LOCUS       NM_011021               2617 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus orthopedia homeobox (Otp), mRNA.
ACCESSION   NM_011021
VERSION     NM_011021.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2617)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2617)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2617)
  AUTHORS   Deska-Gauthier,D., Borowska-Fielding,J., Jones,C., Zhang,H.,
            MacKay,C.S., Michail,R., Bennett,L.A., Bikoff,J.B. and Zhang,Y.
  TITLE     Embryonic temporal-spatial delineation of excitatory spinal V3
            interneuron diversity
  JOURNAL   Cell Rep 43 (1), 113635 (2024)
   PUBMED   38160393
REFERENCE   4  (bases 1 to 2617)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2617)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2617)
  AUTHORS   Schwarz,M., Alvarez-Bolado,G., Dressler,G., Urbanek,P.,
            Busslinger,M. and Gruss,P.
  TITLE     Pax2/5 and Pax6 subdivide the early neural tube into three domains
  JOURNAL   Mech Dev 82 (1-2), 29-39 (1999)
   PUBMED   10354469
REFERENCE   7  (bases 1 to 2617)
  AUTHORS   Acampora,D., Avantaggiato,V., Tuorto,F. and Simeone,A.
  TITLE     Genetic control of brain morphogenesis through Otx gene dosage
            requirement
  JOURNAL   Development 124 (18), 3639-3650 (1997)
   PUBMED   9342056
REFERENCE   8  (bases 1 to 2617)
  AUTHORS   Wang,W. and Lufkin,T.
  TITLE     Otp maps to mouse chromosome 13
  JOURNAL   Mamm Genome 8 (7), 537-538 (1997)
   PUBMED   9196005
REFERENCE   9  (bases 1 to 2617)
  AUTHORS   Avantaggiato,V., Pandolfi,P.P., Ruthardt,M., Hawe,N., Acampora,D.,
            Pelicci,P.G. and Simeone,A.
  TITLE     Developmental analysis of murine Promyelocyte Leukemia Zinc Finger
            (PLZF) gene expression: implications for the neuromeric model of
            the forebrain organization
  JOURNAL   J Neurosci 15 (7 Pt 1), 4927-4942 (1995)
   PUBMED   7623123
REFERENCE   10 (bases 1 to 2617)
  AUTHORS   Simeone,A., D'Apice,M.R., Nigro,V., Casanova,J., Graziani,F.,
            Acampora,D. and Avantaggiato,V.
  TITLE     Orthopedia, a novel homeobox-containing gene expressed in the
            developing CNS of both mouse and Drosophila
  JOURNAL   Neuron 13 (1), 83-101 (1994)
   PUBMED   7913821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140840.3 and LXEJ02010047.1.
            
            On Jul 30, 2020 this sequence version replaced NM_011021.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2672210.1, Y10413.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AC140840.3         120591-120761       c
            172-581             AC140840.3         118875-119284       c
            582-1340            AC140840.3         112549-113307       c
            1341-1541           LXEJ02010047.1     140280-140480
            1542-2617           AC140840.3         111272-112347       c
FEATURES             Location/Qualifiers
     source          1..2617
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 49.22 cM"
     gene            1..2617
                     /gene="Otp"
                     /note="orthopedia homeobox"
                     /db_xref="GeneID:18420"
                     /db_xref="MGI:MGI:99835"
     exon            1..171
                     /gene="Otp"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1112
                     /gene="Otp"
                     /note="orthopedia homolog"
                     /codon_start=1
                     /product="homeobox protein orthopedia"
                     /protein_id="NP_035151.1"
                     /db_xref="CCDS:CCDS26695.1"
                     /db_xref="GeneID:18420"
                     /db_xref="MGI:MGI:99835"
                     /translation="MLSHADLLDARLGMKDAAELLGHREAVKCRLGVGGSDPGGHPGD
                     LAPNSDPVEGATLLPGEDITTVGSTPASLAVSAKDPDKQPGPQGGPNPSQAGQQQGQQ
                     KQKRHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRRAKWK
                     KRKKTTNVFRAPGTLLPTPGLPQFPSAAAAAAAAMGDSLCSFHANDTRWAAAAMPGVS
                     QLPLPPALGRQQAMAQSLSQCSLAAGPPPNSMGLSNSLAGSNGAGLQSHLYQPAFPGM
                     VPASLPGPSNVSGSPQLCSSPDSSDVWRGTSIASLRRKALEHTVSMSFT"
     exon            172..581
                     /gene="Otp"
                     /inference="alignment:Splign:2.1.0"
     exon            582..2617
                     /gene="Otp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2510..2515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otp"
                     /note="hexamer: AATAAA"
     polyA_site      2527
                     /gene="Otp"
                     /note="major polyA site"
ORIGIN      
        1 acaaaccgaa ttttctttca tttaggtgat ctatatatat ctatatcgta tagcttatag
       61 cttatatcta ttttaaataa cttaaagccg ctaaaatttg ggggggaaca gctttcgccc
      121 tggagcggtg cgcgatgctg tctcacgccg acctcctgga cgccaggcta ggtatgaaag
      181 atgccgccga gcttctgggc caccgggagg cggtgaagtg taggctgggt gtggggggct
      241 ctgaccctgg gggtcatcca ggggacctgg cacccaactc ggacccggtc gaaggagcca
      301 ctctgctgcc gggcgaggac atcaccaccg tgggctctac ccctgcttcg ctggcggtga
      361 gcgccaaaga cccagacaag cagccggggc cccagggcgg ccccaacccc agccaagccg
      421 gccaacagca gggccaacag aaacagaagc gccaccggac acgcttcacc ccagcacagc
      481 tcaacgaatt ggagaggagc ttcgccaaga ctcactaccc cgacatcttc atgcgtgagg
      541 agctagcgct gcgtatcggg ctgaccgagt cgcgggtgca ggtctggttc cagaatcgcc
      601 gcgccaagtg gaagaagcgc aagaagacca ccaacgtgtt ccgcgcgcca ggcacgctgc
      661 tgcccacgcc ggggctgccc cagttcccgt cggctgccgc cgccgcggcc gccgccatgg
      721 gcgacagcct gtgctctttc cacgccaacg acacccgctg ggcggcggcc gccatgcctg
      781 gcgtgtccca gctgccgctg ccgcccgcgc tcggccgcca gcaggccatg gcgcagtcgc
      841 tgtcccagtg cagcctggcg gccgggccac cgcccaactc catgggcttg tccaacagcc
      901 tggcgggctc caacggcgcg gggctgcagt cgcacctcta ccagcccgcc ttccccggca
      961 tggtgcccgc ctccctcccc ggccccagca acgtctccgg ctcgccccag ctctgcagct
     1021 ctccggacag cagcgacgtg tggcggggca cgagcatcgc ctccctgcgc cgcaaggcgc
     1081 tcgagcacac agtctccatg agcttcacct aatgccgccg cgcgccgccc gctgcgcccg
     1141 ggcgccgccc ctgcccctgt cccctccccc agacccccgg ccgcgcgcgc cgggctccca
     1201 gcccctcccc ctccccggtg tccccggtcc tccccgagcc ccggcgaggt cgcctcccga
     1261 cttccctccc cgagcccggc tccccgaacc ccgtgctgcc cgccgcctcg gccccctgct
     1321 cgcccaggtc gtgctcgcgc cctcctcccg gcctctgcct ggcagccacc ccgaccacac
     1381 ttcggtcacc accctcccca acccccacga ccccccgcct cgcccgcgcc tccctttggg
     1441 ctcagtcttt ccccgagcct cacgtccctg ctcccgcgcc cggcagaaag catccttccc
     1501 gccattttac ttaccaggga gtcgactcag gatctgaaat cagacaccaa tggactggtt
     1561 tgtgggcaga aacacgcaca cacacacaca cacacacaca cacacacaca cacacacaca
     1621 cactcgcacc atagctcacg ctcagacact acacgcgcgc gcgcaaacac acacagtgca
     1681 tcttggtcac acatggacgt gttcaaggta cagcacaatg ctagggattt ttgtcttaaa
     1741 ggtggacaag cattgctacc aaccgcctca tttgagggcc caactgatgc catttgattt
     1801 agccccgtat tctttctctg acctcccttt tttctttccc ggaccaccac cctaccctgt
     1861 ctatccagtc actgtccatg caaccctcga ttggcttgca aaagaccgct ttcgttgtta
     1921 tagtttggtt tttcttttct taagctcagc tgtgaggggg tagaagggaa ggcgtctcag
     1981 gaggaacatg gcagtggatt gggtggctgg agcggactta ggcacttatg tgatgaagag
     2041 gtggtctttc ccattttgat aggcctttct aggaagaaca aaacacacgt gtaaggaatc
     2101 ttttttttcc tttttgtaaa agcaaaaagc cacatctctt ttctagatcc ttcaagactg
     2161 gcgttcgttt gcttcctttt tcgtcttttc ttctcttctc gctgctctgt gcccttggtt
     2221 gttttgtggt cgtcctatcg cgtccttcgt gcccccttgg cctcctgccg gccaccggtg
     2281 ggtgcaggcg gacatctaca accctgcaac tttgtacaga gaaacacaat cagctctttc
     2341 tgcatgtgct ggtcaaatcc aaacccagag aacagaagcg ctttctaaga atgaacaaac
     2401 atgtgaaata ggatgttttg tgtagataaa gcattcttgt tacatactgg tcaatttgtg
     2461 atatgtttta acttattgtc tgtgcttatt tatggacttt ggttttctta ataaatgttt
     2521 gagctaatat aaagcatatt atttgacttt tccggacaag tttatatcaa gttaaatgta
     2581 aatggataaa ataaaatcat tttccgtatg tgataca
//
