LOCUS       NM_001130166            4616 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus oxidation resistance 1 (Oxr1), transcript variant 5,
            mRNA.
ACCESSION   NM_001130166
VERSION     NM_001130166.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4616)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4616)
  AUTHORS   Sahu,B., Leon,L.M., Zhang,W., Puranik,N., Periasamy,R., Khanna,H.
            and Volkert,M.
  TITLE     Oxidative Stress Resistance 1 Gene Therapy Retards
            Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy
  JOURNAL   Invest Ophthalmol Vis Sci 62 (12), 8 (2021)
   PUBMED   34505865
  REMARK    GeneRIF: Oxidative Stress Resistance 1 Gene Therapy Retards
            Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy.
REFERENCE   3  (bases 1 to 4616)
  AUTHORS   Castroflorio,E., den Hoed,J., Svistunova,D., Finelli,M.J.,
            Cebrian-Serrano,A., Corrochano,S., Bassett,A.R., Davies,B. and
            Oliver,P.L.
  TITLE     The Ncoa7 locus regulates V-ATPase formation and function,
            neurodevelopment and behaviour
  JOURNAL   Cell Mol Life Sci 78 (7), 3503-3524 (2021)
   PUBMED   33340069
REFERENCE   4  (bases 1 to 4616)
  AUTHORS   Yang,M., Lin,X., Segers,F., Suganthan,R., Hildrestrand,G.A.,
            Rinholm,J.E., Aas,P.A., Sousa,M.M.L., Holm,S., Bolstad,N.,
            Warren,D., Berge,R.K., Johansen,R.F., Yndestad,A., Kristiansen,E.,
            Klungland,A., Luna,L., Eide,L., Halvorsen,B., Aukrust,P. and
            Bjoras,M.
  TITLE     OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine
            Methylation
  JOURNAL   Cell Rep 30 (12), 4165-4178 (2020)
   PUBMED   32209476
REFERENCE   5  (bases 1 to 4616)
  AUTHORS   Jiang,Y., Liu,J., Chen,L., Jin,Y., Zhang,G., Lin,Z., Du,S., Fu,Z.,
            Chen,T., Qin,Y. and Sun,X.
  TITLE     Serum secreted miR-137-containing exosomes affects oxidative stress
            of neurons by regulating OXR1 in Parkinson's disease
  JOURNAL   Brain Res 1722, 146331 (2019)
   PUBMED   31301273
  REMARK    GeneRIF: Serum secreted miR-137-containing exosomes affects
            oxidative stress of neurons by regulating OXR1 in Parkinson's
            disease.
REFERENCE   6  (bases 1 to 4616)
  AUTHORS   Prows,D.R., Hafertepen,A.P., Winterberg,A.V., Gibbons,W.J. Jr.,
            Liu,C. and Nick,T.G.
  TITLE     Genetic analysis of hyperoxic acute lung injury survival in
            reciprocal intercross mice
  JOURNAL   Physiol Genomics 30 (3), 271-281 (2007)
   PUBMED   17488888
REFERENCE   7  (bases 1 to 4616)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 4616)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   9  (bases 1 to 4616)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4616)
  AUTHORS   Fischer,H., Zhang,X.U., O'Brien,K.P., Kylsten,P. and Engvall,E.
  TITLE     C7, a novel nucleolar protein, is the mouse homologue of the
            Drosophila late puff product L82 and an isoform of human OXR1
  JOURNAL   Biochem Biophys Res Commun 281 (3), 795-803 (2001)
   PUBMED   11237729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE988908.1, AK158703.1 and AF333985.1.
            
            Transcript Variant: This variant (5) encodes the longest isoform
            (E). Variants 5 and 7 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158703.1, SRR1660819.184744.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BE988908.1         1-19
            20-4596             AK158703.1         2-4578
            4597-4616           AF333985.1         4157-4176
FEATURES             Location/Qualifiers
     source          1..4616
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 16.06 cM"
     gene            1..4616
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /note="oxidation resistance 1"
                     /db_xref="GeneID:170719"
                     /db_xref="MGI:MGI:2179326"
     exon            1..108
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            109..266
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..2844
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /note="isoform E is encoded by transcript variant 5;
                     oxidation resistance protein 1; protein C7; nucleolar
                     protein C7"
                     /codon_start=1
                     /product="oxidation resistance protein 1 isoform E"
                     /protein_id="NP_001123638.1"
                     /db_xref="CCDS:CCDS49598.1"
                     /db_xref="GeneID:170719"
                     /db_xref="MGI:MGI:2179326"
                     /translation="MSVSNLSWLKKKSQSVDITAPGFNPLGGAGKQAPQASKPPAPKT
                     PIIEEEQNNSANTQKHPSRKSELKRFYTIDTGQKKTLDKKDGRRMSFQKPKGTIEYTV
                     ESRDSLNSIALKFDTTPNELVQLNKLFSRAVVTGQVLYVPDPEYVSSVESSPSLSPVS
                     PLSPTSSEAEFDKTTTPDVAHPKEAPPASTVSGIRPARVVSSTSEEEEAFTEKFLKIN
                     CKYITIGKGTVSGVLLVTPNNIMFDPHKTDPLVQENGCEEYGIMCPMEEVMSAAMYKE
                     ILDSKIKESLPIELDQLSGRGSCHSKKATGVSAEDADPRARDQGNDSASTAPRSTEES
                     LSEDAFTESELSPIREELLSSEPRQEKSSDASSESVQTVSQMEVQSLTATSEAANVPD
                     RTSSNPGALSHETGLSGLETATKGGDKATESLQEVSGPKEQSTEVKGQDNQDSSHQES
                     SLQQEAGEDSVSSGETVELKEKPAVLKDQQGQELKRDSETEVEELRKLWKTHSMQQAK
                     QQRDTIQQVSQRESKHSSAAADAHGEGSSLLKEKRRHRLHKFLCLRVGKPMRKTFVSQ
                     ASATMQQYAQRDKKHEYWFAVPQERTDHLYAFFIQWSPEIYAEDSGEYTREPGFIVVK
                     KMDESEANEAPAGEAAAREWEVVSVAEYHRRIDALNTEELRTLCRRLQITTREDINSK
                     QVAPAKADLEPESFRPNLSDPSELLLPDQIEKLTKHLPPRTIGYPWTLVYGTGKHGTS
                     LKTLYRTMTGLDTPVLMVIKDSDGQVFGALASEPFKVSDGFYGTGETFVFTFCPEFEV
                     FKWTGDNMFFIKGDMDSLAFGGGGGEFALWLDGDLYHGRSHSCKTFGNHTLSKKEDFF
                     IQDIEIWAFE"
     exon            267..463
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            464..546
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            547..654
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            655..768
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            769..921
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1106
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1846
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2015
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2178
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2259
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2385
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2538
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2634
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2708
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..4599
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3772..3777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /note="hexamer: AATAAA"
     polyA_site      3794
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /note="major polyA site"
     regulatory      4580..4585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /note="hexamer: ATTAAA"
     polyA_site      4599
                     /gene="Oxr1"
                     /gene_synonym="2210416C20Rik; C7; C7B"
                     /note="major polyA site"
ORIGIN      
        1 gcggccgcgg gagcgcagtg ccagcgccgc ccggccccac cgagaggggc gcactcgccg
       61 ctacggggct cgcaccgctc gccgcagccc cctcccgccg acccgcaagt cctcccaagc
      121 ctggagtcat taagtggttc tgcctgttcc aagggcggag cagaagcagg ccgtggtcct
      181 gccaagcgga tgtcctgatt ccctattctg actctagaga agactccatc acagattgct
      241 gcaatgtctg tatctaatct atcatggttg aagaaaaagt cccagtcagt ggatattact
      301 gctccagggt tcaacccttt aggtggtgca gggaagcaag caccacaagc cagcaagccc
      361 ccggcaccca agacccccat catcgaagaa gaacagaaca actcagcaaa cacccagaag
      421 catccttcca gaaaaagtga actgaagagg ttctatacca ttgacactgg ccaaaagaag
      481 accttagaca agaaagatgg gagaaggatg tcttttcaga agcctaaagg aaccattgaa
      541 tatactgttg aatcaaggga ttctttgaat agcatagccc tgaaatttga taccacaccc
      601 aatgaacttg ttcagttaaa taagttattc tctcgagcag tcgtgactgg acaggtttta
      661 tacgttcctg atcctgaata tgtctctagt gttgagagtt ccccatccct cagccctgta
      721 agccctctgt cgccaacgtc atccgaggct gaatttgata aaaccacgac tccagatgta
      781 gcccatccaa aagaagcacc cccggcatcg actgtgagcg gtattcggcc tgcgagagtt
      841 gtgtcttcaa cttctgaaga agaagaagcc tttactgaga aatttcttaa aattaattgc
      901 aaatatatca ccattggcaa gggcacagtc agtggcgtcc tgctagtcac accaaataac
      961 ataatgtttg atccacacaa gacagacccc ttggttcaag agaacggttg tgaggaatac
     1021 ggcatcatgt gtccgatgga agaggtgatg tcagctgcca tgtacaaaga gattttggat
     1081 agcaaaataa aggaatcact gcccatagaa ctagatcagt tgtcaggaag ggggtcctgc
     1141 cattcaaaga aagcgacagg agtctctgct gaggacgcag acccgagagc gcgtgaccag
     1201 ggtaacgaca gtgccagcac tgctcccagg agcaccgagg agtctctctc ggaagacgct
     1261 ttcacagagt cagaactctc tcctatccgc gaggagctgc tctcctcgga gccgagacag
     1321 gagaagtcat ctgatgcctc gtcagaatct gtgcagactg tcagtcagat ggaagtccag
     1381 tccttgacag ccacgtcaga ggctgctaac gttcctgacc gcactagctc taaccctggg
     1441 gctctatctc atgaaactgg cttaagtggt ctggaaacag ccactaaagg aggagataaa
     1501 gctacagaaa gccttcaaga agtctcaggc ccaaaggaac aaagcacaga agtaaaaggt
     1561 caggataacc aggattcttc ccaccaggaa agttcactgc agcaagaggc aggtgaagac
     1621 agtgtatctt ctggagaaac agtagaactg aaagaaaaac cagctgttct taaggatcaa
     1681 caagggcagg agctaaaacg ggactcagag acagaagtag aggagctgcg caaactctgg
     1741 aaaactcact ctatgcagca agccaagcag caaagggaca cgattcagca ggtgtcacag
     1801 agagaaagta aacacagcag cgcagcagca gacgcacatg gagagggctc ctcgctgtta
     1861 aaggaaaagc gaaggcatcg attacataag ttcctatgtc tcagagtcgg aaaaccaatg
     1921 aggaagacct ttgtatcgca agcaagtgct acgatgcaac agtatgcaca aagagataaa
     1981 aaacacgaat attggtttgc agtgccacaa gaaaggacag accacttgta tgccttcttc
     2041 attcagtgga gtccagaaat ctatgcagaa gattctggtg aatacaccag agagcctgga
     2101 ttcatagtag tcaaaaagat ggacgagtct gaagcgaatg aagcccctgc tggtgaagca
     2161 gcagccaggg agtgggaggt agtgtcggtg gctgagtatc accgcaggat cgatgctcta
     2221 aatactgaag aactgcgcac actctgcaga cggctccaga ttactacaag ggaagacatc
     2281 aactcaaagc aggttgctcc agcaaaagca gacctggagc ctgaatcttt ccgaccaaac
     2341 ctaagcgacc ccagtgaact cttactgcct gatcagattg aaaagcttac taagcacctt
     2401 ccaccaagaa ccattggcta tccatggacg cttgtgtacg gtactgggaa gcatggtaca
     2461 agtttgaaga ccctttatcg aacaatgaca ggtttagaca ctccggtgct gatggtgatt
     2521 aaagacagtg atggacaggt ttttggtgca ttagcatcag agccatttaa agtaagtgat
     2581 ggcttttacg gtactggaga aacatttgtt ttcacattct gcccagaatt tgaggtcttt
     2641 aagtggacag gagataatat gttttttatc aaaggagaca tggattcatt agcatttggt
     2701 ggtggaggag gggaatttgc tctttggctt gatggagatc tctaccatgg aagaagccat
     2761 tcctgtaaaa cgtttgggaa tcatacactt tctaagaagg aagatttctt tatccaagac
     2821 attgaaatct gggcttttga ataaacacag tgctcttggt tgtagcagga catcggccca
     2881 aacctgaatg gacaaacgca tcgtttggaa tgttcaagaa gcaatacaat taatatgtca
     2941 ctcgtgcttt aaagtcagtc tgtttggcca tttactgcaa ctataatttt ggagtttatt
     3001 tttccaatcc tgtttctgtc ccagagttct tttgtttaca ccatggcctg ggatccagta
     3061 gtgggatcca gtagtgtaac agcgggtgga atttgtcagc acagtgcagc atttggatca
     3121 tagaggccgc caccttttca gttcacgtca tctcagtcct aactggatgg tgctctgttc
     3181 aacttgtttt taatctgtat tgattctttt tatagagcag tgtactcggg gcattgagga
     3241 aatggagcct agatactttt gtatctggtg gagttggcac aggtgacatt tgggcctact
     3301 tacatttagt tctaaataag aaaccacatg ccaaaataat acatgcttca tagacctctt
     3361 ctagttctaa ttcactacag cattctcttt attcattttg taaacattct ctatttcatt
     3421 ttaagaatga aattggaggg gcagtctgat tggcatagac cacagcgcac acagtctgca
     3481 ggtttgggcg catgttttca tcactgaata gaggagaatt gacagaggag aatgggaatt
     3541 caatgattct attggattta atatattaag caagtaatac tatttacata tttgtagctt
     3601 aatagggcat tatcataagt acaaaactaa aacgtgcata tttcttcaac attgtgtcag
     3661 atacactgtt ttacagttct cttgttcagc cttgttgcat accaactacc ccaagacatt
     3721 tttgttttgt tttgttttgt ttcttctcaa aaggaaaaaa aattgttttg aaataaaaac
     3781 gtgttttttt ctaagtggta tatgttatta gttaccatta gcatctgctc ttataaaagg
     3841 gcagtgactg tagtagacaa tactgtaatt cagtagactt ggtgaatgtg caagcttact
     3901 gtcaagtggc ctcaaaaacg aaaaggtaga ataaactagc aattgtattc tttcttgtag
     3961 gaaaccaaca ataagccatg tggcaacaat tcgtcagtta aatttcagag cttcatgtta
     4021 tgcaaaaaaa taaatcctgc tgttatacgt gacagtgaca ttgtgctgaa aattcagctg
     4081 ttccacacaa atgttgtata tcttgtaaat tgatgtctaa agatagtttt gttcttatag
     4141 aaagtgttga ctgccaggtt gcttatagca ctttaaatta ttctgaagat gaaattacca
     4201 gccaagtatg ttggcttaag tagttttagt tatataactc ttaaaaatac ctagttcttt
     4261 tgggaacagt ttagataatt atctaaagaa aacatactat taatcagaat ctctggtgtt
     4321 gtatgacacg ctgttgctaa agatgaatag aaacggcatc gtttcctcgt ctgtgtaaag
     4381 ctctcattac aagttaggta atagtgtcta ggttagaggt ttataatata atataaggaa
     4441 ctgtaaataa atgtaccctt cctattagtc ttccacagca gtattattgt ctttgtggag
     4501 gtgactaaat cacaaaactt taaacatcct gtaatggatt ccaactacaa aaaggacata
     4561 gagatgtata ccaaataaaa ttaaatgcat aaatgcaaaa aaaaaaaaaa aaaaaa
//
