LOCUS       NM_001242423            2985 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus OTU deubiquitinase with linear linkage specificity
            like (Otulinl), transcript variant 1, mRNA.
ACCESSION   NM_001242423
VERSION     NM_001242423.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2985)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   2  (bases 1 to 2985)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158955.2.
            
            On Jan 13, 2023 this sequence version replaced NM_001242423.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152590.1, AK152120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC158955.2         246532-246679       c
            149-308             AC158955.2         229789-229948       c
            309-340             AC158955.2         229672-229703       c
            341-432             AC158955.2         229479-229570       c
            433-582             AC158955.2         227474-227623       c
            583-711             AC158955.2         225025-225153       c
            712-981             AC158955.2         223180-223449       c
            982-2985            AC158955.2         220203-222206       c
FEATURES             Location/Qualifiers
     source          1..2985
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 10.35 cM"
     gene            1..2985
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
                     /note="OTU deubiquitinase with linear linkage specificity
                     like"
                     /db_xref="GeneID:223433"
                     /db_xref="MGI:MGI:2687281"
     exon            1..148
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1155
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM105A; inactive ubiquitin thioesterase FAM105A;
                     family with sequence similarity 105, member A; inactive
                     ubiquitin thioesterase OTULINL"
                     /codon_start=1
                     /product="inactive ubiquitin thioesterase OTULINL isoform
                     1"
                     /protein_id="NP_001229352.1"
                     /db_xref="CCDS:CCDS88743.1"
                     /db_xref="GeneID:223433"
                     /db_xref="MGI:MGI:2687281"
                     /translation="MEAPRSAPRERERARTTSGSDQVHSWILVTSQVLSAAWRIARAF
                     VMTTLSPLSATFSYFRSLYLYLGHQLKWWIGYLQRKFKRNLSVEAEVDLLSYCAREWK
                     GEAPRARLMRKAYEELFWRHHIKCVRAVKRDNYDALRSVLFQIFSQGLSFPSWMKEKD
                     IVKLPEKLLFSQGCNWIQQYSFGPEKYTGSNVFGKLRKCVELLKLQWTEFSGMRDHHK
                     RGSMCNSLFSDAILECKLYEALKFLMLYQVTEAYEQMKTNKVIPSLFRLLFSRESSPD
                     PLSFMMNHLNSIGDTCGLDQIDMFILGYSLQVKIKVFRLFKFNSRDFAVCYPEEPLRE
                     WPEISLLTENGHHYHIPVF"
     exon            149..308
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
                     /inference="alignment:Splign:2.1.0"
     exon            309..340
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
                     /inference="alignment:Splign:2.1.0"
     exon            341..432
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
                     /inference="alignment:Splign:2.1.0"
     exon            433..582
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
                     /inference="alignment:Splign:2.1.0"
     exon            583..711
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
                     /inference="alignment:Splign:2.1.0"
     exon            712..981
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
                     /inference="alignment:Splign:2.1.0"
     exon            982..2985
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1763..1768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
                     /note="hexamer: AATAAA"
     polyA_site      1783
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
                     /note="major polyA site"
     regulatory      2773..2778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
                     /note="hexamer: AATAAA"
     polyA_site      2802
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
     regulatory      2963..2968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
                     /note="hexamer: AATAAA"
     polyA_site      2985
                     /gene="Otulinl"
                     /gene_synonym="9830126M18; Fam105a"
ORIGIN      
        1 acagtagctg agctcgggac tgcggctgcg gagaagcgag cggggcgccg ggctgtagcg
       61 gagggtgcgc gcgggtggag gcgcgcatcc cgcatggagg cgccgaggag cgcgccgcgg
      121 gagcgggagc gcgctcggac cacctcagga agtgaccaag ttcactcctg gatactagtt
      181 acaagccaag tccttagtgc tgcctggaga atagcaaggg cctttgtgat gacgacgctc
      241 tctcctctgt ccgctacctt cagctacttc agaagcctgt atttatactt agggcatcag
      301 ctgaaatggt ggatcggcta tctacagaga aagttcaaaa gaaacctcag tgtggaggca
      361 gaagtagatt tactcagtta ttgtgcaaga gagtggaagg gagaagcccc gcgtgccaga
      421 ctgatgcgga aggcctatga ggaattgttc tggaggcacc atattaaatg tgttcgagca
      481 gtcaagagag ataactacga tgctctcaga tctgtgttgt tccagatctt cagccaaggc
      541 ctctccttcc catcatggat gaaggaaaaa gacatcgtta agcttcctga aaaactactc
      601 ttttctcaag gctgtaactg gatccagcag tacagtttcg ggcctgagaa gtacacaggt
      661 tccaatgtgt ttggaaagtt acggaaatgt gtggagttac tgaaactgca gtggactgag
      721 tttagtggga tgagagatca ccacaagaga gggagcatgt gtaacagcct cttctccgac
      781 gccatcctgg agtgtaaact gtacgaagct ttgaagttcc tcatgctcta ccaggtcacg
      841 gaagcgtatg agcaaatgaa gaccaacaag gttatcccca gccttttcag actcctgttt
      901 tcccgggagt catcgccgga tcctttgagc ttcatgatga atcacctgaa ttccataggc
      961 gacacttgtg gtttggatca gattgacatg tttatactcg ggtattctct tcaagtaaag
     1021 ataaaagtgt ttcgactgtt caagtttaac tccagagact ttgcagtctg ctaccccgag
     1081 gagcctctca gggagtggcc agagatctcc ctactgactg agaatggcca ccactaccac
     1141 attcccgtct tttaagtctg ccgtggactg gacatcagtt cttctcagag acagtgggca
     1201 cacgtgcaga aaagcacttc taaaagaccc acagtggtgc ttcagccaag gagggcatcg
     1261 agatgggtgg agagagacgg gtggttcgcc ttctgtttga gtgaggttct ccaatgcagc
     1321 acacatctgt gcactgactt tgccattgag ggatcctctg ggttgggtct ttaagacgaa
     1381 gggaaactta atatggacaa aaattggaag ggacacaacc tgagcagtgg ggattgtttt
     1441 atctcggatc ttcatgttct tcagtaagaa tctctctgtg gatttggaac aatcgtaaat
     1501 aaacagggcc aagttttaca agcattaccc tcctgggggg agggggtctt tgttgtttac
     1561 taattatcca gaacagcctg attaatgtta aaatactgtg tgtgtttatg tacatttgtg
     1621 tgtattatag acacacaaat gtatgtattt gtatatgcgc atacaccgca aacaacctct
     1681 ggtttgtaat attgtacagt ttctttatat gtctacagct tttggtattc ttgtatctgt
     1741 ccagcttaaa tcaatttatt taaataaaag aagataaatt gtatggattt gggcaactgt
     1801 ataatttttg agctgccata aaaatattaa gctatgcttt aatttaatct atatttacaa
     1861 atccatttaa tgaatagaat cttgtgatta gcttagtaaa attccagata cagatgtgtt
     1921 tgcgtcattg ccccagaatc ccagaagaca ttgattaaag agaatttgtg tcacctcctc
     1981 gacccctaaa caaaacatga caagtacagg cttaaattca aacccgtatt cctagagctg
     2041 tggttctcaa cctgtgggtc tggaccccct taggggttcc cttatcagat atcctacata
     2101 tcagatgttt attacaattc ctaagattag cgatattaga gttatgaagt agcaagggaa
     2161 taactttatg gttgggggtc cccacaacag gagtccatgc acttggtcta caggtggccc
     2221 tggtgtgatg aaagcctgta aagatggaag agaaaccaaa cctcagaaga taaaggactg
     2281 catgcgcagc tggcaatcct gttcatgtcc tttataaact ggtccattct gtgtgtgatc
     2341 tgaagcatgc tcaagaatct catctggcta taaagggttt ccgttgaatt aatcgtgagc
     2401 cttgagtaca ggatacttgc ctggatttct actctcacag aacatttcca gaaggaaata
     2461 agttttccat tgacttgttc aagaattcag caatgaaaac acttcgccga tgataagtga
     2521 tgacgttatt ccgtaagttg tcatacttta tcatgtgtat gcaatcactc aaaaagtttt
     2581 ggatgagaaa atgatcccaa ttagaggaaa caagatggtt gtttaagtgg aaacctggca
     2641 tatagttgtt aaatccatga atgagctagt atagcagata ttgtgtttcc taggaaggtg
     2701 ctcaaaaaat gtacatagta agtcagccag ggcttccatg tcatgtggaa attctaagaa
     2761 gaacaaaact ataataaaat catcattttt ggaaaacttc aacaggtttc agttagccag
     2821 tcacatgcct gttccgagag gatggctgtg gcccgggacc tgtccgtggt gctgaaaagg
     2881 cgatgccaca gatgttcaag gatgccctga aactgtgaac caggttttct tccaggtttc
     2941 tgtttccaat ggcagcgcta gtaataaaaa ttattatttt ataga
//
