LOCUS       NM_001163191            2346 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus OTU domain containing 6A (Otud6a), mRNA.
ACCESSION   NM_001163191 XM_486733 XM_986294
VERSION     NM_001163191.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2346)
  AUTHORS   Fang,Z., Han,J., Lin,L., Ye,B., Qu,X., Zhang,Y., Zhao,Y., Xu,D.,
            Lin,W., Shen,S., Min,J., Wu,G., Huang,Z. and Liang,G.
  TITLE     Deubiquitinase OTUD6a drives cardiac inflammation and hypertrophy
            by deubiquitination of STING
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167061 (2024)
   PUBMED   38342418
  REMARK    GeneRIF: Deubiquitinase OTUD6a drives cardiac inflammation and
            hypertrophy by deubiquitination of STING.
REFERENCE   2  (bases 1 to 2346)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2346)
  AUTHORS   Sun,X., Chen,S., Zhao,Y., Wu,T., Zhao,Z., Luo,W., Han,J., Fang,Z.,
            Ye,B., Cao,G., Huang,S. and Liang,G.
  TITLE     OTUD6A in tubular epithelial cells mediates angiotensin II-induced
            kidney injury by targeting STAT3
  JOURNAL   Am J Physiol Cell Physiol 326 (2), C400-C413 (2024)
   PUBMED   38105755
  REMARK    GeneRIF: OTUD6A in tubular epithelial cells mediates angiotensin
            II-induced kidney injury by targeting STAT3.
REFERENCE   4  (bases 1 to 2346)
  AUTHORS   Li,Z., Li,G., Li,Y., Luo,Y., Jiang,Y., Zhang,Z., Zhou,Z., Liu,S.,
            Wu,C. and You,F.
  TITLE     Deubiquitinase OTUD6A Regulates Innate Immune Response via
            Targeting UBC13
  JOURNAL   Viruses 15 (8), 1761 (2023)
   PUBMED   37632103
  REMARK    GeneRIF: Deubiquitinase OTUD6A Regulates Innate Immune Response via
            Targeting UBC13.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2346)
  AUTHORS   Liu,X., Fang,Y., Lv,X., Hu,C., Chen,G., Zhang,L., Jin,B., Huang,L.,
            Luo,W., Liang,G. and Wang,Y.
  TITLE     Deubiquitinase OTUD6A in macrophages promotes intestinal
            inflammation and colitis via deubiquitination of NLRP3
  JOURNAL   Cell Death Differ 30 (6), 1457-1471 (2023)
   PUBMED   36932155
  REMARK    GeneRIF: Deubiquitinase OTUD6A in macrophages promotes intestinal
            inflammation and colitis via deubiquitination of NLRP3.
REFERENCE   6  (bases 1 to 2346)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   7  (bases 1 to 2346)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671299.18.
            
            On Feb 2, 2022 this sequence version replaced NM_001163191.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC153817.1, BN000372.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2346              AL671299.18        34324-36669
FEATURES             Location/Qualifiers
     source          1..2346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.72 cM"
     gene            1..2346
                     /gene="Otud6a"
                     /gene_synonym="EG408193; Hshin6"
                     /note="OTU domain containing 6A"
                     /db_xref="GeneID:408193"
                     /db_xref="MGI:MGI:3644685"
     exon            1..2346
                     /gene="Otud6a"
                     /gene_synonym="EG408193; Hshin6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2325..2330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otud6a"
                     /gene_synonym="EG408193; Hshin6"
                     /note="hexamer: AATAAA"
     polyA_site      2346
                     /gene="Otud6a"
                     /gene_synonym="EG408193; Hshin6"
                     /note="major polyA site"
ORIGIN      
        1 aagcagactg ccacagctac cgctcggaga ggttgtgctg cctgactggc gatttgaact
       61 gttcctgttt cctccagact tgaactccca ttttccactg gtaagatgtc tgacaccgag
      121 caggaactcc aacgggtgat ccgtcgccac tatcgcgaaa aaagggagct acaagcacac
      181 atccagactt tgaaagcttc cgtcccaaag aacgacaagg gcagacggaa gcagatgctc
      241 gcggacatct cccgcctcga ggccgagatg gagcagaggc acaagcagga gctggagaaa
      301 tttggagaaa atcctgacag cagtgtggat tcggttacag ccgacctcga aaagatgaat
      361 ctcgagaata tgcctccacg cccacccaag gcccagaaac ggcgcgaccg aagagctcac
      421 caggagagac ggcaccagga gaggatgcct gcggcccagg ccgaacaact ggctgccaac
      481 cgtcgtgagg aggaggaaaa ggtcgctgcc attctagggg ctaaaaattt ggagatgaag
      541 accatcccag ctgacggcca ctgcatgtat cgtgccatcc aggatcagct ggtgttctcc
      601 gtgacaatcg agagccttcg ctaccgcact gcctactaca tgcggaaaca tattgatgac
      661 ttcttacctt tcttcaccga gcccgaggcc ggcaacttct acacccgaga ggacttcctg
      721 aggtactgtg atgacattgt gcacaatgct tcgtggggag gtcagctgga gctgagagcc
      781 ctgtcgcatg tcctgcagac ccccatcgag gtggtacagg ccaactcacc caccattgtc
      841 atcggggagg agtacaccag gaagccggtc acgctggtct atctgcacta cgcctgcgac
      901 ttcggagagc actacaattc ggtgaagccc attgaggttg ctggagcatt tggaggaatg
      961 gcaccgcgcc tcttctagaa ctttccagca gacgcgaagg aactctgccc taggcgccat
     1021 ctttgtcacc tctccggccg cggttcctct ggaagaatag aagcagctcc ggctgctggg
     1081 agaactgaaa ctgctacggc gtctcttagt aagagcagtt gcttttcctt tgctggtttg
     1141 catttatgtt tgtttttcaa gatttgttta atgtctgtgt cctgcctctt ttttgtttgt
     1201 gtgtttgggg cgggggttgt taggttgttt tggtttggga ggcgttgggt attttttgtt
     1261 cgtttttccc cccctctcag attttttttt tttttttttt ttggtgtggc tcctttcatg
     1321 tggcagggaa cggcaggcag tctatacaca ggataatacg tctttgggac acctaagggg
     1381 ctttaagatt caactctaac ttcatttggc ccttaggtac cattttctta aagttttaat
     1441 taatgttagg ctgaaaatgg aaattgtggg ttttctcaat gtttacctgg gctgaaataa
     1501 gtttagtaga atggttcagg ttgtgggatt ttccctgcaa agtagagttg gtgtggctga
     1561 aatgacttat acgtgttttt cagttagaaa aaaaaaatgc cccagccggc tggcttgctc
     1621 ttaagcaatg ttaaaatgcc tgggttatga ataagccttc aaggaataat ttgcttgttt
     1681 ggttttattt ttcattcaaa cttgtgcaac cagccataaa tgggttttag ctgcccagat
     1741 attttctttt ttcctttttt cttttctttt tttttttttt tttggagggg gggggttggt
     1801 tcacagactt tgttgattca acagtgaaca gcaaagaaaa acgttatcat tccaggggct
     1861 tcaacgtagt cgtgaaagcc acccttggaa gcccagatag tttctaagca ctaacacaac
     1921 tgtttttttt ttttttttct aataggtaaa tgtaactgtt agatgcagaa attcagttta
     1981 aatgaaccag tacctgaagt aagctttatc ttaaagatgt gaaagacctg aacttagtga
     2041 catggtttgt taatttttag agagaaaaat atatattaaa agtttttgta taaaggaaag
     2101 cagagaacaa tacagctcgg tttctattag aaattccttg ttctcttaaa tgtggcattc
     2161 aaaaggaaga gcaagaatgg aatggtttac aggtttaaaa ttcactactg tatgttagtg
     2221 aacttactta aatacatttt aaaaatgcat tgtcacttcc aaatgatctc aaatagtata
     2281 tgttagttta aaaacttttt ggaaaacgta tgcaatgtgt taaaaataaa agcagctttt
     2341 gaaata
//
