LOCUS       NP_081991                454 aa            linear   ROD 03-SEP-2024
DEFINITION  OTU domain-containing protein 1 [Mus musculus].
ACCESSION   NP_081991
VERSION     NP_081991.1
DBSOURCE    REFSEQ: accession NM_027715.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 454)
  AUTHORS   Zhang,Q., Chen,Z., Li,J., Huang,K., Ding,Z., Chen,B., Ren,T.,
            Xu,P., Wang,G., Zhang,H., Zhang,X.D., Zhang,J. and Wang,H.
  TITLE     The deubiquitinase OTUD1 stabilizes NRF2 to alleviate hepatic
            ischemia/reperfusion injury
  JOURNAL   Redox Biol 75, 103287 (2024)
   PUBMED   39079388
  REMARK    GeneRIF: The deubiquitinase OTUD1 stabilizes NRF2 to alleviate
            hepatic ischemia/reperfusion injury.
REFERENCE   2  (residues 1 to 454)
  AUTHORS   Zheng,S., Li,Y., Song,X., Wu,M., Yu,L., Huang,G., Liu,T., Zhang,L.,
            Shang,M., Zhu,Q., Gao,C., Chen,L. and Liu,H.
  TITLE     OTUD1 ameliorates cerebral ischemic injury through inhibiting
            inflammation by disrupting K63-linked deubiquitination of RIP2
  JOURNAL   J Neuroinflammation 20 (1), 281 (2023)
   PUBMED   38012669
  REMARK    GeneRIF: OTUD1 ameliorates cerebral ischemic injury through
            inhibiting inflammation by disrupting K63-linked deubiquitination
            of RIP2.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 454)
  AUTHORS   Song,J., Zhang,Y., Bai,Y., Sun,X., Lu,Y., Guo,Y., He,Y., Gao,M.,
            Chi,X., Heng,B.C., Zhang,X., Li,W., Xu,M., Wei,Y., You,F.,
            Zhang,X., Lu,D. and Deng,X.
  TITLE     The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil
            Polarization And Ameliorates Immunopathology of Periodontitis
  JOURNAL   Adv Sci (Weinh) 10 (30), e2303207 (2023)
   PUBMED   37639212
  REMARK    GeneRIF: The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil
            Polarization And Ameliorates Immunopathology of Periodontitis.
REFERENCE   4  (residues 1 to 454)
  AUTHORS   Wang,M., Han,X., Yu,T., Wang,M., Luo,W., Zou,C., Li,X., Li,G.,
            Wu,G., Wang,Y. and Liang,G.
  TITLE     OTUD1 promotes pathological cardiac remodeling and heart failure by
            targeting STAT3 in cardiomyocytes
  JOURNAL   Theranostics 13 (7), 2263-2280 (2023)
   PUBMED   37153745
  REMARK    GeneRIF: OTUD1 promotes pathological cardiac remodeling and heart
            failure by targeting STAT3 in cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 454)
  AUTHORS   Huang,Z., Shen,S., Wang,M., Li,W., Wu,G., Huang,W., Luo,W. and
            Liang,G.
  TITLE     Mouse endothelial OTUD1 promotes angiotensin II-induced vascular
            remodeling by deubiquitinating SMAD3
  JOURNAL   EMBO Rep 24 (3), e56135 (2023)
   PUBMED   36579465
  REMARK    GeneRIF: Mouse endothelial OTUD1 promotes angiotensin II-induced
            vascular remodeling by deubiquitinating SMAD3.
REFERENCE   6  (residues 1 to 454)
  AUTHORS   Oikawa,D., Shiota,M., Goto,E., Komakura,K., Wanibuchi,H. and
            Tokunaga,F.
  TITLE     Generation of Rat Monoclonal Antibodies Against a Deubiquitinase,
            Ovarian Tumor Domain-Containing Protein 1
  JOURNAL   Monoclon Antib Immunodiagn Immunother 37 (4), 180-184 (2018)
   PUBMED   30130141
  REMARK    GeneRIF: we report the establishment of OTUD1-specific monoclonal
            antibodies (mAbs), using the rat medial iliac lymph node method.
            The generated antibodies recognize the N-terminal portion (aa.
            1-290) of human and mouse OTUD1 proteins
REFERENCE   7  (residues 1 to 454)
  AUTHORS   Zhang,L., Liu,J., Qian,L., Feng,Q., Wang,X., Yuan,Y., Zuo,Y.,
            Cheng,Q., Miao,Y., Guo,T., Zheng,X. and Zheng,H.
  TITLE     Induction of OTUD1 by RNA viruses potently inhibits innate immune
            responses by promoting degradation of the MAVS/TRAF3/TRAF6
            signalosome
  JOURNAL   PLoS Pathog 14 (5), e1007067 (2018)
   PUBMED   29734366
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 454)
  AUTHORS   Lugani,F., Arora,R., Papeta,N., Patel,A., Zheng,Z., Sterken,R.,
            Singer,R.A., Caridi,G., Mendelsohn,C., Sussel,L., Papaioannou,V.E.
            and Gharavi,A.G.
  TITLE     A retrotransposon insertion in the 5' regulatory domain of Ptf1a
            results in ectopic gene expression and multiple congenital defects
            in Danforth's short tail mouse
  JOURNAL   PLoS Genet 9 (2), e1003206 (2013)
   PUBMED   23437001
REFERENCE   9  (residues 1 to 454)
  AUTHORS   Vlangos,C.N., Siuniak,A.N., Robinson,D., Chinnaiyan,A.M.,
            Lyons,R.H. Jr., Cavalcoli,J.D. and Keegan,C.E.
  TITLE     Next-generation sequencing identifies the Danforth's short tail
            mouse mutation as a retrotransposon insertion affecting Ptf1a
            expression
  JOURNAL   PLoS Genet 9 (2), e1003205 (2013)
   PUBMED   23437000
REFERENCE   10 (residues 1 to 454)
  AUTHORS   Hoshino,M., Nakamura,S., Mori,K., Kawauchi,T., Terao,M.,
            Nishimura,Y.V., Fukuda,A., Fuse,T., Matsuo,N., Sone,M.,
            Watanabe,M., Bito,H., Terashima,T., Wright,C.V., Kawaguchi,Y.,
            Nakao,K. and Nabeshima,Y.
  TITLE     Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal
            fates in cerebellum
  JOURNAL   Neuron 47 (2), 201-213 (2005)
   PUBMED   16039563
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928877.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7345562.2692734.1, SRR7974084.1471.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 13.78 cM"
     Protein         1..454
                     /product="OTU domain-containing protein 1"
                     /EC_number="3.4.19.12"
                     /note="likely ortholog of H. sapiens OTU domain containing
                     1 (OTUD1)"
                     /calculated_mol_wt=48692
     Region          36..64
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CUB6.2)"
     Region          116..257
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CUB6.2)"
     Region          262..410
                     /region_name="OTU_OTUD1"
                     /note="OTU (ovarian tumor) domain of OTU domain-containing
                     protein 1 and similar proteins; cd22747"
                     /db_xref="CDD:438584"
     Region          287..293
                     /region_name="Cys-loop.
                     /evidence=ECO:0000250|UniProtKB:Q5VV17"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CUB6.2)"
     Site            order(293,338,341,348..351,381,383,399,403..405)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:438584"
     Site            order(325..326,328..332,348,351,355,369,372,375,379,381,
                     384..387,399,405)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:438584"
     Region          342..352
                     /region_name="His-loop.
                     /evidence=ECO:0000250|UniProtKB:Q5VV17"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CUB6.2)"
     Region          399..404
                     /region_name="Variable-loop.
                     /evidence=ECO:0000250|UniProtKB:Q5VV17"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CUB6.2)"
     CDS             1..454
                     /gene="Otud1"
                     /gene_synonym="4933428L19Rik"
                     /coded_by="NM_027715.2:332..1696"
                     /db_xref="CCDS:CCDS50508.1"
                     /db_xref="GeneID:71198"
                     /db_xref="MGI:MGI:1918448"
ORIGIN      
        1 mqlyssvcth ypagtpgpta aappataaaa fkvslqsasp aaaapepdtg erppaaatep
       61 reaaaaaamp afsacfersg saaappgacs kpplpphfts tahiavralg aerlllppps
      121 apspprrgss awlleellrp depaapnavr dapdrnfrls ehrqalaasq hrapapapvg
      181 pepgagpgsg pwgeerraer ssrgwdrasg rsdasgsdal rrqdpeaeah pvpaparssg
      241 epaqngegea vgtsradprd eklalylaev erqdkylrqr nkyrfhiipd gnclyravsk
      301 tvygdqslhr elreqtvhyi adhldhfspl iegdvgefii aaaqdgawag ypellamgqm
      361 lnvnihlttg grlesptvst mihylgpeds lrpsiwlswl snghydavfd hsypnpeydn
      421 wckqtqiqkk rdeelaksma islskmyieq nacs
//
