LOCUS       NM_020595               1042 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus otoraplin (Otor), mRNA.
ACCESSION   NM_020595
VERSION     NM_020595.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1042)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1042)
  AUTHORS   Bohnenpoll,T., Trowe,M.O., Wojahn,I., Taketo,M.M., Petry,M. and
            Kispert,A.
  TITLE     Canonical Wnt signaling regulates the proliferative expansion and
            differentiation of fibrocytes in the murine inner ear
  JOURNAL   Dev Biol 391 (1), 54-65 (2014)
   PUBMED   24727668
REFERENCE   3  (bases 1 to 1042)
  AUTHORS   Monks,D.C. and Morrow,B.E.
  TITLE     Identification of putative retinoic acid target genes downstream of
            mesenchymal Tbx1 during inner ear development
  JOURNAL   Dev Dyn 241 (3), 563-573 (2012)
   PUBMED   22275070
REFERENCE   4  (bases 1 to 1042)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (bases 1 to 1042)
  AUTHORS   Lin,S., Ikegami,M., Xu,Y., Bosserhoff,A.K., Malkinson,A.M. and
            Shannon,J.M.
  TITLE     Misexpression of MIA disrupts lung morphogenesis and causes
            neonatal death
  JOURNAL   Dev Biol 316 (2), 441-455 (2008)
   PUBMED   18342301
REFERENCE   6  (bases 1 to 1042)
  AUTHORS   Ficker,M., Powles,N., Warr,N., Pirvola,U. and Maconochie,M.
  TITLE     Analysis of genes from inner ear developmental-stage cDNA
            subtraction reveals molecular regionalization of the otic capsule
  JOURNAL   Dev Biol 268 (1), 7-23 (2004)
   PUBMED   15031101
REFERENCE   7  (bases 1 to 1042)
  AUTHORS   Moser,M., Bosserhoff,A.K., Hunziker,E.B., Sandell,L., Fassler,R.
            and Buettner,R.
  TITLE     Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient
            mice
  JOURNAL   Mol Cell Biol 22 (5), 1438-1445 (2002)
   PUBMED   11839810
REFERENCE   8  (bases 1 to 1042)
  AUTHORS   Rendtorff,N.D., Frodin,M., Attie-Bitach,T., Vekemans,M. and
            Tommerup,N.
  TITLE     Identification and characterization of an inner ear-expressed human
            melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent
            polymorphism that abolishes translation
  JOURNAL   Genomics 71 (1), 40-52 (2001)
   PUBMED   11161796
REFERENCE   9  (bases 1 to 1042)
  AUTHORS   Cohen-Salmon,M., Frenz,D., Liu,W., Verpy,E., Voegeling,S. and
            Petit,C.
  TITLE     Fdp, a new fibrocyte-derived protein related to MIA/CD-RAP, has an
            in vitro effect on the early differentiation of the inner ear
            mesenchyme
  JOURNAL   J Biol Chem 275 (51), 40036-40041 (2000)
   PUBMED   10998416
REFERENCE   10 (bases 1 to 1042)
  AUTHORS   Robertson,N.G., Heller,S., Lin,J.S., Resendes,B.L., Weremowicz,S.,
            Denis,C.S., Bell,A.M., Hudspeth,A.J. and Morton,C.C.
  TITLE     A novel conserved cochlear gene, OTOR: identification, expression
            analysis, and chromosomal mapping
  JOURNAL   Genomics 66 (3), 242-248 (2000)
   PUBMED   10873378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC139152.1 and AJ243939.1.
            
            On Jan 24, 2017 this sequence version replaced NM_020595.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ243939.1, AF243504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-837               BC139152.1         1-837
            838-1042            AJ243939.1         754-958
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 70.89 cM"
     gene            1..1042
                     /gene="Otor"
                     /gene_synonym="CDRAP; Fdp; MIA; MIAL"
                     /note="otoraplin"
                     /db_xref="GeneID:57329"
                     /db_xref="MGI:MGI:1888678"
     exon            1..222
                     /gene="Otor"
                     /gene_synonym="CDRAP; Fdp; MIA; MIAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..494
                     /gene="Otor"
                     /gene_synonym="CDRAP; Fdp; MIA; MIAL"
                     /note="melanoma inhibitory activity-like protein"
                     /codon_start=1
                     /product="otoraplin precursor"
                     /protein_id="NP_065620.1"
                     /db_xref="CCDS:CCDS16809.1"
                     /db_xref="GeneID:57329"
                     /db_xref="MGI:MGI:1888678"
                     /translation="MARILILLLGGLVVLCAGHGVFMDKLSSKKLCADEECVYTISLA
                     RAQEDYNAPDCRFIDVKKGQQIYVYSKLVTENGAGEFWAGSVYGDHQDEMGIVGYFPS
                     NLVKEQRVYQEATKEIPTTDIDFFCE"
     exon            223..362
                     /gene="Otor"
                     /gene_synonym="CDRAP; Fdp; MIA; MIAL"
                     /inference="alignment:Splign:2.1.0"
     exon            363..470
                     /gene="Otor"
                     /gene_synonym="CDRAP; Fdp; MIA; MIAL"
                     /inference="alignment:Splign:2.1.0"
     exon            471..1029
                     /gene="Otor"
                     /gene_synonym="CDRAP; Fdp; MIA; MIAL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggttggccc cttcctattg gctgggtatt tacccagaga gtcagctttc aaataaaaga
       61 acccttgaat caggcaaaga gtgctagtca aaacagcaag aaggaagatg gcaaggatat
      121 tgattctttt gcttgggggc cttgtggttc tatgtgccgg gcatggtgta tttatggata
      181 aactttcttc taagaagttg tgtgcggatg aggagtgtgt ctatactatt tctctggcaa
      241 gagcacagga agattacaat gccccagact gtaggttcat cgatgtcaag aaagggcagc
      301 agatctatgt ttactccaag ctggtaacag aaaacggagc tggagagttt tgggctggca
      361 gtgtttatgg tgaccaccag gatgagatgg gaattgtagg ttatttcccc agcaacttgg
      421 tgaaggagca gcgtgtatac caggaggcca ccaaggagat cccaaccacg gatattgact
      481 tcttctgtga ataagaaatt aattaaaaca gcagataaaa cagaaacacc agtgatgaag
      541 aagagaagaa gtggaaataa ctgaacctgt gtatctgtac cttcctggct ttatttggtg
      601 gcaggaggtt ggatcttgaa ggtgctaaga tatggaaatt gtcaactcag tcttgtttac
      661 tcttgccccg gtctttccac caactgcgac tacgtgctgt gtgaatcata taggtcattt
      721 ataacccaat acttagcttt cagcgaggag aatctttatt tactcagtga tgaacatata
      781 aggtgtttta tctgtagtta tttctaaatg gtcattctcc ccagctctga ctccatgtcc
      841 ttaagcttgc tgagttagaa gtctgacttt tgggtgtgtt ttctgttatt tgtctctctg
      901 gtcatgtgaa gtcttaataa tgtatttgtc atgataactt cctattgtta ctttttatat
      961 ctgatgccct tggatagaag aatgttaggt ataaaacaag tttttgtact cataaacatt
     1021 tggactatga aaaaaaaaaa aa
//
