LOCUS       NM_011025                555 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus oxytocin (Oxt), mRNA.
ACCESSION   NM_011025
VERSION     NM_011025.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 555)
  AUTHORS   Borie,A.M., Dromard,Y., Chakraborty,P., Fontanaud,P., Andre,E.M.,
            Francois,A., Colson,P., Muscatelli,F., Guillon,G., Desarmenien,M.G.
            and Jeanneteau,F.
  TITLE     Neuropeptide therapeutics to repress lateral septum neurons that
            disable sociability in an autism mouse model
  JOURNAL   Cell Rep Med 5 (11), 101781 (2024)
   PUBMED   39423809
REFERENCE   2  (bases 1 to 555)
  AUTHORS   Fischer,S., Duffield,C., Swaney,W.T., Bolton,R.L., Davidson,A.J.,
            Hurst,J.L. and Stockley,P.
  TITLE     Egalitarian cooperation linked to central oxytocin levels in
            communal breeding house mice
  JOURNAL   Commun Biol 7 (1), 1193 (2024)
   PUBMED   39333722
  REMARK    GeneRIF: Egalitarian cooperation linked to central oxytocin levels
            in communal breeding house mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 555)
  AUTHORS   Worth,A.A., Feetham,C.H., Morrissey,N.A. and Luckman,S.M.
  TITLE     Paraventricular oxytocin neurons impact energy intake and
            expenditure: projections to the bed nucleus of the stria terminalis
            reduce sucrose consumption
  JOURNAL   Front Endocrinol (Lausanne) 15, 1449326 (2024)
   PUBMED   39286269
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 555)
  AUTHORS   Sofer,Y., Zilkha,N., Gimpel,E., Wagner,S., Chuartzman,S.G. and
            Kimchi,T.
  TITLE     Sexually dimorphic oxytocin circuits drive intragroup social
            conflict and aggression in wild house mice
  JOURNAL   Nat Neurosci 27 (8), 1565-1573 (2024)
   PUBMED   38969756
  REMARK    GeneRIF: Sexually dimorphic oxytocin circuits drive intragroup
            social conflict and aggression in wild house mice.
REFERENCE   5  (bases 1 to 555)
  AUTHORS   Wolf,D., Hartig,R., Zhuo,Y., Scheller,M.F., Articus,M., Moor,M.,
            Grinevich,V., Linster,C., Russo,E., Weber-Fahr,W., Reinwald,J.R.
            and Kelsch,W.
  TITLE     Oxytocin induces the formation of distinctive cortical
            representations and cognitions biased toward familiar mice
  JOURNAL   Nat Commun 15 (1), 6274 (2024)
   PUBMED   39054324
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 555)
  AUTHORS   Nishimori,K., Young,L.J., Guo,Q., Wang,Z., Insel,T.R. and
            Matzuk,M.M.
  TITLE     Oxytocin is required for nursing but is not essential for
            parturition or reproductive behavior
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11699-11704 (1996)
   PUBMED   8876199
REFERENCE   7  (bases 1 to 555)
  AUTHORS   Ratty,A.K., Jeong,S.W., Nagle,J.W., Chin,H., Gainer,H., Murphy,D.
            and Venkatesh,B.
  TITLE     A systematic survey of the intergenic region between the murine
            oxytocin- and vasopressin-encoding genes
  JOURNAL   Gene 174 (1), 71-78 (1996)
   PUBMED   8863731
REFERENCE   8  (bases 1 to 555)
  AUTHORS   Schonemann,M.D., Ryan,A.K., McEvilly,R.J., O'Connell,S.M.,
            Arias,C.A., Kalla,K.A., Li,P., Sawchenko,P.E. and Rosenfeld,M.G.
  TITLE     Development and survival of the endocrine hypothalamus and
            posterior pituitary gland requires the neuronal POU domain factor
            Brn-2
  JOURNAL   Genes Dev 9 (24), 3122-3135 (1995)
   PUBMED   8543156
REFERENCE   9  (bases 1 to 555)
  AUTHORS   Marini,J.C., Nelson,K.K., Battey,J. and Siracusa,L.D.
  TITLE     The pituitary hormones arginine vasopressin-neurophysin II and
            oxytocin-neurophysin I show close linkage with interleukin-1 on
            mouse chromosome 2
  JOURNAL   Genomics 15 (1), 200-202 (1993)
   PUBMED   8432536
REFERENCE   10 (bases 1 to 555)
  AUTHORS   Hara,Y., Battey,J. and Gainer,H.
  TITLE     Structure of mouse vasopressin and oxytocin genes
  JOURNAL   Brain Res Mol Brain Res 8 (4), 319-324 (1990)
   PUBMED   2176709
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL731707.12, AK003042.1 and
            AW455577.1.
            
            On Dec 13, 2013 this sequence version replaced NM_011025.3.
            
            Summary: This gene encodes a preproprotein that is processed to
            produce oxytocin and neurophysin 1. Oxytocin is a posterior
            pituitary hormone which is synthesized as an inactive precursor in
            the hypothalamus along with its carrier protein neurophysin 1.
            Together with neurophysin, it is packaged into neurosecretory
            vesicles and transported axonally to the nerve endings in the
            neurohypophysis, where it is either stored or secreted into the
            bloodstream. The precursor seems to be activated while it is being
            transported along the axon to the posterior pituitary. This hormone
            contracts smooth muscle during parturition and lactation. It is
            also involved in cognition, tolerance, adaptation, the stress
            response and complex sexual and maternal behavior, as well as in
            the regulation of water excretion, salt appetite, blood pressure
            and cardiovascular functions. Deletion of this gene in mouse
            reduces bone formation resulting in osteoporosis. [provided by
            RefSeq, Dec 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW455577.1, BE955499.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL731707.12        123430-123433
            5-475               AK003042.1         2-472
            476-555             AW455577.1         1-80                c
FEATURES             Location/Qualifiers
     source          1..555
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.24 cM"
     gene            1..555
                     /gene="Oxt"
                     /gene_synonym="OT; Oxy"
                     /note="oxytocin"
                     /db_xref="GeneID:18429"
                     /db_xref="MGI:MGI:97453"
     exon            1..161
                     /gene="Oxt"
                     /gene_synonym="OT; Oxy"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..419
                     /gene="Oxt"
                     /gene_synonym="OT; Oxy"
                     /note="oxytocin-neurophysin 1; OT-NPI"
                     /codon_start=1
                     /product="oxytocin-neurophysin 1 preproprotein"
                     /protein_id="NP_035155.1"
                     /db_xref="CCDS:CCDS16745.1"
                     /db_xref="GeneID:18429"
                     /db_xref="MGI:MGI:97453"
                     /translation="MACPSLACCLLGLLALTSACYIQNCPLGGKRAVLDLDMRKCLPC
                     GPGGKGRCFGPSICCADELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAATG
                     ICCSPDGCRTDPACDPESAFSER"
     exon            162..363
                     /gene="Oxt"
                     /gene_synonym="OT; Oxy"
                     /inference="alignment:Splign:2.1.0"
     exon            364..541
                     /gene="Oxt"
                     /gene_synonym="OT; Oxy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      518..523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oxt"
                     /gene_synonym="OT; Oxy"
                     /note="hexamer: AATAAA"
     polyA_site      541
                     /gene="Oxt"
                     /gene_synonym="OT; Oxy"
                     /note="major polyA site"
ORIGIN      
        1 aaccatcacc tacagcggat ctcagactga gcaccatcgc catggcctgc cccagtctcg
       61 cttgctgcct gcttggctta ctggctctga cctcggcctg ctacatccag aactgccccc
      121 tgggcggcaa gagggctgtg ctggacctgg atatgcgcaa gtgtctcccc tgcggcccgg
      181 gcggcaaagg acgctgcttc ggaccaagca tctgctgcgc ggacgagctg ggctgcttcg
      241 tgggcaccgc cgaggcgctg cgctgccagg aggagaacta cctgccttcg ccctgccagt
      301 ctggccagaa gccctgcggg agcggaggcc gctgcgccgc cacaggcatc tgctgcagcc
      361 cggatggctg ccgcacagac cccgcctgcg accctgagtc tgccttctcg gagcgctgag
      421 cccactttct gggaatacct ttagcgcgct tccttcgttc cccatggcca ctgccagaaa
      481 aaaaaaaaaa aaagaaaaga aaagaaaaga aaagaaaaat aaagtagatt tcctcttcaa
      541 aaaaaaaaaa aaaaa
//
