LOCUS       NM_022033               1805 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus 3-oxoacid CoA transferase 2A (Oxct2a), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_022033
VERSION     NM_022033.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1805)
  AUTHORS   Zhang,L., Lu,Y., An,J., Wu,Y., Liu,Z. and Zou,M.H.
  TITLE     AMPKalpha2 regulates fasting-induced hyperketonemia by suppressing
            SCOT ubiquitination and degradation
  JOURNAL   Sci Rep 14 (1), 1713 (2024)
   PUBMED   38242911
  REMARK    GeneRIF: AMPKalpha2 regulates fasting-induced hyperketonemia by
            suppressing SCOT ubiquitination and degradation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1805)
  AUTHORS   Lu,Y., Oura,S., Matsumura,T., Oji,A., Sakurai,N., Fujihara,Y.,
            Shimada,K., Miyata,H., Tobita,T., Noda,T., Castaneda,J.M.,
            Kiyozumi,D., Zhang,Q., Larasati,T., Young,S.A.M., Kodani,M.,
            Huddleston,C.A., Robertson,M.J., Coarfa,C., Isotani,A.,
            Aitken,R.J., Okabe,M., Matzuk,M.M., Garcia,T.X. and Ikawa,M.
  TITLE     CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched
            genes dispensable for male fertility in micedagger
  JOURNAL   Biol Reprod 101 (2), 501-511 (2019)
   PUBMED   31201419
REFERENCE   3  (bases 1 to 1805)
  AUTHORS   Wang,Y., Peng,F., Tong,W., Sun,H., Xu,N. and Liu,S.
  TITLE     The nitrated proteome in heart mitochondria of the db/db mouse
            model: characterization of nitrated tyrosine residues in SCOT
  JOURNAL   J Proteome Res 9 (8), 4254-4263 (2010)
   PUBMED   20527992
  REMARK    GeneRIF: Two tyrosine residues of SCOT are the priority sites
            attacked by nitric oxide, and their nitration status is a causal
            factor leading to inhibition of SCOT catalysis.
REFERENCE   4  (bases 1 to 1805)
  AUTHORS   Onishi,M., Yasunaga,T., Tanaka,H., Nishimune,Y. and Nozaki,M.
  TITLE     Gene structure and evolution of testicular haploid germ
            cell-specific genes, Oxct2a and Oxct2b
  JOURNAL   Genomics 83 (4), 647-657 (2004)
   PUBMED   15028287
  REMARK    GeneRIF: Oxct2a and Oxct2b are testicular haploid germ
            cell-specific genes
REFERENCE   5  (bases 1 to 1805)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 1805)
  AUTHORS   Tanaka,H., Iguchi,N., Miyagawa,Y., Koga,M., Kohroki,J. and
            Nishimune,Y.
  TITLE     Differential expression of succinyl CoA transferase (SCOT) genes in
            somatic and germline cells of the mouse testis
  JOURNAL   Int J Androl 26 (1), 52-56 (2003)
   PUBMED   12534938
  REMARK    GeneRIF: germ cells and somatic cells differentially express the
            SCOT enzymes and that the SCOT activity of sperm caused exclusively
            by SCOT-t should play an important role in sperm activity.
REFERENCE   7  (bases 1 to 1805)
  AUTHORS   Tanaka,H., Kohroki,J., Iguchi,N., Onishi,M. and Nishimune,Y.
  TITLE     Cloning and characterization of a human orthologue of
            testis-specific succinyl CoA: 3-oxo acid CoA transferase (Scot-t)
            cDNA
  JOURNAL   Mol Hum Reprod 8 (1), 16-23 (2002)
   PUBMED   11756565
REFERENCE   8  (bases 1 to 1805)
  AUTHORS   Koga,M., Tanaka,H., Yomogida,K., Nozaki,M., Tsuchida,J., Ohta,H.,
            Nakamura,Y., Masai,K., Yoshimura,Y., Yamanaka,M., Iguchi,N.,
            Nojima,H., Matsumiya,K., Okuyama,A. and Nishimune,Y.
  TITLE     Isolation and characterization of a haploid germ cell-specific
            novel complementary deoxyribonucleic acid; testis-specific
            homologue of succinyl CoA:3-Oxo acid CoA transferase
  JOURNAL   Biol Reprod 63 (6), 1601-1609 (2000)
   PUBMED   11090426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC137887.1 and AB022180.2.
            
            On Dec 22, 2011 this sequence version replaced NM_022033.3.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1750              BC137887.1         1-1750
            1751-1805           AB022180.2         1689-1743
FEATURES             Location/Qualifiers
     source          1..1805
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.42 cM"
     gene            1..1805
                     /gene="Oxct2a"
                     /gene_synonym="Oxct; Oxct2; Scot; Scot-t1"
                     /note="3-oxoacid CoA transferase 2A"
                     /db_xref="GeneID:64059"
                     /db_xref="MGI:MGI:1891061"
     exon            1..1805
                     /gene="Oxct2a"
                     /gene_synonym="Oxct; Oxct2; Scot; Scot-t1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1656
                     /gene="Oxct2a"
                     /gene_synonym="Oxct; Oxct2; Scot; Scot-t1"
                     /EC_number="2.8.3.5"
                     /note="haploid germ cell specific succinyl CoA
                     transferase; succinyl-CoA:3-oxoacid CoA-transferase;
                     testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1;
                     succinyl-CoA:3-ketoacid coenzyme A transferase 2A,
                     mitochondrial"
                     /codon_start=1
                     /product="succinyl-CoA:3-ketoacid coenzyme A transferase
                     2A, mitochondrial precursor"
                     /protein_id="NP_071316.1"
                     /db_xref="CCDS:CCDS18617.1"
                     /db_xref="GeneID:64059"
                     /db_xref="MGI:MGI:1891061"
                     /translation="MAALRLLAWALPRGVSALRPPPALPHRLIRRYVSDRSGSVHFYT
                     DPVKAVEGVKDGSTVMLGGFGLCGIPENLIGALKTKGVKDLKIVSSNVGVDDFGLGIL
                     LASKQVRRVVCSYLGENALCEKLYLAGELELEMTPQGTLAERIRAGGTGVPAFYTPTG
                     YGTLVQEGGSPIRYAPDGHLITLSEPREVREFQGRFYLLEHAIRADFALIKGWKADRS
                     GNVIFRGSARNFNVPMCKAADISVVEVEEIVDVGTFAPEDIHVPNIYVDRVIKGPKFE
                     KRIERLTTRDSKPAPGSKDNDPSRTRIIKRAALEFQDGMYANLGIGIPVLASNYISPK
                     MTVYLHSENGILGLGPFPLKNEVDADVINAGKQTVTVVPGGCFFASDDSFAMIRGGHL
                     QLTMLGAMQVSQYGDLANWMVPGKKVKGMGGAMDLVSSKKTRVVVTMEHCTKTKQPKI
                     LKKCTMPLTGKRCVDLIITEKAVFEVNHSKGLTLVELWEGSSVDDIKATTACSFAVSP
                     NLKPMQQIKLDA"
     regulatory      1787..1792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oxct2a"
                     /gene_synonym="Oxct; Oxct2; Scot; Scot-t1"
                     /note="hexamer: ATTAAA"
     polyA_site      1805
                     /gene="Oxct2a"
                     /gene_synonym="Oxct; Oxct2; Scot; Scot-t1"
                     /note="major polyA site"
ORIGIN      
        1 gacgcagcgc agaggtaatg tgcactgctc tgcaaaggtg aacctggcct ttctctctct
       61 gtcccggagc tgggagcccc gtggccgtgg acgatggcgg cgctgaggct tctggcctgg
      121 gcgctcccac gtggggtatc tgctctccgc ccaccacccg cgctgcccca ccgccttatc
      181 cgccgctatg tttcggaccg cagcgggagt gtccatttct acacggaccc ggtgaaggcg
      241 gtggagggcg tcaaggacgg gtctaccgtc atgctcgggg gcttcgggct ctgcggcatc
      301 cccgagaacc tgatcggtgc gctgaagacc aagggcgtga aggacctgaa gatcgtcagc
      361 agcaacgtgg gcgtggacga cttcggcctg ggcatcttgc tggcctccaa gcaggtcagg
      421 cgcgtggtgt gctcctacct gggggagaac gcgctctgcg agaagctcta cctggcgggc
      481 gagctggaac tggagatgac gccgcaggga actttggccg agcgcatccg cgcgggtggc
      541 actggcgtgc ccgccttcta cacgcccaca ggctatggaa cgctggtgca ggaagggggc
      601 tctccaatcc ggtacgcgcc cgatggccac ctgattactc taagtgagcc gcgagaagta
      661 cgcgagttcc agggccgctt ctacctgcta gagcacgcta tccgcgctga cttcgcactg
      721 atcaagggct ggaaggccga ccgctccggc aacgtgatct tcaggggcag cgcgcgcaac
      781 ttcaatgtgc ccatgtgcaa ggccgcggac atctcggtgg tggaagtgga ggagatcgtg
      841 gacgtgggta ctttcgcccc ggaagacatc cacgtcccca acatctatgt ggaccgcgtg
      901 atcaaggggc cgaagttcga gaagcgcatc gagcgcctaa ccacacgtga cagcaagccc
      961 gcgcccggga gcaaagacaa tgacccttcc aggacgcgca tcatcaagcg cgcggctctg
     1021 gagttccagg acggcatgta tgccaatctg ggcatcggga tccctgtctt ggcgagcaac
     1081 tacatcagcc ccaagatgac cgtctacctg cacagtgaaa acggaatcct gggcttgggc
     1141 ccgttccctt tgaaaaatga ggtagatgcc gacgtcatca acgcaggcaa gcagacagtg
     1201 acggtggttc ccgggggctg tttcttcgcc agcgatgact cttttgccat gatccgtggc
     1261 ggacacctcc aactgaccat gcttggggcc atgcaggttt ctcaatacgg cgacctggcc
     1321 aactggatgg tgccaggcaa gaaggtgaag ggcatgggcg gggccatgga cttggtgtct
     1381 agtaaaaaga ccagagttgt agtcaccatg gaacactgca ccaagacaaa gcagcccaaa
     1441 atcttgaaga aatgcaccat gccattgacc ggcaagcgct gcgtggacct catcatcact
     1501 gagaaggcag tgtttgaagt gaaccactca aaggggctga cactggtgga gctgtgggag
     1561 ggctcgtcgg tagatgacat caaggccacc acagcctgtt catttgccgt gtcccccaac
     1621 ctcaagccca tgcagcagat taaacttgat gcttgaggag ccctccaggg ctaatttgcc
     1681 agttagtgac aactggacat ccttagcagc acctgaccac tgtgccacac tggctcctcc
     1741 agcttccttc tgctagatgg tgtctatcga gagccatgtg accttaatta aaaaccctaa
     1801 cttga
//
