LOCUS       NM_152812               3087 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus OTU domain containing 6B (Otud6b), transcript variant
            1, mRNA.
ACCESSION   NM_152812
VERSION     NM_152812.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3087)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3087)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3087)
  AUTHORS   Santiago-Sim,T., Burrage,L.C., Ebstein,F., Tokita,M.J., Miller,M.,
            Bi,W., Braxton,A.A., Rosenfeld,J.A., Shahrour,M., Lehmann,A.,
            Cogne,B., Kury,S., Besnard,T., Isidor,B., Bezieau,S., Hazart,I.,
            Nagakura,H., Immken,L.L., Littlejohn,R.O., Roeder,E., Kara,B.,
            Hardies,K., Weckhuysen,S., May,P., Lemke,J.R., Elpeleg,O.,
            Abu-Libdeh,B., James,K.N., Silhavy,J.L., Issa,M.Y., Zaki,M.S.,
            Gleeson,J.G., Seavitt,J.R., Dickinson,M.E., Ljungberg,M.C.,
            Wells,S., Johnson,S.J., Teboul,L., Eng,C.M., Yang,Y.,
            Kloetzel,P.M., Heaney,J.D. and Walkiewicz,M.A.
  CONSRTM   EuroEPINOMICS RES Consortium Autosomal Recessive working group, S.
            Hande Caglayan
  TITLE     Biallelic Variants in OTUD6B Cause an Intellectual Disability
            Syndrome Associated with Seizures and Dysmorphic Features
  JOURNAL   Am J Hum Genet 100 (4), 676-688 (2017)
   PUBMED   28343629
REFERENCE   4  (bases 1 to 3087)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 3087)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3087)
  AUTHORS   Xu,Z., Zheng,Y., Zhu,Y., Kong,X. and Hu,L.
  TITLE     Evidence for OTUD-6B participation in B lymphocytes cell cycle
            after cytokine stimulation
  JOURNAL   PLoS One 6 (1), e14514 (2011)
   PUBMED   21267069
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3087)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   8  (bases 1 to 3087)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831792.6.
            
            On Jan 10, 2023 this sequence version replaced NM_152812.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087552.1, AK155761.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AL831792.6         26462-26584         c
            124-278             AL831792.6         25670-25824         c
            279-359             AL831792.6         22863-22943         c
            360-672             AL831792.6         18347-18659         c
            673-734             AL831792.6         15774-15835         c
            735-841             AL831792.6         12624-12730         c
            842-3087            AL831792.6         9674-11919          c
FEATURES             Location/Qualifiers
     source          1..3087
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 6.38 cM"
     gene            1..3087
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /note="OTU domain containing 6B"
                     /db_xref="GeneID:72201"
                     /db_xref="MGI:MGI:1919451"
     exon            1..123
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..926
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1; OTU
                     domain-containing protein 6B; ortholog of human CGI-77;
                     deubiquitinase OTUD6B"
                     /codon_start=1
                     /product="deubiquitinase OTUD6B isoform 1"
                     /protein_id="NP_690025.3"
                     /db_xref="CCDS:CCDS17980.3"
                     /db_xref="GeneID:72201"
                     /db_xref="MGI:MGI:1919451"
                     /translation="MEEVVAEELDDEEQLVRRHRKEKKELQAKIQGMKNAVPKNDKKR
                     RKQLTEDVAKLEREMEQKHREELEQLKQLTFKDSKIDSVAVNISNLVLENQPPRISKA
                     QKRREKKAALEKEREERIAEAEIENLSGARHLESEKLAQILAARELEIKQIPSDGHCM
                     YGALEDQLREQDCALTVASLRRQTAEYMQTHSDDFLPFLTNPSTGDMYTPEEFGKYCD
                     DIVNTAAWGGQLELRALSHILQTPIEILQADAPPIIVGEEYPRNPLVLVYMRHAYGLG
                     EHYNSVTRLVNSATENCS"
     exon            124..278
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            279..359
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            360..672
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            673..734
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            735..841
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            842..3087
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1198..1203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1227
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /note="major polyA site"
     regulatory      2528..2533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2546
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /note="major polyA site"
     regulatory      2853..2858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2882
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /note="major polyA site"
     regulatory      2907..2912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2933
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
     regulatory      3067..3072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
                     /note="hexamer: GATAAA"
     polyA_site      3087
                     /gene="Otud6b"
                     /gene_synonym="2600013N14Rik"
ORIGIN      
        1 gcggatctcc ttcagcgcgg gtgccgggcc gcctggtcgt catggaggag gtcgtggctg
       61 aagagctcga tgatgaggag cagctggtga gaaggcatcg gaaggagaag aaggagctgc
      121 aagccaaaat tcagggaatg aagaacgctg ttcccaaaaa cgacaaaaag aggaggaagc
      181 agctcacgga agatgttgct aaattggaaa gagaaatgga gcaaaaacac agggaagaac
      241 tggagcaatt gaagcaattg actttcaagg acagtaagat agattctgtt gctgttaaca
      301 tttcaaactt ggtacttgag aatcaaccac ctcggatttc aaaagcacaa aagagacggg
      361 aaaagaaggc tgcattggaa aaggagcggg aagaaaggat agcagaggct gaaattgaga
      421 acttatctgg agccagacat cttgagagtg aaaaacttgc tcaaatattg gcagccagag
      481 aattggaaat taaacagatt ccatctgatg gtcactgtat gtatggagca cttgaggatc
      541 agctgagaga acaagactgt gcgctgactg tggcttccct gaggaggcag actgctgagt
      601 acatgcaaac ccattcagac gacttcctgc cgtttctaac aaaccccagc acaggagata
      661 tgtacacgcc agaagagttt gggaagtact gtgacgatat tgtgaacaca gcggcatggg
      721 gcggtcagct cgagctaaga gctttgtctc acatcttaca aacaccaatc gagatactac
      781 aggcagatgc tcctcctatt atagtcggtg aagagtatcc gaggaatcca ttagtactag
      841 tatacatgag gcacgcgtat ggcttaggag aacattataa ttctgttaca cggttggtga
      901 actcagctac tgaaaattgc agctagttta caaaatgtta cactgcttta tagagtgtgc
      961 caatctacca agtgctagat tgttgtaaat gctactgaag aacacagcta ccttacacga
     1021 gttttatgaa taagcttcct aacagcttta agaaacacgt tggattaact ttaaccagtg
     1081 ctctctcagt ggcagttgta gaacttaaag tctattgtgg aggacgtcgt catcacacac
     1141 caaggtgtta ctcttcccgc taattatttt ttaggtgtcc tgctcattct ggcttggaat
     1201 aaattttgtt ttagattttg gcccccagct ttatgttcca aaaatgaaga tttcaattta
     1261 atttttctta aaagtgtggc gactcggtgt ctgtcatcat aggaacatat tgtcgtgaca
     1321 gcagctttat cagccttata aagtgctggt gatcccagtg accttggtgt tactagggtc
     1381 aggagtgcgc cgcttttatc agcacatctc tgctgctaag aggaaactac tacagcagtt
     1441 aagaattttt gaatacttat gagaatcagc ataaagaaat gaatgaaatc agtggtaaac
     1501 aggtgttaat tgtgtcagtt ttgaatcttt ctaacaaact ggagatctcc cttttatgta
     1561 tgtgtagctt cctaagtctg taactcctgc attgctggtt tctccagcag aggctggagt
     1621 cagggttgaa ccttgtttct cttcaactga gaatttgtat ccttgcccca acactactca
     1681 gctgctttgc tttctctgga gcctttccta ctgagaggca tccagtggcc tctcactgct
     1741 cacctgtgca aggtgatgct gaagtaatgc agaaagggag ggccatggcc acactcgctt
     1801 gttaagtctt cccccctcca gctgtcctaa caagacctct gcttgtgctc actttctagg
     1861 attcaatgaa aaccctggct acacattatt ttgttaaata atgtatcact tgttttcact
     1921 caagtgtttg attattatat tttatgtata gcaagagttg aaggtggcag aagcagagag
     1981 ctgtgtggta aaatcagtac agaaggattt tatgcggaat gactcgtgtt actcagattt
     2041 tcaatcactt cgagaagtat tctttgtaac agagctgtgc ccacacacaa gtctgtttgc
     2101 tcttcttatg taacaaagtg ccatgggatg gggacacagc tctagcagag cacttgcctg
     2161 ccatgtgagg ctcaaggttc agtttctagc accaacaaaa caacaattta tgaaaatgaa
     2221 acgttttgtt gcaatctgtt tttttccaac ttagaactac aactaagtag agcatcatgt
     2281 gtataatatc tgggcttttg acccatgtat actgtctatg agtaaacact gggcttatga
     2341 tgttaaaagc aggtaatagt ctggcaggct ggcagagact gctcagcaga gcacggactt
     2401 tctgagacca ttccagctga ctaaaacata ctctgcctgc tatacagtgt attctgaagg
     2461 gtgtattctg ctttgtaact tttgattctt tttttattct gaaatttata aaaacataaa
     2521 gttgtaaaat aaatgctttg aacctatttt gaagtaatgt tatcttcatc ttatagtatc
     2581 agtcttaagg agtaataaaa caaaacatta tgaaacagtt attgaaaatt ccattttcaa
     2641 caaagatact ctaaagtaac tcattaatgt tttgttgttt tgacaaggat tcaaatgtac
     2701 ttaattatgt atttctaatt tttgtttatg ttttatttta aaatggccag tatatttatg
     2761 aataaaatgt atggcccact tctaccattt tagtgataaa tggaaaagtc ttctaaaaac
     2821 ggtaggtgtt aatttaagaa ccatgtatgc caattaaatt tgctgctgct ggtctgatgg
     2881 aacttccaca gctttcttta gtcttgatta aaaacattta tatcaaaatt ctagaatgtg
     2941 tcttcaccaa gaattttatc tacttacata tatttatagc ctgtaaaaag taaaacaaag
     3001 aatgtgtaac tattgtgagc aagatagctt tgctcataat atctgatgtt taccaagaga
     3061 ataaatgata aaggagttga atcaaca
//
