LOCUS       NM_001018031            2161 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus otolin 1 (Otol1), mRNA.
ACCESSION   NM_001018031 XM_143327
VERSION     NM_001018031.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2161)
  AUTHORS   Goodrich,E.J. and Deans,M.R.
  TITLE     Emx2 lineage tracing reveals antecedent patterns of planar polarity
            in the mouse inner ear
  JOURNAL   Development 151 (10) (2024)
   PUBMED   38682291
REFERENCE   2  (bases 1 to 2161)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2161)
  AUTHORS   Holubowicz,R., Wojtas,M., Taube,M., Kozak,M., Ozyhar,A. and
            Dobryszycki,P.
  TITLE     Effect of calcium ions on structure and stability of the C1q-like
            domain of otolin-1 from human and zebrafish
  JOURNAL   FEBS J 284 (24), 4278-4297 (2017)
   PUBMED   29076638
REFERENCE   4  (bases 1 to 2161)
  AUTHORS   Xu,Y., Zhang,Y. and Lundberg,Y.W.
  TITLE     Spatiotemporal differences in otoconial gene expression
  JOURNAL   Genesis 54 (12), 613-625 (2016)
   PUBMED   27792272
REFERENCE   5  (bases 1 to 2161)
  AUTHORS   Moreland,K.T., Hong,M., Lu,W., Rowley,C.W., Ornitz,D.M., De
            Yoreo,J.J. and Thalmann,R.
  TITLE     In vitro calcite crystal morphology is modulated by otoconial
            proteins otolin-1 and otoconin-90
  JOURNAL   PLoS One 9 (4), e95333 (2014)
   PUBMED   24748133
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2161)
  AUTHORS   Andrade,L.R., Lins,U., Farina,M., Kachar,B. and Thalmann,R.
  TITLE     Immunogold TEM of otoconin 90 and otolin - relevance to
            mineralization of otoconia, and pathogenesis of benign positional
            vertigo
  JOURNAL   Hear Res 292 (1-2), 14-25 (2012)
   PUBMED   22841569
  REMARK    GeneRIF: Report otoconin 90 is attached to a scaffold consisting of
            the hexagonal fibrillar meshwork, characteristic of otolin, in the
            otoconia.
REFERENCE   7  (bases 1 to 2161)
  AUTHORS   Yang,H., Zhao,X., Xu,Y., Wang,L., He,Q. and Lundberg,Y.W.
  TITLE     Matrix recruitment and calcium sequestration for spatial specific
            otoconia development
  JOURNAL   PLoS One 6 (5), e20498 (2011)
   PUBMED   21655225
REFERENCE   8  (bases 1 to 2161)
  AUTHORS   Deans,M.R., Peterson,J.M. and Wong,G.W.
  TITLE     Mammalian Otolin: a multimeric glycoprotein specific to the inner
            ear that interacts with otoconial matrix protein Otoconin-90 and
            Cerebellin-1
  JOURNAL   PLoS One 5 (9), e12765 (2010)
   PUBMED   20856818
  REMARK    GeneRIF: Otolin 1 interacts with otoconial matrix protein
            Otoconin-90 and Cerebellin-1 in the inner ear.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2161)
  AUTHORS   Marino,G., Fernandez,A.F., Cabrera,S., Lundberg,Y.W.,
            Cabanillas,R., Rodriguez,F., Salvador-Montoliu,N., Vega,J.A.,
            Germana,A., Fueyo,A., Freije,J.M. and Lopez-Otin,C.
  TITLE     Autophagy is essential for mouse sense of balance
  JOURNAL   J Clin Invest 120 (7), 2331-2344 (2010)
   PUBMED   20577052
REFERENCE   10 (bases 1 to 2161)
  AUTHORS   Murayama,E., Herbomel,P., Kawakami,A., Takeda,H. and Nagasawa,H.
  TITLE     Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal
            otolith growth and their correct anchoring onto the sensory maculae
  JOURNAL   Mech Dev 122 (6), 791-803 (2005)
   PUBMED   15905077
  REMARK    GeneRIF: Identification and functional characterization of a
            similar protein in zebrafish.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140315.3, BC150904.1 and AK158454.1.
            
            On Oct 1, 2009 this sequence version replaced NM_001018031.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ002405.2, AK158454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC140315.3         154275-154380
            107-2044            BC150904.1         1-1938
            2045-2157           AK158454.1         1984-2096
            2158-2161           AC140315.3         175367-175370
FEATURES             Location/Qualifiers
     source          1..2161
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 32.41 cM"
     gene            1..2161
                     /gene="Otol1"
                     /gene_synonym="Gm414"
                     /note="otolin 1"
                     /db_xref="GeneID:229389"
                     /db_xref="MGI:MGI:2685260"
     exon            1..121
                     /gene="Otol1"
                     /gene_synonym="Gm414"
                     /inference="alignment:Splign:2.1.0"
     exon            122..517
                     /gene="Otol1"
                     /gene_synonym="Gm414"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1578
                     /gene="Otol1"
                     /gene_synonym="Gm414"
                     /note="otolin 1 homolog"
                     /codon_start=1
                     /product="otolin-1 precursor"
                     /protein_id="NP_001018041.2"
                     /db_xref="CCDS:CCDS17409.1"
                     /db_xref="GeneID:229389"
                     /db_xref="MGI:MGI:2685260"
                     /translation="MWIFSSLCAVLTILAMDDVATEAKTTPYTKFTKKSEGKEMLKGL
                     KPSSGFFLDGEETVHTETAAMAEPTTGSPALAMAESTAGPSASATTRLLPFESFSLDT
                     TGFVLNCCHCCSFVTGQKGEPGKMGKQGPKGETGDTGSPGHPGTTGPQGPKGQKGEKG
                     LKGDRGDQGAGGIPGYPGKPGEQGALGPKGDKGTIGPAGTKGQKGSKGELCGNGTKGE
                     KGDPGASGAHGFIGEPGAKGEKGGVGEKGYRGDLGERGEKGQKGEKGMEGEKGSRGDV
                     GSEGKRGSDGLPGLRGDSGPKGEKGEIGSPGFTGPAGPKGELGSKGVRGPTGKKGSRG
                     VKGSKGEATQVPQSAFSALLSKPFPPPNVPIKFDKILSNDQGDYSPVTGKFNCSVPGT
                     YIFSYHVTVRGRPARISLVARNRKQFKSRETLYGQQVDQASLLLILKLSAGDQVWLEV
                     SKDWNGLYVGPEDDSIFSGFLLYPEETFSKSP"
     exon            518..607
                     /gene="Otol1"
                     /gene_synonym="Gm414"
                     /inference="alignment:Splign:2.1.0"
     exon            608..679
                     /gene="Otol1"
                     /gene_synonym="Gm414"
                     /inference="alignment:Splign:2.1.0"
     exon            680..2161
                     /gene="Otol1"
                     /gene_synonym="Gm414"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcattgg gtaagggcaa acctcggaag aaagaaatca gacccttgtc taatgacaaa
       61 tgaaattgaa tctgtcagtg ctgtccagga gaaggattgg cgataaggga acacccataa
      121 gcctcgaata tgtggatatt ttcttcgctt tgtgctgttt taactatttt ggctatggat
      181 gatgtggcca cagaagcaaa gaccacacca tacaccaaat ttacgaagaa atctgaagga
      241 aaagagatgt tgaagggctt aaagccgtcc agtggcttct ttctggatgg agaagaaacc
      301 gtccatacgg aaacggctgc catggcagag cccaccaccg gctcccctgc cttggcaatg
      361 gctgagtcca ccgcaggccc ctcggcctct gccacaaccc gtctccttcc cttcgagagc
      421 ttctctctgg acacaactgg tttcgttttg aattgctgcc attgttgttc atttgtcact
      481 gggcagaaag gagaacccgg aaagatggga aaacaaggcc ctaaaggaga gactggtgac
      541 actggcagcc caggacaccc aggaaccact ggacctcaag gtcccaaagg ccagaaagga
      601 gagaaaggac taaagggaga ccggggggac caaggagcag gtggcattcc ggggtaccca
      661 ggaaaaccag gagagcaagg tgcacttggt cccaagggag ataaaggaac catcggcccg
      721 gcaggaacga aaggacaaaa aggctctaag ggagaactgt gtgggaatgg cactaaagga
      781 gagaaagggg accctggggc ctctggggcc catggcttca ttggagagcc tggggccaag
      841 ggcgagaagg gtggtgttgg ggagaaaggc taccgaggag atttggggga aaggggagaa
      901 aaggggcaga aaggcgagaa agggatggag ggagagaaag gtagcagagg agatgttggg
      961 tcagaaggca aaaggggttc agatggtcta ccagggctca gaggcgattc tggtcctaaa
     1021 ggagaaaaag gagagatagg ttctcctggt ttcaccggac ctgcgggacc aaagggtgag
     1081 cttggaagca aaggtgttcg agggccaaca gggaagaagg gctctcgggg tgtcaagggt
     1141 tccaaaggcg aggccacaca agtcccacag tcggctttca gtgccctttt atccaagccc
     1201 ttccctcccc ccaacgttcc catcaagttt gacaagattc tctctaatga ccaaggggat
     1261 tacagccccg tcactgggaa atttaactgt agtgttcctg ggacatacat attttcctat
     1321 catgtcactg tcaggggtcg acctgctcgg atcagcctcg tggcccgcaa caggaagcag
     1381 ttcaaatcca gagagacgct ctatggtcag caagtagatc aggcctccct cctcctcatt
     1441 ctgaaattga gtgcaggaga tcaagtgtgg ctggaagtgt caaaggactg gaatgggctg
     1501 tatgtcggcc ccgaggatga cagcatcttt agtgggttcc ttctgtaccc agaggaaact
     1561 tttagtaagt caccataaat ttgggctttg gacactgtac ttctgattta ttctattaac
     1621 ctggagtaaa gctcttataa actttgattt ttttcatgat tatagataca atactgaaac
     1681 attttaaaaa atatccagca tagtgtcaac tattcctatt tcaaacatct ccattgaaat
     1741 atttatatgt atttgagaat ctgtatattg tttgtagcta acatttttca ttgagcattt
     1801 aatggcatta ctgattccat ttaaggaatt aataatgaca acattcgaag ctatgaatga
     1861 gacttatgat taataagtaa ttgtgtggtg gtttgaataa gaatggcacc cagaggttca
     1921 aatatatttt aatatttggt tgcagggagt tgaactgttt gaaaggatta ggaggtgtgg
     1981 ccttattgga ataggagtgg cttttttgga ggaagtgtgt ctctaggggt gggctttgag
     2041 gtttcaaagt ttatatatca ggtcctcctt cttgatttgg atatagagct tcctaccatg
     2101 atggtcatat actctactat tctctggaac catgagcccc aaattaaata cttgctaagg
     2161 g
//
