LOCUS       NM_027715               3549 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus OTU domain containing 1 (Otud1), mRNA.
ACCESSION   NM_027715
VERSION     NM_027715.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3549)
  AUTHORS   Zhang,Q., Chen,Z., Li,J., Huang,K., Ding,Z., Chen,B., Ren,T.,
            Xu,P., Wang,G., Zhang,H., Zhang,X.D., Zhang,J. and Wang,H.
  TITLE     The deubiquitinase OTUD1 stabilizes NRF2 to alleviate hepatic
            ischemia/reperfusion injury
  JOURNAL   Redox Biol 75, 103287 (2024)
   PUBMED   39079388
  REMARK    GeneRIF: The deubiquitinase OTUD1 stabilizes NRF2 to alleviate
            hepatic ischemia/reperfusion injury.
REFERENCE   2  (bases 1 to 3549)
  AUTHORS   Zheng,S., Li,Y., Song,X., Wu,M., Yu,L., Huang,G., Liu,T., Zhang,L.,
            Shang,M., Zhu,Q., Gao,C., Chen,L. and Liu,H.
  TITLE     OTUD1 ameliorates cerebral ischemic injury through inhibiting
            inflammation by disrupting K63-linked deubiquitination of RIP2
  JOURNAL   J Neuroinflammation 20 (1), 281 (2023)
   PUBMED   38012669
  REMARK    GeneRIF: OTUD1 ameliorates cerebral ischemic injury through
            inhibiting inflammation by disrupting K63-linked deubiquitination
            of RIP2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3549)
  AUTHORS   Song,J., Zhang,Y., Bai,Y., Sun,X., Lu,Y., Guo,Y., He,Y., Gao,M.,
            Chi,X., Heng,B.C., Zhang,X., Li,W., Xu,M., Wei,Y., You,F.,
            Zhang,X., Lu,D. and Deng,X.
  TITLE     The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil
            Polarization And Ameliorates Immunopathology of Periodontitis
  JOURNAL   Adv Sci (Weinh) 10 (30), e2303207 (2023)
   PUBMED   37639212
  REMARK    GeneRIF: The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil
            Polarization And Ameliorates Immunopathology of Periodontitis.
REFERENCE   4  (bases 1 to 3549)
  AUTHORS   Wang,M., Han,X., Yu,T., Wang,M., Luo,W., Zou,C., Li,X., Li,G.,
            Wu,G., Wang,Y. and Liang,G.
  TITLE     OTUD1 promotes pathological cardiac remodeling and heart failure by
            targeting STAT3 in cardiomyocytes
  JOURNAL   Theranostics 13 (7), 2263-2280 (2023)
   PUBMED   37153745
  REMARK    GeneRIF: OTUD1 promotes pathological cardiac remodeling and heart
            failure by targeting STAT3 in cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3549)
  AUTHORS   Huang,Z., Shen,S., Wang,M., Li,W., Wu,G., Huang,W., Luo,W. and
            Liang,G.
  TITLE     Mouse endothelial OTUD1 promotes angiotensin II-induced vascular
            remodeling by deubiquitinating SMAD3
  JOURNAL   EMBO Rep 24 (3), e56135 (2023)
   PUBMED   36579465
  REMARK    GeneRIF: Mouse endothelial OTUD1 promotes angiotensin II-induced
            vascular remodeling by deubiquitinating SMAD3.
REFERENCE   6  (bases 1 to 3549)
  AUTHORS   Oikawa,D., Shiota,M., Goto,E., Komakura,K., Wanibuchi,H. and
            Tokunaga,F.
  TITLE     Generation of Rat Monoclonal Antibodies Against a Deubiquitinase,
            Ovarian Tumor Domain-Containing Protein 1
  JOURNAL   Monoclon Antib Immunodiagn Immunother 37 (4), 180-184 (2018)
   PUBMED   30130141
  REMARK    GeneRIF: we report the establishment of OTUD1-specific monoclonal
            antibodies (mAbs), using the rat medial iliac lymph node method.
            The generated antibodies recognize the N-terminal portion (aa.
            1-290) of human and mouse OTUD1 proteins
REFERENCE   7  (bases 1 to 3549)
  AUTHORS   Zhang,L., Liu,J., Qian,L., Feng,Q., Wang,X., Yuan,Y., Zuo,Y.,
            Cheng,Q., Miao,Y., Guo,T., Zheng,X. and Zheng,H.
  TITLE     Induction of OTUD1 by RNA viruses potently inhibits innate immune
            responses by promoting degradation of the MAVS/TRAF3/TRAF6
            signalosome
  JOURNAL   PLoS Pathog 14 (5), e1007067 (2018)
   PUBMED   29734366
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3549)
  AUTHORS   Lugani,F., Arora,R., Papeta,N., Patel,A., Zheng,Z., Sterken,R.,
            Singer,R.A., Caridi,G., Mendelsohn,C., Sussel,L., Papaioannou,V.E.
            and Gharavi,A.G.
  TITLE     A retrotransposon insertion in the 5' regulatory domain of Ptf1a
            results in ectopic gene expression and multiple congenital defects
            in Danforth's short tail mouse
  JOURNAL   PLoS Genet 9 (2), e1003206 (2013)
   PUBMED   23437001
REFERENCE   9  (bases 1 to 3549)
  AUTHORS   Vlangos,C.N., Siuniak,A.N., Robinson,D., Chinnaiyan,A.M.,
            Lyons,R.H. Jr., Cavalcoli,J.D. and Keegan,C.E.
  TITLE     Next-generation sequencing identifies the Danforth's short tail
            mouse mutation as a retrotransposon insertion affecting Ptf1a
            expression
  JOURNAL   PLoS Genet 9 (2), e1003205 (2013)
   PUBMED   23437000
REFERENCE   10 (bases 1 to 3549)
  AUTHORS   Hoshino,M., Nakamura,S., Mori,K., Kawauchi,T., Terao,M.,
            Nishimura,Y.V., Fukuda,A., Fuse,T., Matsuo,N., Sone,M.,
            Watanabe,M., Bito,H., Terashima,T., Wright,C.V., Kawaguchi,Y.,
            Nakao,K. and Nabeshima,Y.
  TITLE     Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal
            fates in cerebellum
  JOURNAL   Neuron 47 (2), 201-213 (2005)
   PUBMED   16039563
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928877.6.
            
            On Jun 21, 2019 this sequence version replaced NM_027715.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7345562.2692734.1, SRR7974084.1471.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3549              AL928877.6         132568-136116
FEATURES             Location/Qualifiers
     source          1..3549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 13.78 cM"
     gene            1..3549
                     /gene="Otud1"
                     /gene_synonym="4933428L19Rik"
                     /note="OTU domain containing 1"
                     /db_xref="GeneID:71198"
                     /db_xref="MGI:MGI:1918448"
     exon            1..3549
                     /gene="Otud1"
                     /gene_synonym="4933428L19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2834..2839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otud1"
                     /gene_synonym="4933428L19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2852
                     /gene="Otud1"
                     /gene_synonym="4933428L19Rik"
                     /note="major polyA site"
     regulatory      3528..3533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otud1"
                     /gene_synonym="4933428L19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3549
                     /gene="Otud1"
                     /gene_synonym="4933428L19Rik"
ORIGIN      
        1 atccgcgcgc tgcactcctg cttgcgggcg ggcggcgctc gtctgagcgg gcagctcctc
       61 caaccgtccc cagcggccgg cgcggggcac agctgcgcca gcgtcctacg cccgagtccc
      121 cggccgagcg cgcgccctcc ggtgccctcg gaccgcccgc gcgctgtggc gcagcacgaa
      181 ttgggtcgcg gcccgggcgc tattcgcggc tcctgacgcg gcggcccgcg gcgctgagct
      241 cagcgctatt ctcgggctcc ggggcactgc gcccgagggt gtgtctccaa gccgggctcg
      301 cagctataag gggccgcggg cggccgcggc catgcagctc tacagcagcg tgtgcaccca
      361 ttaccctgcg ggcacgccgg ggcccacggc cgccgccccg cctgccaccg ccgccgccgc
      421 cttcaaggtc tccttgcagt cagccagccc cgccgccgcg gccccggagc cggataccgg
      481 agagcgccca cccgccgcgg ccaccgaacc acgcgaagcc gccgccgccg ctgccatgcc
      541 cgccttctct gcctgcttcg agcggtccgg gtccgccgcc gccccgccgg gcgcgtgcag
      601 caagccgccg ctgccgccgc acttcacgtc cacggcgcac atcgccgtgc gggccctggg
      661 cgccgagcgc ctcctgctgc cgccaccctc agccccctcg ccgccgcgtc gcggttcctc
      721 tgcctggctg ctggaagagc tgctccggcc cgacgagccc gcggccccga acgccgtccg
      781 cgacgctccg gacaggaact tccgactgag cgagcaccgc caggccctgg cagcctccca
      841 gcaccgggcc cctgcaccgg cccccgtcgg cccggagccc ggcgccggcc cgggctccgg
      901 cccgtggggt gaagagcgcc gggcggagcg cagttcccgg ggttgggacc gggcgagcgg
      961 tcgcagcgac gcctccgggt ctgacgcgct ccgacggcaa gatcccgaag ccgaggctca
     1021 cccggttccg gcacccgctc ggagcagcgg cgagccggcc cagaacggcg aaggcgaagc
     1081 cgtaggcacg tcccgggcgg atcccaggga cgagaagcta gccctgtacc tggccgaggt
     1141 ggagaggcag gacaagtacc tgaggcagag aaacaagtac cgattccaca tcatccccga
     1201 cggcaactgc ctctaccgag ctgtcagcaa gactgtgtac ggggaccaga gcctgcaccg
     1261 ggagctgagg gagcagaccg tgcactacat cgcggaccac ctggaccact tcagcccact
     1321 cattgagggc gacgtggggg agtttattat cgctgctgcc caagatgggg cgtgggccgg
     1381 atatcccgaa ttgctggcca tggggcagat gctgaatgtg aatatacact taactactgg
     1441 agggaggctg gagagcccca ccgtgtctac catgatccac tatctgggcc cagaggattc
     1501 tctacggccc agtatttggc tcagttggct cagcaatgga cactatgatg ctgtttttga
     1561 ccactcctat cctaacccag agtatgacaa ttggtgcaag caaacccaga tacagaaaaa
     1621 acgcgatgaa gaacttgcca agtccatggc catatccctg tccaaaatgt atattgaaca
     1681 aaatgcatgc tcttgaaaag tctgaggacc tgacaagttg ggggaaatgg cgcgtgtcag
     1741 ttgtgttggg agaaccacac gaactctaat tagggtaatg gcacttttca ctttcctagt
     1801 agactgactt taggtgtaat gccttaatca gtttttgaat gtcctctcag agccgcaggt
     1861 tgctgggcac ctgaatgatg tttcctgata gctttgggtg agcctactgc tatttaaaat
     1921 ttgctgtata aagtgagtgc tacttaattt gcaagctgat gtctcacggt atgaatttgt
     1981 tcattcctgg tagtctattt tctataaaaa tgtatttttg cacattttta aaaatgggtg
     2041 tactttcatc tattgccttg ttccaatttc gagaaatggc ttttaagcag aatccagaga
     2101 agtgctttct atgaagttta tttcagtttg tgatttagta actagtttat tgttggaata
     2161 tttcacaatt cttaattatt tcaaatggat attgacacat tatgttacca gatgattagc
     2221 ccattccatt ttgatgaaaa aaacctattg gggagggggg gagagaagat gttatttttt
     2281 taagaaatgg ttcattttga agaagttaag gaagggatag ctttgggacg attttttttt
     2341 ttttaatgac agtaccaggc cttacttgaa gtctgctatt tgctgacggc agaatgataa
     2401 ttctgtactc ttatgtttat agagtagatt ggtgttctcg attgtgttcg ttttattcat
     2461 caacttagga aaggctttta tgaacttttg tgagaaggtc agcctcctgc attatacagc
     2521 ttcttgattt caacactgtt tttagcagga agcttttgtc ttaatattct gtcgttttaa
     2581 agttcttcca aaaggcaaaa tagaattcac tttgtattat gtaaaaatgt aagccacttg
     2641 tatggtttgc tgggtcaaac agtgtttcca ccccaccccc catcaaaaaa aaatccatgt
     2701 tgccacttta actactttta gtgtatttat taggtaatgc agtttgtact tttttatttt
     2761 gtaacatttt gtgatttttt ttgtacaata attatttgta caatgtagca gttctcagct
     2821 gatggaatga atgaataaaa tgtatacttt tacatctttc tgggtagagt ggtttttaag
     2881 tagccaaatc tcttaagaac tttttttaaa tgtacacatt tttttcaagt gtaaatatgt
     2941 cccagaatcc tgagaggttt gtcaaattct cacatgaatg ggaagtctag tcatattaaa
     3001 gggtaagtct caatgaaata taattgaaag gtgaaatggc taaagaaatt gctcttatta
     3061 tttctaatta taattctatc aaattttatc tgtgcctatt gactaatgaa caagggagtg
     3121 taatttgaca gcccaagtct aattaaatgt tatactttgt gacccattct tttggggtag
     3181 acttttctgt attaaagagt tgccaaagtg gtgtccagaa tttacctaat ctggttgtca
     3241 tggcaatgag aatctacttt aaaatgtgct aaccagattt agttctaaaa tgcattttat
     3301 gttatatatg tgcccccttc agaaatcaca attcccacta ggtggggcat ttggaaagag
     3361 attaaatcct gagggctctg gcctcttaaa taagccccat gaaagggctg gaagatttag
     3421 ctttaggcct tttttggacc tatgcagttc atggatgcct ggaatctgta agtaactgac
     3481 ctttatcaaa catggcagtt tcttggactt cacagcctct aaaagggaat aaatttcttt
     3541 tatacttaa
//
