LOCUS       NM_130880               3461 bp    mRNA    linear   ROD 28-MAY-2024
DEFINITION  Mus musculus OTU domain containing 7A (Otud7a), mRNA.
ACCESSION   NM_130880
VERSION     NM_130880.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3461)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3461)
  AUTHORS   Unda,B.K., Chalil,L., Yoon,S., Kilpatrick,S., Irwin,C., Xing,S.,
            Murtaza,N., Cheng,A., Brown,C., Afonso,A., McCready,E., Ronen,G.M.,
            Howe,J., Caye-Eude,A., Verloes,A., Doble,B.W., Faivre,L.,
            Vitobello,A., Scherer,S.W., Lu,Y., Penzes,P. and Singh,K.K.
  TITLE     Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal
            dysfunction in mouse and human models of the 15q13.3 microdeletion
            syndrome
  JOURNAL   Mol Psychiatry 28 (4), 1747-1769 (2023)
   PUBMED   36604605
REFERENCE   3  (bases 1 to 3461)
  AUTHORS   Yin,J., Chen,W., Chao,E.S., Soriano,S., Wang,L., Wang,W.,
            Cummock,S.E., Tao,H., Pang,K., Liu,Z., Pereira,F.A., Samaco,R.C.,
            Zoghbi,H.Y., Xue,M. and Schaaf,C.P.
  TITLE     Otud7a Knockout Mice Recapitulate Many Neurological Features of
            15q13.3 Microdeletion Syndrome
  JOURNAL   Am J Hum Genet 102 (2), 296-308 (2018)
   PUBMED   29395075
  REMARK    GeneRIF: decreased OTUD7A dosage is a major contributor to the
            neurodevelopmental phenotypes associated with 15q13.3 microdeletion
            syndrome
REFERENCE   4  (bases 1 to 3461)
  AUTHORS   Uddin,M., Unda,B.K., Kwan,V., Holzapfel,N.T., White,S.H.,
            Chalil,L., Woodbury-Smith,M., Ho,K.S., Harward,E., Murtaza,N.,
            Dave,B., Pellecchia,G., D'Abate,L., Nalpathamkalam,T.,
            Lamoureux,S., Wei,J., Speevak,M., Stavropoulos,J., Hope,K.J.,
            Doble,B.W., Nielsen,J., Wassman,E.R., Scherer,S.W. and Singh,K.K.
  TITLE     OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3
            Microdeletion Syndrome
  JOURNAL   Am J Hum Genet 102 (2), 278-295 (2018)
   PUBMED   29395074
  REMARK    GeneRIF: OTUD7A is a major regulatory gene for 15q13.3
            microdeletion syndrome phenotypes.
REFERENCE   5  (bases 1 to 3461)
  AUTHORS   Tran,H., Hamada,F., Schwarz-Romond,T. and Bienz,M.
  TITLE     Trabid, a new positive regulator of Wnt-induced transcription with
            preference for binding and cleaving K63-linked ubiquitin chains
  JOURNAL   Genes Dev 22 (4), 528-542 (2008)
   PUBMED   18281465
REFERENCE   6  (bases 1 to 3461)
  AUTHORS   Stefan,M., Claiborn,K.C., Stasiek,E., Chai,J.H., Ohta,T.,
            Longnecker,R., Greally,J.M. and Nicholls,R.D.
  TITLE     Genetic mapping of putative Chrna7 and Luzp2 neuronal
            transcriptional enhancers due to impact of a transgene-insertion
            and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman
            syndromes
  JOURNAL   BMC Genomics 6, 157 (2005)
   PUBMED   16280085
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ430384.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ430384.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849384,
                                           SAMN01164131 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3461
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 34.52 cM"
     gene            1..3461
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /note="OTU domain containing 7A"
                     /db_xref="GeneID:170711"
                     /db_xref="MGI:MGI:2158505"
     exon            1..156
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /inference="alignment:Splign:2.1.0"
     exon            157..286
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /inference="alignment:Splign:2.1.0"
     exon            287..380
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /inference="alignment:Splign:2.1.0"
     exon            381..535
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..3165
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /EC_number="3.4.19.12"
                     /note="zinc finger protein Cezanne 2; Cezanne 2 protein"
                     /codon_start=1
                     /product="OTU domain-containing protein 7A"
                     /protein_id="NP_570950.1"
                     /db_xref="CCDS:CCDS21330.1"
                     /db_xref="GeneID:170711"
                     /db_xref="MGI:MGI:2158505"
                     /translation="MVSSLLPNPPSAECWAALLHDPMTLDMDAVLSDFVRSTGAEPGL
                     ARDLLEGKNWDLTAALSDYEQLRQVHTANLPHVFNEGRCAKQAERELPQPGHKVERPC
                     LQRQDDIAQAEKRLSRGISHASSAIVSLARSHVANECNNEQFPLEMPIYTFQLPDLSV
                     YSEDFRSFIERDLIEQATMVALEQAGRLNWWSTVCTSCKRLLPLATTGDGNCLLHAAS
                     LGMWGFHDRDLVLRKALYTMMRTGAEREALKRRWRWQQTQQNKEEEWEREWTELLKLA
                     SSEPRTHFSKNGSGTGGGVDNSEDPVYESLEEFHVFVLAHILRRPIVVVADTMLRDSG
                     GEAFAPIPFGGIYLPLEVPPNRCHCSPLVLAYDQAHFSALVSMEQRDQQREQAVIPLT
                     DSEHKLLPLHFAVDPGKDWEWGKDDNDNARLANLILSLEAKLNLLHSYMNVTWIRIPS
                     ETRAPLAQPESPTASAGEDVQSLAESLDSDRDSVCSNSNSNNGKNGKDKEKEKQRKDK
                     DKTRADSVANKLGSFSKTLGIKLKKNMGGLGGLVHGKMGRANSANGKNGDSAERNKEK
                     KSKSRKGSKEESGASASTSPSEKTTPSPTDKASGASPADKGSGSRGDAWKYSTDVKLS
                     LNILRAAMQGERKFIFAGLLLTSHRHQFHEEMIGYYLTSAQERFSAEQEQRRRDAAAA
                     AAAATATATVKRPARRPEAEGAPGPERASPGPTAAQPTQLVLKLKERPSPGTGASARA
                     ARAAGGAASPGPGGGARRAAPGTGGPTPGRSPPAPARQSVIHVQAAARDEACAPTVGA
                     LRPCATYPQQNRSLWSQSYSPARSALRTVNTVESLAPGGADAPGPAEHKSQTYSNGFG
                     AARDGLEFADADAPAARSNAECGRGGPGPAQRRCQRENCAFYGRAETEHFCSYCYREE
                     LRRRREARAARP"
     exon            536..718
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /inference="alignment:Splign:2.1.0"
     exon            719..940
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1042
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1170
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1265
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1393
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1543
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1658
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1743
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..3461
                     /gene="Otud7a"
                     /gene_synonym="Otud7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaggaga ggcccgggcg ccgcgcggca gctggggagg gggccgcggc tgggcgcgag
       61 cggaacagct gatctggttt tcccgaagcc agggaagatg gaagtcggct agcggcgact
      121 gcggcgctgc gggcggaccg gcgggctgcg cggcagagtc ctcaggagct gactgggctc
      181 tcgttcttcc cctgtggcag caatgggcca tttccatcag agacggtgcc atgctgaccc
      241 aaatgcctga gtgctactca cctccagaga gtgaggagtc tgaaaagtga cagtgacaga
      301 agaggagacc tttgcggctg aagctgcact gcatgaggcg aaggaagaag gagtctccta
      361 actggtgcca catacatcag atggatggtc tctagcctgc ttccaaaccc gccctcggct
      421 gagtgctggg cagcacttct acatgatcct atgacgcttg atatggacgc agtcctgtca
      481 gactttgttc ggtccacggg ggcagaacct ggtctggcca gagatctgct ggaaggtaaa
      541 aactgggacc tgacagctgc actaagcgac tatgagcaac tgcgacaggt gcacacagcc
      601 aacctgccac atgtgttcaa cgaagggagg tgtgccaagc aggccgagcg agaattgccc
      661 cagcctgggc acaaggtgga gcggccttgc ctgcagaggc aggacgatat tgcccaagca
      721 gagaagcgcc tgtcccgggg gatctcccat gccagctcag ccatcgtctc cctggcccga
      781 tcccacgtgg caaatgagtg caacaatgag cagttcccac tggagatgcc catctataca
      841 ttccagctgc cggacctgag cgtgtacagt gaggacttca ggagcttcat cgaacgggac
      901 ctgatcgagc aggccactat ggtagctctg gagcaagcag gtcgcctgaa ctggtggtct
      961 accgtgtgca cgagctgtaa aaggcttctt cctttggcca caacaggaga tgggaactgc
     1021 ctcttacatg ccgcctcgct aggaatgtgg ggctttcatg accgggacct ggttttgcgg
     1081 aaagctctct acaccatgat gaggacgggt gctgagcggg aagccctgaa gcggaggtgg
     1141 aggtggcagc agacacagca gaacaaggag gaggaatggg agcgagagtg gacagagctg
     1201 ctaaaactgg cctccagcga gcctcgcaca cacttcagca agaatggcag tggcacaggt
     1261 ggtggtgtgg acaactctga ggaccctgta tatgaaagcc tggaagagtt ccatgtcttt
     1321 gtcctcgccc acatactacg gagacccatt gtggtggtgg cagacaccat gctaagagac
     1381 tctggtggag aagcatttgc acccatccca ttcggaggga tctacctgcc cttggaggtg
     1441 cctcccaaca ggtgccactg ctcacccctg gttctggcct acgatcaagc tcacttttca
     1501 gccctagtgt ccatggaaca gagagaccaa cagagagaac aagctgtgat ccctctgacg
     1561 gattcggaac acaagctgct gcccttgcac tttgctgtgg acccgggaaa ggactgggaa
     1621 tgggggaaag atgacaacga caatgcccgg ttagccaacc tcatcctgtc cctagaagcc
     1681 aagctgaacc ttctacacag ctacatgaat gtgacgtgga tccgcatccc ctccgagacc
     1741 cgggctcccc ttgcacagcc agagtctcca acggcctcag caggggagga tgtacagtcc
     1801 ctggcggaat cgctggactc ggaccgcgat tctgtgtgca gcaattccaa cagcaataat
     1861 ggcaagaatg gtaaggacaa agagaaggag aaacagcgca aggacaagga caagacgcgc
     1921 gcggactccg tggccaacaa gctgggcagc ttcagcaaga cgctgggcat caagctaaag
     1981 aaaaacatgg gcgggctagg cggcctggtg cacggtaaga tgggtcgtgc caactctgcc
     2041 aacggcaaaa acggcgacag cgctgagcgc aacaaggaga aaaagtccaa gtcgcgcaag
     2101 ggcagcaagg aggaatcggg agcgtcagcg agcacctcgc cgtcggagaa gaccacgccg
     2161 tcgcccacgg acaaagcgtc gggagcgtcg ccggccgaca aggggagcgg gtcaagaggc
     2221 gatgcctgga agtacagcac ggacgtaaag ctgagcctca acatcctgcg cgccgccatg
     2281 caaggcgagc gcaaattcat cttcgccggc ctgctgctca ccagccaccg gcaccagttt
     2341 cacgaggaga tgatcggcta ctacctgacc agcgcgcagg agcgctttag cgcggagcaa
     2401 gaacagcggc ggcgggacgc cgcggcggct gccgcagcag ccacggccac cgccacggtc
     2461 aagcggccag cgcgcaggcc agaggccgaa ggtgcgccgg gcccggagcg cgcctcgccg
     2521 ggcccgacag ccgcgcagcc cacgcagctg gtgctcaagc tcaaggagcg gccgagcccc
     2581 gggactggag cgagcgcacg ggcggctcgg gcggcgggcg gcgcagcatc cccgggtccg
     2641 ggcggcggcg cgcgacgcgc ggctcccggt acgggcggac cgactcccgg ccgcagcccg
     2701 cccgcgcccg cgcgccagag cgtcatccac gtgcaggcgg cggcccggga cgaggcgtgc
     2761 gcgccgacag tgggcgcgct acggccgtgc gcgacgtacc cgcagcagaa ccgctcgctg
     2821 tggtcgcaga gctacagccc agcgcgcagc gcgctgcgca ccgtcaatac agtggagtcc
     2881 ctggcgcccg gaggagcgga cgccccggga cccgcggagc acaagtcgca gacctacagc
     2941 aacggcttcg gcgcagcccg cgacgggctg gagttcgccg acgccgacgc gccggccgcg
     3001 cgctcgaacg ctgagtgcgg ccgcggaggc ccggggcccg ctcagcggcg ctgccagcgg
     3061 gagaactgcg cgttctacgg gcgcgcggag accgagcact tctgctccta ttgctaccga
     3121 gaggagctgc ggcggcggcg cgaggcgcgc gcggcgcgac cctgagccgt ccaggactgc
     3181 tttttccatc ctgtgggtct ttttttactt gctctggtca gccgaagggc cggcgcctcc
     3241 tcggtcagtg ccgtgtacgt gtttggtcaa acgttcctaa tggtgcctga acctacactg
     3301 atgccactca ggtagtagac ggataggaaa caagtcatac tgttggaagt gggtgtgcta
     3361 gcctagcatc tgcctcgtac ctgtggaaac tcaatagcca ttgcaagagt atttttgttc
     3421 ctctatacga gaaataaaga aaatcgcagc cctttgtttt t
//
