LOCUS       NM_001290536            4262 bp    mRNA    linear   ROD 12-NOV-2023
DEFINITION  Mus musculus OTU domain containing 5 (Otud5), transcript variant 1,
            mRNA.
ACCESSION   NM_001290536 XM_006527663
VERSION     NM_001290536.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4262)
  AUTHORS   Guo Y, Jiang F, Kong L, Wu H, Zhang H, Chen X, Zhao J, Cai B, Li Y,
            Ma C, Yi F, Zhang L, Liu B, Zheng Y, Zhang L and Gao C.
  TITLE     OTUD5 promotes innate antiviral and antitumor immunity through
            deubiquitinating and stabilizing STING
  JOURNAL   Cell Mol Immunol 18 (8), 1945-1955 (2021)
   PUBMED   32879469
  REMARK    GeneRIF: OTUD5 promotes innate antiviral and antitumor immunity
            through deubiquitinating and stabilizing STING.
REFERENCE   2  (bases 1 to 4262)
  AUTHORS   Li F, Sun Q, Liu K, Zhang L, Lin N, You K, Liu M, Kon N, Tian F,
            Mao Z, Li T, Tong T, Qin J, Gu W, Li D and Zhao W.
  TITLE     OTUD5 cooperates with TRIM25 in transcriptional regulation and
            tumor progression via deubiquitination activity
  JOURNAL   Nat Commun 11 (1), 4184 (2020)
   PUBMED   32826889
  REMARK    GeneRIF: OTUD5 cooperates with TRIM25 in transcriptional regulation
            and tumor progression via deubiquitination activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4262)
  AUTHORS   Rutz S, Kayagaki N, Phung QT, Eidenschenk C, Noubade R, Wang X,
            Lesch J, Lu R, Newton K, Huang OW, Cochran AG, Vasser M, Fauber BP,
            DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick DS, Lill JR,
            Ouyang W and Dixit VM.
  TITLE     Deubiquitinase DUBA is a post-translational brake on interleukin-17
            production in T cells
  JOURNAL   Nature 518 (7539), 417-421 (2015)
   PUBMED   25470037
  REMARK    GeneRIF: data identify DUBA as a cell-intrinsic suppressor of IL-17
            production
REFERENCE   4  (bases 1 to 4262)
  AUTHORS   Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q,
            Bosanac I, Arnott D, Dixit VM, Hymowitz SG, Starovasnik MA and
            Cochran AG.
  TITLE     Phosphorylation-dependent activity of the deubiquitinase DUBA
  JOURNAL   Nat Struct Mol Biol 19 (2), 171-175 (2012)
   PUBMED   22245969
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4262)
  AUTHORS   Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko
            SA, Wilkinson JE, Galas D, Ziegler SF and Ramsdell F.
  TITLE     Disruption of a new forkhead/winged-helix protein, scurfin, results
            in the fatal lymphoproliferative disorder of the scurfy mouse
  JOURNAL   Nat Genet 27 (1), 68-73 (2001)
   PUBMED   11138001
REFERENCE   6  (bases 1 to 4262)
  AUTHORS   Means GD, Toy DY, Baum PR and Derry JM.
  TITLE     A transcript map of a 2-Mb BAC contig in the proximal portion of
            the mouse X chromosome and regional mapping of the scurfy mutation
  JOURNAL   Genomics 65 (3), 213-223 (2000)
   PUBMED   10857745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671995.4 and AL671978.2.
            
            [WARNING] On Dec 8, 2023 this sequence was replaced by
            NM_001290536.2.
            
            On Mar 14, 2014 this sequence version replaced XM_006527663.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155131.1, SRR10662774.1437891.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-880               AL671995.4         151477-152356
            881-974             AL671978.2         12601-12694
            975-1039            AL671978.2         23812-23876
            1040-1196           AL671978.2         23964-24120
            1197-1345           AL671978.2         24220-24368
            1346-1549           AL671978.2         28293-28496
            1550-1751           AL671978.2         29851-30052
            1752-1865           AL671978.2         30137-30250
            1866-4262           AL671978.2         30527-32923
FEATURES             Location/Qualifiers
     source          1..4262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.54 cM"
     gene            1..4262
                     /gene="Otud5"
                     /gene_synonym="DUBA; DXImx46e; Sfc7"
                     /note="OTU domain containing 5"
                     /db_xref="GeneID:54644"
                     /db_xref="MGI:MGI:1859615"
     exon            1..880
                     /gene="Otud5"
                     /gene_synonym="DUBA; DXImx46e; Sfc7"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1990
                     /gene="Otud5"
                     /gene_synonym="DUBA; DXImx46e; Sfc7"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1; OTU
                     domain-containing protein 5; deubiquinating enzyme A;
                     deubiquitinating enzyme A"
                     /codon_start=1
                     /product="OTU domain-containing protein 5 isoform 1"
                     /protein_id="NP_001277465.1"
                     /db_xref="CCDS:CCDS72336.1"
                     /db_xref="GeneID:54644"
                     /db_xref="MGI:MGI:1859615"
                     /translation="MTILPKKKPPPPDADPANEPPPPGPLPPAPRRGAGVGVGGGGTG
                     VGGGERDRDSGVVGARPRASPPPQGPLPGPPGALHRWALAVPPGAVAGPRPQQASPPP
                     CGGPGGPGGGPGDALGATTAGVGAAGVVVGVGGTVGVGGCCSGPGHSKRRRQAPGVGA
                     VGGASPEREEVGAGYNSEDEYEAAAARIEAMDPATVEQQEHWFEKALRDKKGFIIKQM
                     KEDGACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKN
                     NCHGNHIEMQAMAEMYNRPVEVYQYSTEPINTFHGIHQNEDEPIRVSYHRNIHYNSVV
                     NPNKATIGVGLGLPSFKPGFAEQSLMKNAIKTSEESWIEQQMLEDKKRATDWEATNEA
                     IEEQVARESYLQWLRDQEKQARQVRGPSQPRKASATCSSATAAASSGLEEWTSRSPRQ
                     RSSASSPEHPELHAELGIKPPSPGTVLALAKPPSPCAPGTSSQFSAGGDRATSPLVSL
                     YPALECRALIQQMSPSAFAGLNDWDDDEILASVLAVSQQEYLDSMKKNKVHREPPPDK
                     S"
     exon            881..974
                     /gene="Otud5"
                     /gene_synonym="DUBA; DXImx46e; Sfc7"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1039
                     /gene="Otud5"
                     /gene_synonym="DUBA; DXImx46e; Sfc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1196
                     /gene="Otud5"
                     /gene_synonym="DUBA; DXImx46e; Sfc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1345
                     /gene="Otud5"
                     /gene_synonym="DUBA; DXImx46e; Sfc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1549
                     /gene="Otud5"
                     /gene_synonym="DUBA; DXImx46e; Sfc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1751
                     /gene="Otud5"
                     /gene_synonym="DUBA; DXImx46e; Sfc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1865
                     /gene="Otud5"
                     /gene_synonym="DUBA; DXImx46e; Sfc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..4262
                     /gene="Otud5"
                     /gene_synonym="DUBA; DXImx46e; Sfc7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgaagccga atcccggaac caggtagcag agagctcggc cggccttgga gggagacaag
       61 gctgcgacca atccgtctcc gtaccgtccc actggacttc acatccggga tctcctcctg
      121 ggcgtgaccc gcgtcccgtc tgcggtcctc gaaccggtgt cctgatctct ttatccaggc
      181 cttgctgttc ccgtcgtgcc tcgcgcacga ccgtagcccc ctcatccggg ttctctcccg
      241 gcgttctccg cgtttgcttt gctgtggggt acttggcggt gccgccatga ctattctccc
      301 caaaaagaag ccgccacctc ccgacgccga cccggccaac gaaccgccgc cgcccgggcc
      361 gctgcccccg gcgcctcggc gcggtgcggg tgtaggcgtg ggtggcggcg gcacgggtgt
      421 gggcggagga gagcgcgacc gtgactccgg cgtcgtgggg gcccgtcccc gggcttcgcc
      481 gccacctcag ggcccgctcc cggggccgcc tggtgctctt catcgttggg cactggccgt
      541 gccgcctggc gcagtcgcgg gccctcggcc acagcaggct tctccacctc cttgtggggg
      601 ccccggtggc cccggcggcg gtcctggtga cgctcttggt gcgacaactg cgggggtggg
      661 cgcggcaggg gtggtggtgg gcgtgggtgg taccgtgggc gtgggcggct gctgctcggg
      721 gcccgggcac agcaagcggc ggcgtcaagc tcccggcgtt ggcgcagttg gcggggccag
      781 tccggaacgt gaagaggtcg gagcgggcta caacagtgaa gacgagtatg aagctgccgc
      841 agcgcgaatc gaggccatgg atcccgccac tgtagaacag caggaacact ggtttgaaaa
      901 ggccttgcgg gacaagaaag gcttcatcat caagcagatg aaggaggacg gtgcctgtct
      961 atttcgggct gtagctgacc aggtgtatgg agaccaggac atgcatgagg ttgttcgaaa
     1021 gcattgcatg gactatctga tgaagaacgc tgattacttc tccaactatg tcacagaaga
     1081 cttcaccacc tatatcaacc ggaagcggaa aaacaactgc catggcaacc acattgaaat
     1141 gcaggctatg gcagagatgt acaaccgtcc tgtggaggtg tatcaatata gcacagaacc
     1201 tatcaacaca ttccatggga tccatcaaaa tgaagatgaa cccatccgtg tcagctacca
     1261 ccggaatatc cactataatt cagtggtgaa tcctaacaag gccactattg gtgtggggct
     1321 gggcctaccg tcatttaagc cagggtttgc agagcagtcc ctgatgaaga atgccataaa
     1381 gacatcagaa gagtcatgga ttgaacagca aatgctggaa gacaagaaac gagctacaga
     1441 ctgggaggcc acaaatgagg ccatagagga gcaggtggct cgagaatctt accttcagtg
     1501 gctgagggat caagagaaac aggcccgcca ggtccgggga cccagccagc cccggaaagc
     1561 cagtgccaca tgcagttcag ccacagcagc agcctccagt ggcctggagg aatggactag
     1621 tcggtcccca cggcaacgaa gttcagcctc gtcacctgag caccctgaac tgcatgccga
     1681 gctaggcatt aagccccctt ccccaggcac tgtgttagct cttgccaaac ctccttcacc
     1741 ctgtgcacca ggtacaagca gtcagttctc agcagggggt gatcgggcca cctctcctct
     1801 tgtgtccctc taccctgctc tggagtgccg ggccctcatc cagcagatgt ccccctctgc
     1861 ctttgcaggt ctgaatgatt gggacgatga tgagatccta gcatcggtgc tggcagtgtc
     1921 ccaacaggaa tacctagaca gtatgaagaa aaacaaagtg cacagagagc cacccccaga
     1981 caagagttga tggacaccca gggactggac atcattcccg atcccccact cctgcccttt
     2041 gatgccaccc aaacttcttt ggctttcttc cctcttggct tccttctttt gtttcctctt
     2101 ttcctttttt ttttccactt ccctctggcc ggcccaccca tgcgctccat ccatctcatc
     2161 cctgccacca ccattggtct ctgccagctg aagtgcccta ttgcccccgc acagcaccat
     2221 ctcagcattc cacaggggac tctggaaagg gtgcggaagg taggcaagag gcccacagag
     2281 acagaccatc tggcagccag gcagccccag aagagagaca ttcagacaaa ggaagtcttc
     2341 tgctcaccct tccttaaaga tcagataaac ttgtcatccc ttcccagcaa tgatgacagg
     2401 aaaatggaag tggcaagttt tccttctagt atccgaagaa tctgagcctt caatgttaaa
     2461 atttttctta attaaaatgt gctttatttc acaaaatcaa caaatcaaaa agaatattca
     2521 tggcaacgtt ggtcctttga gggtggcatc tctggtttgg agctaggcag gctggccatg
     2581 ggacagaaag ggcagaaaaa agatggattt ctgctgtctt ttggccccta gttccttgga
     2641 agggcaaagg ctatgaggta gagggaggtg acaggcattg caggtggcag actgactttg
     2701 gacagtgaga ccctgacctt gctgcattgc tttgccttca ccaccgctag tctgtttgga
     2761 aggcttgagg tggggtgtct tgggaaatta gggccactac ccaagatttg aatttaggga
     2821 gtgggagcag cctcagcaga tggggcaccc gtgcactgca ggtgttgaca agatccacca
     2881 tctgtaatgt ccttggcaca ataaaaccaa atgtcagttt ccctgagcaa ctctattctg
     2941 tgtgggacac gggtggatgg gcctctggga agcacaggat ttgctttgac cagaggtctg
     3001 cttgttctcc agtaggtgct ctctgtaagc tggggttcat atttgatctt ctgtttatta
     3061 aattaacttc ttgtcttgag actgatggca gagaatctct agagcccagg tgggttaaga
     3121 ctaacctaac ccacataacc aagattgttt cttaaaagaa caaaaccaac aacaactcta
     3181 caactggtcg tggtcatgcc tttgatccca gcactgagga gggcagaggc agaggtggat
     3241 cttttgagtt gcaggccagc tgggctatac agcaagacgc ttttattaaa aatcataaac
     3301 ttcagaacca aatcgactga aactgaagtc cctactccca cctaccatat ttgcattagg
     3361 gagcctaggg ctaatttaaa ggactgtatg agccagaggc caagactggt gtctgaattt
     3421 ctactctcaa ccttaatgct cattcattct tgtgataatc tgatgaaata agcaatcact
     3481 aatgagttca gtgaccagag gtggcccttg cccaactggg ttttaaacgt tggaggatga
     3541 aatggctaaa tccttttttt gttgtttgtt cctcaggtct gttgacacct ctgtccatac
     3601 ccctgctagg gtttgtaaag cccagctaga gaaggctggc tggccctcag gtttcctcag
     3661 agcagtcttc tcccactccc caatgcctca gtgaggtcct ttcagaagaa ggctgtgtag
     3721 ggtggcccta cggtgagggt atggcttgcc cagtgggtgg ctacaggata tctgaaatac
     3781 gtggtcaagc atgagcacgc caagagggtt gattcatttc aaatctacct gccttgtctc
     3841 actgtgtggc tttgggctct ctttgacttt aaagtgtccc atctgcaact acaggggtca
     3901 ttaatgtctg ctacctcatg ctctctgatt tgtgagtatt gacagagaat gtgtatggtc
     3961 aataatgtac tactgggaac agtacctggt acactcttag agcacaaatg ttggggttct
     4021 taccagactt taggggtggg ggtattaccg tattttgtaa gtttgtacca tttggcctca
     4081 gcctgactct tgctactctt ggcttttact tgcaatttgc cctaacccta tcttcagcaa
     4141 gacaaaggga tcacctgaaa aaaccctgtg tgatcccatt ggcactctcc cttctgtcta
     4201 cgactattcc gaagaactgt actataaata aacttctggg ctggggctgt gatgcttact
     4261 ta
//
