LOCUS       NM_026924               1473 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus ovo like zinc finger 2 (Ovol2), transcript variant A,
            mRNA.
ACCESSION   NM_026924
VERSION     NM_026924.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1473)
  AUTHORS   Jeyarajah,M.J., Patterson,V.S., Jaju Bhattad,G., Zhao,L.,
            Whitehead,S.N. and Renaud,S.J.
  TITLE     Placental extracellular vesicles promote cardiomyocyte maturation
            and fetal heart development
  JOURNAL   Commun Biol 7 (1), 1254 (2024)
   PUBMED   39363116
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1473)
  AUTHORS   Zheng,W., Zhang,Y., Xu,P., Wang,Z., Shao,X., Chen,C., Cai,H.,
            Wang,Y., Sun,M.A., Deng,W., Liu,F., Lu,J., Zhang,X., Cheng,D.,
            Mysorekar,I.U., Wang,H., Wang,Y.L., Hu,X. and Cao,B.
  TITLE     TFEB safeguards trophoblast syncytialization in humans and mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2404062121 (2024)
   PUBMED   38968109
REFERENCE   3  (bases 1 to 1473)
  AUTHORS   Elfeky,M., Matsuoka,S., Yamamoto,I., Elewa,Y.H.A., Nakamura,K.,
            Suzuki,H., Kamikawa,A., Okamatu-Ogura,Y. and Kimura,K.
  TITLE     Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in Mouse
            Mammary Gland Development During Pregnancy, Lactation, and Weaning
  JOURNAL   Microsc Microanal 30 (3), 552-563 (2024)
   PUBMED   38833344
  REMARK    GeneRIF: Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in
            Mouse Mammary Gland Development During Pregnancy, Lactation, and
            Weaning.
REFERENCE   4  (bases 1 to 1473)
  AUTHORS   Lu,R., Hong,J., Fu,T., Zhu,Y., Tong,R., Ai,D., Wang,S., Huang,Q.,
            Chen,C., Zhang,Z., Zhang,R., Guo,H. and Li,B.
  TITLE     Loss of OVOL2 in Triple-Negative Breast Cancer Promotes Fatty Acid
            Oxidation Fueling Stemness Characteristics
  JOURNAL   Adv Sci (Weinh) 11 (24), e2308945 (2024)
   PUBMED   38627980
  REMARK    GeneRIF: Loss of OVOL2 in Triple-Negative Breast Cancer Promotes
            Fatty Acid Oxidation Fueling Stemness Characteristics.
REFERENCE   5  (bases 1 to 1473)
  AUTHORS   Zhong,X., Peddada,N., Wang,J., Moresco,J.J., Zhan,X., Shelton,J.M.,
            SoRelle,J.A., Keller,K., Lazaro,D.R., Moresco,E.M.Y., Choi,J.H. and
            Beutler,B.
  TITLE     OVOL2 sustains postnatal thymic epithelial cell identity
  JOURNAL   Nat Commun 14 (1), 7786 (2023)
   PUBMED   38012144
  REMARK    GeneRIF: OVOL2 sustains postnatal thymic epithelial cell identity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1473)
  AUTHORS   Li,B., Nair,M., Mackay,D.R., Bilanchone,V., Hu,M., Fallahi,M.,
            Song,H., Dai,Q., Cohen,P.E. and Dai,X.
  TITLE     Ovol1 regulates meiotic pachytene progression during
            spermatogenesis by repressing Id2 expression
  JOURNAL   Development 132 (6), 1463-1473 (2005)
   PUBMED   15716349
REFERENCE   7  (bases 1 to 1473)
  AUTHORS   Unezaki,S., Nishizawa,M., Okuda-Ashitaka,E., Masu,Y., Mukai,M.,
            Kobayashi,S., Sawamoto,K., Okano,H. and Ito,S.
  TITLE     Characterization of the isoforms of MOVO zinc finger protein, a
            mouse homologue of Drosophila Ovo, as transcription factors
  JOURNAL   Gene 336 (1), 47-58 (2004)
   PUBMED   15225875
REFERENCE   8  (bases 1 to 1473)
  AUTHORS   Li,B., Dai,Q., Li,L., Nair,M., Mackay,D.R. and Dai,X.
  TITLE     Ovol2, a mammalian homolog of Drosophila ovo: gene structure,
            chromosomal mapping, and aberrant expression in blind-sterile mice
  JOURNAL   Genomics 80 (3), 319-325 (2002)
   PUBMED   12213202
  REMARK    GeneRIF: Ovol2 transcription was dramatically reduced in testes
            from blind-sterile mice, suggesting that Ovol2 is expressed in male
            germ cells
REFERENCE   9  (bases 1 to 1473)
  AUTHORS   Dai,X., Schonbaum,C., Degenstein,L., Bai,W., Mahowald,A. and
            Fuchs,E.
  TITLE     The ovo gene required for cuticle formation and oogenesis in flies
            is involved in hair formation and spermatogenesis in mice
  JOURNAL   Genes Dev 12 (21), 3452-3463 (1998)
   PUBMED   9808631
REFERENCE   10 (bases 1 to 1473)
  AUTHORS   Masu,Y., Ikeda,S., Okuda-Ashitaka,E., Sato,E. and Ito,S.
  TITLE     Expression of murine novel zinc finger proteins highly homologous
            to Drosophila ovo gene product in testis
  JOURNAL   FEBS Lett 421 (3), 224-228 (1998)
   PUBMED   9468311
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808123.9.
            
            On Nov 17, 2006 this sequence version replaced NM_026924.2.
            
            Transcript Variant: This variant (A) represents the longer
            transcript and encodes the longer isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031771.1, AK167697.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AL808123.9         71194-71513         c
            321-538             AL808123.9         70337-70554         c
            539-728             AL808123.9         57144-57333         c
            729-1473            AL808123.9         44608-45352         c
FEATURES             Location/Qualifiers
     source          1..1473
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 70.99 cM"
     gene            1..1473
                     /gene="Ovol2"
                     /gene_synonym="1700108N11Rik; 1810007D21Rik; M-OVO;
                     M-OVO-A; M-OVO-B; MOVO; movo2; Ovo2; Zfp339"
                     /note="ovo like zinc finger 2"
                     /db_xref="GeneID:107586"
                     /db_xref="MGI:MGI:1338039"
     exon            1..320
                     /gene="Ovol2"
                     /gene_synonym="1700108N11Rik; 1810007D21Rik; M-OVO;
                     M-OVO-A; M-OVO-B; MOVO; movo2; Ovo2; Zfp339"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1045
                     /gene="Ovol2"
                     /gene_synonym="1700108N11Rik; 1810007D21Rik; M-OVO;
                     M-OVO-A; M-OVO-B; MOVO; movo2; Ovo2; Zfp339"
                     /note="isoform A is encoded by transcript variant A; zinc
                     finger protein 339; transcription factor Ovo-like 2; zinc
                     finger OVO2; ovo-like 2; MOVO-B zinc finger protein;
                     MOVO-C zinc finger protein; zinc finger protein mOVO; OVO
                     homolog-like 2"
                     /codon_start=1
                     /product="transcription factor Ovo-like 2 isoform A"
                     /protein_id="NP_081200.2"
                     /db_xref="CCDS:CCDS16817.1"
                     /db_xref="GeneID:107586"
                     /db_xref="MGI:MGI:1338039"
                     /translation="MPKVFLVKRRSPGVSVRSWDELPDDKRADTYIPVSLGCLLRDPP
                     EDCRSDGGSSSGCSSSAGEPGGAESSSSPRAPEPETPELHDAQGTDGHLAAMQRPVAR
                     SKIKFTTGTCDNSVIHNCDLCGKSFRLQRMLNRHLKCHNQVKRHLCTFCGKGFNDTFD
                     LKRHVRTHTGIRPYKCEVCNKAFTQRCSLESHLKKIHGVQQQYAYKQRRDKLYVCEDC
                     GYTGPTQEDLYLHVNSDHPGSTFLKKTSKKLAALMQNKLTSPLQENSTLSEEEEKK"
     exon            321..538
                     /gene="Ovol2"
                     /gene_synonym="1700108N11Rik; 1810007D21Rik; M-OVO;
                     M-OVO-A; M-OVO-B; MOVO; movo2; Ovo2; Zfp339"
                     /inference="alignment:Splign:2.1.0"
     exon            539..728
                     /gene="Ovol2"
                     /gene_synonym="1700108N11Rik; 1810007D21Rik; M-OVO;
                     M-OVO-A; M-OVO-B; MOVO; movo2; Ovo2; Zfp339"
                     /inference="alignment:Splign:2.1.0"
     exon            729..1473
                     /gene="Ovol2"
                     /gene_synonym="1700108N11Rik; 1810007D21Rik; M-OVO;
                     M-OVO-A; M-OVO-B; MOVO; movo2; Ovo2; Zfp339"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1454..1459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ovol2"
                     /gene_synonym="1700108N11Rik; 1810007D21Rik; M-OVO;
                     M-OVO-A; M-OVO-B; MOVO; movo2; Ovo2; Zfp339"
                     /note="hexamer: AATGAA"
     polyA_site      1473
                     /gene="Ovol2"
                     /gene_synonym="1700108N11Rik; 1810007D21Rik; M-OVO;
                     M-OVO-A; M-OVO-B; MOVO; movo2; Ovo2; Zfp339"
                     /note="major polyA site"
ORIGIN      
        1 cgcgcgattt aaggcatagg tgtcgccgag cccggaggct gcgagtaacc tggagtgagg
       61 gggagagtac cgagcaacgc ggcggggggt gcaggaagag ggcaggctag gcgggaaggt
      121 gggctccgga ctccaggagc ggggggaccc aggcgccacc gccgccacta gcggggagca
      181 gcgggaggag ggggccgcag tcggaagaga ggatcccacc atgcccaaag tctttttggt
      241 gaagaggagg agcccgggag tctctgtccg cagctgggat gagctcccgg atgacaaaag
      301 ggcagacact tacatcccag tgagcctggg ctgtctgctc cgcgacccgc ccgaagactg
      361 ccgcagcgac ggcggcagta gcagcggctg cagcagcagc gccggggagc ccggaggggc
      421 cgaaagcagc tcgtccccgc gcgcgccgga gcctgaaact ccagagcttc acgacgccca
      481 aggcaccgat ggacatctgg cagcgatgca gcgcccggtt gccaggtcaa aaatcaagtt
      541 taccaccggc acatgcgaca actctgtgat tcacaactgt gacctttgtg gcaagagctt
      601 ccgcctgcag cgcatgctca accgtcacct taagtgccac aaccaggtaa agaggcacct
      661 gtgcaccttc tgcggcaagg gcttcaatga caccttcgac ctgaagaggc acgtacgcac
      721 gcacactggc atccgcccct acaaatgtga ggtgtgtaac aaggccttca cccagcggtg
      781 ttccttggag tcccacctaa agaagatcca cggggtacag cagcagtatg cctacaagca
      841 gcgtcgcgac aaactctacg tgtgtgagga ttgcggctac acgggcccca cccaggagga
      901 cctgtatctg catgtgaaca gtgaccatcc agggagcaca tttctcaaaa agacttccaa
      961 aaagttggcg gcccttatgc agaacaagct gacgtccccg ctgcaggaga attccaccct
     1021 gagtgaagag gaggaaaaaa agtgaagagc gagcaagaaa aagcagagga gagacgccgg
     1081 cgccacgttt actccgactt atggtctgag gcgtacccct ctgctcccct ggatcttttc
     1141 atattcagtc cacctctctc ttcttttggg acagcaacag taagaagcac cccaaagttg
     1201 tcagtcattc tgccacaaca ggccctgtga attgtttctt ggtggctgag gtcacatacg
     1261 ggtttctgtg tgtatgtgtg tctgtctgtc tgtctgttat gtgtgggttt ttttttgttt
     1321 cctagtagaa ttttcacgta tgaatagaga gaggtgttct taaagagact gtcatcttaa
     1381 ggtgccttga aatgcttccc atgcaaggaa aatgtatatt cttctgaaag agtttacaga
     1441 aattatttta ataaatgaaa tgttcgtgtg aaa
//
