LOCUS       NM_001359883            3469 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus 3-oxoacyl-ACP synthase, mitochondrial (Oxsm),
            transcript variant 3, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001359883 XM_006518100
VERSION     NM_001359883.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3469)
  AUTHORS   Gao,T., Qian,S., Shen,S., Zhang,X., Liu,J., Jia,W., Chen,Z. and
            Ye,J.
  TITLE     Reduction of mitochondrial 3-oxoacyl-ACP synthase (OXSM) by
            hyperglycemia is associated with deficiency of alpha-lipoic acid
            synthetic pathway in kidney of diabetic mice
  JOURNAL   Biochem Biophys Res Commun 512 (1), 106-111 (2019)
   PUBMED   30871779
  REMARK    GeneRIF: LA (alpha-lipoic acid) deficiency was observed with a
            reduction in lipoylation of pyruvate dehydrogenase in the kidney of
            streptozotocin-induced diabetic mice. Proteins of three enzymes
            (MCAT, OXSM and LIAS) in the LA synthetic pathway were examined in
            the kidney. A reduction was observed in OXSM, but not in the other
            two.
REFERENCE   2  (bases 1 to 3469)
  AUTHORS   Zhang,L., Joshi,A.K., Hofmann,J., Schweizer,E. and Smith,S.
  TITLE     Cloning, expression, and characterization of the human
            mitochondrial beta-ketoacyl synthase. Complementation of the yeast
            CEM1 knock-out strain
  JOURNAL   J Biol Chem 280 (13), 12422-12429 (2005)
   PUBMED   15668256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK084829.1, AK034243.1, BG229916.1 and AC173482.1.
            
            On Jan 18, 2018 this sequence version replaced XM_006518100.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084829.1, AK034243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2206              AK084829.1         2-2207
            2207-3434           AK034243.1         2205-3432
            3435-3465           BG229916.1         1-31                c
            3466-3469           AC173482.1         146923-146926       c
FEATURES             Location/Qualifiers
     source          1..3469
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 7.08 cM"
     gene            1..3469
                     /gene="Oxsm"
                     /gene_synonym="4933425A18Rik"
                     /note="3-oxoacyl-ACP synthase, mitochondrial"
                     /db_xref="GeneID:71147"
                     /db_xref="MGI:MGI:1918397"
     exon            1..42
                     /gene="Oxsm"
                     /gene_synonym="4933425A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            43..1050
                     /gene="Oxsm"
                     /gene_synonym="4933425A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..3469
                     /gene="Oxsm"
                     /gene_synonym="4933425A18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1480..1485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oxsm"
                     /gene_synonym="4933425A18Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1490
                     /gene="Oxsm"
                     /gene_synonym="4933425A18Rik"
                     /note="major polyA site"
     polyA_site      1536
                     /gene="Oxsm"
                     /gene_synonym="4933425A18Rik"
     regulatory      2188..2193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oxsm"
                     /gene_synonym="4933425A18Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2209
                     /gene="Oxsm"
                     /gene_synonym="4933425A18Rik"
     regulatory      3363..3368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oxsm"
                     /gene_synonym="4933425A18Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      3385
                     /gene="Oxsm"
                     /gene_synonym="4933425A18Rik"
ORIGIN      
        1 gcgcatgcgc actcggtggg cgcccgcaaa ggcttgtttc aggaatgtgt ttctgatctt
       61 ctgaatttca accatgttgt caaaatgctt gcaacatttt ctaaaagcca caatctccca
      121 tccatatcca gcgtcatatt cttggttaat aagcaaacac agattttatg gaactgtgcc
      181 agcagccatg ttgcgcagac gagttgtcat cacaggcatt ggcctagtga caccacttgg
      241 cgttgggact caactagttt gggatcggct tctccgagga gaaagtggaa ttgtttctgt
      301 ggttggtgat gagtacaaga atatcccttg cagtgtagct gcttatgtac caagaggtcc
      361 acatgaaggt cagtttaatg aagaaaactt tgtgtccaaa tcagatgcca agtccatgtc
      421 ttcttccacc atcatggctg ttggggcagc agagttggcc ctgaaagact ccggctggca
      481 tccgaaacga gaagcagatc aggtggctac tggcgttgcc attggcatgg gcatggttcc
      541 tcttgaagtt atttctgaaa ctgctttgct gtttcagacc aaaggttata ataaagtcag
      601 cccattcttt gtccctaaga ttctgatcaa tatggctgca ggccaggtta gcattcgcta
      661 caaactcaag ggccccaatc actcagtgtc cacagcctgc accacaggtg cacatgctgt
      721 gggagactcc tttagattca tagcccatgg tgacgcagat gtgatggtgg ctgggggcac
      781 agactcttgc attagtccat tatctctcgc tgggttttcc agagcccggg ctctgagctc
      841 aaacccagat cctaagctag cctgccggcc gtttcatcca gagagagatg gttttgtcat
      901 gggtgaggga gctgctgtgc tggtgctgga agaacatgag catgctgttc agagaggagc
      961 tcggatctac gcagaaattt tgggttatgg actctcgggt gatgccggtc acataactgc
     1021 ccccgatccc gaaggagaag gtgctttaag atgcatggct gctgctgtaa aagatgcagg
     1081 cgtatcacct gagcagatat cctatgtcaa cgcacatgcc acttccacac cactgggtga
     1141 tgccgctgag aacagagcca tcaagaggct ctttagggac catgcttgtg cccttgccat
     1201 atcctccaca aagggagcca ctgggcatct tctgggtgct gcaggggcag ttgaggcaac
     1261 ttttactgca ctggcttgtt accaccagaa actcccacca actttaaacc tggattgtac
     1321 agagcctgaa tttgatctca attatgttcc actggagtca caggaatgga aagctgaggg
     1381 tcggtgtatt ggactcacca attcctttgg gtttggtggt actaatgcaa ctctttgtat
     1441 tgctggcatg taaacactgg cttttaatgg tcataaattt ataaatatta tatatgtaga
     1501 tatgtcttat atcaatatcc aatgacttta gcacaattgg tatttgtata gttctttggt
     1561 agggaacagg gtgcccagta cttgttattt tatagcatct tggtgtctcc attgagattt
     1621 cagtggcaac tagtgacaac cagaaatgtc tatggaggac agaataacct gcacacagaa
     1681 ccattgattt atgtttttct agtgcacgat ttcatccatc atggtccttt tcagatattt
     1741 atttagagac cagcttctct gagcaaggct gtgctgctcc atggtgtaac taactctagg
     1801 gtcaccactg ttgtacagca tataaacagg actacaatac aagtactcct atttgtatca
     1861 ccactcagca tccctttagg acagctgtca gccagtgatt cacccctgac ccatgtagtg
     1921 tccttggtgg aatttcccca agctcccaag atttcagttc tctgaaggag gaagtaaaac
     1981 aggatttcct ttttcttgcc tgttcttgac cgacctccct cccttccttc cttcctttct
     2041 ttccttcctt tcttcgtcat ctttttttcg ccttctttga gacatggtta ctcaggtaac
     2101 cctagctgtc ttggaactca ctctatagac cctggctgac cttgatctct atagggattt
     2161 gcctgcctct gcctcctaag tgctgcaatt aaaggtgtac accagcatag cctggctggt
     2221 ttggcttttc tcattctaga tatgtttgtg atgtggtgaa tggacataaa gatctttgga
     2281 aaaaactctt gttaagttag gccagctcct ctctaacttc taactttgtg actgtgacaa
     2341 tgttctccaa gcttcctact actagggtag caagttcttc agaggtgaca gccatccagg
     2401 aaagcatttg gtaggcaggg cttttatctc ttctgagtaa gtgttttcat gtctatgcag
     2461 gtccacaatg atatggagct tcagtcaagt gcctacattt cctgggctca gtaacacctt
     2521 taatggcttt ctgtccttgt actgtttaat gatttttatt ccaattccat gacaaactgc
     2581 cttttggcct ctgctttctt agtggcacac acacacacac acacacacac acacacacac
     2641 acacacacag tgtgagagaa agggagatag taaaaaagga gataaatggc tatatgccta
     2701 tgtgcctttc tgcagaatgg ggagcagtct cacattttac ttaaaacttt ttgttcttgt
     2761 tttagttttt ttaaaaaaat aatgtgtatg agtgttttcc ctgaggagca gaagatggcc
     2821 tagtcagcca tcattgggaa agaaaggccc cttggtcgtg caaactttat atgcctcagt
     2881 atgggggaat gctaaggcca agaagtggga gtgggtgggt aggggagtgg gggaggaggg
     2941 tatgggggac ttttgggata gcattggaaa tgtaaatgaa gaaaatacct aattaaaaaa
     3001 agagctaaaa aaaaggcaaa aacaatgaga ggattgttgt gtatactgta catgcatcct
     3061 tgggaagagc actagctaat aatgcaatca gcacatacaa tggtgagcct ctccctacgg
     3121 taaatgtcat ttaaacattg tcaacaatta tatctccttt caaaactgtt gcctgtaaaa
     3181 tgattgaaaa gcactaagta gactatatca gaatgggaat gaaatctaga cagtgtgatt
     3241 cttttcaagc tgtggtcaca cagttaaggg gaaacaaagc tgggaaagaa aaattattaa
     3301 ttttaaaatt cactatttga atgtaacaat attgtatgaa ctcaaaaatg tactttaaaa
     3361 ggaagaaatt gtttttaatg tgtaattcat ggttggtgaa tgaaattttt atttttggta
     3421 caataatata aatgaaaata aaaatgttgt aagataaaca acaaaaaaa
//
