LOCUS       NM_019935               2900 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus ovo like zinc finger 1 (Ovol1), mRNA.
ACCESSION   NM_019935
VERSION     NM_019935.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2900)
  AUTHORS   Bugacov,H., Der,B., Briantseva,B.M., Guo,Q., Kim,S., Lindstrom,N.O.
            and McMahon,A.P.
  TITLE     Dose-dependent responses to canonical Wnt transcriptional complexes
            in the regulation of mammalian nephron progenitors
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39250420
REFERENCE   2  (bases 1 to 2900)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2900)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   4  (bases 1 to 2900)
  AUTHORS   Dragan,M., Sun,P., Chen,Z., Ma,X., Vu,R., Shi,Y., Villalta,S.A. and
            Dai,X.
  TITLE     Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately
            Regulates Barrier Maintenance and Neutrophil Accumulation in
            Psoriasis-Like Inflammation
  JOURNAL   J Invest Dermatol 142 (3 Pt A), 583-593 (2022)
   PUBMED   34461129
  REMARK    GeneRIF: Epidermis-Intrinsic Transcription Factor Ovol1
            Coordinately Regulates Barrier Maintenance and Neutrophil
            Accumulation in Psoriasis-Like Inflammation.
REFERENCE   5  (bases 1 to 2900)
  AUTHORS   Sun,P., Vu,R., Dragan,M., Haensel,D., Gutierrez,G., Nguyen,Q.,
            Greenberg,E., Chen,Z., Wu,J., Atwood,S., Pearlman,E., Shi,Y.,
            Han,W., Kessenbrock,K. and Dai,X.
  TITLE     OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal
            Hyperplasia
  JOURNAL   J Invest Dermatol 141 (6), 1542-1552 (2021)
   PUBMED   33333123
  REMARK    GeneRIF: OVOL1 Regulates Psoriasis-Like Skin Inflammation and
            Epidermal Hyperplasia.
REFERENCE   6  (bases 1 to 2900)
  AUTHORS   Teng,A., Nair,M., Wells,J., Segre,J.A. and Dai,X.
  TITLE     Strain-dependent perinatal lethality of Ovol1-deficient mice and
            identification of Ovol2 as a downstream target of Ovol1 in skin
            epidermis
  JOURNAL   Biochim Biophys Acta 1772 (1), 89-95 (2007)
   PUBMED   17049212
  REMARK    GeneRIF: Ovol1 mutant mice suffered perinatal lethality accompanied
            by kidney epithelial cysts of embryonic onset and delayed skin
            barrier acquisition; Ovol2 is a downstream target of Ovol1.
REFERENCE   7  (bases 1 to 2900)
  AUTHORS   Li,B., Nair,M., Mackay,D.R., Bilanchone,V., Hu,M., Fallahi,M.,
            Song,H., Dai,Q., Cohen,P.E. and Dai,X.
  TITLE     Ovol1 regulates meiotic pachytene progression during
            spermatogenesis by repressing Id2 expression
  JOURNAL   Development 132 (6), 1463-1473 (2005)
   PUBMED   15716349
  REMARK    GeneRIF: regulates pachytene progression of male germ cells, Id2 is
            target
REFERENCE   8  (bases 1 to 2900)
  AUTHORS   Li,B., Mackay,D.R., Dai,Q., Li,T.W., Nair,M., Fallahi,M.,
            Schonbaum,C.P., Fantes,J., Mahowald,A.P., Waterman,M.L., Fuchs,E.
            and Dai,X.
  TITLE     The LEF1/beta -catenin complex activates movo1, a mouse homolog of
            Drosophila ovo required for epidermal appendage differentiation
  JOURNAL   Proc Natl Acad Sci U S A 99 (9), 6064-6069 (2002)
   PUBMED   11983900
  REMARK    GeneRIF: The LEF1/beta -catenin complex activates movo1
REFERENCE   9  (bases 1 to 2900)
  AUTHORS   Dai,X., Schonbaum,C., Degenstein,L., Bai,W., Mahowald,A. and
            Fuchs,E.
  TITLE     The ovo gene required for cuticle formation and oogenesis in flies
            is involved in hair formation and spermatogenesis in mice
  JOURNAL   Genes Dev 12 (21), 3452-3463 (1998)
   PUBMED   9808631
REFERENCE   10 (bases 1 to 2900)
  AUTHORS   Farese,R.V. Jr., Ruland,S.L., Flynn,L.M., Stokowski,R.P. and
            Young,S.G.
  TITLE     Knockout of the mouse apolipoprotein B gene results in embryonic
            lethality in homozygotes and protection against diet-induced
            hypercholesterolemia in heterozygotes
  JOURNAL   Proc Natl Acad Sci U S A 92 (5), 1774-1778 (1995)
   PUBMED   7878058
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028577.1.
            
            On Apr 6, 2007 this sequence version replaced NM_019935.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028577.1, AK132505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2900              AK028577.1         2-2901
FEATURES             Location/Qualifiers
     source          1..2900
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..2900
                     /gene="Ovol1"
                     /gene_synonym="movo1; Ovo1"
                     /note="ovo like zinc finger 1"
                     /db_xref="GeneID:18426"
                     /db_xref="MGI:MGI:1330290"
     exon            1..375
                     /gene="Ovol1"
                     /gene_synonym="movo1; Ovo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1079
                     /gene="Ovol1"
                     /gene_synonym="movo1; Ovo1"
                     /note="mOvo1a; OVO homolog-like 1"
                     /codon_start=1
                     /product="putative transcription factor Ovo-like 1"
                     /protein_id="NP_064319.1"
                     /db_xref="CCDS:CCDS29469.1"
                     /db_xref="GeneID:18426"
                     /db_xref="MGI:MGI:1330290"
                     /translation="MPRAFLVKKPCVSTCKRNWSELPDEERGEIYVPVSLGFCPPQPY
                     REPEASVAEPPSCPLALDMSLRDSSYSVAPGPCVVAQLPSEDVSHLTDPQSRDQGFLR
                     TKMKVTLGDSPNGDLFTCHICQKSFTHQRMLNRHMKCHNDVKRHLCTYCGKGFNDTFD
                     LKRHVRTHTGVRPYKCSLCDKAFTQRCSLESHLKKIHGVQQKYAYKERRAKLYVCEEC
                     GCTSESQEGHVLHLKERHPDSPLLRKTSKKVAVALQNTVTSLLQGSPHL"
     exon            376..593
                     /gene="Ovol1"
                     /gene_synonym="movo1; Ovo1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..783
                     /gene="Ovol1"
                     /gene_synonym="movo1; Ovo1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..2900
                     /gene="Ovol1"
                     /gene_synonym="movo1; Ovo1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1899..1904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ovol1"
                     /gene_synonym="movo1; Ovo1"
                     /note="hexamer: ATTAAA"
     polyA_site      1926
                     /gene="Ovol1"
                     /gene_synonym="movo1; Ovo1"
                     /note="major polyA site"
     regulatory      2254..2259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ovol1"
                     /gene_synonym="movo1; Ovo1"
                     /note="hexamer: AATAAA"
     polyA_site      2276
                     /gene="Ovol1"
                     /gene_synonym="movo1; Ovo1"
     regulatory      2784..2789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ovol1"
                     /gene_synonym="movo1; Ovo1"
                     /note="hexamer: AGTAAA"
     polyA_site      2804
                     /gene="Ovol1"
                     /gene_synonym="movo1; Ovo1"
ORIGIN      
        1 agtcgagcta aaggacgctg gcttagcgct tctgcgatcc cggtgcacct ggctgcaccc
       61 tctctgtgga caccggcgac cttcggcgta gttggaaacg ccacgcgtgg tccctggtac
      121 actctgtcct aagaacgtgg acacgcctcg gcgactcttt ccttgaactg tccctattcc
      181 cgcgcctcaa ccccgatccg gtggaagaaa aggtgggacg accacacgaa ctcgacttac
      241 cagagcgaac cgcgccgggc caggaggaac tgaagatgcc tcgcgcgttc ctggtgaaga
      301 agccatgcgt ctccacgtgc aagaggaact ggagcgagct cccggacgaa gagcgcggcg
      361 agatctacgt gccagtcagc ctcggcttct gcccaccaca gccctaccgg gaaccagagg
      421 catcggtggc cgagcctcct tcctgccccc tggctttgga catgagcctt cgagactcca
      481 gctatagcgt ggctccaggg ccctgcgtgg tggcccagct accctctgaa gatgtgagcc
      541 atctgacaga tccccagagc agagaccagg gctttctacg aaccaagatg aaggtgacct
      601 tgggggacag tccaaatgga gaccttttta cctgccacat ctgccagaag tccttcaccc
      661 accagcgcat gctgaatcga cacatgaagt gtcacaacga cgtcaagagg cacctctgca
      721 cttactgtgg gaagggcttc aatgacacct ttgacctcaa gagacatgtc cgaacccaca
      781 ctggtgtgcg gccctacaag tgcagtctgt gtgataaggc cttcactcag cgctgctctc
      841 tggagtccca cctcaagaag atccacggag tgcagcagaa gtatgcatac aaggagcgcc
      901 gggccaagct ctacgtgtgt gaggagtgcg gttgcacatc cgagagtcaa gagggtcatg
      961 tcctgcacct caaggaacgc caccccgaca gcccactgct gcgcaagacc tccaagaaag
     1021 tggctgtggc tctgcagaac actgtcacgt ccctgctgca gggcagcccc catctctgag
     1081 cagcacaggc cctgggaagg accaggttca cttccctgct gcccagccat tcaccttcct
     1141 gcaacctctt gctagaacac cagtgactgg gaccagcgct ctaacacctc actccaggca
     1201 cacttgcaca attgggcact gacttctgct ctgtttgggg agtctgtctt acaggcagag
     1261 cacaccctga gcttgggacc ataggtgttt gtgtcccagc aggagtgagg acaagtgagc
     1321 aagaagaacc acttacagag acaggccctg tttccttgca gcaaaacttt gcagatgtgc
     1381 taagaggggg tcctgagtac aagatgggca atggattccc ctggagagca ggatggagac
     1441 accagcaaag agcatcccgg caaacaaccg cagtggtgct ggcagcggcc ctcgtgcatg
     1501 cagggctaac tctcagggtt ccaagggctc tctgcccttt catcagagac ccacatgtga
     1561 acagccgcgt gtatgtcaca ctgctctgtg tgtgatttct tcacgtgtgc atgtgcgctc
     1621 ttggtctttc cacttattgc ctcgttcgta agaaaccaac cataaggtgc caaggaggtt
     1681 ttattccttt tttttttaaa gatgacaaat gtacagatgt tagtacagat gttaatgtac
     1741 agatgttaat atatttttgg tgcccacagt aagactcagg gggggagctg gcttttctcc
     1801 acccccactg gttctattta tcctggacat ttcaaacctc ctctgtgcct tggtcctggg
     1861 gtggttttgc agacccaccc tgttctctga gatgtttcat taaagacctt cctcctgctt
     1921 tgcccagaga tggactattc ctcctgtcct tcccgggaca gtgcctctcc tctttcttcc
     1981 ctccctggct ccacaccctt ctcagggccc cagttttcct gctaaacctg atgacacctg
     2041 actgctcggg tgtggccgga ggctgacggt gggtcctact gatgctcctc aagcaaatgg
     2101 gatggcgatg gcgattcgac accaagtcta agtccacatc tgaagtacta aggcaagggc
     2161 aagaacaggc tgggagtcta ggtgtttttc ttcgctaagt ccgcaaaatt tgaggcagaa
     2221 taataatcca cataccagaa actttgagag gctaataaaa cttctctgtt gtcttacttc
     2281 tgttttccaa atgcctttga accgagtagc tcctctgagg gagggagtct ttgtccactg
     2341 gtgtgtctgg gtatcctgct gagaccaaaa agggctgtgg gtcaaaaggg tgtatgtctc
     2401 gtgcatccga ggagttatag ccaacctgaa gagagtgaaa gactgagccc taagacatgc
     2461 aggctgggaa gcccctgaat gccaaacagt cccacctccc ccacgttact gatgtcataa
     2521 gcacacaggt gcaggatctg accccagcca tgggctcact cgagagaaag aaatcttcta
     2581 gactatctct gaactaagca tggctgatct gaaggcttgc ttcacttttc cttatcgtgt
     2641 ctgggctgct gcactctgaa tgtaagaact caccttgtcc agaagcactg tgttggcatc
     2701 tttgtgtctg taagctcgtt gccaatctgg ggccatcata agctttatgt tgtctgtctt
     2761 gttttgtaag cacccgtcca actagtaaag tgagagaact aatactttct gtatttctgg
     2821 ggttttgttg ttggtgtttt cctcttgggc ctttttttcc ttcacgcaga gaaaacatta
     2881 aaacaattgc tgcttcttgc
//
