LOCUS       NM_028453               6007 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus OTU domain containing 3 (Otud3), transcript variant 2,
            mRNA.
ACCESSION   NM_028453 XM_001477728 XM_131770
VERSION     NM_028453.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6007)
  AUTHORS   Dai,H., Wu,B., Ge,Y., Hao,Y., Zhou,L., Hong,R., Zhang,J., Jiang,W.,
            Zhang,Y., Li,H. and Zhang,L.
  TITLE     Deubiquitylase OTUD3 regulates integrated stress response to
            suppress progression and sorafenib resistance of liver cancer
  JOURNAL   Cell Rep 43 (7), 114487 (2024)
   PUBMED   38996071
REFERENCE   2  (bases 1 to 6007)
  AUTHORS   Zhou,N., Qi,H., Liu,J., Zhang,G., Liu,J., Liu,N., Zhu,M., Zhao,X.,
            Song,C., Zhou,Z., Gong,J., Li,R., Bai,X., Jin,Y., Song,Y. and
            Yin,Y.
  TITLE     Deubiquitinase OTUD3 regulates metabolism homeostasis in response
            to nutritional stresses
  JOURNAL   Cell Metab 34 (7), 1023-1041 (2022)
   PUBMED   35675826
  REMARK    GeneRIF: Deubiquitinase OTUD3 regulates metabolism homeostasis in
            response to nutritional stresses.
REFERENCE   3  (bases 1 to 6007)
  AUTHORS   Cai,X., Zhou,Z., Zhu,J., Liu,X., Ouyang,G., Wang,J., Li,Z., Li,X.,
            Zha,H., Zhu,C., Rong,F., Tang,J., Liao,Q., Chen,X. and Xiao,W.
  TITLE     Opposing effects of deubiquitinase OTUD3 in innate immunity against
            RNA and DNA viruses
  JOURNAL   Cell Rep 39 (10), 110920 (2022)
   PUBMED   35675783
  REMARK    GeneRIF: Opposing effects of deubiquitinase OTUD3 in innate
            immunity against RNA and DNA viruses.
REFERENCE   4  (bases 1 to 6007)
  AUTHORS   Jia,F., Li,H., Jiao,Q., Li,C., Fu,L., Cui,C., Jiang,H. and Zhang,L.
  TITLE     Deubiquitylase OTUD3 prevents Parkinson's disease through
            stabilizing iron regulatory protein 2
  JOURNAL   Cell Death Dis 13 (4), 418 (2022)
   PUBMED   35490179
  REMARK    GeneRIF: Deubiquitylase OTUD3 prevents Parkinson's disease through
            stabilizing iron regulatory protein 2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6007)
  AUTHORS   Wang,M., Li,Y., Xiao,Y., Yang,M., Chen,J., Jian,Y., Chen,X.,
            Shi,D., Chen,X., Ouyang,Y., Kong,L., Huang,X., Bai,J., Lin,C. and
            Song,L.
  TITLE     Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay
            to promote lymphatic metastasis of human esophageal cancer
  JOURNAL   Nat Commun 12 (1), 7006 (2021)
   PUBMED   34853315
  REMARK    GeneRIF: Nicotine-mediated OTUD3 downregulation inhibits VEGF-C
            mRNA decay to promote lymphatic metastasis of human esophageal
            cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6007)
  AUTHORS   Zhang,Z., Fang,X., Wu,X., Ling,L., Chu,F., Li,J., Wang,S., Zang,J.,
            Zhang,B., Ye,S., Zhang,L., Yang,B., Lin,S., Huang,H., Wang,A. and
            Zhou,F.
  TITLE     Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation
            in Innate Antiviral Immunity
  JOURNAL   Mol Cell 79 (2), 304-319 (2020)
   PUBMED   32679077
  REMARK    GeneRIF: Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS
            Activation in Innate Antiviral Immunity.
REFERENCE   7  (bases 1 to 6007)
  AUTHORS   Du,T., Li,H., Fan,Y., Yuan,L., Guo,X., Zhu,Q., Yao,Y., Li,X.,
            Liu,C., Yu,X., Liu,Z., Cui,C.P., Han,C. and Zhang,L.
  TITLE     The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung
            tumorigenesis
  JOURNAL   Nat Commun 10 (1), 2914 (2019)
   PUBMED   31266968
  REMARK    GeneRIF: Knockdown of OTUD3 results in a decrease in the level of
            GRP78 protein, suppression of cell growth and migration, and
            tumorigenesis in lung cancer.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6007)
  AUTHORS   Yuan,L., Lv,Y., Li,H., Gao,H., Song,S., Zhang,Y., Xing,G., Kong,X.,
            Wang,L., Li,Y., Zhou,T., Gao,D., Xiao,Z.X., Yin,Y., Wei,W., He,F.
            and Zhang,L.
  TITLE     Deubiquitylase OTUD3 regulates PTEN stability and suppresses
            tumorigenesis
  JOURNAL   Nat Cell Biol 17 (9), 1169-1181 (2015)
   PUBMED   26280536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929473.7.
            
            On Dec 12, 2019 this sequence version replaced NM_028453.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.5026.1,
                                           SRR10223970.6960.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               AL929473.7         28419-28777         c
            360-508             AL929473.7         24291-24439         c
            509-621             AL929473.7         19966-20078         c
            622-744             AL929473.7         16661-16783         c
            745-876             AL929473.7         12816-12947         c
            877-973             AL929473.7         12366-12462         c
            974-1155            AL929473.7         11525-11706         c
            1156-6007           AL929473.7         5872-10723          c
FEATURES             Location/Qualifiers
     source          1..6007
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.57 cM"
     gene            1..6007
                     /gene="Otud3"
                     /gene_synonym="3110030K17Rik"
                     /note="OTU domain containing 3"
                     /db_xref="GeneID:73162"
                     /db_xref="MGI:MGI:1920412"
     exon            1..359
                     /gene="Otud3"
                     /gene_synonym="3110030K17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1332
                     /gene="Otud3"
                     /gene_synonym="3110030K17Rik"
                     /EC_number="3.4.19.12"
                     /note="isoform 2 is encoded by transcript variant 2; OTU
                     domain-containing protein 3"
                     /codon_start=1
                     /product="OTU domain-containing protein 3 isoform 2"
                     /protein_id="NP_082729.1"
                     /db_xref="CCDS:CCDS51337.1"
                     /db_xref="GeneID:73162"
                     /db_xref="MGI:MGI:1920412"
                     /translation="MSRKQAAKSRPGSGGRRAEAERKRDERAARRALAKERRNRPDPG
                     GSGCEEEFVSFANQLQALGLKLREVPGDGNCLFRALGDQLEGHSRNHLKHRQETVDYM
                     IRQREDFEPFVEDDIPFEKHVASLSKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLWQ
                     IRGTDKGSTRELHIAYRYGEHYDSVRRINDNSEAPAHLLTDFQMLHQDGANKKEKMKT
                     KGVDVKDGLRDDVEDAVHKVGSATGCTDFNLIVQNLEAENYNIKSAITALLQVNQGTG
                     NDAEENHEPGDRVKQRGPSREEAGSGRRLSGNQGRNEGRMETSEARASPAEESKAHKS
                     QLPKVTNKQRREQQRLEKKKRQEERHRLKALENRNGSRDTGRSEADMNTQVTLVKTFA
                     ALNI"
     exon            360..508
                     /gene="Otud3"
                     /gene_synonym="3110030K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            509..621
                     /gene="Otud3"
                     /gene_synonym="3110030K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            622..744
                     /gene="Otud3"
                     /gene_synonym="3110030K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            745..876
                     /gene="Otud3"
                     /gene_synonym="3110030K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..973
                     /gene="Otud3"
                     /gene_synonym="3110030K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1155
                     /gene="Otud3"
                     /gene_synonym="3110030K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..6007
                     /gene="Otud3"
                     /gene_synonym="3110030K17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5984..5989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otud3"
                     /gene_synonym="3110030K17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6007
                     /gene="Otud3"
                     /gene_synonym="3110030K17Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcagtggccg cgccgctgtc gccaggcgtc gtccccctgc gccgctccgc ccggtggccg
       61 gctgaggctg cggccccggg ctctgcggct ccggctccgg cttcggctcc ttccgcggcg
      121 aagccgtgtg ccgccgcagc catgtcccga aagcaagcgg cgaagagccg gccgggcagc
      181 ggcggccgca gagccgaggc ggagcgtaag cgggacgagc gggcggcgcg ccgggcgctg
      241 gccaaggagc ggcggaaccg gcccgatcct ggcggcagcg gctgcgaaga agagtttgtg
      301 agcttcgcca accaactgca ggccctgggg ctgaagctgc gggaggtgcc gggggacggc
      361 aattgcctgt tccgggctct gggcgaccag ttggagggcc actctcggaa ccatctcaag
      421 catcgccagg agaccgtgga ctacatgata aggcagcggg aggactttga gcccttcgtg
      481 gaagatgaca ttccctttga gaagcacgtg gccagtttgt caaagcctgg tacttttgct
      541 ggcaatgatg caattgtagc ctttgcaaga aaccatcaat tgaatgtggt gatccatcag
      601 cttaatgccc ctttgtggca gattcgaggc acggacaaag gcagcacgag ggagctccac
      661 atcgcctacc gctacggtga acactatgac agcgtccgga ggatcaatga caactcggaa
      721 gcgccagctc atctcctaac cgacttccag atgcttcatc aagacggagc aaataaaaaa
      781 gagaagatga agacaaaagg ggtggacgtt aaagatggcc tgagagatga cgtggaagat
      841 gctgtccaca aagttggcag tgcaactgga tgcacggatt ttaatttaat agtccagaac
      901 ctggaagctg aaaattacaa cattaagtct gcaataactg ccctgcttca ggtgaaccag
      961 gggacaggaa acgatgcgga ggagaaccat gagcctggtg acagagtgaa gcagcggggc
     1021 ccttcacgtg aggaggcagg cagcggccgt agactctctg gaaatcaggg cagaaatgaa
     1081 ggcaggatgg agaccagtga ggctcgggcc agccctgctg aagagagcaa agcacacaag
     1141 agccagctcc caaaggtcac aaacaagcag cggcgggaac aacagcggct ggagaagaag
     1201 aaacgccagg aggagaggca ccgcctcaaa gccctggaga acagaaacgg cagcagggac
     1261 acgggcagaa gcgaggcaga catgaatacg caggtcacct tggtgaagac cttcgctgct
     1321 ctgaacatct gactctcggg ccctgagagg tgaaggatgt acctacgctg cagacaaggc
     1381 ttcccagcca cacctcctcc gaggatgaga caactctcag cgcccacaca ggagcccaca
     1441 ggagccagtg tccttcaagc tgttttgttg tgtgacggtg tggtgacacc attcacctcc
     1501 tagaactcaa aacactgagc cataggctgg tcacagagcg gggccatagg ccagtcacgg
     1561 ggcaggggct ttgtgtgccc tgtgggtcag agtgtggtgg gtctaggctc ttcctggatg
     1621 catggggtgg gttccttgta ccgattcttg aagtcgctca gcacaatcat tagagacctt
     1681 cagtgacaat gccctctgtt tctctctcat ttccaagcag gatgagcgtc ttggtttctc
     1741 agctcaggag tgtgttgggg tttgattgct tctgatacgg gtcacccgga cacatcagtg
     1801 gtaggacagg accagtagct cccagcagcc agggaggcca aggccatctc cttcctcctg
     1861 tctctggttc ctttcagaga gtgtgggtgc ccctcccctc tcaccatgtg gtgcatgtgc
     1921 ctggctatgg gtgagagctg ggtttgccgg gagctgcaca gtgcagggga ctttaggaca
     1981 gtgaggagaa ggggtggcat tgctatggct catctctgag ctcagaaata caggctgggt
     2041 ctatatgcag gcggggctgg ggctcttggg ttctccttgg aacaatctaa agacagcagt
     2101 ctacaggagt aagggttcca tgcttgaatt ttaagtcact gtatttttct ttttgctatg
     2161 ctagactcag aaagacgcct acagagaaat gactggttgt ttgctcttac aggttgtaaa
     2221 ctttcttaac atgaaaacgg aatgaagtcc cataacatag attggcatgc tggctataag
     2281 ccaagcctgt aaccccggca ctgacgcaga ggcaggaagc ctgggctacg tgctgagttc
     2341 caggctagct agggaaggtc ccgtttcact ccccacatat gagggggggg ggaatgttac
     2401 aaacaggttt gttttaaggt aaaccttatt tgggatttca gtactgggga aagtatagca
     2461 gtggctggcg aggctgcctg tggctaagct agatggcagg gttgagggcc tgagaggacc
     2521 tgccccgccg gaggtgccat tccacagact aggttatgtg gacattaaac tgtcacgtgt
     2581 cgtgtgaaca acgacgacta agtcagtgcc ctccgggaat ctagtatttg aactagtcct
     2641 gtatactggg tcaaaagata aatgatttct tctcactaaa ggcaaaacag aaattacaaa
     2701 agcatctaga tgtagacgcc gctgtctggg caggtctcag ggaggcccgt cgactgatca
     2761 gcaggctgct agcttcttca gggtaaggat ggcctctgat tgtccgtttg ttcagctttg
     2821 gaactctgtg tttggaacac ccaaagtctc ctggactccc ccaggacgct gcgttgttcc
     2881 tgcctacagt ataggacatt gcaacgctgt gcagatttgt agatggcatg gtcagtccca
     2941 acaagtaagg gagggtggtg gccgctgtgc tctgagggat gggagccagt gtttcctggg
     3001 gtcacccggg cagggtctga atgaaagctc tctgctccca gctttgtact gcctgacgtc
     3061 agaacgccag gtcctcgctg aaaggtcagg gctgttacca aaacctcagg attggaagtc
     3121 cacagtggca ggcctgggta gcgtgctcgc tggtggagtg cttgtctaga gtgtgggaag
     3181 cctgggttcc gtccccagca ctttaaaatc caagctgtgg gcagctctca gcagcccgag
     3241 tggtgccttc tccgagctgc tgtgctgtgt gcctggcaga ggaagctgcc ttgggtttcc
     3301 tgggtatcag agtcatcaaa gagcgcctct ctttacaaat ttgcatttag ttctgggtta
     3361 ctggcagtag cctctgcttt ctggaacaca gtagcactta cttcaaaaca agtttgtctt
     3421 gtcaccgtcc agctttccag tttcagttgg ttgacttagt gtgctgatta ttggaaatgg
     3481 ggtccctgct accagctcag gctcagaatg tgggttccac tacctcagtc tctcagaggg
     3541 aaaggtagag ggtggtctgt cgcatcacca cattagtggg tacctgacag ttacctcatt
     3601 ggcagccaag gtgaggccca gtgcgttgag ctttgggaca atgatggttg gcactgttcc
     3661 tccagtctca gagaagctgt cctgggaagg gaacctgtca gcctcctggc tgtgtcccgg
     3721 ctgctacccg agaatgtcat ggtagctcac aaggtggcca caaagaaaag ccatggtgct
     3781 tcgtagcagc tcccaggcct tgatactgtg tagggaggtt tgctaggttt tcagaataat
     3841 ttaaggttaa agttaaagaa aaaattgatg gcagcacgtt tgtattgtag ggagatgagt
     3901 tagcacaggc tagacttgta gatagcgcag cccaccagga gttatcaccg gggatacaga
     3961 ccttccttca gttctcagca agaacatcta ccttggagtg acgtgtggcc agggactgtg
     4021 gtaacaagaa gcagctttgg gggtgtatca gcttgcatgt ggtttcttcc ataagctctg
     4081 agaacacctc ggaccatatc gggattgtga aagtgaagag ggctgacctg gcagggcacc
     4141 tggggtgggg atcagtgggg aaccttcctg tagctctggc acagttccca cttccctggg
     4201 gaacggagca atatgtcctt cggtggcagg gctggaggca gtggctcagg ttaccaggtg
     4261 gtgtcaggtg gacttggcct gtgcactgcg gcccagagtg agctcccccc cccccccagt
     4321 ctctcatgtt ctgaggaatt actgtctgcc tgggttttac caggataaca tagagtgccc
     4381 ttattttacc tctgaaacaa tcagctcggg catccagctg ggtagaggaa acccgaatcc
     4441 ccaggcagag ggtgtgagca aagccaggag gcacctccca gagccgtggc cttcatggcc
     4501 ctcctggacc cgtctccagc cccagcatca gcttcttacc tctaggccca ggtcaggtgc
     4561 agggcttcag ttgtctctct caggttgggg agtgctcaca cagtgctgtc ccgagcagac
     4621 cagacccaga ggcaccgtcc ttgttgttgt tgttgttgtt tctctgtgta gccctgtctg
     4681 tcctggaact cgctctgtag accaggctat cctcaaactc agagatccgc ctgcctctgc
     4741 ctcttgtgag cgccaggatc aaaggtgtgc atgggttacc acgcctggcc ccaagaggca
     4801 ctttgacagg aacgtccccc acgtccttac acgtccgctg ttccaccacc atccttgtgt
     4861 gtgctaaggt tctaacagtt gactgctggg cccagttggt ggtttctgct gaggggagga
     4921 agggagggag ggagggagag aggcaaccag tgtccctttg ttgtaagtgg gagcgcaatg
     4981 tgtgactccc tgcactttga ggctgggctc agagagctct gtcccaggtc aagttctgac
     5041 agttcattca gtctgtttct ctctagagtc tcagttcagt aagtcagttg aaatggtgac
     5101 tctcctcaca gttactggag aaggctggta gccgtgcgga ggatgctgtc cctgcataca
     5161 gttgcacact tgcacaatga gtttatggta agcggggcgt acctgcaggc cagggctcct
     5221 ttgctgcgtc ccgaacatag gaggaacctt tgggtctggc tctgagcctg cacatgagca
     5281 tcctgcaggc ccctgtttca gcaccagggc agtcactgaa gttcttcagc cctctgacag
     5341 agctctgttg aaacctgagc cctgctgagg tggggctctt cttgtcttcc tgttcttggg
     5401 ggctcatttt ttccatagcg gcctccctac cagcatccct tactagcact aagctcaggg
     5461 aagggagacg agcctgcagt caggctcagc accccacacc ccgctccctt cctggtcaca
     5521 gggatggatg gatggatgga tggatggatg gatggatgga tggatggatg gatggatgga
     5581 tggatggatg gatggagtga gtgcccatcc ccccaggaag agggccagtg tgtctgcctt
     5641 ctctcttttc ctaattgcac tatgcttgtt ctggcttcag tctagaggtg tctgaggtct
     5701 ccatgggatc atgaccctta gactcagcaa gtctgcctta gctctagagc gtagtggtga
     5761 ggaatcacca tttcctggtg tctcgagccc atttccctca ggccatctct ctccacagcg
     5821 tgcgttcatc tgaatcattt actctttatt ttctgaagta ctgtacttgg ctatctgcac
     5881 tgttttaaga accaaatgtt tttgtgtttt taatcctcaa cacttggtgc aatagaagcc
     5941 gcaaagacgt gccactttat ctctggaact gattttgtat accaataaat tctagtttaa
     6001 aagcaaa
//
