LOCUS       NM_172908               1924 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ovochymase 2 (Ovch2), mRNA.
ACCESSION   NM_172908 XM_885249
VERSION     NM_172908.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1924)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1924)
  AUTHORS   Kent,K., Nozawa,K., Sutton,C., Daniel,F., Ikawa,M., Garcia,T.X. and
            Matzuk,M.M.
  TITLE     CUB domains are not required for OVCH2 function in sperm maturation
            in the mouse epididymis
  JOURNAL   Andrology 12 (3), 682-697 (2024)
   PUBMED   37551853
  REMARK    GeneRIF: CUB domains are not required for OVCH2 function in sperm
            maturation in the mouse epididymis.
REFERENCE   3  (bases 1 to 1924)
  AUTHORS   Kiyozumi,D., Noda,T., Yamaguchi,R., Tobita,T., Matsumura,T.,
            Shimada,K., Kodani,M., Kohda,T., Fujihara,Y., Ozawa,M., Yu,Z.,
            Miklossy,G., Bohren,K.M., Horie,M., Okabe,M., Matzuk,M.M. and
            Ikawa,M.
  TITLE     NELL2-mediated lumicrine signaling through OVCH2 is required for
            male fertility
  JOURNAL   Science 368 (6495), 1132-1135 (2020)
   PUBMED   32499443
REFERENCE   4  (bases 1 to 1924)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1924)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140431.4.
            
            On Mar 21, 2007 this sequence version replaced NM_172908.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BN000123.1, BC125288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC140431.4         31809-31896
            89-198              AC140431.4         34869-34978
            199-290             AC140431.4         36377-36468
            291-463             AC140431.4         38034-38206
            464-559             AC140431.4         38534-38629
            560-711             AC140431.4         38883-39034
            712-901             AC140431.4         39565-39754
            902-925             AC140431.4         40848-40871
            926-1016            AC140431.4         42575-42665
            1017-1141           AC140431.4         42785-42909
            1142-1282           AC140431.4         43758-43898
            1283-1413           AC140431.4         44256-44386
            1414-1507           AC140431.4         47493-47586
            1508-1639           AC140431.4         48359-48490
            1640-1720           AC140431.4         50938-51018
            1721-1924           AC140431.4         51241-51444
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.21 cM"
     gene            1..1924
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /note="ovochymase 2"
                     /db_xref="GeneID:244199"
                     /db_xref="MGI:MGI:3045251"
     CDS             1..1830
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /EC_number="3.4.21.120"
                     /note="oviductin"
                     /codon_start=1
                     /product="ovochymase-2 precursor"
                     /protein_id="NP_766496.2"
                     /db_xref="CCDS:CCDS21692.1"
                     /db_xref="GeneID:244199"
                     /db_xref="MGI:MGI:3045251"
                     /translation="MPISKDKLILILGMVCLEQGHSETLSSIRNPDCGQSLVKPQPQN
                     YFSLFSRIVGGSQVEKGSYPWQVSLKQKQKHICGGTIISSQWVITAAHCMANRNIALT
                     LNVTAGEHDLSQAEPGEQTLAIETIIIHPQFSTRKPMIYDIALLKMAGTFQFGQFVRP
                     VCLPEPGEHFNAGFICTTAGWGRLSEGGRLPQVLQQVNLPILTQEECEAVLLTLKNPI
                     TGKTFLCTGSPDGGRDACQGDSGGSLMCQNRKGAWTLAGVTSWGLGCGRSWRNNARKK
                     EQGSPGIFTDLRRVLPWILKHIQTGHRRKSTKALCSEPDGLISGSEGELHFPESLHLY
                     YESKQLCVWTFLVPEDMHMLLNLSHLDIESCHHNYLAMYSLEDRLVGKFCGENLPSSI
                     LIGSSSIRLRFISDATDYATGFNLTYKALKPRYHPDSGCRSLTILFEEGTIQSLHYPE
                     DYSNMASCTWIFQAPNYCLIKLSFQSLEIEENGDCSSDYVTVHSDVEKEKEIARFCDY
                     VIPSPVLSSSSVMLISFQSDENGTARGFQADISFISRADLNISISEDESVPLETWDLP
                     PGAMEIFDAERDTHTKPPYEEDIGEMPAIDSGLLKQGERRGKH"
     exon            1..88
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            89..198
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            199..290
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            291..463
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            464..559
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            560..711
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            712..901
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            902..925
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1016
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1141
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1282
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1413
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1507
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1639
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1720
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1924
                     /gene="Ovch2"
                     /gene_synonym="9230106D23Rik; Ovtn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcctatca gcaaggacaa gctgatttta atattaggaa tggtctgctt ggaacaaggt
       61 cattctgaaa ccctttcctc cataagaaat cctgactgtg ggcagagttt ggttaagccc
      121 caacctcaga attactttag ccttttcagt cgcattgttg gaggaagcca ggtggaaaag
      181 ggttcctatc cttggcaagt gtctctgaaa caaaagcaga agcacatctg tggagggacc
      241 atcatctctt cacagtgggt catcacagcc gctcattgca tggctaacag aaacattgca
      301 ttaactttga atgtaactgc tggagaacat gacttgagcc aagccgagcc aggagagcaa
      361 acacttgcca ttgaaaccat catcatacac ccgcagttct ccaccagaaa acctatgatc
      421 tatgatatag cccttctgaa gatggctgga accttccaat ttggacagtt tgtgaggcct
      481 gtgtgtcttc cagagccagg agaacacttt aatgctggat ttatttgtac aactgcaggc
      541 tggggtcgct tgtccgaagg tggcaggctc ccacaagtct tgcagcaggt aaacctgcca
      601 attttgactc aggaggaatg tgaggccgtt ctgttgacct taaagaatcc cattactggg
      661 aagacctttc tctgcacagg atcccctgat ggagggagag atgcttgtca gggagattca
      721 ggagggtcac ttatgtgcca gaataggaaa ggggcctgga ctctggctgg agtgacttct
      781 tggggtttgg gctgtggtcg aagctggaga aacaatgcaa gaaagaaaga gcaaggatct
      841 cctggaatct tcacagatct taggagagtg cttccctgga tcctcaaaca tatccagact
      901 ggccatcgaa ggaagagcac caaagcttta tgcagtgagc ctgatggtct catcagtggg
      961 tctgagggag agctgcactt cccagaaagc ctccacctgt actatgagag caagcaactg
     1021 tgtgtctgga ccttcctggt tccagaggac atgcatatgt tgctcaattt gtcacacttg
     1081 gatatagagt cttgtcacca caattacctg gcaatgtact ctttagaaga cagactcgtt
     1141 gggaaattct gtggagaaaa tctcccttca tccattctca ttggctccag ttccatccgg
     1201 ctgaggttca tctctgatgc cacagattat gccactgggt ttaatctcac ctataaagca
     1261 cttaagccga gataccatcc tgattccggc tgcaggtctc taactatcct ctttgaagaa
     1321 ggcactatac agagtcttca ctatcctgaa gactacagta acatggctag ctgtacctgg
     1381 atttttcaag cccccaacta ttgcctaatt aagctgtcat ttcagagcct agaaatagaa
     1441 gaaaatggag actgctcctc tgactatgtg actgtacaca gtgatgtcga gaaggagaag
     1501 gaaatagctc ggttctgcga ctatgtgata cccagccctg tgctgagttc ctccagtgtg
     1561 atgctcatca gcttccaatc agatgaaaat ggcactgcca ggggcttcca ggctgacatt
     1621 tccttcattt ctagagcaga tttaaatatc tccatatcag aggatgaatc agtgcctctg
     1681 gagacatggg acctaccacc tggagcaatg gaaattttcg atgcagagag agacacacat
     1741 acaaaaccac catacgaaga agacatcggg gagatgccag ctattgacag tggtcttctg
     1801 aagcaagggg agaggcgtgg aaagcattga gaagcattgc aacgctcaga aagaatcaac
     1861 ctgctgacac actggccttt gccctctttc ctccagaaat gtgagacaat aaatctctgc
     1921 tatt
//
