LOCUS       NM_024188               3496 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus 3-oxoacid CoA transferase 1 (Oxct1), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_024188
VERSION     NM_024188.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3496)
  AUTHORS   Qiu,J.Y., Gao,S.Q., Chen,Y.S., Wang,X., Zhuang,Y.S., Miao,S.H.,
            Zheng,X.B., Zhao,R., Sun,Y. and Zhou,M.L.
  TITLE     OXCT1 regulates hippocampal neurogenesis and alleviates cognitive
            impairment via the Akt/GSK-3beta/beta-catenin pathway after
            subarachnoid hemorrhage
  JOURNAL   Brain Res 1827, 148758 (2024)
   PUBMED   38199308
  REMARK    GeneRIF: OXCT1 regulates hippocampal neurogenesis and alleviates
            cognitive impairment via the Akt/GSK-3beta/beta-catenin pathway
            after subarachnoid hemorrhage.
REFERENCE   2  (bases 1 to 3496)
  AUTHORS   Cui,H., Hu,D., Liu,Y. and Zhao,J.
  TITLE     Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising
            biomarkers of sarcopenia in various models
  JOURNAL   Gene 896, 148053 (2024)
   PUBMED   38042218
  REMARK    GeneRIF: Identifying Acss1, Mtfp1 and Oxct1 as key regulators and
            promising biomarkers of sarcopenia in various models.
REFERENCE   3  (bases 1 to 3496)
  AUTHORS   Ma,W., Sun,Y., Yan,R., Zhang,P., Shen,S., Lu,H., Zhou,Z., Jiang,Z.,
            Ye,L., Mao,Q., Xiong,N., Jia,W., Sun,L., Gao,P. and Zhang,H.
  TITLE     OXCT1 functions as a succinyltransferase, contributing to
            hepatocellular carcinoma via succinylating LACTB
  JOURNAL   Mol Cell 84 (3), 538-551 (2024)
   PUBMED   38176415
REFERENCE   4  (bases 1 to 3496)
  AUTHORS   Luda,K.M., Longo,J., Kitchen-Goosen,S.M., Duimstra,L.R., Ma,E.H.,
            Watson,M.J., Oswald,B.M., Fu,Z., Madaj,Z., Kupai,A., Dickson,B.M.,
            DeCamp,L.M., Dahabieh,M.S., Compton,S.E., Teis,R., Kaymak,I.,
            Lau,K.H., Kelly,D.P., Puchalska,P., Williams,K.S., Krawczyk,C.M.,
            Levesque,D., Boisvert,F.M., Sheldon,R.D., Rothbart,S.B.,
            Crawford,P.A. and Jones,R.G.
  TITLE     Ketolysis drives CD8+ T cell effector function through effects on
            histone acetylation
  JOURNAL   Immunity 56 (9), 2021-2035 (2023)
   PUBMED   37516105
REFERENCE   5  (bases 1 to 3496)
  AUTHORS   Enders,J., Jack,J., Thomas,S., Lynch,P., Lasnier,S., Cao,X.,
            Swanson,M.T., Ryals,J.M., Thyfault,J.P., Puchalska,P.,
            Crawford,P.A. and Wright,D.E.
  TITLE     Ketolysis is required for the proper development and function of
            the somatosensory nervous system
  JOURNAL   Exp Neurol 365, 114428 (2023)
   PUBMED   37100111
REFERENCE   6  (bases 1 to 3496)
  AUTHORS   Cotter,D.G., d'Avignon,D.A., Wentz,A.E., Weber,M.L. and
            Crawford,P.A.
  TITLE     Obligate role for ketone body oxidation in neonatal metabolic
            homeostasis
  JOURNAL   J Biol Chem 286 (9), 6902-6910 (2011)
   PUBMED   21209089
  REMARK    GeneRIF: Although Oxct1(-/-) mice exhibit normal prenatal
            development, all develop ketoacidosis, hypoglycemia, and reduced
            plasma lactate concentrations within the first 48 h of birth
REFERENCE   7  (bases 1 to 3496)
  AUTHORS   Thorrez,L., Laudadio,I., Van Deun,K., Quintens,R., Hendrickx,N.,
            Granvik,M., Lemaire,K., Schraenen,A., Van Lommel,L., Lehnert,S.,
            Aguayo-Mazzucato,C., Cheng-Xue,R., Gilon,P., Van Mechelen,I.,
            Bonner-Weir,S., Lemaigre,F. and Schuit,F.
  TITLE     Tissue-specific disallowance of housekeeping genes: the other face
            of cell differentiation
  JOURNAL   Genome Res 21 (1), 95-105 (2011)
   PUBMED   21088282
REFERENCE   8  (bases 1 to 3496)
  AUTHORS   Millien,G., Beane,J., Lenburg,M., Tsao,P.N., Lu,J., Spira,A. and
            Ramirez,M.I.
  TITLE     Characterization of the mid-foregut transcriptome identifies genes
            regulated during lung bud induction
  JOURNAL   Gene Expr Patterns 8 (2), 124-139 (2008)
   PUBMED   18023262
REFERENCE   9  (bases 1 to 3496)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 3496)
  AUTHORS   Tanaka,H., Iguchi,N., Miyagawa,Y., Koga,M., Kohroki,J. and
            Nishimune,Y.
  TITLE     Differential expression of succinyl CoA transferase (SCOT) genes in
            somatic and germline cells of the mouse testis
  JOURNAL   Int J Androl 26 (1), 52-56 (2003)
   PUBMED   12534938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078086.1, AK167681.1, AK151662.1 and BE952161.1.
            
            On Feb 22, 2008 this sequence version replaced NM_024188.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146158.1, AK151662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AK078086.1         2-172
            172-2100            AK167681.1         2-1930
            2101-2591           AK151662.1         1840-2330
            2592-3479           AK151662.1         2332-3219
            3480-3496           BE952161.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3496
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 1.86 cM"
     gene            1..3496
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /note="3-oxoacid CoA transferase 1"
                     /db_xref="GeneID:67041"
                     /db_xref="MGI:MGI:1914291"
     exon            1..422
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..1907
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /EC_number="2.8.3.5"
                     /note="succinyl-CoA:3-ketoacid CoA transferase;
                     somatic-type succinyl-CoA:3-oxoacid CoA-transferase;
                     succinyl-CoA:3-ketoacid coenzyme A transferase 1,
                     mitochondrial; succinyl-CoA:3-oxoacid CoA transferase"
                     /codon_start=1
                     /product="succinyl-CoA:3-ketoacid coenzyme A transferase
                     1, mitochondrial precursor"
                     /protein_id="NP_077150.1"
                     /db_xref="CCDS:CCDS27361.1"
                     /db_xref="GeneID:67041"
                     /db_xref="MGI:MGI:1914291"
                     /translation="MAALKLLSSGLRLGASARSSRGALHKGCVCYFSVSTRHHTKFYT
                     DPVEAVKDIPNGATLLVGGFGLCGIPENLIGALLKTGVKDLTAVSNNAGVDNFGLGLL
                     LRSKQIKRMISSYVGENAEFERQFLSGELEVELTPQGTLAERIRAGGAGVPAFYTSTG
                     YGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRA
                     GNVIFRKSARNFNLPMCKAAGTTVVEVEEIVDIGSFAPEDIHIPKIYVHRLIKGEKYE
                     KRIERLSLRKEGDGKGKSGKPGGDVRERIIKRAALEFEDGMYANLGIGIPLLASNFIS
                     PNMTVHLQSENGVLGLGPYPLKDEADADLINAGKETVTVLPGASFFSSDESFAMIRGG
                     HVNLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSSKTKVVVTMEHSAKGNAH
                     KIMEKCTLPLTGKQCVNRIITEKGVFDVDKKNGLTLIELWEGLTVDDIKKSTGCDFAV
                     SPNLMPMQQIST"
     exon            423..531
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            532..622
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            623..758
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            759..908
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1015
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1076
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1184
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1299
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1394
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1443
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1516
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1592
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1682
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1763
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1865
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..3482
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2219..2224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /note="hexamer: ATTAAA"
     polyA_site      2242
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /note="major polyA site"
     polyA_site      2597
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
     regulatory      3458..3463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /note="hexamer: AATAAA"
     polyA_site      3482
                     /gene="Oxct1"
                     /gene_synonym="2610008O03Rik; Oxct; Oxct2a; SCOT; Scot-s"
                     /note="major polyA site"
ORIGIN      
        1 agcctgagtg cagcgcccgc cgctgcgggt gtgcccgcag atgagctgga gcccagcacc
       61 tccggccccg gcacaacccg cggggctcgt cctagctgtg cagcctttcc attcctagcc
      121 gtgagcccct ccctgtctcg cttcttgaca agccagcagg cagcaagggg cggcaccgct
      181 ctgaggtccc gaggacgtca ctgacgcgcg gtcgagcctc cagcccgccc taccgctcgc
      241 cttgccttct ctcttcttag ccggtgacgc cgccgcggcc ccgggcaacc agcactcgca
      301 cgcactcccg cgcgcgccac cgtctcccgc acccggggcc gaagatggcg gctctcaaac
      361 tcctgtcctc tgggcttcgg ctcggcgcct cagcccgcag ctcgcggggc gccctgcata
      421 aggggtgtgt ctgctacttc tctgtcagta ctcgtcacca caccaaattt tacacagatc
      481 ccgtggaagc tgtaaaagat attcctaatg gtgcaacctt gctggttggt ggttttgggc
      541 tgtgtggtat tccagagaat cttataggag ctttactgaa gactggagta aaagatctaa
      601 ctgcagtcag caacaatgca ggggttgaca acttcggcct gggcctttta cttcgatcca
      661 agcagataaa acgaatgatc tcctcatatg tgggagaaaa tgcagaattt gagcgacagt
      721 tcctttctgg tgaattagaa gtagagctga cacctcaggg cacacttgcc gagaggatcc
      781 gtgccggtgg agctggagtc cctgccttct acaccagcac agggtatggg actctggtac
      841 aggaaggagg atcacccatc aaatataaca aagatggcag tgttgccatt gccagcaagc
      901 cacgagaggt gagggagttt aacggtcagc acttcatttt ggaggaagcc atcacgggag
      961 attttgctct ggtgaaagca tggaaagcag accgggcagg caatgtgatt ttcaggaaaa
     1021 gtgcaagaaa cttcaatctg ccaatgtgca aagctgcagg aactaccgtg gtggaggttg
     1081 aagaaattgt agacattggc tcatttgccc cagaagatat ccacattcca aagatttatg
     1141 tgcaccgcct cataaaggga gagaaatatg agaagagaat tgagcgttta tcactccgaa
     1201 aggaaggaga tggaaaaggc aaatccggta agcctggagg cgatgtgagg gaacggatca
     1261 tcaagcgagc cgccctggag tttgaggacg gcatgtacgc taacttgggt attgggattc
     1321 ctcttctggc cagcaacttc atcagtccca acatgactgt tcatcttcaa agtgaaaatg
     1381 gagtcttggg cctgggccca tacccactga aagacgaagc tgatgcggat ctcatcaatg
     1441 caggaaagga aacagttact gttctcccag gagcctcttt cttctccagc gatgagtcat
     1501 tcgccatgat tagaggggga catgtcaatc taacaatgtt aggagccatg caggtttcta
     1561 agtatggtga cctggccaac tggatgatac ctggaaaaat ggtgaaagga atgggaggag
     1621 ctatggattt ggtgtccagt tccaaaacca aagtggtggt caccatggag cactctgcga
     1681 agggaaatgc tcataaaatc atggagaaat gtacactacc actgacgggc aaacagtgtg
     1741 tcaaccgcat cattacagaa aagggtgtgt ttgacgtgga caagaaaaat ggtttgacac
     1801 tgattgagct ctgggaaggc ctgactgttg atgacatcaa gaagagcaca ggctgtgact
     1861 ttgcagtttc accaaacctc atgccaatgc agcagatttc aacttgaagc atccactgaa
     1921 catttgtccc aggctgccaa gattgcattt tcaacacata ggatttaaac ggaaggatgt
     1981 cagtaatcaa tagttacatt acacatttag caagaagttt cggctagttt tcttctagta
     2041 tttctggatt tgtgcagcca tagacattgt tctctccatc gtgatatatc agttccgtgg
     2101 gaaaaaaaaa aaaaaaaagg aaaacatttt attgtggtct tgcttcatga gtgctaagaa
     2161 ggttgtcttt atcattgttg ctcacagtgg atatatgctc atcttttatg ctatatgtat
     2221 taaacctcga cttagccctg aaggtgaatt ttcatgtgca tttgtgattt ggtagaatac
     2281 ttttttgatg actatgtatc ttttaccttc ctctgttttg agagatgcca gttatgcttg
     2341 ctttcttaga aagtcctcct tccctccaca cttcttatag ctaaatagat actcgaaaaa
     2401 gcgaacagga atgtccctgt gaaaagtaag tagaagaaag gacaaggcat atgctctgct
     2461 ggtgctgaca tcccactaaa tgttgccttt aaagacaacc aaccgtctac ctatggtgtg
     2521 ctataccttt gtattctgaa gactgttttt ctgtattgat caccaatgtt tacttataca
     2581 tctcttgagc aaaaaaagaa ccatgggcaa ttgatcatga gtcctgaatc atagtgacag
     2641 cagtatttaa agagatgata ttccaagata tctccccttt agcctctcca ttctgctcag
     2701 caaagattgt aaacactgag ttactttttt acactacagt ggtattctgc ataggttagt
     2761 tctcttcaca aagggctact gctttagcct tatctgtgct ggggaaatga tgggaaaggc
     2821 tcagatctga gtggctagca gggtttgtgt ggcagagtga atgcagtagc ttgcattcat
     2881 cagggatgct tcctcagaag tagccacaat acagacagtt gccagggggc atcactccag
     2941 aagcttcctt gccttggtat cagatatctg aaaacctagg caccctgaag ccagactgga
     3001 cagctggcgt ctgcacagtg aaacgtatcg tctttctggc actaattaga ggaatttata
     3061 cacgtcttag gtgatggttg gcactggaac tcactcctca agcataacca cagttagctt
     3121 gcacatgttg tgaaggggag ataagctttt cctccatagt acaccctcta ggtaggactg
     3181 ctttagtgga tggccacgtg gctgaaagca tcctctgcca gtgttggtaa gaagaacccg
     3241 tcttagatgg tacaaggccc aggagagtac gtatgttaga gcacacattt gagaaatcat
     3301 cttgctgata ttgatatgtc ttcaggcgca cttgcttatc attccggtct gttactttaa
     3361 cgcaaggggc ttctaagaat gtcttaaact tcaaagcctg aatagacaac tttctaagag
     3421 tgccatgata ttttttaaaa aatgtgttaa atgacacaat aaaaattgca agttgatgga
     3481 gaaaaaaaaa aaaaaa
//
