LOCUS       NM_001347647            2391 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus otopetrin 3 (Otop3), transcript variant 2, mRNA.
ACCESSION   NM_001347647 XM_006534116
VERSION     NM_001347647.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2391)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2391)
  AUTHORS   Fujii,T., Shimizu,T., Kaji,Y., Katoh,M. and Sakai,H.
  TITLE     Activation of mouse Otop3 proton channels by Zn2
  JOURNAL   Biochem Biophys Res Commun 658, 55-61 (2023)
   PUBMED   37023615
REFERENCE   3  (bases 1 to 2391)
  AUTHORS   Tu,Y.H., Cooper,A.J., Teng,B., Chang,R.B., Artiga,D.J.,
            Turner,H.N., Mulhall,E.M., Ye,W., Smith,A.D. and Liman,E.R.
  TITLE     An evolutionarily conserved gene family encodes proton-selective
            ion channels
  JOURNAL   Science 359 (6379), 1047-1050 (2018)
   PUBMED   29371428
REFERENCE   4  (bases 1 to 2391)
  AUTHORS   Peng,Y., Shinde,D.N., Valencia,C.A., Mo,J.S., Rosenfeld,J., Truitt
            Cho,M., Chamberlin,A., Li,Z., Liu,J., Gui,B., Brockhage,R.,
            Basinger,A., Alvarez-Leon,B., Heydemann,P., Magoulas,P.L.,
            Lewis,A.M., Scaglia,F., Gril,S., Chong,S.C., Bower,M.,
            Monaghan,K.G., Willaert,R., Plona,M.R., Dineen,R., Milan,F.,
            Hoganson,G., Powis,Z., Helbig,K.L., Keller-Ramey,J., Harris,B.,
            Anderson,L.C., Green,T., Sukoff Rizzo,S.J., Kaylor,J., Chen,J.,
            Guan,M.X., Sellars,E., Sparagana,S.P., Gibson,J.B., Reinholdt,L.G.,
            Tang,S. and Huang,T.
  TITLE     Biallelic mutations in the ferredoxin reductase gene cause novel
            mitochondriopathy with optic atrophy
  JOURNAL   Hum Mol Genet 26 (24), 4937-4950 (2017)
   PUBMED   29040572
  REMARK    Erratum:[Hum Mol Genet. 2018 Jun 15;27(12):2224. doi:
            10.1093/hmg/ddy072.. PMID: 29554255]
REFERENCE   5  (bases 1 to 2391)
  AUTHORS   Hurle,B., Ignatova,E., Massironi,S.M., Mashimo,T., Rios,X.,
            Thalmann,I., Thalmann,R. and Ornitz,D.M.
  TITLE     Non-syndromic vestibular disorder with otoconial agenesis in
            tilted/mergulhador mice caused by mutations in otopetrin 1
  JOURNAL   Hum Mol Genet 12 (7), 777-789 (2003)
   PUBMED   12651873
REFERENCE   6  (bases 1 to 2391)
  AUTHORS   Kikkawa,Y., Shitara,H., Wakana,S., Kohara,Y., Takada,T.,
            Okamoto,M., Taya,C., Kamiya,K., Yoshikawa,Y., Tokano,H.,
            Kitamura,K., Shimizu,K., Wakabayashi,Y., Shiroishi,T., Kominami,R.
            and Yonekawa,H.
  TITLE     Mutations in a new scaffold protein Sans cause deafness in Jackson
            shaker mice
  JOURNAL   Hum Mol Genet 12 (5), 453-461 (2003)
   PUBMED   12588793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY136301.1, AB087505.1 and AK043266.1.
            
            On Dec 3, 2016 this sequence version replaced XM_006534116.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB087505.1, AK043266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BY136301.1         2-49
            49-876              AB087505.1         1-828
            877-909             AK043266.1         829-861
            910-2391            AB087505.1         862-2343
FEATURES             Location/Qualifiers
     source          1..2391
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.84 cM"
     gene            1..2391
                     /gene="Otop3"
                     /gene_synonym="2310011E08Rik"
                     /note="otopetrin 3"
                     /db_xref="GeneID:69602"
                     /db_xref="MGI:MGI:1916852"
     exon            1..172
                     /gene="Otop3"
                     /gene_synonym="2310011E08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1887
                     /gene="Otop3"
                     /gene_synonym="2310011E08Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     proton channel OTOP3"
                     /codon_start=1
                     /product="proton channel OTOP3 isoform 2"
                     /protein_id="NP_001334576.1"
                     /db_xref="CCDS:CCDS83926.1"
                     /db_xref="GeneID:69602"
                     /db_xref="MGI:MGI:1916852"
                     /translation="MASQTSAPAEPAPMPSPEAKTTEGASSYDQADMETKHAGSPCPP
                     KQKSWLARHFSLLLRRDRQAQKAGQLFSGLLALNVVFLGGAFICSMIFNKVSVTLGDV
                     WILLAALKVLSLLWLLYYTVGTTRKPHAVLYRDPHAGPIWVRGSLVLFGSCTVCLNIF
                     RMGYDVSHIHCKSEVELIFPAIEIVFMIIQTWVLWRHCKDCVQVQTNFTRCGLMLTLA
                     TNLLMWVLAVTNDSMHREIEAELDALMEKFSGNGTNTCMCLNTTVCEVFRKGYLMLYP
                     FSTEYCLICCAVLFVMWKNVSRSLAAHTGAHPNRSPFRLHGTIFGPLLGLLALVAGVC
                     VFVLFQIEASGPDIARQYFTLYYAFYVAVLPTMSLACLAGTAIHGLEERELDTLKNPT
                     RSLDVVLLMGAALGQMGIAYFSIVAIVATQPHELLNQLILAYSLLLILQHITQNLFII
                     EGLHRRPLWEPAVSGVMEKQDVELPRRGSLRELGQDLRRASRAYIHSFSHLNWKRRML
                     KEISLFLILCNITLWMMPAFGIHPEFENGLEKDFYGYRTWFTIVNFGLPLGVFYRMHS
                     VGGLVEVYLGA"
     exon            173..586
                     /gene="Otop3"
                     /gene_synonym="2310011E08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            587..723
                     /gene="Otop3"
                     /gene_synonym="2310011E08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            724..782
                     /gene="Otop3"
                     /gene_synonym="2310011E08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            783..901
                     /gene="Otop3"
                     /gene_synonym="2310011E08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1716
                     /gene="Otop3"
                     /gene_synonym="2310011E08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..2369
                     /gene="Otop3"
                     /gene_synonym="2310011E08Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcgatgggc cttggagccc gagcggcgac tgcgcagtct cgcggggggg tcggagggag
       61 gaaagggcgt cgaggcatct gtctcaaggc acctgggacc ttaccaagac ggaggatccg
      121 cgctgcaacc caagaggtgg ggagcccgcg accatggctt cgcagacttc agcccctgct
      181 gagcctgcac ccatgccttc tccagaagca aagaccactg agggagcatc ctcctatgac
      241 caagcagaca tggagactaa gcatgcgggg tccccatgcc ccccgaagca gaagtcctgg
      301 ctggctcggc atttctccct gctgttgcgg agagaccgac aggcccagaa ggccgggcag
      361 ctcttctccg ggctcctggc tctcaatgtg gtattcctgg gtggggcttt tatctgtagc
      421 atgatattca acaaggtgtc tgtcactctg ggggacgtgt ggatcctgct ggctgcactg
      481 aaggtcctct ccctgttgtg gctcctctac tacacagtgg gtaccacccg gaagccccac
      541 gcagtcctgt accgtgatcc ccacgcggga cccatctggg tgaggggctc cctggtgctc
      601 ttcggcagct gtaccgtctg cctgaacata tttcgaatgg gttatgacgt gagccacatt
      661 cactgcaagt cagaagtgga actcatcttt ccggccattg agattgtctt tatgattatt
      721 cagacatggg tgctctggag acactgtaag gactgtgttc aggtgcagac caacttcacc
      781 aggtgtggac tcatgctgac tctggccaca aacttgctga tgtgggtttt ggctgtgacc
      841 aatgactcca tgcaccgtga gattgaggct gagctcgacg ccctcatgga gaagttctca
      901 ggtaacggga ccaacacttg catgtgcctc aacaccacag tgtgcgaggt cttccggaag
      961 ggctatctga tgctctaccc cttcagcact gagtactgcc tcatctgctg tgctgtgctc
     1021 ttcgtcatgt ggaagaacgt gagccgcagc ctggcagccc acacaggtgc ccatcccaac
     1081 agatcaccct tccgcctgca cgggaccatc tttgggccac tgctgggcct tttggcactg
     1141 gtggctggcg tatgtgtctt tgtgctcttc caaatcgaag cgagtggccc tgacatagcc
     1201 cgccagtact tcaccctcta ctatgcgttc tatgtggctg tgctgcccac catgagcctg
     1261 gcgtgcctgg ctggtacagc catccatggg ctggaggagc gcgaattgga cacgctcaaa
     1321 aaccccacac gcagcctgga tgtggtgctg ttgatgggcg ctgcactggg ccagatgggc
     1381 atcgcctact tctccatcgt ggctatcgtg gccacccagc cgcacgagct actcaaccag
     1441 cttatcctgg cctactcact gctgctaatc ctgcagcaca tcactcagaa tctcttcatc
     1501 atcgagggcc tgcaccgccg ccccctctgg gagcctgcgg tctcaggtgt gatggagaag
     1561 caggatgttg agctaccccg cagaggctcc ctgcgggagc tgggtcagga cctacggaga
     1621 gcctcaaggg cctacatcca ctccttcagc cacctcaact ggaaacgcag gatgctcaag
     1681 gagatctctc tcttcctcat cctctgcaac atcacactgt ggatgatgcc cgccttcggc
     1741 atacacccag agtttgagaa cgggctggaa aaggattttt acggctacag gacctggttc
     1801 accattgtta acttcggcct gcccctgggt gtgttctacc gcatgcactc tgtcgggggg
     1861 ctggtggagg tctacctggg ggcctgagtg cccgaggaac ccagccacag cggaaccccg
     1921 aaagtgccaa ggcagaaaaa gaaactcggg agtatctggg cagacacgtc gcatcaagag
     1981 gtgcagaaac ctgcctgggg ttcccaaagt gacctatcct caacctgact gaggaggaga
     2041 ggatactgcc tggagctcaa aaccaagggt ggggcttgga aactgagcct cttgacaaca
     2101 ggccaaggat gtaccccggg tggctgccaa aggctgtgag ggtcagtatg aaattgtggc
     2161 gtctgggggc tggaagaggt tgagtccttc tgtgggacat cctagaagct cagaactcca
     2221 actgagagct caaaccccag cactccaagc ttggcaggca gccctgccca tctccccaca
     2281 cgcccatctc ctaatgagct cattcattag ctgccaggca gggcccaaca actctttccg
     2341 gcttccataa accctgtttg tttgatcgaa aaaaaaaaaa aaaaaaaaaa a
//
