LOCUS       NM_153114                814 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus otospiralin (Otos), mRNA.
ACCESSION   NM_153114
VERSION     NM_153114.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 814)
  AUTHORS   Trowe,M.O., Maier,H., Petry,M., Schweizer,M., Schuster-Gossler,K.
            and Kispert,A.
  TITLE     Impaired stria vascularis integrity upon loss of E-cadherin in
            basal cells
  JOURNAL   Dev Biol 359 (1), 95-107 (2011)
   PUBMED   21925491
REFERENCE   2  (bases 1 to 814)
  AUTHORS   Decourt,B., Hillman,D., Bouleau,Y., Dulon,D. and Hafidi,A.
  TITLE     Is otospiralin inner ear specific? Evidence for its expression in
            mouse brain
  JOURNAL   Int J Dev Neurosci 27 (1), 87-96 (2009)
   PUBMED   18832023
  REMARK    GeneRIF: Collectively, our observations suggest that otospiralin is
            possibly involved in signaling pathways, and could play a role in
            repair mechanisms subsequent to an injury in the central nervous
            system.
REFERENCE   3  (bases 1 to 814)
  AUTHORS   Trowe,M.O., Maier,H., Schweizer,M. and Kispert,A.
  TITLE     Deafness in mice lacking the T-box transcription factor Tbx18 in
            otic fibrocytes
  JOURNAL   Development 135 (9), 1725-1734 (2008)
   PUBMED   18353863
REFERENCE   4  (bases 1 to 814)
  AUTHORS   Delprat,B., Ruel,J., Guitton,M.J., Hamard,G., Lenoir,M., Pujol,R.,
            Puel,J.L., Brabet,P. and Hamel,C.P.
  TITLE     Deafness and cochlear fibrocyte alterations in mice deficient for
            the inner ear protein otospiralin
  JOURNAL   Mol Cell Biol 25 (2), 847-853 (2005)
   PUBMED   15632083
  REMARK    GeneRIF: Data suggest that impairment of fibrocytes caused by the
            loss in otospiralin leads to abnormal cochlear physiology and
            auditory function.
REFERENCE   5  (bases 1 to 814)
  AUTHORS   Pompeia,C., Hurle,B., Belyantseva,I.A., Noben-Trauth,K., Beisel,K.,
            Gao,J., Buchoff,P., Wistow,G. and Kachar,B.
  TITLE     Gene expression profile of the mouse organ of Corti at the onset of
            hearing
  JOURNAL   Genomics 83 (6), 1000-1011 (2004)
   PUBMED   15177554
REFERENCE   6  (bases 1 to 814)
  AUTHORS   Delprat,B., Boulanger,A., Wang,J., Beaudoin,V., Guitton,M.J.,
            Venteo,S., Dechesne,C.J., Pujol,R., Lavigne-Rebillard,M., Puel,J.L.
            and Hamel,C.P.
  TITLE     Downregulation of otospiralin, a novel inner ear protein, causes
            hair cell degeneration and deafness
  JOURNAL   J Neurosci 22 (5), 1718-1725 (2002)
   PUBMED   11880501
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100323.1.
            
            On Aug 7, 2005 this sequence version replaced NM_153114.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100323.1, CK031001.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..814
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.55 cM"
     gene            1..814
                     /gene="Otos"
                     /gene_synonym="OTOSP"
                     /note="otospiralin"
                     /db_xref="GeneID:260301"
                     /db_xref="MGI:MGI:2672814"
     exon            1..91
                     /gene="Otos"
                     /gene_synonym="OTOSP"
                     /inference="alignment:Splign:2.1.0"
     exon            92..284
                     /gene="Otos"
                     /gene_synonym="OTOSP"
                     /inference="alignment:Splign:2.1.0"
     exon            285..377
                     /gene="Otos"
                     /gene_synonym="OTOSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..589
                     /gene="Otos"
                     /gene_synonym="OTOSP"
                     /note="organ of Corti 10 kDa protein"
                     /codon_start=1
                     /product="otospiralin precursor"
                     /protein_id="NP_694754.1"
                     /db_xref="CCDS:CCDS35668.1"
                     /db_xref="GeneID:260301"
                     /db_xref="MGI:MGI:2672814"
                     /translation="MQACVLWWLALGMLLGIPAGAKPMPEEADPHTQPPAMPYWPFST
                     SDFWNYVQYFQTQGAYPQIEDMARTFFAHFPLGSTLGFHVPYQED"
     exon            378..404
                     /gene="Otos"
                     /gene_synonym="OTOSP"
                     /inference="alignment:Splign:2.1.0"
     exon            405..704
                     /gene="Otos"
                     /gene_synonym="OTOSP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      682..687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otos"
                     /gene_synonym="OTOSP"
                     /note="hexamer: AATAAA"
     polyA_site      704
                     /gene="Otos"
                     /gene_synonym="OTOSP"
                     /note="major polyA site"
ORIGIN      
        1 cagctgtggt ggcgtggagg gacttccacc ttgacaggct ttgccaagtc agctcaacac
       61 gctcccagaa ttctcccttt tcatgtccaa gctgctccca caggccctcc tgccagcaga
      121 gaaacagaga cctacagtcc tctgctgggg aatgaaatat tcagtttgat ggctcaggaa
      181 ggtgacgctt ccttccttgt cccagcccta ctataaagag tagccggaac attggcagtg
      241 gccccacaag gctgcagatt gcactgaaca gaccagcaaa caaggtggtc ctcagtgaac
      301 tgaattgccc ttggtaagga tgcaggcctg tgtgctgtgg tggctggccc ttggcatgct
      361 gctggggatt cctgcaggag ccaagccaat gccagaggaa gcagatcccc acacacagcc
      421 accagctatg ccctactggc ctttctccac ctctgacttc tggaactacg tgcaatattt
      481 ccagacccag ggcgcctacc cacagatcga ggacatggcc agaaccttct ttgcacactt
      541 tcctctgggg agcaccctag gcttccatgt tccctaccag gaggattgag cagtgtctag
      601 tcttctgcct ccctggctgc actgcccggg gctgaaggta gttcagagac acggggggtg
      661 gggggagtgg agcacatgag caataaactc tctctgaagc tgcaaaaaaa aaaaaaaaaa
      721 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      781 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
