LOCUS       NM_134150               1677 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus OTU domain, ubiquitin aldehyde binding 1 (Otub1),
            mRNA.
ACCESSION   NM_134150 XM_912373 XM_922343
VERSION     NM_134150.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1677)
  AUTHORS   Xu,F., Chen,H., Zhou,C., Zang,T., Wang,R., Shen,S., Li,C., Yu,Y.,
            Pei,Z., Shen,L., Qian,J. and Ge,J.
  TITLE     Targeting deubiquitinase OTUB1 protects vascular smooth muscle
            cells in atherosclerosis by modulating PDGFRbeta
  JOURNAL   Front Med 18 (3), 465-483 (2024)
   PUBMED   38644399
  REMARK    GeneRIF: Targeting deubiquitinase OTUB1 protects vascular smooth
            muscle cells in atherosclerosis by modulating PDGFRbeta.
REFERENCE   2  (bases 1 to 1677)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1677)
  AUTHORS   Shen,J., Xue,X., Yuan,H., Song,Y., Wang,J., Cui,R. and Ke,K.
  TITLE     Deubiquitylating Enzyme OTUB1 Facilitates Neuronal Survival After
            Intracerebral Hemorrhage Via Inhibiting NF-kappaB-triggered
            Apoptotic Cascades
  JOURNAL   Mol Neurobiol 61 (3), 1726-1736 (2024)
   PUBMED   37775718
  REMARK    GeneRIF: Deubiquitylating Enzyme OTUB1 Facilitates Neuronal
            Survival After Intracerebral Hemorrhage Via Inhibiting
            NF-kappaB-triggered Apoptotic Cascades.
REFERENCE   4  (bases 1 to 1677)
  AUTHORS   Luo,V.M., Shen,C., Worme,S., Bhagrath,A., Simo-Cheyou,E.,
            Findlay,S., Hebert,S., Wai Lam Poon,W., Aryanpour,Z., Zhang,T.,
            Zahedi,R.P., Boulais,J., Buchwald,Z.S., Borchers,C.H., Cote,J.F.,
            Kleinman,C.L., Mandl,J.N. and Orthwein,A.
  TITLE     The Deubiquitylase Otub1 Regulates the Chemotactic Response of
            Splenic B Cells by Modulating the Stability of the gamma-Subunit
            Gng2
  JOURNAL   Mol Cell Biol 44 (1), 1-16 (2024)
   PUBMED   38270191
  REMARK    GeneRIF: The Deubiquitylase Otub1 Regulates the Chemotactic
            Response of Splenic B Cells by Modulating the Stability of the
            gamma-Subunit Gng2.
REFERENCE   5  (bases 1 to 1677)
  AUTHORS   Zhu,Q., Fu,Y., Cui,C.P., Ding,Y., Deng,Z., Ning,C., Hu,F., Qiu,C.,
            Yu,B., Zhou,X., Yang,G., Peng,J., Zou,W., Liu,C.H. and Zhang,L.
  TITLE     OTUB1 promotes osteoblastic bone formation through stabilizing
            FGFR2
  JOURNAL   Signal Transduct Target Ther 8 (1), 142 (2023)
   PUBMED   37024477
  REMARK    GeneRIF: OTUB1 promotes osteoblastic bone formation through
            stabilizing FGFR2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1677)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1677)
  AUTHORS   Taher,L., Collette,N.M., Murugesh,D., Maxwell,E., Ovcharenko,I. and
            Loots,G.G.
  TITLE     Global gene expression analysis of murine limb development
  JOURNAL   PLoS One 6 (12), e28358 (2011)
   PUBMED   22174793
REFERENCE   8  (bases 1 to 1677)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1677)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1677)
  AUTHORS   Soares,L., Seroogy,C., Skrenta,H., Anandasabapathy,N., Lovelace,P.,
            Chung,C.D., Engleman,E. and Fathman,C.G.
  TITLE     Two isoforms of otubain 1 regulate T cell anergy via GRAIL
  JOURNAL   Nat Immunol 5 (1), 45-54 (2004)
   PUBMED   14661020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140307.3.
            
            On Nov 17, 2006 this sequence version replaced NM_134150.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022575.1, AK145970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC140307.3         69632-69714         c
            84-145              AC140307.3         67820-67881         c
            146-244             AC140307.3         67488-67586         c
            245-363             AC140307.3         63373-63491         c
            364-448             AC140307.3         63093-63177         c
            449-643             AC140307.3         62802-62996         c
            644-1677            AC140307.3         61636-62669         c
FEATURES             Location/Qualifiers
     source          1..1677
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.27 cM"
     gene            1..1677
                     /gene="Otub1"
                     /note="OTU domain, ubiquitin aldehyde binding 1"
                     /db_xref="GeneID:107260"
                     /db_xref="MGI:MGI:2147616"
     exon            1..83
                     /gene="Otub1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..841
                     /gene="Otub1"
                     /EC_number="3.4.19.12"
                     /note="otubain 1; deubiquitinating enzyme OTUB1;
                     ubiquitin-specific-processing protease OTUB1; OTU
                     domain-containing ubiquitin aldehyde-binding protein 1"
                     /codon_start=1
                     /product="ubiquitin thioesterase OTUB1"
                     /protein_id="NP_598911.1"
                     /db_xref="CCDS:CCDS29520.1"
                     /db_xref="GeneID:107260"
                     /db_xref="MGI:MGI:2147616"
                     /translation="MAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQ
                     NPLVSERLELSVLYKEYAEDDNIYQQKIKDLHKKYSYIRKTRPDGNCFYRAFGFSHLE
                     ALLDDSKELQRFKAVSAKSKEDLVSQGFTEFTIEDFHNTFMDLIEQVEKQTSVADLLA
                     SFNDQSTSDYLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKESDHI
                     HIIALAQALSVSIQVEYMDRGEGGTTNPHVFPEGSEPKVYLLYRPGHYDILYK"
     exon            84..145
                     /gene="Otub1"
                     /inference="alignment:Splign:2.1.0"
     exon            146..244
                     /gene="Otub1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..363
                     /gene="Otub1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..448
                     /gene="Otub1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..643
                     /gene="Otub1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..1677
                     /gene="Otub1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1015..1020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otub1"
                     /note="hexamer: ATTAAA"
     polyA_site      1037
                     /gene="Otub1"
                     /note="major polyA site"
     regulatory      1651..1656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otub1"
                     /note="hexamer: AATAAA"
     polyA_site      1677
                     /gene="Otub1"
ORIGIN      
        1 atcgccagtg cggcgctgtt taaagatggc ggcggaggaa cctcagcagc agaagcagga
       61 gccactgggt agcgactccg aaggtgttaa ctgtttggcc tatgatgaag ccattatggc
      121 tcagcaggac cgaattcagc aagagattgc tgtgcagaat cctctggtgt cagagcggct
      181 ggaactctca gtcctgtaca aggagtatgc tgaggatgac aacatctacc aacagaagat
      241 caaggacctc cacaaaaagt actcatacat acggaagacc cggcctgatg gcaactgctt
      301 ctaccgagcg tttggcttct cccacctgga ggcactgcta gatgacagca aggaactgca
      361 gcggttcaaa gccgtgtctg ccaagagtaa agaggacctg gtatcccagg gcttcactga
      421 attcacaatt gaagacttcc acaacacgtt catggacctt atcgagcagg tggagaagca
      481 gacctcagta gctgacctgc tggcctcctt caatgaccag agcacctcag actaccttgt
      541 ggtctacctg cgactgctca cctcaggcta cctacagcgg gagagcaagt tcttcgagca
      601 cttcatcgag ggtggccgga ctgttaagga gttctgccag caggaggtgg aacccatgtg
      661 caaggagagc gaccacatcc acatcatagc cctggcccag gccctcagtg tgtccatcca
      721 agtggagtac atggaccgcg gcgagggcgg caccaccaac ccacacgtct tccccgaggg
      781 ctccgagccc aaggtctacc ttctctaccg acctggacac tacgatatcc tctacaaata
      841 ggaccggctg gcctgttgtg ccccgcctgc ctcccctgcc aggcgctaga catgtacaga
      901 gggttttctt tctttctctt ctttttcttt tttttttttt tttttttttg tgtgtggttg
      961 taaatggtca tatttcactc ctcccttctc ctgtcataga accttccatg ttttattaaa
     1021 ggggatgctg gtggtgagcc cgagtgtgcg cttccctgct ctgccgccct tccctacctg
     1081 cccgctggct gccttgtgtc tggctgtccc tttcccgagg atgggtcccc agctttccaa
     1141 ccatctaccc caagcattcc tgccaagaga agttggaagg gaccaggcct ctgtgggccc
     1201 cttctggttc cttggagttc tgctcccata ggcctgccct ttcttcctta gcctcccaag
     1261 ggtttctgtg ggaacttgac cagaggtctc aagccaccca tacaaagcac ttacagactt
     1321 gctgttctgg ccagggcccc agatacaact ctctgccaac cttcaagggc ctgcatgatt
     1381 gaggagtact ggggtgagag attcatggga ggaggctggc ctagagtggg tggagcagct
     1441 aggcatcctc tgggccctgg aggagctgac ctggtgtgag agagacactc tagtagagct
     1501 tgcctgtccc ctgttcccca gagcccctgc ctgtgcctgc tctgcacccc ctttgcttgg
     1561 gccatatctg cattacctgc cttctcctcc ccacccccag cacatgtggg gtctcagccc
     1621 aggctgtgag ctccttgggg gcaggccctc aataaatgtg aagtgctgct gccgctg
//
