q. and Zhao,J.
  TITLE     P2rx1 deficiency alleviates acetaminophen-induced acute liver
            failure by regulating the STING signaling pathway
  JOURNAL   Cell Biol Toxicol 39 (6), 2761-2774 (2023)
   PUBMED   37046119
  REMARK    GeneRIF: P2rx1 deficiency alleviates acetaminophen-induced acute
            liver failure by regulating the STING signaling pathway.
REFERENCE   2  (bases 1 to 2441)
  AUTHORS   He,X., Xu,Y., Huang,D., Yu,Z., Yu,J., Xie,L., Liu,L., Yu,Y.,
            Chen,C., Wan,J., Zhang,Y. and Zheng,J.
  TITLE     P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways
  JOURNAL   Leukemia 37 (2), 265-275 (2023)
   PUBMED   36418376
  REMARK    GeneRIF: P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways.
REFERENCE   3  (bases 1 to 2441)
  AUTHORS   Bujko,K., Adamiak,M., Abdelbaset-Ismail,A., Thapa,A., Ilowska,N.,
            Ratajczak,J., Kucia,M. and Ratajczak,M.Z.
  TITLE     Novel evidence that the P2X1 purinergic receptor-Nlrp3 inflammasome
            axis orchestrates optimal trafficking of hematopoietic stem
            progenitors cells
  JOURNAL   Folia Histochem Cytobiol 60 (3), 280-290 (2022)
   PUBMED   36177744
  REMARK    GeneRIF: Novel evidence that the P2X1 purinergic receptor-Nlrp3
            inflammasome axis orchestrates optimal trafficking of hematopoietic
            stem progenitors cells.
REFERENCE   4  (bases 1 to 2441)
  AUTHORS   Wang,X., Liu,D., Qin,W., Liu,Y., Yuan,X., Zhang,X., Dai,C. and
            Zhang,D.
  TITLE     P2RX1-Involved Glycolytic Metabolism Supports Neutrophil Activation
            in Acute Pancreatitis
  JOURNAL   Front Immunol 11, 549179 (2021)
   PUBMED   33603729
  REMARK    GeneRIF: P2RX1-Involved Glycolytic Metabolism Supports Neutrophil
            Activation in Acute Pancreatitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2441)
  AUTHORS   Wang,X., Hu,L.P., Qin,W.T., Yang,Q., Chen,D.Y., Li,Q., Zhou,K.X.,
            Huang,P.Q., Xu,C.J., Li,J., Yao,L.L., Wang,Y.H., Tian,G.A.,
            Yang,J.Y., Yang,M.W., Liu,D.J., Sun,Y.W., Jiang,S.H., Zhang,X.L.
            and Zhang,Z.G.
  TITLE     Identification of a subset of immunosuppressive P2RX1-negative
            neutrophils in pancreatic cancer liver metastasis
  JOURNAL   Nat Commun 12 (1), 174 (2021)
   PUBMED   33420030
  REMARK    GeneRIF: Identification of a subset of immunosuppressive
            P2RX1-negative neutrophils in pancreatic cancer liver metastasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2441)
  AUTHORS   Liang,S.X., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Phillips,W.D.
  TITLE     Structure and chromosome location of the mouse P2X(1) purinoceptor
            gene (P2rx1)
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 333-336 (2001)
   PUBMED   11435708
REFERENCE   7  (bases 1 to 2441)
  AUTHORS   Mulryan,K., Gitterman,D.P., Lewis,C.J., Vial,C., Leckie,B.J.,
            Cobb,A.L., Brown,J.E., Conley,E.C., Buell,G., Pritchard,C.A. and
            Evans,R.J.
  TITLE     Reduced vas deferens contraction and male infertility in mice
            lacking P2X1 receptors
  JOURNAL   Nature 403 (6765), 86-89 (2000)
   PUBMED   10638758
REFERENCE   8  (bases 1 to 2441)
  AUTHORS   Kunapuli,S.P. and Daniel,J.L.
  TITLE     P2 receptor subtypes in the cardiovascular system
  JOURNAL   Biochem J 336 (Pt 3) (Pt 3), 513-523 (1998)
   PUBMED   9841859
  REMARK    Review article
REFERENCE   9  (bases 1 to 2441)
  AUTHORS   Valera,S., Talabot,F., Evans,R.J., Gos,A., Antonarakis,S.E.,
            Morris,M.A. and Buell,G.N.
  TITLE     Characterization and chromosomal localization of a human P2X
            receptor from the urinary bladder
  JOURNAL   Recept Channels 3 (4), 283-289 (1995)
   PUBMED   8834001
REFERENCE   10 (bases 1 to 2441)
  AUTHORS   Hacker,G. and Vaux,D.L.
  TITLE     Expression of candidate cell death genes in cell lines during
            apoptosis
  JOURNAL   Biochem Cell Biol 72 (11-12), 451-454 (1994)
   PUBMED   7654317
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035304.1 and AK007650.1.
            
            On Oct 26, 2007 this sequence version replaced NM_008771.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015084.1, AK035304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2439              AK035304.1         2-2440
            2440-2441           AK007650.1         1803-1804
FEATURES             Location/Qualifiers
     source          1..2441
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.09 cM"
     gene            1..2441
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /note="purinergic receptor P2X, ligand-gated ion channel,
                     1"
                     /db_xref="GeneID:18436"
                     /db_xref="MGI:MGI:1098235"
     exon            1..307
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1370
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /note="ATP receptor; P2X1 receptor; programmed cell death
                     3"
                     /codon_start=1
                     /product="P2X purinoceptor 1"
                     /protein_id="NP_032797.3"
                     /db_xref="CCDS:CCDS24992.1"
                     /db_xref="GeneID:18436"
                     /db_xref="MGI:MGI:1098235"
                     /translation="MARRLQDELSAFFFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYV
                     IGWVFVYEKGYQTSSGLISSVSVKLKGLAVTQLQGLGPQVWDVADYVFPAHGDSSFVV
                     MTNFIMTPQQAQGHCAENPEGGICQDDSGCTPGKAERKAQGIRTGNCVPFNGTVKTCE
                     IFGWCPVEVDDKIPSPALLHEAENFTLFIKNSISFPRFKVNRRNLVEEVNGTYMKKCL
                     YHKILHPLCPVFSLGYVVRESGQDFRSLAEKGGVVGITIDWECDLDWHVRHCKPIYQF
                     HGLYGEKNLSPGFNFRFARHFVQNGTNRRHLFKVFGIRFDILVDGKAGKFDIIPTMTT
                     IGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGEGERDPAATSSTLGL
                     QENMRTS"
     exon            308..455
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            456..527
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            528..597
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..694
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            695..775
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..917
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1045
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1136
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1202
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1304
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..2441
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2424..2429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2rx1"
                     /gene_synonym="P2x; Pdcd3; RP-2"
                     /note="putative"
ORIGIN      
        1 agatcccacc aacgaacctc caactctggc cccacttggc ctgctctgtt cttaaggggc
       61 tgggaagcct ccagccactc cactgctctc tctgtagaca cagatgctag cctgcccttg
      121 accacagagg ccgtgcgggg ggcttgtctc tgagcccctt ctggcccacc atggctcggc
      181 ggctgcagga tgagctgtca gccttcttct ttgagtatga cactccccgg atggtgctgg
      241 tacgaaacaa gaaggtggga gtcattttcc gtctgatcca gttggtggtt ctggtctacg
      301 tcattgggtg ggtgtttgtc tatgaaaaag gataccagac ctcaagtggc cttatcagca
      361 gtgtgtcagt gaaactcaag ggcttggctg tgacccagct ccagggcctg ggaccccagg
      421 tctgggacgt ggctgactat gtcttcccag cacatgggga cagctccttt gtagttatga
      481 ccaatttcat catgacccct cagcaggctc aaggacattg tgcagagaac ccagaaggtg
      541 gcatatgcca agatgacagt ggctgcactc caggaaaagc agaaaggaaa gcccaaggta
      601 ttcgcacagg caactgtgtg cccttcaatg gcactgtgaa gacgtgtgag atctttggct
      661 ggtgtcctgt agaggtggat gacaagatcc caagccctgc tcttcttcat gaggctgaga
      721 acttcaccct cttcatcaaa aacagcatca gctttccacg cttcaaggtc aacaggcgca
      781 acctggtgga ggaggtgaat ggtacctaca tgaagaaatg cctctaccac aagattctac
      841 acccgctgtg cccagtcttc agccttggct atgtggtgcg agagtcgggc caggacttcc
      901 gaagccttgc tgagaagggc ggggtggttg gtatcaccat cgactgggag tgtgacctgg
      961 actggcatgt acggcactgc aaacccatct accagttcca tggactgtac ggggagaaga
     1021 acctgtctcc aggcttcaac ttcagatttg ccaggcactt tgtgcagaat gggacaaacc
     1081 gtcgtcacct cttcaaggtg tttgggattc gctttgatat ccttgtggat ggcaaggctg
     1141 ggaagtttga catcatccct actatgacta ccatcggctc tgggattggc atctttggag
     1201 tggccacagt tctctgtgat ctcttattgc tccacatcct gcctaagagg cactactaca
     1261 agcagaagaa gttcaagtat gcggaggaca tggggcctgg ggagggtgaa cgtgaccccg
     1321 cggccaccag ctccactctg ggcctgcagg agaacatgag gacctcctga ccttaatctt
     1381 gagctccgga cttgactcag tgtgtggctt ccagcaaggg ctggtggctt tgagccaggg
     1441 cagaggtcat tgccagaggc tttcctgcaa ggcagatacc agttgccctc tggttcagcc
     1501 aagacattgg aatccagagc tctgggtcca gatccacact tcccttcctg agggatggcc
     1561 cctcaatttt tcactattct gggtccctct ggctgggttc ctcacacacc agtaccctag
     1621 cttcgtgctt atggctcagg ctgccactgt ctaccccaca gcctcacctg cctggctttg
     1681 ggctcttcca catggtagcc actagccaga tgtgtcagtt tgaacttaaa ttaattaaaa
     1741 tataataaaa aaagatggct gggttgaact agttatgggg acacttttgg cctgtgactg
     1801 ccatactgga tagcaacaga tgttttcatt gtaggaagtt ccaaaggaat tccctgggag
     1861 gctcatcaac agtgcgggtg cctgatacgc accccacctc ctcctaaaat agaaacacag
     1921 ggcactttgt agctgaggct taagaattgc tatcctagag ctttctgact cttaagctcc
     1981 caatcagcct tgggtcagcc ccaactggca ggtgcaggca ctgagcaggg tctcaaacac
     2041 ccacagcaag tgtgtagtgt tgttctcgtg ccacacaggg atcacaaacc cccatgtgca
     2101 caccccctct acacatacaa ccctccaccc cctctgtggg ttggaacagc ttgggtgctg
     2161 caggcacagc catctgaaca cacctacact cccaggcagg gacacacggt ctccatacag
     2221 tatcaccccc atggggcgat gctctccttc ctgagggagt cataccagac cagcccttct
     2281 agccactgaa ccttactcag ctacctcagg tggagaagta accctgatga atcttggctc
     2341 cttgcctgtg gcccagtccc agcttccacg gcctgcccag cttggctgga acatgagggc
     2401 tgaggaggca aggggtgaga cacaataaaa agaatgagga c
//
