LOCUS       NM_001013792            1505 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus OTU deubiquitinase with linear linkage specificity
            (Otulin), transcript variant 1, mRNA.
ACCESSION   NM_001013792 XM_484453
VERSION     NM_001013792.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1505)
  AUTHORS   Staels,F., Bucken,L., De Vuyst,L., Willemsen,M., Van
            Nieuwenhove,E., Gerbaux,M., Neumann,J., Malviya,V., Van
            Meerbeeck,L., Haughton,J., Seldeslachts,L., Gouwy,M., Martinod,K.,
            Vande Velde,G., Proost,P., Yshii,L., Schlenner,S., Schrijvers,R.,
            Liston,A. and Humblet-Baron,S.
  TITLE     OTULIN haploinsufficiency predisposes to environmentally directed
            inflammation
  JOURNAL   Front Immunol 15, 983686 (2024)
   PUBMED   38827742
  REMARK    GeneRIF: OTULIN haploinsufficiency predisposes to environmentally
            directed inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1505)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1505)
  AUTHORS   Doglio,M.G., Verboom,L., Ruilova Sosoranga,E., Frising,U.C.,
            Asaoka,T., Gansemans,Y., Van Nieuwerburgh,F., van Loo,G. and
            Wullaert,A.
  TITLE     Myeloid OTULIN deficiency couples RIPK3-dependent cell death to
            Nlrp3 inflammasome activation and IL-1beta secretion
  JOURNAL   Sci Immunol 8 (89), eadf4404 (2023)
   PUBMED   38000038
REFERENCE   4  (bases 1 to 1505)
  AUTHORS   Verboom,L., Anderson,C.J., Jans,M., Petta,I., Blancke,G.,
            Martens,A., Sze,M., Hochepied,T., Ravichandran,K.S., Vereecke,L.
            and van Loo,G.
  TITLE     OTULIN protects the intestinal epithelium from apoptosis during
            inflammation and infection
  JOURNAL   Cell Death Dis 14 (8), 534 (2023)
   PUBMED   37598207
  REMARK    GeneRIF: OTULIN protects the intestinal epithelium from apoptosis
            during inflammation and infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1505)
  AUTHORS   Almeida,S.M., Ivantsiv,S., Niibori,R., Dunham,W.H., Green,B.A.,
            Zhao,L., Gingras,A.C. and Cordes,S.P.
  TITLE     An interaction between OTULIN and SCRIB uncovers roles for linear
            ubiquitination in planar cell polarity
  JOURNAL   Dis Model Mech 16 (8) (2023)
   PUBMED   37589075
REFERENCE   6  (bases 1 to 1505)
  AUTHORS   van Wijk,S.J.L., Fricke,F., Herhaus,L., Gupta,J., Hotte,K.,
            Pampaloni,F., Grumati,P., Kaulich,M., Sou,Y.S., Komatsu,M.,
            Greten,F.R., Fulda,S., Heilemann,M. and Dikic,I.
  TITLE     Linear ubiquitination of cytosolic Salmonella Typhimurium activates
            NF-kappaB and restricts bacterial proliferation
  JOURNAL   Nat Microbiol 2, 17066 (2017)
   PUBMED   28481361
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1505)
  AUTHORS   Damgaard,R.B., Walker,J.A., Marco-Casanova,P., Morgan,N.V.,
            Titheradge,H.L., Elliott,P.R., McHale,D., Maher,E.R.,
            McKenzie,A.N.J. and Komander,D.
  TITLE     The Deubiquitinase OTULIN Is an Essential Negative Regulator of
            Inflammation and Autoimmunity
  JOURNAL   Cell 166 (5), 1215-1230 (2016)
   PUBMED   27523608
REFERENCE   8  (bases 1 to 1505)
  AUTHORS   Takiuchi,T., Nakagawa,T., Tamiya,H., Fujita,H., Sasaki,Y.,
            Saeki,Y., Takeda,H., Sawasaki,T., Buchberger,A., Kimura,T. and
            Iwai,K.
  TITLE     Suppression of LUBAC-mediated linear ubiquitination by a specific
            interaction between LUBAC and the deubiquitinases CYLD and OTULIN
  JOURNAL   Genes Cells 19 (3), 254-272 (2014)
   PUBMED   24461064
REFERENCE   9  (bases 1 to 1505)
  AUTHORS   Rivkin,E., Almeida,S.M., Ceccarelli,D.F., Juang,Y.C., MacLean,T.A.,
            Srikumar,T., Huang,H., Dunham,W.H., Fukumura,R., Xie,G., Gondo,Y.,
            Raught,B., Gingras,A.C., Sicheri,F. and Cordes,S.P.
  TITLE     The linear ubiquitin-specific deubiquitinase gumby regulates
            angiogenesis
  JOURNAL   Nature 498 (7454), 318-324 (2013)
   PUBMED   23708998
  REMARK    GeneRIF: two distinct mutations in the (uro)chordate-specific gumby
            (also called Fam105b) gene cause an embryonic angiogenic phenotype
            in gumby mice
REFERENCE   10 (bases 1 to 1505)
  AUTHORS   Mar,L., Rivkin,E., Kim,D.Y., Yu,J.Y. and Cordes,S.P.
  TITLE     A genetic screen for mutations that affect cranial nerve
            development in the mouse
  JOURNAL   J Neurosci 25 (50), 11787-11795 (2005)
   PUBMED   16354937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158955.2.
            
            On Jan 11, 2023 this sequence version replaced NM_001013792.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150371.1, SRR13422591.374997.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AC158955.2         195593-195842       c
            251-327             AC158955.2         188417-188493       c
            328-422             AC158955.2         184664-184758       c
            423-566             AC158955.2         181459-181602       c
            567-692             AC158955.2         176647-176772       c
            693-962             AC158955.2         173727-173996       c
            963-1505            AC158955.2         171054-171596       c
FEATURES             Location/Qualifiers
     source          1..1505
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 10.31 cM"
     gene            1..1505
                     /gene="Otulin"
                     /gene_synonym="Fam105b; m3Sapc; m7-1Sapc"
                     /note="OTU deubiquitinase with linear linkage specificity"
                     /db_xref="GeneID:432940"
                     /db_xref="MGI:MGI:3577015"
     exon            1..250
                     /gene="Otulin"
                     /gene_synonym="Fam105b; m3Sapc; m7-1Sapc"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1157
                     /gene="Otulin"
                     /gene_synonym="Fam105b; m3Sapc; m7-1Sapc"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM105B; gumby; ubiquitin thioesterase Gumby;
                     deubiquitinating enzyme otulin; OTU domain-containing
                     deubiquitinase with linear linkage specificity; ubiquitin
                     thioesterase otulin; family with sequence similarity 105,
                     member B"
                     /codon_start=1
                     /product="ubiquitin thioesterase otulin isoform 1"
                     /protein_id="NP_001013814.2"
                     /db_xref="CCDS:CCDS49586.1"
                     /db_xref="GeneID:432940"
                     /db_xref="MGI:MGI:3577015"
                     /translation="MSRGTMPQPGAWPGASCAETPAREAGAAARDGGKVTAGAQPRAA
                     TRCPAEHEEDMYRAADEIEKEKELLIHERGISEPRLSVAPEMDIMDYCKKEWRGNTQK
                     ATCMKKGYEEVSQKFTSIRRVRGDNYCALRATLFQAMSQLAELPPWLQDLELILLPEK
                     LINKYTWIKQWKLGLKFDGKSEDLVEKIKESLALLRKKWVSLAAMKTAEARQTACDEL
                     FTNEEEEYSLYEAVKFLMLNRAIELYDDKEKGKEVPFFSVLLFARDTSNDPEQLLRNH
                     LNQVGHTGGLEQVEMFLLAYAVRHSIRVYRLSKYNTEEFITVYPTDPPKDWPMVTLIA
                     EDDRHYNIPVRVCEETSV"
     exon            251..327
                     /gene="Otulin"
                     /gene_synonym="Fam105b; m3Sapc; m7-1Sapc"
                     /inference="alignment:Splign:2.1.0"
     exon            328..422
                     /gene="Otulin"
                     /gene_synonym="Fam105b; m3Sapc; m7-1Sapc"
                     /inference="alignment:Splign:2.1.0"
     exon            423..566
                     /gene="Otulin"
                     /gene_synonym="Fam105b; m3Sapc; m7-1Sapc"
                     /inference="alignment:Splign:2.1.0"
     exon            567..692
                     /gene="Otulin"
                     /gene_synonym="Fam105b; m3Sapc; m7-1Sapc"
                     /inference="alignment:Splign:2.1.0"
     exon            693..962
                     /gene="Otulin"
                     /gene_synonym="Fam105b; m3Sapc; m7-1Sapc"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1505
                     /gene="Otulin"
                     /gene_synonym="Fam105b; m3Sapc; m7-1Sapc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1461..1466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otulin"
                     /gene_synonym="Fam105b; m3Sapc; m7-1Sapc"
                     /note="hexamer: AATGAA"
     polyA_site      1505
                     /gene="Otulin"
                     /gene_synonym="Fam105b; m3Sapc; m7-1Sapc"
                     /note="major polyA site"
ORIGIN      
        1 agtgacgctt acggaagcgc tctgcggacc tcgcggggtg cggggcagcg cagccacggc
       61 tccggacggc gggacggcag ggcccggcgt ggccgcggat gagtcgggga accatgcccc
      121 agcccggagc gtggcccggt gcaagctgcg ccgagacgcc ggcgcgcgag gccggggccg
      181 cggcgcggga cggcgggaag gtgacggccg gcgcgcagcc ccgggccgcg acgcgatgcc
      241 cggccgagca cgaggaggac atgtaccgtg ctgcagatga aatagaaaag gagaaagaat
      301 tgctaataca tgaaagaggg atatcagaac ccaggttaag tgtggctcct gaaatggata
      361 tcatggacta ctgcaaaaaa gaatggagag gaaatactca gaaagccaca tgtatgaaaa
      421 agggctatga ggaagtgtct cagaaattca cttccataag gcgagtccgt ggtgataact
      481 actgtgcact gagggccaca ctgttccagg ccatgagcca gctggccgag ctgcccccct
      541 ggctgcagga cttggagctc atactgttac cagagaagct gataaacaag tatacctgga
      601 tcaagcagtg gaaacttgga ctgaaatttg atgggaagag tgaggacctg gttgaaaaaa
      661 ttaaggaatc ccttgccctg ctaaggaaga agtgggtaag cctggctgca atgaaaactg
      721 ctgaagcgag gcagacagct tgtgatgagc tgttcaccaa cgaagaggag gagtacagcc
      781 tctacgaagc tgtgaagttc ctgatgttaa acagagccat cgaactgtac gatgacaagg
      841 agaagggaaa ggaagtgccg ttcttctctg tgctcttgtt tgcccgagac acatccaatg
      901 accctgaaca gctcctgagg aaccacctaa accaggtggg acacacgggg ggccttgagc
      961 aggttgagat gttccttctt gcctatgctg tccgccacag catccgggtg taccggctgt
     1021 ccaagtataa cacagaggag ttcatcacag tctaccccac tgatcccccc aaggactggc
     1081 caatggtgac cctcatagct gaggatgatc ggcactataa catccctgtc agagtgtgtg
     1141 aggagaccag tgtgtgaggg acacacatgt gactgccaag agatgcgcat gtgcagctcc
     1201 tcctctgggg gcctcagatc tgcaggtctc caaggacaat ctgggagaac tctcgggccc
     1261 ctggagccaa ctttggacca ttatgttctg aagactagct gttgataatg agaattaatt
     1321 agccaagcct tcactccttg ttctgttatg cagtgtgttc cactgggggc ttcagcacgt
     1381 gcctttggaa ggtgcaaact atgtctccat aaggcggatg cttttgggtc aaagaaaact
     1441 gtttggaaag gaatctgtcc aatgaaagtt ctgacggtaa actggtttta cttctctttt
     1501 taaaa
//
