LOCUS       NM_001001490            3732 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus oxoglutarate (alpha-ketoglutarate) receptor 1 (Oxgr1),
            mRNA.
ACCESSION   NM_001001490 XM_139267
VERSION     NM_001001490.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3732)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3732)
  AUTHORS   Zeng,Y.R., Song,J.B., Wang,D., Huang,Z.X., Zhang,C., Sun,Y.P.,
            Shu,G., Xiong,Y., Guan,K.L., Ye,D. and Wang,P.
  TITLE     The immunometabolite itaconate stimulates OXGR1 to promote
            mucociliary clearance during the pulmonary innate immune response
  JOURNAL   J Clin Invest 133 (6), e160463 (2023)
   PUBMED   36919698
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3732)
  AUTHORS   Ualiyeva,S., Lemire,E., Aviles,E.C., Wong,C., Boyd,A.A., Lai,J.,
            Liu,T., Matsumoto,I., Barrett,N.A., Boyce,J.A., Haber,A.L. and
            Bankova,L.G.
  TITLE     Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically
            initiate lung type 2 inflammation
  JOURNAL   Sci Immunol 6 (66), eabj0474 (2021)
   PUBMED   34932383
REFERENCE   4  (bases 1 to 3732)
  AUTHORS   Yuan,Y., Xu,P., Jiang,Q., Cai,X., Wang,T., Peng,W., Sun,J., Zhu,C.,
            Zhang,C., Yue,D., He,Z., Yang,J., Zeng,Y., Du,M., Zhang,F.,
            Ibrahimi,L., Schaul,S., Jiang,Y., Wang,J., Sun,J., Wang,Q., Liu,L.,
            Wang,S., Wang,L., Zhu,X., Gao,P., Xi,Q., Yin,C., Li,F., Xu,G.,
            Zhang,Y. and Shu,G.
  TITLE     Exercise-induced alpha-ketoglutaric acid stimulates muscle
            hypertrophy and fat loss through OXGR1-dependent adrenal activation
  JOURNAL   EMBO J 39 (7), e103304 (2020)
   PUBMED   32104923
  REMARK    GeneRIF: Exercise-induced alpha-ketoglutaric acid stimulates muscle
            hypertrophy and fat loss through OXGR1-dependent adrenal
            activation.
            Erratum:[EMBO J. 2021 Jul 15;40(14):e108434. doi:
            10.15252/embj.2021108434. PMID: 34263469]
REFERENCE   5  (bases 1 to 3732)
  AUTHORS   Sasaki,F. and Yokomizo,T.
  TITLE     The leukotriene receptors as therapeutic targets of inflammatory
            diseases
  JOURNAL   Int Immunol 31 (9), 607-615 (2019)
   PUBMED   31135881
  REMARK    Review article
REFERENCE   6  (bases 1 to 3732)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3732)
  AUTHORS   Tokonami,N., Morla,L., Centeno,G., Mordasini,D., Ramakrishnan,S.K.,
            Nikolaeva,S., Wagner,C.A., Bonny,O., Houillier,P., Doucet,A. and
            Firsov,D.
  TITLE     alpha-Ketoglutarate regulates acid-base balance through an
            intrarenal paracrine mechanism
  JOURNAL   J Clin Invest 123 (7), 3166-3171 (2013)
   PUBMED   23934124
REFERENCE   8  (bases 1 to 3732)
  AUTHORS   Kanaoka,Y., Maekawa,A. and Austen,K.F.
  TITLE     Identification of GPR99 protein as a potential third cysteinyl
            leukotriene receptor with a preference for leukotriene E4 ligand
  JOURNAL   J Biol Chem 288 (16), 10967-10972 (2013)
   PUBMED   23504326
  REMARK    GeneRIF: Identification of GPR99 protein as a potential third
            cysteinyl leukotriene receptor with a preference for leukotriene E4
            ligand.
REFERENCE   9  (bases 1 to 3732)
  AUTHORS   He,W., Miao,F.J., Lin,D.C., Schwandner,R.T., Wang,Z., Gao,J.,
            Chen,J.L., Tian,H. and Ling,L.
  TITLE     Citric acid cycle intermediates as ligands for orphan
            G-protein-coupled receptors
  JOURNAL   Nature 429 (6988), 188-193 (2004)
   PUBMED   15141213
REFERENCE   10 (bases 1 to 3732)
  AUTHORS   Inbe,H., Watanabe,S., Miyawaki,M., Tanabe,E. and Encinas,J.A.
  TITLE     Identification and characterization of a cell-surface receptor,
            P2Y15, for AMP and adenosine
  JOURNAL   J Biol Chem 279 (19), 19790-19799 (2004)
   PUBMED   15001573
  REMARK    GeneRIF: P2Y15 is a cell surface receptor for AMP and adenosine
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142510.1 and AC161271.2.
            
            On Mar 24, 2009 this sequence version replaced NM_001001490.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142510.1, BB660768.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1047              AK142510.1         2-1048
            1048-3732           AC161271.2         117075-119759       c
FEATURES             Location/Qualifiers
     source          1..3732
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 63.63 cM"
     gene            1..3732
                     /gene="Oxgr1"
                     /gene_synonym="Cysltr3; Gm299; Gpr80; Gpr99; P2Y15"
                     /note="oxoglutarate (alpha-ketoglutarate) receptor 1"
                     /db_xref="GeneID:239283"
                     /db_xref="MGI:MGI:2685145"
     exon            1..156
                     /gene="Oxgr1"
                     /gene_synonym="Cysltr3; Gm299; Gpr80; Gpr99; P2Y15"
                     /inference="alignment:Splign:2.1.0"
     exon            157..309
                     /gene="Oxgr1"
                     /gene_synonym="Cysltr3; Gm299; Gpr80; Gpr99; P2Y15"
                     /inference="alignment:Splign:2.1.0"
     exon            310..449
                     /gene="Oxgr1"
                     /gene_synonym="Cysltr3; Gm299; Gpr80; Gpr99; P2Y15"
                     /inference="alignment:Splign:2.1.0"
     exon            450..3732
                     /gene="Oxgr1"
                     /gene_synonym="Cysltr3; Gm299; Gpr80; Gpr99; P2Y15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2843..2848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oxgr1"
                     /gene_synonym="Cysltr3; Gm299; Gpr80; Gpr99; P2Y15"
                     /note="hexamer: AGTAAA"
     polyA_site      2860
                     /gene="Oxgr1"
                     /gene_synonym="Cysltr3; Gm299; Gpr80; Gpr99; P2Y15"
                     /note="major polyA site"
ORIGIN      
        1 agactaacct ggagtccacg gctccgggaa acggtcttta ggaggccttg gacatacggg
       61 gaagtcccgt ttctttaagc acgtgattct tcagagctca caagagttgg tcaggaggag
      121 aggagcagca acttgaaaag ccagaattct gccaagagtt cggggaacag aggacaccaa
      181 gatgcccttg ctctctaatt agagaggttg gagcctattg atcatcatgg agataagcct
      241 gtgacctact tcaaaggagc aatttcagca catggcaggt gacacctggg cttctacggg
      301 gctgtgactt gagcccagca gcagagtttc tgaggctggt ggaggaagtc ccacggtcca
      361 ggtattcacc tgcctagtcc ccaggcagat ctccacaaag aagagacagc tctgcacgtg
      421 acattggagc aacaccagaa atgcttaggc tggttcactt tcgctggact cacatggcca
      481 agccaaactc ttccctttcc ttgcaagatg aaagaaagga gccatgattg agccactgga
      541 cagtccagcc agtgattcgg atttcctgga ttacccaagt gctctgggaa actgcaccga
      601 cgagcaaatc tcattcaaga tgcagtacct tcccgtcatc tatagcatca tcttcctcgt
      661 gggcttcccg gggaacacag tggccatctc catctacatt ttcaagatgc ggccgtggag
      721 gggcagtaca gtcatcatgc tgaacctggc cttgacggac ttgctgtatc tgaccagcct
      781 cccgttcctc atccattact atgccagtgg tgaaaactgg atctttggag atttcatgtg
      841 caagttcatc cgcttcggct tccacttcaa cctctacagc agcattctct tcctcacctg
      901 cttcagtctc ttccgttacg ttgtgatcat tcacccgatg agctgctttt ctattcagaa
      961 aactcgctgg gcagtggtag cttgtgccgg ggtgtgggtc atttctttgg tagctgtcat
     1021 gcccatgact ttcctgatca catcaaccac ccggaccaat aggtctgctt gccttgacct
     1081 caccagttca gatgacctca ctactatcaa gtggtacaat ctcattttga cagccaccac
     1141 tttctgcctg ccattggtga tagtgacact ttgctacacg acaattatca gtaccctgac
     1201 tcacgggcct cggacccaca gctgctttaa gcagaaggct cggagactga ctattctgct
     1261 cctccttgtt ttctatatat gtttcttacc cttccacatc ttgagggtca ttcggatcga
     1321 atctcgcctg ctttcaatca gctgctccat cgagagtcac atccacgaag cttacattgt
     1381 ttctagacca ttagctgctc tcaacacctt tggcaacctg ctgttatatg ttgtggtcag
     1441 caataacttc cagcaggcat tctgctctat agtgagatgc aaagccagtg gggaccttga
     1501 acaaggaaag aaagacagtt gctcaaacaa cccttgagta atgccatttt cgtcaaggcc
     1561 agagagatgg ctcagtggta aagctcttga catgcaaatg tgagggtctg agatagactc
     1621 ttcagagccc acataaattg tgtgtggtag caactatcta caatcccagt gcctctgtgg
     1681 tgagatagat atggagatag aatccttaaa ggctcgaagg ctaactggcc agctctacac
     1741 agtgactagc ctcaaagaga ccttctttcc aaggagataa aagggaagga ccaatgctta
     1801 aggctgtcct ttgagctcta catgttcact gtgacatgta tcagaccttg acataaacag
     1861 ccacgcatca ttcacacata catacttatc aaatatcagt ctttccatca atcaatcaat
     1921 caatcaatca atcaattaac acgccctgat aatttgtata taacttccaa gaaatcctga
     1981 ataccctctc agtggagccc acagtaacta ctgagtattc aggtcattat gaaccaaagc
     2041 catgggtaag ggcccttatg agatctttgc aatatgtttg ttgatatctt tgggtagaga
     2101 atgggctaca cgagtatcaa taaagtatat agaaagatta gaaaccatgg aactcagagt
     2161 atttctgttg ccaccaacta attgcctcca cacagaaact agtgctcgta cactaaaccc
     2221 cggacctcct acagctttaa tgccaagatg ggaaggctca aacaaaccag aaccaagcaa
     2281 aagccaagac acagaaatat gtggctgagg cagatctacc gctttctgcc accaggaagt
     2341 gaatatttag tgaggataac tccctggaac tcagatgcat ggaatctgcg aagatcaaag
     2401 caaagtattc caacctggtt cctgtgatca tggaaaaagt ctctggctct cagattgttg
     2461 acactgagaa aaggaagtac ttggtcccat ctgacatcac cttggctcag ttcctgcgat
     2521 gatcaggaaa agcatccagc tgtcctccga gaaggccacc ttcctgattg tggacaggac
     2581 agtcccacag tccagcctaa ctatgagata gctttacaag aaggaaaaag aggaagatgg
     2641 attcttgtat gtggcctaca tcggagagaa cacttttggc ttctgaggcc cttgctgggc
     2701 taggctcacc cttcctgctt gtgtatcttg taaataactg gctgttctca gttactccgc
     2761 cagagccttc acacagacct gctagtgcat ttgtaactgg atttatttct tactatatgg
     2821 gaaggttttg tttccttaga ttagtaaatt atcatacagg ggaaaaaaga gtgttctttc
     2881 atgcctagtt tcctgtgctt tcagactttg gggcttgtgt tcactggaat cctagattat
     2941 ccaaaggcat cttgtgcttt cttaatgttt ttacaactca ttatctttac aagtttttct
     3001 tcctttattg gtctgagttt tcctttcagc tctggctagc tctttagact gaaggaatac
     3061 attagttctt tagtcagaag aaagactgtg gaaatggccc agtcagcaaa atgcctgcta
     3121 tacaagcatg aaggcttggg tctggtcctt agaactcaca cacaaaagcc tgatgcaaag
     3181 acatgcactt ggaaccccag ctctgggctg gcaggagcag gcaggtccct ggagggtgag
     3241 ggccagccag cctagactac ttagtgagct ctaacacaaa tagaaaccct gactccaaaa
     3301 ctgacgaacc acagcaaggt ggccctctgg cctgagtttt cagcgttgta ggccacctta
     3361 acaattgctt aatttataaa tcatattaag ttttattggt aattgtcaac atttcctggg
     3421 gaaggaaatt ggtgaaatag agctactcgt tagtatcata tatacattag gcgctaagtc
     3481 aaatctaaca ttgttttgat tttcatggga tagatctcca ggaaacactt attctcttta
     3541 ggtattgtaa tcctttagta ctataataaa aaataataac tgtagaaatt gctaaagtta
     3601 ttcttgggct atgttgtgct taattagtag taaatataag tcagttgata taaatatttg
     3661 aggaaatgca tggtctagat cttttaaacc ttaaagaatg tgttgatatg actaataaac
     3721 ttacatacaa tt
//
