LOCUS       NM_001362400            2327 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus otopetrin 2 (Otop2), transcript variant 2, mRNA.
ACCESSION   NM_001362400 XM_006533256
VERSION     NM_001362400.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2327)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2327)
  AUTHORS   Slone,J.D., Yang,L., Peng,Y., Queme,L.F., Harris,B., Rizzo,S.J.S.,
            Green,T., Ryan,J.L., Jankowski,M.P., Reinholdt,L.G. and Huang,T.
  TITLE     Integrated analysis of the molecular pathogenesis of
            FDXR-associated disease
  JOURNAL   Cell Death Dis 11 (6), 423 (2020)
   PUBMED   32499495
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2327)
  AUTHORS   Yang,L., Slone,J., Zou,W., Queme,L.F., Jankowski,M.P., Yin,F. and
            Huang,T.
  TITLE     Systemic Delivery of AAV-Fdxr Mitigates the Phenotypes of
            Mitochondrial Disorders in Fdxr Mutant Mice
  JOURNAL   Mol Ther Methods Clin Dev 18, 84-97 (2020)
   PUBMED   32995353
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2327)
  AUTHORS   Slone,J., Peng,Y., Chamberlin,A., Harris,B., Kaylor,J.,
            McDonald,M.T., Lemmon,M., El-Dairi,M.A., Tchapyjnikov,D.,
            Gonzalez-Krellwitz,L.A., Sellars,E.A., McConkie-Rosell,A.,
            Reinholdt,L.G. and Huang,T.
  TITLE     Biallelic mutations in FDXR cause neurodegeneration associated with
            inflammation
  JOURNAL   J Hum Genet 63 (12), 1211-1222 (2018)
   PUBMED   30250212
REFERENCE   5  (bases 1 to 2327)
  AUTHORS   Tu,Y.H., Cooper,A.J., Teng,B., Chang,R.B., Artiga,D.J.,
            Turner,H.N., Mulhall,E.M., Ye,W., Smith,A.D. and Liman,E.R.
  TITLE     An evolutionarily conserved gene family encodes proton-selective
            ion channels
  JOURNAL   Science 359 (6379), 1047-1050 (2018)
   PUBMED   29371428
REFERENCE   6  (bases 1 to 2327)
  AUTHORS   Peng,Y., Shinde,D.N., Valencia,C.A., Mo,J.S., Rosenfeld,J., Truitt
            Cho,M., Chamberlin,A., Li,Z., Liu,J., Gui,B., Brockhage,R.,
            Basinger,A., Alvarez-Leon,B., Heydemann,P., Magoulas,P.L.,
            Lewis,A.M., Scaglia,F., Gril,S., Chong,S.C., Bower,M.,
            Monaghan,K.G., Willaert,R., Plona,M.R., Dineen,R., Milan,F.,
            Hoganson,G., Powis,Z., Helbig,K.L., Keller-Ramey,J., Harris,B.,
            Anderson,L.C., Green,T., Sukoff Rizzo,S.J., Kaylor,J., Chen,J.,
            Guan,M.X., Sellars,E., Sparagana,S.P., Gibson,J.B., Reinholdt,L.G.,
            Tang,S. and Huang,T.
  TITLE     Biallelic mutations in the ferredoxin reductase gene cause novel
            mitochondriopathy with optic atrophy
  JOURNAL   Hum Mol Genet 26 (24), 4937-4950 (2017)
   PUBMED   29040572
  REMARK    Erratum:[Hum Mol Genet. 2018 Jun 15;27(12):2224. doi:
            10.1093/hmg/ddy072.. PMID: 29554255]
REFERENCE   7  (bases 1 to 2327)
  AUTHORS   Fairfield,H., Srivastava,A., Ananda,G., Liu,R., Kircher,M.,
            Lakshminarayana,A., Harris,B.S., Karst,S.Y., Dionne,L.A.,
            Kane,C.C., Curtain,M., Berry,M.L., Ward-Bailey,P.F., Greenstein,I.,
            Byers,C., Czechanski,A., Sharp,J., Palmer,K., Gudis,P., Martin,W.,
            Tadenev,A., Bogdanik,L., Pratt,C.H., Chang,B., Schroeder,D.G.,
            Cox,G.A., Cliften,P., Milbrandt,J., Murray,S., Burgess,R.,
            Bergstrom,D.E., Donahue,L.R., Hamamy,H., Masri,A., Santoni,F.A.,
            Makrythanasis,P., Antonarakis,S.E., Shendure,J. and Reinholdt,L.G.
  TITLE     Exome sequencing reveals pathogenic mutations in 91 strains of mice
            with Mendelian disorders
  JOURNAL   Genome Res 25 (7), 948-957 (2015)
   PUBMED   25917818
REFERENCE   8  (bases 1 to 2327)
  AUTHORS   Hurle,B., Ignatova,E., Massironi,S.M., Mashimo,T., Rios,X.,
            Thalmann,I., Thalmann,R. and Ornitz,D.M.
  TITLE     Non-syndromic vestibular disorder with otoconial agenesis in
            tilted/mergulhador mice caused by mutations in otopetrin 1
  JOURNAL   Hum Mol Genet 12 (7), 777-789 (2003)
   PUBMED   12651873
REFERENCE   9  (bases 1 to 2327)
  AUTHORS   Kikkawa,Y., Shitara,H., Wakana,S., Kohara,Y., Takada,T.,
            Okamoto,M., Taya,C., Kamiya,K., Yoshikawa,Y., Tokano,H.,
            Kitamura,K., Shimizu,K., Wakabayashi,Y., Shiroishi,T., Kominami,R.
            and Yonekawa,H.
  TITLE     Mutations in a new scaffold protein Sans cause deafness in Jackson
            shaker mice
  JOURNAL   Hum Mol Genet 12 (5), 453-461 (2003)
   PUBMED   12588793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY004328.1 and AB087504.1.
            
            On Apr 14, 2018 this sequence version replaced XM_006533256.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB087504.1, AK028866.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164131, SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                BY004328.1         2-93
            93-2327             AB087504.1         1-2235
FEATURES             Location/Qualifiers
     source          1..2327
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.84 cM"
     gene            1..2327
                     /gene="Otop2"
                     /gene_synonym="4732464P15"
                     /note="otopetrin 2"
                     /db_xref="GeneID:237987"
                     /db_xref="MGI:MGI:2388365"
     exon            1..92
                     /gene="Otop2"
                     /gene_synonym="4732464P15"
                     /inference="alignment:Splign:2.1.0"
     exon            93..269
                     /gene="Otop2"
                     /gene_synonym="4732464P15"
                     /inference="alignment:Splign:2.1.0"
     exon            270..615
                     /gene="Otop2"
                     /gene_synonym="4732464P15"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..1994
                     /gene="Otop2"
                     /gene_synonym="4732464P15"
                     /codon_start=1
                     /product="proton channel OTOP2"
                     /protein_id="NP_001349329.1"
                     /db_xref="CCDS:CCDS25628.1"
                     /db_xref="GeneID:237987"
                     /db_xref="MGI:MGI:2388365"
                     /translation="MSEELVPHPNESLPGPRASPREVWKKGGRLLSVLLAVNVLLLAC
                     TLISGGAFNKVAVYDTDVFALLTTMMLLAALWIVFYLLRTARCPDAVPYRDAHAGPIW
                     LRGGLVLFGICTLVMDVFKTGYYSSFFECQSAIKILHPIIQAVFVIVQTYFLWISAKD
                     CIHTHLDLTRCGLMFTLATNLAIWMAAVVDESVHQAHSYSGSHGNTSHTRLNPDSKRA
                     GGAAEEDPCLCSTAICQIFQQGYFYLYPFNIEYSLFASTMLYVMWKNVGRLLASTHGH
                     GHTPSRVSLFRETFFAGPVLGLLLFVVGLAVFILYEVQVSGERGHTRQALVIYYSFNI
                     VCLGLMTLVSLSGSVIYRFDRRAMDHHKNPTRTLDVALLMGAALGQYAISYYSIVAVV
                     VGSPRDLQGALNLSHALLMIAQHTFQNVFIIESLHRGPPGAEPREMPPKEPCQGITFA
                     NLDAIRTLPSCPPTPRLVIPNLESPQEAVAIISAPRCHWRRRCLKDISLFLLLCNVIL
                     WIMPAFGARPHFSNTVEVDFYGYSLWAAIVNICLPFGIFYRMHAVSSLLEVYVLS"
     exon            616..752
                     /gene="Otop2"
                     /gene_synonym="4732464P15"
                     /inference="alignment:Splign:2.1.0"
     exon            753..811
                     /gene="Otop2"
                     /gene_synonym="4732464P15"
                     /inference="alignment:Splign:2.1.0"
     exon            812..945
                     /gene="Otop2"
                     /gene_synonym="4732464P15"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1823
                     /gene="Otop2"
                     /gene_synonym="4732464P15"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..2312
                     /gene="Otop2"
                     /gene_synonym="4732464P15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggaacca gactttgcag catccaacca gcatctctgg gcagcagtag tagggataca
       61 ggaagaccga attcggatca ctctgagggc agctcggaga aaagatggat catgtgagtg
      121 ggactgagag gtttatggag ccgaactctt gtggctgtaa atcactctgc cctctccggt
      181 ataaagcacc ggtccagccc ggcgtgggag agaggagacg cttgctgccc cttgaccccc
      241 aacttggtgt cggctcccgg tgcagccagt gatcccttca acctcctcca gtcgccccca
      301 ccatgtcgga ggaactggtc ccgcatccca atgagagcct gccggggcct cgggccagcc
      361 cccgtgaggt gtggaaaaag ggcggccgcc tgctgtcggt gctgttggct gtcaacgtgc
      421 tgctgctcgc ctgcacgctc atcagcggcg gtgccttcaa caaggtggcg gtgtatgaca
      481 cggacgtgtt cgctctgctc accaccatga tgctgctggc cgcgctatgg atagtcttct
      541 acctcctccg caccgctcgc tgtccagacg cggtgcctta ccgggatgct catgctggtc
      601 ccatctggct ccgaggtggg ctggtgctgt ttggaatctg cacccttgtc atggatgtct
      661 tcaagactgg ctactattcc agtttctttg agtgccagtc ggccatcaag atcctgcacc
      721 ccatcatcca agccgtgttt gtcattgtcc agacttactt tctctggatc tccgctaaag
      781 actgtatcca tacccacctg gacctgaccc ggtgtgggct catgttcacc ctcgccacca
      841 acctcgccat ctggatggca gccgtagtgg atgagtccgt gcaccaggcc cactcctaca
      901 gtggttccca tggcaacacc agccacaccc gcctcaaccc tgactcaaag cgtgcaggag
      961 gtgcagctga agaagacccg tgcctctgca gcacagccat ctgtcagatc ttccagcaag
     1021 gctatttcta cctgtatccc ttcaacatcg agtacagcct ctttgcttcc accatgctgt
     1081 atgtcatgtg gaagaatgtg ggaaggctgc tcgcctccac ccacggccac ggccacacac
     1141 cgtccagggt cagcctgttc cgggagacct tctttgccgg cccagtcttg ggcctgctcc
     1201 tctttgtggt ggggttggct gtcttcatcc tttatgaggt ccaggtgagt ggagagagag
     1261 gccacacccg acaggccctg gtcatctact acagctttaa cattgtctgt ctggggctca
     1321 tgactctggt cagcctgagt ggttcagtca tctatcgttt tgaccgtcgg gccatggacc
     1381 atcataagaa cccgacacgg accctggatg tggccctgct aatgggcgcc gccctgggcc
     1441 aatacgctat ctcctactac tctatcgtgg ctgtggtggt gggctctccc agagacctgc
     1501 agggggcgct caacctgtcc cacgctctac tcatgatcgc tcagcacacc ttccagaatg
     1561 tcttcatcat tgagagcctc catcggggac ctcctggggc tgagcctcgt gaaatgcccc
     1621 ccaaggagcc ctgccaaggc atcacctttg ctaacctgga tgctatccgc accttgcctt
     1681 cctgtccacc cacccccagg ctggtcattc ccaacctaga aagtcctcag gaagcagtgg
     1741 ctatcatctc ggcccccagg tgccactggc gacgtcggtg cctgaaagac atctctctgt
     1801 ttctcctgct ctgtaacgtc atcctgtgga tcatgcctgc ctttggcgct cgcccgcact
     1861 tcagcaatac cgtggaggtg gacttttacg gttactccct ctgggcggcc atcgtcaaca
     1921 tctgcctacc ttttggcatc ttctaccgaa tgcacgctgt ctccagtcta ctggaggtct
     1981 atgtactgtc ctgaagctcc acagagagac agagcagagg aactccagca cctggaagtg
     2041 aatcaggctg gcactagctc cctgcctgcc ccagactaga attttcacta aagtttattt
     2101 ttccaggatg agtttttaaa gtcaaaatca agacataccc atttattcct gcatgaccct
     2161 ggagcctcgg gagacggagg cagggaaact gttccctgca gaatccccta ggaccagaca
     2221 ggatcaggaa ataccatctc tgactctatc tctaattcca gccacatggc ctgtgtactc
     2281 tctggagatg agaccaataa acctgcaagc aaaaaaaaaa aaaaaaa
//
