LOCUS       NM_011023               2842 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus orthodenticle homeobox 1 (Otx1), mRNA.
ACCESSION   NM_011023
VERSION     NM_011023.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2842)
  AUTHORS   de Lope,C., Garcia-Lucena,R., Magarinos,M., Leon,Y.,
            Casa-Rodriguez,N., Contreras,N., Escudero-Iriarte,C.,
            Varela-Nieto,I., Maire,P. and Palmero,I.
  TITLE     Dysfunction of programmed embryo senescence is linked to genetic
            developmental defects
  JOURNAL   Development 150 (9) (2023)
   PUBMED   37017267
REFERENCE   2  (bases 1 to 2842)
  AUTHORS   Qiu,T., Huteckova,B., Seppala,M., Cobourne,M.T., Chen,Z.,
            Hovorakova,M., Buchtova,M. and Tucker,A.S.
  TITLE     Molecular profiling of the vestibular lamina highlights a key role
            for Hedgehog signalling
  JOURNAL   Development 150 (7) (2023)
   PUBMED   36971701
REFERENCE   3  (bases 1 to 2842)
  AUTHORS   Song,H. and Morrow,B.E.
  TITLE     Tbx2 and Tbx3 regulate cell fate progression of the otic vesicle
            for inner ear development
  JOURNAL   Dev Biol 494, 71-84 (2023)
   PUBMED   36521641
REFERENCE   4  (bases 1 to 2842)
  AUTHORS   Du,H., Wang,Z., Guo,R., Yang,L., Liu,G., Zhang,Z., Xu,Z., Tian,Y.,
            Yang,Z., Li,X. and Chen,B.
  TITLE     Transcription factors Bcl11a and Bcl11b are required for the
            production and differentiation of cortical projection neurons
  JOURNAL   Cereb Cortex 32 (17), 3611-3632 (2022)
   PUBMED   34963132
REFERENCE   5  (bases 1 to 2842)
  AUTHORS   Balasubramanian,R., Min,X., Quinn,P.M.J., Giudice,Q.L., Tao,C.,
            Polanco,K., Makrides,N., Peregrin,J., Bouaziz,M., Mao,Y., Wang,Q.,
            da Costa,B.L., Buenaventura,D., Wang,F., Ma,L., Tsang,S.H.,
            Fabre,P.J. and Zhang,X.
  TITLE     Phase transition specified by a binary code patterns the vertebrate
            eye cup
  JOURNAL   Sci Adv 7 (46), eabj9846 (2021)
   PUBMED   34757798
REFERENCE   6  (bases 1 to 2842)
  AUTHORS   Acampora,D., Mazan,S., Lallemand,Y., Avantaggiato,V., Maury,M.,
            Simeone,A. and Brulet,P.
  TITLE     Forebrain and midbrain regions are deleted in Otx2-/- mutants due
            to a defective anterior neuroectoderm specification during
            gastrulation
  JOURNAL   Development 121 (10), 3279-3290 (1995)
   PUBMED   7588062
REFERENCE   7  (bases 1 to 2842)
  AUTHORS   Zeitlin,S., Liu,J.P., Chapman,D.L., Papaioannou,V.E. and
            Efstratiadis,A.
  TITLE     Increased apoptosis and early embryonic lethality in mice
            nullizygous for the Huntington's disease gene homologue
  JOURNAL   Nat Genet 11 (2), 155-163 (1995)
   PUBMED   7550343
REFERENCE   8  (bases 1 to 2842)
  AUTHORS   Avantaggiato,V., Pandolfi,P.P., Ruthardt,M., Hawe,N., Acampora,D.,
            Pelicci,P.G. and Simeone,A.
  TITLE     Developmental analysis of murine Promyelocyte Leukemia Zinc Finger
            (PLZF) gene expression: implications for the neuromeric model of
            the forebrain organization
  JOURNAL   J Neurosci 15 (7 Pt 1), 4927-4942 (1995)
   PUBMED   7623123
REFERENCE   9  (bases 1 to 2842)
  AUTHORS   Leussink,B., Brouwer,A., el Khattabi,M., Poelmann,R.E.,
            Gittenberger-de Groot,A.C. and Meijlink,F.
  TITLE     Expression patterns of the paired-related homeobox genes MHox/Prx1
            and S8/Prx2 suggest roles in development of the heart and the
            forebrain
  JOURNAL   Mech Dev 52 (1), 51-64 (1995)
   PUBMED   7577675
REFERENCE   10 (bases 1 to 2842)
  AUTHORS   Simeone,A., Acampora,D., Gulisano,M., Stornaiuolo,A. and
            Boncinelli,E.
  TITLE     Nested expression domains of four homeobox genes in developing
            rostral brain
  JOURNAL   Nature 358 (6388), 687-690 (1992)
   PUBMED   1353865
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Norman Iscove. The reference sequence was
            derived from BB652255.1, BC057105.1 and BC058354.1.
            
            On Sep 29, 2005 this sequence version replaced NM_011023.2.
            
            Summary: This gene encodes a member of the bicoid subfamily of the
            paired homeobox transcription factor family. The encoded protein is
            critical to the maintenance and regionalization of the forebrain
            and midbrain during development. It may also have important
            functions in sense organ development, pituitary function, and in
            the regulation of blood cell production. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042975.1, AK083671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                BB652255.1         59-148
            91-2814             BC057105.1         1-2724
            2815-2842           BC058354.1         2683-2710
FEATURES             Location/Qualifiers
     source          1..2842
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 14.1 cM"
     gene            1..2842
                     /gene="Otx1"
                     /gene_synonym="A730044F23Rik; jv"
                     /note="orthodenticle homeobox 1"
                     /db_xref="GeneID:18423"
                     /db_xref="MGI:MGI:97450"
     exon            1..104
                     /gene="Otx1"
                     /gene_synonym="A730044F23Rik; jv"
                     /inference="alignment:Splign:2.1.0"
     exon            105..172
                     /gene="Otx1"
                     /gene_synonym="A730044F23Rik; jv"
                     /inference="alignment:Splign:2.1.0"
     exon            173..378
                     /gene="Otx1"
                     /gene_synonym="A730044F23Rik; jv"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1349
                     /gene="Otx1"
                     /gene_synonym="A730044F23Rik; jv"
                     /note="orthodenticle homolog 1"
                     /codon_start=1
                     /product="homeobox protein OTX1"
                     /protein_id="NP_035153.1"
                     /db_xref="CCDS:CCDS24468.1"
                     /db_xref="GeneID:18423"
                     /db_xref="MGI:MGI:97450"
                     /translation="MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTT
                     FTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGNG
                     TKTRPVKKKSSPVRESSGSESSGQFTPPAVSSSASSSSSASSASANPAAAAAAGLGGN
                     PVAAASSLSTPTASSIWSPASISPGSAPTSVSVPEPLAAPSNASCMQRSVAAGAATAA
                     ASYPMSYGQGGSYGQGYPAPSSSYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHH
                     HHHPHAHHPLSQSSGHHHHHHHHHHHQGYGGSGLAFNSADCLDYKEPAAAAASSAWKL
                     NFNSPDCLDYKDQASWRFQVL"
     exon            379..530
                     /gene="Otx1"
                     /gene_synonym="A730044F23Rik; jv"
                     /inference="alignment:Splign:2.1.0"
     exon            531..2825
                     /gene="Otx1"
                     /gene_synonym="A730044F23Rik; jv"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2796..2801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otx1"
                     /gene_synonym="A730044F23Rik; jv"
                     /note="hexamer: AATAAA"
     polyA_site      2817
                     /gene="Otx1"
                     /gene_synonym="A730044F23Rik; jv"
                     /note="major polyA site"
ORIGIN      
        1 tcgcgttcac atacccgggg agggcagtag aaaggtgatc aatcttcatc aggctacatt
       61 tccaatcacc taaacaaccg agcaagacaa gccactccga caaggttggc tgccggcgag
      121 tctcggtgaa ggcgagaggt agatggtgaa aagccgcgac tgcggagggc aggccaggcc
      181 cccagaagca acagcttgaa ggacttcgca gtgggagccc tgaactgctc ctggcctcag
      241 gccccctgga tccgtcgggg cacctccacc cggctgttag catgatgtct tacctcaaac
      301 aacccccata cggcatgaac gggctgggcc tagctggccc tgccatggac ctcctgcacc
      361 cctccgtggg ctaccctgcc accccgcgga agcagcgacg ggagcgcacc accttcacgc
      421 gctcacagct ggacgtgctc gaggcgctgt tcgcaaagac tcgctaccca gacatcttca
      481 tgcgcgagga ggtggcactc aagatcaacc tgccagagtc cagagtccag gtttggttca
      541 agaaccgccg cgccaagtgc cgccagcagc agcagagcgg gaatggaacg aaaacccggc
      601 cggtcaagaa gaagtcgtct ccagtacgcg agagctcggg ttcagagagc agcggccagt
      661 tcacgccgcc cgccgtatct agctctgctt cttcgtctag ctcagcgtcc agtgcctccg
      721 ccaaccccgc ggctgctgcg gccgcgggcc tgggtgggaa cccagtggca gcagcgtcct
      781 ctctgagcac gcctactgct tcgtccatct ggagcccggc ctccatctcg ccgggctcag
      841 cgccgacatc cgtatcggtg ccagagccac tggccgctcc gagcaacgcc tcgtgcatgc
      901 agcgctcggt agccgcaggt gcggccactg ccgcagcctc ctaccctatg tcctatggcc
      961 agggcggaag ctatggtcag ggataccccg cgccctcctc ttcttacttt ggcggtgtag
     1021 actgcagctc ctacctagcg cccatgcact ctcatcacca cccgcaccag cttagcccca
     1081 tggcaccctc ctccatggct ggccatcatc accatcaccc tcatgcgcac cacccactga
     1141 gccaatcttc aggccaccac caccaccatc accaccacca ccaccaccaa ggttatggag
     1201 gctctgggct cgccttcaat tctgccgatt gcttggatta caaggagccc gccgccgccg
     1261 ctgcttcctc tgcctggaaa ctcaatttca actctcccga ctgtctggac tataaggacc
     1321 aagcctcgtg gcggttccag gtcttgtgag cccaggaggg aaaggaagtg gagaagaaac
     1381 gcaactacct ataccctcca tggtccccat cctgttgctg ctgctgcacc acccgccttt
     1441 gccttggctt ttccaaaact taattttcag tcccccaaaa gatattcatt gcctgcactg
     1501 ccgctcccat ctgtgtgcca cttggttggg ggtggaggat gcagcccttc tcccccttgg
     1561 aggtggggcc cggtgctccc acttggccct ccgtttcttc ccggaatagc agtacgctct
     1621 cgctctcagc tcgtgcgtca ccccttcaag tctttctgga cagcttttat gcacctggag
     1681 ccttctgggg ctcttcgctc tgaccctctg ttttgagctc aaccgtttta tttattcttt
     1741 ctggacactg aagtcactaa ctggcgtata tcaaccgttt ggagtgtgtc catacataca
     1801 cactcctaat caaaccctcc actgtttctc ctagcagact gtcgcccctt cagctgccct
     1861 tgatctagct ccccacccgc aggcccgagc ttccagcatt tctgtctcac cagtggtgag
     1921 cgttgggcca ggctcgcggc aggagtgtgc cccagcctcc tttcctaccc tgcgctggac
     1981 tgattcaagc ttccgcctca gcgggaatgc tgtacatagt caggtccgtt ccagggacca
     2041 cttaaagttt ttagttgctg ttggttgaac tgagcatctc tcttgtttta gcgtccaaga
     2101 aacagaactt taaaatatat acatcacata tatatatata tatatacaca cgcacacaca
     2161 cacatatata tataacagaa gcaaaaaaat tatttcccct ttgttcccgt tcctctcttc
     2221 ctcaaacgat ggtggttctt atttttcagt tattacaaag ctgtcctgcc ctcttcacac
     2281 ctccctttgt gtatttatta aagaaacccg cttggttcca ggaagctggg cgctagagga
     2341 tcggaagtga aggaaacagc taagtcagga tacaggggtc ggggctaggc tggtcagggc
     2401 gcacgactga cccttcgcca gtctaagcac agtatcaaag cttccgctta gaaacaaaca
     2461 gacaaacaaa caaggtgaaa ttacagcatt gtggaaagaa aaccaagccc gagttccagg
     2521 tccaatgttt ctctctctct ctctctctct ctctctctct ctctctctct ctctctcaaa
     2581 caccctgtct gttctgtgag tttttagtga accttccttc tccgaaatct gcggagagta
     2641 cctgtgtacc tatcggtttt ggttttggcc gcttggttca gtaggtggga aagtaatttg
     2701 taaatttgat ttgtccgatg tgaagatcac aaattacttg ttgagatgta aggcagtccg
     2761 tctcctcttc ctctttatct acattatttc ccgaaaataa aagcaaatta atgagtggct
     2821 tgtcaaaaaa aaaaaaaaaa aa
//
